{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:25:24Z","timestamp":1790799924958,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"],"award-info":[{"award-number":["FAPEMA EDITAL BM-01425\/20 and FAPEMA UNIVERSAL-00944\/18"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-024-05582-w","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T01:02:54Z","timestamp":1709946174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of articaine anesthesia with needle-free\/Comfort-in method and conventional needle injection in dental patients with irreversible pulpitis: a randomized clinical trial"],"prefix":"10.1007","volume":"28","author":[{"given":"Amanda Palmeira Arruda","family":"Nogueira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meire Coelho","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia de Castro Rizzi","family":"MAIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna La\u00eds Lins","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etevaldo Maia","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrene Piazera","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Gavini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Grazziotin-Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceci Nunes","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,9]]},"reference":[{"key":"5582_CR1","doi-asserted-by":"publisher","unstructured":"Zanini M, Meyer E, Simon S (2017) Pulp Inflammation Diagnosis from Clinical to Inflammatory Mediators: A Systematic Review. J Endod. 2017;43(7):1033\u20131051. https:\/\/doi.org\/10.1016\/j.joen.2017.02.009","DOI":"10.1016\/j.joen.2017.02.009"},{"issue":"9","key":"5582_CR2","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.joen.2021.07.004","volume":"47","author":"O Erdogan","year":"2021","unstructured":"Erdogan O, Malek M, Gibbs JL (2021) Associations between Pain Severity, Clinical findings, and Endodontic Disease: a cross-sectional study. J Endod 47(9):1376\u20131382. https:\/\/doi.org\/10.1016\/j.joen.2021.07.004","journal-title":"J Endod"},{"key":"5582_CR3","volume-title":"Cohen`s pathways of the pulp","author":"AF Fouad","year":"2020","unstructured":"Fouad AF, Levin LG (2020) Pulp reactions to Caries and Dental procedures. In: Berman LH, Hargreaves KM, Rotstein I (eds) Cohen`s pathways of the pulp, 12th edn. St Lous, Missouri, USA. Chapter 14. pg. 557. 2021.","edition":"12"},{"key":"5582_CR4","doi-asserted-by":"publisher","unstructured":"Ogle OE, Mahjoubi G (2012) Local anesthesia: agents, techniques, and complications. Dent Clin North Am. 2012;56(1):133\u2009\u2013\u200948. https:\/\/doi.org\/10.1016\/j.cden.2011.08.003","DOI":"10.1016\/j.cden.2011.08.003"},{"issue":"Suppl 4","key":"5582_CR5","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/iej.13697","volume":"55","author":"M Parirokh","year":"2022","unstructured":"Parirokh M, Abbott PV (2022) Present status and future directions-mechanisms and management of local anaesthetic failures. Int Endodontic J - IEJ 55(Suppl 4):951\u2013994. https:\/\/doi.org\/10.1111\/iej.13697","journal-title":"Int Endodontic J - IEJ"},{"key":"5582_CR6","doi-asserted-by":"publisher","unstructured":"Guimaraes CC, Lopes Motta RH, Bergamaschi CC, Ara\u00fajo JO, Andrade NK, Figueir\u00f3 MF, Ramacciato JC, Lopes LC (2017) Local anaesthetics combined with vasoconstrictors in patients with cardiovascular disease undergoing dental procedures: systematic review and meta-analysis protocol. BMJ Open. 2017;7(11). https:\/\/doi.org\/10.1136\/bmjopen-2020-044357","DOI":"10.1136\/bmjopen-2020-044357"},{"issue":"2018","key":"5582_CR7","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jobcr.2018.04.001","volume":"8","author":"R Gupta","year":"2018","unstructured":"Gupta R, Kaur S, Dahiya P, Kumar M (2018) Comparative evaluation of efficacy of EMLA and needleless jet anesthesia in non-surgical periodontal therapy. J Oral Biology Craniofac Res 8(2018):118\u2013121. https:\/\/doi.org\/10.1016\/j.jobcr.2018.04.001","journal-title":"J Oral Biology Craniofac Res"},{"key":"5582_CR8","doi-asserted-by":"publisher","unstructured":"Capetillo J, Drum M, Reader A, Fowler S, Nusstein J, Beck (2019) Anesthetic Efficacy of Intranasal 3% Tetracaine plus 0.05% Oxymetazoline (Kovanaze) in Maxillary Teeth. J Endod. 2019;45(3):257\u2013262. https:\/\/doi.org\/10.1016\/j.joen.2018.12.003","DOI":"10.1016\/j.joen.2018.12.003"},{"key":"5582_CR9","doi-asserted-by":"publisher","unstructured":"Y\u0131ld\u0131r\u0131m S, Toku\u00e7 M, Ayd\u0131n MN (2020) The effect of pre-anesthesia with a needle-free system versus topical anesthesia on injection pain of the inferior alveolar nerve block: a randomized clinical trial. Clin Oral Invest, May 2020. https:\/\/doi.org\/10.1007\/s00784-020-03301-9","DOI":"10.1007\/s00784-020-03301-9"},{"issue":"1","key":"5582_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12871-021-01524-1","volume":"21","author":"H Altan","year":"2021","unstructured":"Altan H, Belevcikli M, Co\u015fgun A, Demir O (2021) Comparative evaluation of pain perception with a new needle-free system and dental needle method in children: a randomized clinical trial. BMC Anesthesiol 21(1):301. https:\/\/doi.org\/10.1186\/s12871-021-01524-1","journal-title":"BMC Anesthesiol"},{"issue":"1","key":"5582_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.17245\/jdapm.2023.23.1.1","volume":"23","author":"M Belevcikli","year":"2023","unstructured":"Belevcikli M, Altan H, Demir O (2023) Effect of the new needle-free injection system on pain perception and dental anxiety during anesthesia: randomized controlled split-mouth study. J Dent Anesth pain Med 23(1):1\u20138. https:\/\/doi.org\/10.17245\/jdapm.2023.23.1.1","journal-title":"J Dent Anesth pain Med"},{"key":"5582_CR12","doi-asserted-by":"publisher","unstructured":"Oliveira ACA, Amorim KS, Nascimento EMJ, Duarte ACB, Groppo FC, Takeshita WM, Souza LMA (2019) Assessment of anesthetic properties and pain during needleless jet injection anesthesia: a randomized clinical trial. J Appl Oral Sci. 2019. https:\/\/doi.org\/10.1590\/1678-7757-2018-0195","DOI":"10.1590\/1678-7757-2018-0195"},{"key":"5582_CR13","doi-asserted-by":"publisher","unstructured":"Robertson D, Nusstein J, Reader A, Beck M, McCartney M (2007) The anesthetic efficacy of articaine in buccal infiltration of mandibular posterior teeth. JADA, Vol. 138 August 2007. https:\/\/doi.org\/10.14219\/jada.archive.2007.0324","DOI":"10.14219\/jada.archive.2007.0324"},{"key":"5582_CR14","doi-asserted-by":"publisher","unstructured":"Jaber A, Whitworth JM, Corbett IP, Al-Baqshi B, Kanaa MD, Meechan JG (2010) The efficacy of infiltration anaesthesia for adult mandibular incisors: a randomised double-blind cross-over trial comparing articaine and lidocaine buccal and buccal plus lingual infiltrations. Br Dent J. 2010;209(9):E16. https:\/\/doi.org\/10.1038\/sj.bdj.2010.974","DOI":"10.1038\/sj.bdj.2010.974"},{"key":"5582_CR15","doi-asserted-by":"publisher","unstructured":"Nagendrababu HF, Duncan J, Whitworth MH, Nekoofar SJ, Pulikkotil1 SK, Veettil PMH (2020) Dummer. Is articaine more effective than lidocaine in patients with irreversible pulpitis? An umbrela review. International Endodontic Journal, 53, 200\u2013213, 2020. https:\/\/doi.org\/10.1111\/iej.13215","DOI":"10.1111\/iej.13215"},{"key":"5582_CR16","doi-asserted-by":"publisher","unstructured":"Pope RLE, Brown AM (2020) A primer on tissue pH and local anesthetic potency. Adv Physiol Educ 44: 305\u2013308, 2020. https:\/\/doi.org\/10.1152\/advan.00018.2020","DOI":"10.1152\/advan.00018.2020"},{"key":"5582_CR17","unstructured":"Instruction Manual. Comfort-intm Needle Free Injection System [Internet]. [acessed Jan 22 2017]. Available from: http:\/\/www.comfort-in.com\/file\/English-French%20manual.pdf"},{"key":"5582_CR18","doi-asserted-by":"publisher","unstructured":"Oliveira BH, Nadanovsky P (2005) Psychometric properties of the Brazilian version of the Oral Health Impact Profile-short form. Community Dent Oral Epidemiol. 2005;33(4):307\u2009\u2013\u200914. https:\/\/doi.org\/10.1111\/j.1600-0528.2005.00225.x","DOI":"10.1111\/j.1600-0528.2005.00225.x"},{"key":"5582_CR19","doi-asserted-by":"publisher","unstructured":"Lorentz MN, Albergaria VF, De Lima FAZ (2007) Anesthesia for Morbid Obesity. Rev Bras Anestesiol 2007; 57: 2: 199\u2013213. https:\/\/doi.org\/10.1590\/s0034-70942007000200010","DOI":"10.1590\/s0034-70942007000200010"},{"key":"5582_CR20","doi-asserted-by":"publisher","unstructured":"Sharma S, Arora L (2020) Anesthesia for the Morbidly Obese Patient. Anesthesiol Clin. 2020;38(1):197\u2013212. https:\/\/doi.org\/10.1016\/j.anclin.2019.10.008","DOI":"10.1016\/j.anclin.2019.10.008"},{"key":"5582_CR21","doi-asserted-by":"publisher","unstructured":"O\u2019Neal LY, Nusstein J, Drum M, Fowler S, Reader A, Ni A (2022) Comparison of Maxillary Lateral Incisor Infiltration Pain Using the Dentapen and a Traditional Syringe: A Prospective Randomized Study. J Endod. 2022;48(7):840\u2013844. https:\/\/doi.org\/10.1016\/j.joen.2022.04.008","DOI":"10.1016\/j.joen.2022.04.008"},{"key":"5582_CR22","doi-asserted-by":"crossref","unstructured":"Gao Q, No\u00ebl G, Khatchadourian ZD, Taqi D, Abusamak M, Henley A, Menassa K, Velly A, Emami E, Mongeau L, Tamimi F (2021) Needle-free injection: Dental infiltration anestesia. Int J Pharm 2021;604:120765","DOI":"10.1016\/j.ijpharm.2021.120765"},{"key":"5582_CR23","doi-asserted-by":"publisher","unstructured":"Liu P, McGrath C, Cheung G (2014) What are the key endodontic factors associated with oral health-related quality of life? Int Endod J. 2014;47(3):238\u2009\u2013\u200945. https:\/\/doi.org\/10.1111\/iej.12139","DOI":"10.1111\/iej.12139"},{"key":"5582_CR24","doi-asserted-by":"publisher","unstructured":"Neelakantan P, Liu P, Dummer PMH, McGrath C (2020) Oral health-related quality of life (OHRQoL) before and after endodontic treatment: a systematic review. Clin Oral Investig. 2020;24(1):25\u201336. https:\/\/doi.org\/10.1007\/s00784-019-03076-8","DOI":"10.1007\/s00784-019-03076-8"},{"key":"5582_CR25","unstructured":"Fristad I, Berggreen E (2021) Structure and Functions of the Dentin-Pulp Complex. In: Berman LH, Hargreaves KM, Rotstein I. Cohen`s Pathways of the Pulp. 12th Ed. St Lous, Missouri, USA. Chapter 13. pg. 512. 2021"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05582-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-05582-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05582-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T06:12:18Z","timestamp":1710915138000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-05582-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,9]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["5582"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-05582-w","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,9]]},"assertion":[{"value":"22 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for the trial protocol was obtained from the CEUMA University Research Ethics Committee (#4,776,212) and was registered in REBEC (RBR-107dyj7w).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All individual participants provided written and signed informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"205"}}