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The methodological quality and the level of evidence for the included studies were analyzed using QUADAS-2 and GRADE, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The preliminary search yielded 6746 records, of which 42 articles that met the predefined inclusion criteria were included in the final analysis. All the included articles reported the construction of the mid-sagittal reference plane (MSP) using varied methods. The risk of bias and concerns regarding the applicability of the included studies were judged to be \u2018low\u2019. The level of evidence was determined to be \u2018low\u2019 for the effectiveness of the technique and \u2018moderate\u2019 for the ease of clinical applicability.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Despite methodological heterogeneity, this review substantiates the comparable efficacy of cephalometric and morphometric MSP construction methods. A fully automated morphometric MSP holds promise as a viable option for routine clinical use. Nevertheless, future prospective studies with an emphasis on the impact, accuracy, and clinical applicability of MSP construction techniques in cases of facial asymmetry are required.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The present review will assist clinicians in selecting the most suitable method for MSP construction, leading to improved treatment planning and ultimately more favorable treatment outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05620-7","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T03:27:30Z","timestamp":1712287650000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Establishment of the mid-sagittal reference plane for three-dimensional assessment of facial asymmetry: a systematic review"],"prefix":"10.1007","volume":"28","author":[{"given":"Deepal Haresh","family":"Ajmera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiu Yan","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balvinder S.","family":"Khambay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"5620_CR1","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.ics.2005.03.174","volume":"1281","author":"W Tung-Yiu","year":"2005","unstructured":"Tung-Yiu W, Jing-Jing F, Tung-Chin W (2005) A novel method of quantifying facial asymmetry. 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