{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:42:05Z","timestamp":1784302925759,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-024-05691-6","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T01:02:37Z","timestamp":1714438957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effects of NLRP3 inflammasome inhibition or knockout in experimental apical periodontitis induced in mice"],"prefix":"10.1007","volume":"28","author":[{"given":"Carolina Maschietto","family":"Pucinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Assed Bezerra","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Nelson-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Barbosa","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Pac\u00edfico","family":"Lucisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Teresa","family":"Marchesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a Assed Bezerra","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"issue":"13","key":"5691_CR1","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3390\/ijms20133328","volume":"20","author":"N Kelley","year":"2019","unstructured":"Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci 20(13):3328. https:\/\/doi.org\/10.3390\/ijms20133328","journal-title":"Int J Mol Sci"},{"key":"5691_CR2","doi-asserted-by":"publisher","unstructured":"Huang Y, Xu W, Zhou R (2021) NLRP3 inflammasome activation and cell death. Cell Mol Immunol 92114\u20132127. https:\/\/doi.org\/10.1038\/s41423-021-00740-6","DOI":"10.1038\/s41423-021-00740-6"},{"issue":"1","key":"5691_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/imr.12286","volume":"265","author":"EI Elliott","year":"2015","unstructured":"Elliott EI, Sutterwala FS (2015) Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev 265(1):35\u201352. https:\/\/doi.org\/10.1111\/imr.12286","journal-title":"Immunol Rev"},{"issue":"2","key":"5691_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/cmi.2015.95","volume":"13","author":"EK Jo","year":"2016","unstructured":"Jo EK, Kim JK, Shin DM, Sasakawa C (2016) Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol 13(2):148\u2013159. https:\/\/doi.org\/10.1038\/cmi.2015.95","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"5691_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00011-016-0992-4","volume":"66","author":"Y Yamaguchi","year":"2017","unstructured":"Yamaguchi Y, Kurita-Ochiai T, Kobayashi R, Suzuki T, Ando T (2017) Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease. Inflamm Res 66(1):59\u201365. https:\/\/doi.org\/10.1007\/s00011-016-0992-4","journal-title":"Inflamm Res"},{"key":"5691_CR6","doi-asserted-by":"publisher","first-page":"101523","DOI":"10.1016\/j.redox.2020.101523","volume":"34","author":"C Zeng","year":"2020","unstructured":"Zeng C, Duan F, Hu J et al (2020) NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy. Redox Biol 34:101523. https:\/\/doi.org\/10.1016\/j.redox.2020.101523","journal-title":"Redox Biol"},{"issue":"4","key":"5691_CR7","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1074\/jbc.RA119.011751","volume":"295","author":"JY Li","year":"2020","unstructured":"Li JY, Wang YY, Shao T et al (2020) The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1\u03b2 maturation and gasdermin E-mediated pyroptosis. J Biol Chem 295(4):1120\u20131141. https:\/\/doi.org\/10.1074\/jbc.RA119.011751","journal-title":"J Biol Chem"},{"key":"5691_CR8","doi-asserted-by":"publisher","first-page":"114385","DOI":"10.1016\/j.bcp.2020.114385","volume":"187","author":"P Pelegrin","year":"2021","unstructured":"Pelegrin P (2021) P2X7 receptor and the NLRP3 inflammasome: partners in crime. Biochem Pharmacol 187:114385. https:\/\/doi.org\/10.1016\/j.bcp.2020.114385","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"5691_CR9","doi-asserted-by":"publisher","first-page":"8225","DOI":"10.3390\/ijms24098225","volume":"24","author":"R Sluyter","year":"2023","unstructured":"Sluyter R, Adriouch S, Fuller SJ, Nicke A, Sophocleous RA, Watson D (2023) Animal models for the investigation of P2X7 receptors. Int J Mol Sci 24(9):8225. https:\/\/doi.org\/10.3390\/ijms24098225","journal-title":"Int J Mol Sci"},{"key":"5691_CR10","doi-asserted-by":"publisher","first-page":"116593","DOI":"10.1016\/j.lfs.2019.116593","volume":"231","author":"C Lee","year":"2019","unstructured":"Lee C, Do HTT, Her J, Kim Y, Seo D, Rhee I (2019) Inflammasome as a promising therapeutic target for cancer. Life Sci 231:116593. https:\/\/doi.org\/10.1016\/j.lfs.2019.116593","journal-title":"Life Sci"},{"issue":"1","key":"5691_CR11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13045-019-0755-0","volume":"12","author":"S Xu","year":"2019","unstructured":"Xu S, Li X, Liu Y, Xia Y, Chang R, Zhang C (2019) Inflammasome inhibitors: promising therapeutic approaches against cancer. J Hematol Oncol 12(1):64. https:\/\/doi.org\/10.1186\/s13045-019-0755-0","journal-title":"J Hematol Oncol"},{"key":"5691_CR12","doi-asserted-by":"publisher","first-page":"102299","DOI":"10.1016\/j.jaut.2019.06.010","volume":"103","author":"JI Shin","year":"2019","unstructured":"Shin JI, Lee KH, Joo YH et al (2019) Inflammasomes and autoimmune and rheumatic diseases: a comprehensive review. J Autoimmun 103:102299. https:\/\/doi.org\/10.1016\/j.jaut.2019.06.010","journal-title":"J Autoimmun"},{"key":"5691_CR13","doi-asserted-by":"publisher","first-page":"104484","DOI":"10.1016\/j.neuint.2019.104484","volume":"129","author":"F Sun","year":"2019","unstructured":"Sun F, Deng Y, Han X et al (2019) A secret that underlies Parkinson\u2019s disease: the damaging cycle. Neurochem Int 129:104484. https:\/\/doi.org\/10.1016\/j.neuint.2019.104484","journal-title":"Neurochem Int"},{"issue":"8","key":"5691_CR14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41581-019-0158-z","volume":"15","author":"T Komada","year":"2019","unstructured":"Komada T, Muruve DA (2019) The role of inflammasomes in kidney disease. Nat Rev Nephrol 15(8):501\u2013520. https:\/\/doi.org\/10.1038\/s41581-019-0158-z","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"5691_CR15","doi-asserted-by":"publisher","first-page":"92","DOI":"10.5114\/ceji.2019.83615","volume":"44","author":"LM Sur","year":"2019","unstructured":"Sur LM, Sur G, Samasca G, Lupan I (2019) Investigations of cellular immunity in juvenile idiopathic arthritis. Cent Eur J Immunol 44(1):92\u201396. https:\/\/doi.org\/10.5114\/ceji.2019.83615","journal-title":"Cent Eur J Immunol"},{"key":"5691_CR16","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.intimp.2019.05.006","volume":"73","author":"N Parsamanesh","year":"2019","unstructured":"Parsamanesh N, Moossavi M, Bahrami A, Fereidouni M, Barreto G, Sahebkar A (2019) NLRP3 inflammasome as a treatment target in atherosclerosis: a focus on statin therapy. Int Immunopharmacol 73:146\u2013155. https:\/\/doi.org\/10.1016\/j.intimp.2019.05.006","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"5691_CR17","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/nep.12785","volume":"221","author":"HL Hutton","year":"2016","unstructured":"Hutton HL, Ooi JD, Holdsworth SR, Kitching AR (2016) The NLRP3 inflammasome in kidney disease and autoimmunity. Nephrol (Carlton) 221(9):736\u2013744. https:\/\/doi.org\/10.1111\/nep.12785","journal-title":"Nephrol (Carlton)"},{"issue":"2","key":"5691_CR18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.14744\/eej.2020.42714","volume":"5","author":"K Karamifar","year":"2020","unstructured":"Karamifar K, Tondari A, Saghiri MA (2020) Endodontic periapical lesion: an overview on the etiology, diagnosis and current treatment modalities. Eur Endod J 5(2):54\u201367. https:\/\/doi.org\/10.14744\/eej.2020.42714","journal-title":"Eur Endod J"},{"key":"5691_CR19","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/iej.13677","volume":"55","author":"JF Siqueira Jr","year":"2022","unstructured":"Siqueira JF Jr, R\u00f4\u00e7as IN (2022) Present status and future directions: microbiology of endodontic infections. Int Endod J 55:512\u2013530. https:\/\/doi.org\/10.1111\/iej.13677","journal-title":"Int Endod J"},{"issue":"5","key":"5691_CR20","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/iej.13467","volume":"54","author":"CS Tib\u00farcio-Machado","year":"2021","unstructured":"Tib\u00farcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA (2021) The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int Endod J 54(5):712\u2013735. https:\/\/doi.org\/10.1111\/iej.13467","journal-title":"Int Endod J"},{"key":"5691_CR21","doi-asserted-by":"publisher","first-page":"908859","DOI":"10.3389\/fcimb.2022.908859","volume":"12","author":"X Luo","year":"2022","unstructured":"Luo X, Wan Q, Cheng L, Xu R (2022) Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis. Front Cell Infect Microbiol 12:908859. https:\/\/doi.org\/10.3389\/fcimb.2022.908859","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"5691_CR22","doi-asserted-by":"publisher","first-page":"e12973","DOI":"10.1111\/cpr.12973","volume":"54","author":"Y Chen","year":"2021","unstructured":"Chen Y, Yang Q, Lv C (2021) NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation. Cell Prolif 54(2):e12973. https:\/\/doi.org\/10.1111\/cpr.12973","journal-title":"Cell Prolif"},{"issue":"10","key":"5691_CR23","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.7150\/ijms.74575","volume":"19","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Quan Y, Lei T, Fan L, Ge X, Hu S (2022) The role of inflammasome NLPR3 in the development and therapy of periodontitis. Int J Med Sci 19(10):1603\u20131614. https:\/\/doi.org\/10.7150\/ijms.74575","journal-title":"Int J Med Sci"},{"issue":"4","key":"5691_CR24","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1177\/0022034518820289","volume":"98","author":"TM Taira","year":"2019","unstructured":"Taira TM, Lima V, Prado DS et al (2019) NLRP12 attenuates inflammatory bone loss in experimental apical periodontitis. J Dent Res 98(4):476\u2013484. https:\/\/doi.org\/10.1177\/0022034518820289","journal-title":"J Dent Res"},{"key":"5691_CR25","doi-asserted-by":"publisher","unstructured":"Huang C, Zhang C, Yang P et al (2020) Eldecalcitol inhibits LPS-Induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2\/HO-1 signaling pathway. Drug Des Devel Ther 2020 14:4901\u20134913. https:\/\/doi.org\/10.2147\/DDDT.S269223","DOI":"10.2147\/DDDT.S269223"},{"issue":"5","key":"5691_CR26","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3892\/mmr.2023.12993","volume":"27","author":"H Li","year":"2023","unstructured":"Li H, Sun L, Wang Y (2023) Inhibition of LPS\u2013induced NLRP3 inflammasome activation by stem cell\u2013conditioned culture media in human gingival epithelial cells. Mol Med Rep 27(5):106. https:\/\/doi.org\/10.3892\/mmr.2023.12993","journal-title":"Mol Med Rep"},{"issue":"2","key":"5691_CR27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1590\/s1678-77572004000200002","volume":"12","author":"MR Leonardo","year":"2004","unstructured":"Leonardo MR, da Silva RAB, Assed S, Nelson-Filho P (2004) Importance of bacterial endotoxin (LPS) in endodontics. J Appl Oral Sci 12(2):93\u201398. https:\/\/doi.org\/10.1590\/s1678-77572004000200002","journal-title":"J Appl Oral Sci"},{"issue":"7","key":"5691_CR28","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.joen.2016.04.018","volume":"42","author":"L Wang","year":"2016","unstructured":"Wang L, Jin H, Ye D et al (2016) Enterococcus faecalis lipoteichoic acid-induced NLRP3 inflammasome via the activation of the nuclear factor kappa B pathway. J Endod 42(7):1093\u20131100. https:\/\/doi.org\/10.1016\/j.joen.2016.04.018","journal-title":"J Endod"},{"key":"5691_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.archoralbio.2017.02.006","volume":"78","author":"S Ran","year":"2018","unstructured":"Ran S, Liu B, Gu S, Sun Z, Liang J (2018) Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth. Arch Oral Biol 78:39\u201347. https:\/\/doi.org\/10.1016\/j.archoralbio.2017.02.006","journal-title":"Arch Oral Biol"},{"issue":"1","key":"5691_CR30","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.bbadis.2017.10.025","volume":"1864","author":"R Cheng","year":"2018","unstructured":"Cheng R, Feng Y, Zhang R, Liu W, Lei L, Hu T (2018) The extent of pyroptosis varies in different stages of apical periodontitis. Biochim Biophys Acta Mol Basis Dis 1864(1):226\u2013237. https:\/\/doi.org\/10.1016\/j.bbadis.2017.10.025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"6","key":"5691_CR31","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/iej.13481","volume":"54","author":"V Nagendrababu","year":"2021","unstructured":"Nagendrababu V, Kishen A, Murray PE et al (2021) PRIASE 2021 guidelines for reporting animal studies in Endodontology: explanation and elaboration. Int Endod J 54(6):858\u2013886. https:\/\/doi.org\/10.1111\/iej.13481","journal-title":"Int Endod J"},{"issue":"6","key":"5691_CR32","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1111\/iej.13477","volume":"54","author":"V Nagendrababu","year":"2021","unstructured":"Nagendrababu V, Kishen A, Murray PE et al (2021) PRIASE 2021 guidelines for reporting animal studies in Endodontology: a consensus-based development. Int Endod J 54(6):848\u2013857. https:\/\/doi.org\/10.1111\/iej.13477","journal-title":"Int Endod J"},{"key":"5691_CR33","doi-asserted-by":"publisher","first-page":"e20170512","DOI":"10.1590\/1678-7757-2017-0512","volume":"26","author":"D Barreiros","year":"2018","unstructured":"Barreiros D, Pucinelli CM, Oliveira KMH et al (2018) Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice. J Appl Oral Sci 26:e20170512. https:\/\/doi.org\/10.1590\/1678-7757-2017-0512","journal-title":"J Appl Oral Sci"},{"issue":"10","key":"5691_CR34","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1111\/iej.13802","volume":"55","author":"CM Pucinelli","year":"2022","unstructured":"Pucinelli CM, Lima RB, Almeida LKY et al (2022) Interferon-gamma inducible protein 16 and type I interferon receptors expression in experimental apical periodontitis induced in wild-type mice. Int Endod J 55(10):1042\u20131052. https:\/\/doi.org\/10.1111\/iej.13802","journal-title":"Int Endod J"},{"issue":"8","key":"5691_CR35","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1111\/iej.13472","volume":"54","author":"IBF Petean","year":"2021","unstructured":"Petean IBF, Almeida-Junior LA, Arnez MFM et al (2021) Celecoxib treatment dampens LPS-induced periapical bone resorption in a mouse model. Int Endod J 54(8):1289\u20131299. https:\/\/doi.org\/10.1111\/iej.13472","journal-title":"Int Endod J"},{"issue":"1","key":"5691_CR36","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/iej.13206","volume":"53","author":"RAB da Silva","year":"2020","unstructured":"da Silva RAB, Sousa-Pereira AP, Lucisano MP et al (2020) Alendronate inhibits osteocyte apoptosis and inflammation via IL-6, inhibiting bone resorption in periapical lesions of ovariectomized rats. Int Endod J 53(1):84\u201396. https:\/\/doi.org\/10.1111\/iej.13206","journal-title":"Int Endod J"},{"issue":"6","key":"5691_CR37","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.joen.2012.03.017","volume":"38","author":"RA da Silva","year":"2012","unstructured":"da Silva RA, Ferreira PD, De Rossi A, Nelson-Filho P, da Silva LAB (2012) Toll-like receptor 2 knockout mice showed increased periapical lesion size and osteoclast number. J Endod 38(6):803\u2013813. https:\/\/doi.org\/10.1016\/j.joen.2012.03.017","journal-title":"J Endod"},{"issue":"7","key":"5691_CR38","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/iej.12204","volume":"47","author":"RA da Silva","year":"2014","unstructured":"da Silva RA, Nelson-Filho P, Lucisano MP, De Rossi A, Queiroz AM, da Silva LA (2014) MyD88 knockout mice develop initial enlarged periapical lesions with increased numbers of neutrophils. Int Endod J 47(7):675\u2013686. https:\/\/doi.org\/10.1111\/iej.12204","journal-title":"Int Endod J"},{"issue":"4","key":"5691_CR39","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"1","key":"5691_CR40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10753-019-01098-8","volume":"43","author":"D Wu","year":"2020","unstructured":"Wu D, Chen Y, Sun Y et al (2020) Target of MCC950 in inhibition of NLRP3 inflammasome activation: a literature review. Inflammation 43(1):17\u201323. https:\/\/doi.org\/10.1007\/s10753-019-01098-8","journal-title":"Inflammation"},{"key":"5691_CR41","doi-asserted-by":"publisher","first-page":"175091","DOI":"10.1016\/j.ejphar.2022.175091","volume":"928","author":"H Li","year":"2022","unstructured":"Li H, Guan Y, Liang B et al (2022) Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome. Eur J Pharmacol 928:175091. https:\/\/doi.org\/10.1016\/j.ejphar.2022.175091","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"5691_CR42","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3390\/cells11071188","volume":"11","author":"C Paget","year":"2022","unstructured":"Paget C, Doz-Deblauwe E, Winter N, Briard B (2022) Specific NLRP3 inflammasome assembling and regulation in neutrophils: relevance in inflammatory and infectious diseases. Cells 11(7):1188. https:\/\/doi.org\/10.3390\/cells11071188","journal-title":"Cells"},{"key":"5691_CR43","doi-asserted-by":"publisher","first-page":"683803","DOI":"10.3389\/fimmu.2021.683803","volume":"12","author":"P M\u00fcnzer","year":"2021","unstructured":"M\u00fcnzer P, Negro R, Fukui S et al (2021) NLRP3 inflammasome assembly in neutrophils is supported by PAD4 and promotes NETosis under sterile conditions. Front Immunol 12:683803. https:\/\/doi.org\/10.3389\/fimmu.2021.683803","journal-title":"Front Immunol"},{"issue":"1","key":"5691_CR44","doi-asserted-by":"publisher","first-page":"19305","DOI":"10.1038\/s41598-021-98437-3","volume":"11","author":"W Zeng","year":"2021","unstructured":"Zeng W, Wu D, Sun Y et al (2021) The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages. Sci Rep 11(1):19305. https:\/\/doi.org\/10.1038\/s41598-021-98437-3","journal-title":"Sci Rep"},{"issue":"4","key":"5691_CR45","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/jcpe.13258","volume":"47","author":"J Zhang","year":"2020","unstructured":"Zhang J, Liu X, Wan C et al (2020) NLRP3 inflammasome mediates M1 macrophage polarization and IL-1\u03b2 production in inflammatory root resorption. J Clin Periodontol 47(4):451\u2013460. https:\/\/doi.org\/10.1111\/jcpe.13258","journal-title":"J Clin Periodontol"},{"issue":"5","key":"5691_CR46","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","volume":"66","author":"AR Mridha","year":"2017","unstructured":"Mridha AR, Wree A, Robertson AAB et al (2017) NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. J Hepatol 66(5):1037\u20131046. https:\/\/doi.org\/10.1016\/j.jhep.2017.01.022","journal-title":"J Hepatol"},{"issue":"64","key":"5691_CR47","doi-asserted-by":"publisher","first-page":"eabj3859","DOI":"10.1126\/sciimmunol.abj3859","volume":"6","author":"C Wang","year":"2021","unstructured":"Wang C, Yang T, Xiao J et al (2021) NLRP3 inflammasome activation triggers gasdermin D-independent inflammation. Sci Immunol 6(64):eabj3859. https:\/\/doi.org\/10.1126\/sciimmunol.abj3859","journal-title":"Sci Immunol"},{"issue":"1","key":"5691_CR48","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11302-018-9640-5","volume":"15","author":"S Mitra","year":"2019","unstructured":"Mitra S, Sarkar A (2019) Microparticulate P2X7 and GSDM-D mediated regulation of functional IL-1\u03b2 release. Purinergic Signal 15(1):119\u2013123. https:\/\/doi.org\/10.1007\/s11302-018-9640-5","journal-title":"Purinergic Signal"},{"issue":"2","key":"5691_CR49","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/iej.13855","volume":"56","author":"B Al Natour","year":"2023","unstructured":"Al Natour B, Lundy FT, About I, Jeanneau C, Dombrowski Y, El Karim IA (2023) Regulation of caries-induced pulp inflammation by NLRP3 inflammasome: a laboratory-based investigation. Int Endod J 56(2):193\u2013202. https:\/\/doi.org\/10.1111\/iej.13855","journal-title":"Int Endod J"},{"issue":"2","key":"5691_CR50","first-page":"660","volume":"12","author":"X Guan","year":"2020","unstructured":"Guan X, Guan Y, Shi C et al (2020) Estrogen deficiency aggravates apical periodontitis by regulating NLRP3\/caspase-1\/IL-1\u03b2 axis. Am J Transl Res 12(2):660\u2013671","journal-title":"Am J Transl Res"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05691-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-05691-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05691-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T10:09:04Z","timestamp":1716804544000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-05691-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["5691"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-05691-6","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]},"assertion":[{"value":"25 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were approved by the Animal Research Committee (CEUA), School of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo (FORP\/USP), Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil (CEUA \u2212\u20092019.1.1019.58.9).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"285"}}