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Standardized digital images were obtained before, one-day, one-week, one-month, three-months and six-months after treatment using a DSLR camera and a matching polarization filter. A grey reference card was used for color standardization. A Matlab routine was used to measure the color difference between adjacent healthy enamel and treated WSL. The independent-samples t-test was used for intergroup and paired-samples t-test for intragroup comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Images of 116 teeth from 36 patients were analyzed. The \u0394E for the \u201cIcon\u201d treated WSL was smaller (T1\n                      <jats:sub>ICON<\/jats:sub>\n                      \u2009=\u20095.0\u2009\u00b1\u20091.4) than in the fluoride group (T1\n                      <jats:sub>Fluoride<\/jats:sub>\n                      \u2009=\u20098.4\u2009\u00b1\u20093.2). Caries infiltration significantly improved the aesthetic appearance of WSL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), which remained satisfactory at six months (T5\n                      <jats:sub>ICON<\/jats:sub>\n                      \u2009=\u20095.2\u2009\u00b1\u20091.6).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>WSL infiltration management during orthodontic treatment was superior to topical fluoridation in not only arresting the enamel lesions but also significantly improving the aesthetic appearance of demineralized regions around the brackets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>WSL treatment in orthodontic patients is usually initiated after debonding. Research has shown that the earlier WSL is treated, the better the aesthetic outcome. There is limited data on the efficacy of resin infiltration of WSL during orthodontic treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-024-05695-2","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T11:01:18Z","timestamp":1715425278000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Resin infiltration versus fluoride varnish for visual improvement of white spot lesions during multibracket treatment. 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