{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:39:45Z","timestamp":1788593985586,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>The aim of this study was to: (1) investigate the expression patterns of antimicrobial peptides (AMPs), specifically psoriasin (S100A7) and calgranulin A and B (S100A8\/A9), in patients with oral lichen planus (OLP) compared to healthy individuals; (2) evaluate the oral health-related quality of life (OHrQoL) in OLP patients versus healthy controls; (3) investigate the impact of clinical severity of OLP on OHrQoL; and (4) assess the influence of AMP expression on clinical severity and OHrQoL in OLP patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Oral mucosal biopsies (<jats:italic>n<\/jats:italic>\u2009=\u200938) were collected from healthy individuals (<jats:italic>n<\/jats:italic>\u2009=\u200917) and patients with OLP (<jats:italic>n<\/jats:italic>\u2009=\u200921). Levels of AMPs (S100A7, S100A8, S100A9) and pro-inflammatory cytokines interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF\u03b1) were assessed by RT-qPCR. AMP protein localization was identified by indirect immunofluorescence analysis. OHrQoL was assessed using the OHIP-G14 questionnaire, and clinical severity was evaluated with the Oral Disease Severity Score (ODSS). Correlations between OLP manifestation, OHrQoL, and AMP expression were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>(1) S100A7 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), IL-8 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and TNF\u03b1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) mRNA levels were significantly upregulated in OLP tissue compared to healthy tissue, while S100A8 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and S100A9 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) mRNA levels were downregulated. Immunofluorescence staining revealed an enhanced expression of S100A7 and decreased protein expression of S100A9 in OLP tissue. (2) OLP patients (9.58\u2009\u00b1\u20098.32) reported significantly higher OHIP-G14 scores compared to healthy individuals (0.67\u2009\u00b1\u20090.87; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), particularly in the categories \u201cphysical pain\u201d (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and \u201cpsychological discomfort\u201d (<jats:italic>p<\/jats:italic>\u2009=\u20090.025). (3,4) Clinical severity (25.21\u2009\u00b1\u20099.77) of OLP correlated positively with OHrQoL (\u03c1\u2009=\u20090.497) and psoriasin expression (\u03c1\u2009=\u20090.402).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study demonstrated differential expression patterns of AMPs in OLP and highlighted the correlation between the clinical manifestation of OLP and OHrQoL. Further research approaches should address the role of psoriasin in the risk of malignant transformation of OLP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Psoriasin is a putative biomarker to monitor disease severity including malignant transformation of OLP lesions. OHIP-G14 scores can be useful to monitor OHrQoL in OLP patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05717-z","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T01:02:03Z","timestamp":1715821323000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Upregulation of psoriasin\/S100A7 correlates with clinical severity in patients with oral lichen planus"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-0310","authenticated-orcid":false,"given":"Kim Natalie","family":"Stolte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Danker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Ebhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-2651","authenticated-orcid":false,"given":"Henrik","family":"Dommisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"5717_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.humpath.2017.05.014","volume":"66","author":"AK El-Naggar","year":"2017","unstructured":"El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ (2017) The fourth edition of the head and neck World Health Organization blue book: editors\u2019 perspectives. 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