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We tested the hypothesis that oral microbiota dysbiosis is associated with oral cavity cancer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Patients with primary oral cavity cancer who met the inclusion and exclusion criteria were included in the study. Matching healthy individuals were recruited as controls. Data on socio-demographic and behavioral factors, self-reported periodontal measures and habits, and current dental status were collected using a structured questionnaire and periodontal chartings. In addition to self-reported oral health measures, each participant received a standard and detailed clinical examination. DNA was extracted from saliva samples from patients and healthy controls. Next-generation sequencing was performed by targeting V3-V4 gene regions of the 16\u00a0S rRNA with subsequent bioinformatic analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients with oral cavity cancers had a lower quality of oral health than healthy controls. <jats:italic>Proteobacteria, Aggregatibacter, Haemophilus<\/jats:italic>, and <jats:italic>Neisseria<\/jats:italic> decreased, while <jats:italic>Firmicutes, Bacteroidetes, Actinobacteria, Lactobacillus, Gemella<\/jats:italic>, and <jats:italic>Fusobacteria<\/jats:italic> increased in oral cancer patients. At the species level, <jats:italic>C. durum, L. umeaens, N. subflava, A. massiliensis<\/jats:italic>, and <jats:italic>V. dispar<\/jats:italic> were significantly lower, while <jats:italic>G. haemolysans<\/jats:italic> was significantly increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Major periodontopathogens associated with periodontal disease (<jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>F.nucleatum<\/jats:italic>) increased 6.5- and 2.8-fold, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These data suggested that patients with oral cancer had worse oral health conditions and a distinct oral microbiome composition that is affected by personal daily habits and may be associated with the pathogenicity of the disease and interspecies interactions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>This paper demonstrates the link between oral bacteria and oral cancers, identifying mechanistic interactions between species of oral microbiome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05770-8","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T06:02:16Z","timestamp":1718604136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Oral microbial dysbiosis in patients with oral cavity cancers"],"prefix":"10.1007","volume":"28","author":[{"given":"Ozge","family":"Unlu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugce","family":"Paksoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu Baygul","family":"Eden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Deniz","family":"Tansuker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Dalmizrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagdas","family":"Aktan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdevs","family":"Senel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Volkan","family":"Sunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Yigit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak Omur","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpdogan","family":"Kantarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"5770_CR1","unstructured":"Cancer (IARC) (2024) https:\/\/gco.iarc.fr\/"},{"issue":"12","key":"5770_CR2","doi-asserted-by":"publisher","first-page":"6909","DOI":"10.1007\/s00784-021-03981-x","volume":"25","author":"J Adeoye","year":"2021","unstructured":"Adeoye J, Hui L, Tan JY, Koohi-Moghadam M, Choi SW, Thomson P (2021) Prognostic value of non-smoking, non-alcohol drinking status in oral cavity cancer. 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