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Its anti-fibrotic effect has been experimentally demonstrated in the pancreas and liver. This study aims to determine the anti-proliferative effect of resveratrol on fibroblasts obtained from hyperplastic gingival tissues from a patient diagnosed with Juvenile Hyaline Fibromatosis (JHF).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Primary gingival fibroblast cell lines were obtained from gingival growth tissues by the gingivectomy of a patient with JHF. Gingival fibroblasts were treated with or without 3 different doses of resveratrol (50, 100, 200 \u00b5M). Cytotoxicity and cell proliferation were evaluated after 24, 48, and 72\u00a0h. Collagen, TGF, and CTGF were analyzed by ELISA in the 48-hour supernatants.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All three doses of resveratrol suppressed the proliferation of JHF gingival fibroblasts at 24 and 48\u00a0h without showing any cytotoxic effect compared to the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). At 72\u00a0h, 100 and 200 \u00b5M resveratrol showed significantly less proliferation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), less collagen, CTGF, and TGF- \u03b2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) than the control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Resveratrol had a profound anti-proliferative effect on gingival fibroblasts obtained from gingival enlargements with JHF, suggesting that it can be used as a therapeutic to prevent excessive cell growth by suppressing collagen, CTGF, and TGF- \u03b2 synthesis in the pathogenesis of hyperplasia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05771-7","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T21:05:15Z","timestamp":1722027915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti-proliferative impact of resveratrol on gingival fibroblasts from juvenile hyaline fibromatosis"],"prefix":"10.1007","volume":"28","author":[{"given":"I\u015f\u0131l","family":"Saygun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melis \u00d6zg\u00fcl","family":"Slezovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansel K\u00f6se","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahdi Umut","family":"Bengi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"El\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhittin","family":"Serdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpdogan","family":"Kantarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"issue":"1","key":"5771_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13023-016-0395-1","volume":"11","author":"K Gawron","year":"2016","unstructured":"Gawron K, \u0141azarz-Bartyzel K, Potempa J, Chomyszyn-Gajewska M (2016) Gingival fibromatosis: clinical, molecular and therapeutic issues. 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