{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:10:59Z","timestamp":1779927059526,"version":"3.53.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Lokman Hekim University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This study compares the biofilm inhibition effects of denture cleaning tablets, carvacrol, and their combined use against <jats:italic>Candida albicans<\/jats:italic> on denture bases produced with different techniques. Additionally, the surface roughness and contact angles of these denture bases were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Test samples were prepared from four different denture base materials (cold-polymerized, heat-polymerized, CAD\/CAM milling, and 3D-printed). The surface roughness and contact angles of the test samples were measured using a profilometer and goniometer, respectively. For the evaluation of biofilm inhibition, samples were divided into 5 subgroups: Corega and carvacrol, separately and combined treatments, positive (inoculated with <jats:italic>C. albicans<\/jats:italic>) and negative control (non-inoculated with <jats:italic>C. albicans<\/jats:italic>, only medium). Biofilm mass was determined using the crystal violet method. An additional prepared test sample for each subgroup was examined under scanning electron microscopy (SEM).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The surface roughness values of the 3D-printed test samples were found to be statistically higher than the other groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The water contact angle of all test materials was not statistically different from each other (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.001). Corega and carvacrol, separately and combined, significantly decreased the amount of biofilm on all surfaces (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). Treatment of corega alone and in combination with carvacrol to the 3D-printed material caused less <jats:italic>C. albicans<\/jats:italic> inhibition than the other groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The surface roughness values of all test groups were within the clinically acceptable threshold. Although Corega and carvacrol inhibited <jats:italic>C. albicans<\/jats:italic> biofilms, their combined use did not show a synergistic effect.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Carvacrol may be used as one of the disinfectant agents for denture cleaning due to its biofilm inhibition property.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05810-3","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T03:33:53Z","timestamp":1720150433000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biofilm inhibition of denture cleaning tablets and carvacrol on denture bases produced with different techniques"],"prefix":"10.1007","volume":"28","author":[{"given":"Zeynep","family":"Sahin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazire Esra","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulhamit","family":"Cal\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"5810_CR1","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.3390\/polym15081836","volume":"15","author":"RB Osman","year":"2023","unstructured":"Osman RB, Khoder G, Fayed B, Kedia RA, Elkareimi Y, Alharbi N (2023) Influence of fabrication technique on adhesion and biofilm formation of Candida albicans to conventional, milled, and 3D-printed denture base resin materials: a comparative in vitro study. 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