{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:28:26Z","timestamp":1787740106264,"version":"build-2784847793"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Istanbul University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>We assessed the levels of Interleukin-10 (IL-10), Interleukin-12 (IL-12), and Interleukin-18 (IL-18) in the gingival crevicular fluid (GCF) of subjects with advanced periodontitis (SIII-SIV) compared to healthy controls and evaluated their correlations with clinical measurements.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This cross-sectional study involved subjects (<jats:italic>n<\/jats:italic>\u2009=\u200960) diagnosed with stage III grade B-C (<jats:italic>n<\/jats:italic>\u2009=\u200913) to stage IV grade C (<jats:italic>n<\/jats:italic>\u2009=\u200917) periodontitis, and periodontally healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200930). Clinical periodontal measurements involved full-mouth. The concentrations of IL-10, IL-12, and IL-18 were determined using enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were no significant differences in IL-12 level and IL-18\/IL-10 ratio between the healthy and periodontitis groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.413, <jats:italic>p<\/jats:italic>\u2009=\u20090.636, respectively). The IL-10 and IL-18 levels were significantly higher in the periodontitis group than in controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). Significant associations were observed between the periodontitis and IL-10 and IL-18 levels (OR\u2009=\u20091.46, %95 CI 1.19\u20131.795; OR\u2009=\u20091.13, %95 CI 1.059\u20131.207, respectively) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>There was a correlation between pocket depth and the presence of IL-18 and a strong association between periodontitis and a high level of IL-18. However, there were no direct correlations among the three biomarkers and IL-18\/IL-10 ratio, indicating that their roles in periodontal health are complex and multidimensional.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Understanding the cytokine dynamics in GCF provides valuable insights into their potential clinical implications for periodontal disease diagnosis, risk assessment, and tailored therapeutic interventions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05843-8","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:01:57Z","timestamp":1722384117000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations between interleukin-10, -12, and \u2212\u200918 and periodontal health and disease: a cross-sectional study"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0979-1661","authenticated-orcid":false,"given":"Elif Ilke","family":"Cebesoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5850-9565","authenticated-orcid":false,"given":"M\u00fcge","family":"Altaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-6345","authenticated-orcid":false,"given":"Necla Asli","family":"Kocak-Oztug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-3541","authenticated-orcid":false,"given":"Ilknur","family":"Bing\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-0940","authenticated-orcid":false,"given":"Emine","family":"Cifcibasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"issue":"Suppl 20","key":"5843_CR1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1111\/jcpe.12935","volume":"45","author":"JG Caton","year":"2018","unstructured":"Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M, Tonetti MS (2018) A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification. 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