{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:23:09Z","timestamp":1785428589603,"version":"3.56.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Sch\u00e4fersnolte-Ged\u00e4chtnis-Stiftung Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","award":["Fonds 361717 MKG"],"award-info":[{"award-number":["Fonds 361717 MKG"]}]},{"name":"Sch\u00e4fersnolte-Ged\u00e4chtnis-Stiftung Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","award":["Fonds 361717 MKG"],"award-info":[{"award-number":["Fonds 361717 MKG"]}]},{"name":"Sch\u00e4fersnolte-Ged\u00e4chtnis-Stiftung Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","award":["Fonds 361717 MKG"],"award-info":[{"award-number":["Fonds 361717 MKG"]}]},{"name":"Sch\u00e4fersnolte-Ged\u00e4chtnis-Stiftung Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","award":["Fonds 361717 MKG"],"award-info":[{"award-number":["Fonds 361717 MKG"]}]},{"name":"Sch\u00e4fersnolte-Ged\u00e4chtnis-Stiftung Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","award":["Fonds 361717 MKG"],"award-info":[{"award-number":["Fonds 361717 MKG"]}]},{"name":"Sch\u00e4fersnolte-Ged\u00e4chtnis-Stiftung Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","award":["Fonds 361717 MKG"],"award-info":[{"award-number":["Fonds 361717 MKG"]}]},{"name":"Sch\u00e4fersnolte-Ged\u00e4chtnis-Stiftung Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","award":["Fonds 361717 MKG"],"award-info":[{"award-number":["Fonds 361717 MKG"]}]},{"name":"Sch\u00e4fersnolte-Ged\u00e4chtnis-Stiftung Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","award":["Fonds 361717 MKG"],"award-info":[{"award-number":["Fonds 361717 MKG"]}]},{"name":"Universit\u00e4tsklinikum RWTH Aachen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Inadequate resection margins of less than 5\u00a0mm impair local tumor control. This weak point in oncological safety is exacerbated in bone-infiltrating tumors because rapid bone analysis procedures do not exist. This study aims to assess the bony resection margin status of bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>LIBS experiments were performed on natively lasered, tumor-infiltrated mandibular cross-sections from 10 patients. In total, 5,336 spectra were recorded at defined distances from the tumor border. Resection margins\u2009&lt;\u20091\u00a0mm were defined as very close, from 1\u20135\u00a0mm as close, and\u2009&gt;\u20095\u00a0mm as clear. The spectra were histologically validated. Based on the LIBS spectra, the discriminatory power of potassium (K) and soluble calcium (Ca) between bone-infiltrating tumor tissue and very close, close, and clear resection margins was determined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>LIBS-derived electrolyte emission values of K and soluble Ca as well as histological parameters for bone neogenesis\/fibrosis and lymphocyte\/macrophage infiltrates differ significantly between bone-infiltrating tumor tissue spectra and healthy bone spectra from very close, close, and clear resection margins (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Using LIBS, the transition from very close resection margins to bone-infiltrating tumor tissue can be determined with a sensitivity of 95.0%, and the transition from clear to close resection margins can be determined with a sensitivity of 85.3%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>LIBS can reliably determine the boundary of bone-infiltrating tumors and might provide an orientation for determining a clear resection margin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>LIBS could facilitate intraoperative decision-making and avoid inadequate resection margins in bone-invasive oral cancer.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05862-5","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T03:40:21Z","timestamp":1723088421000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy"],"prefix":"10.1007","volume":"28","author":[{"given":"Philipp","family":"Winnand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ooms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Heitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Vohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"H\u00f6lzle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Olaf","family":"Boernsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Modabber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"5862_CR1","unstructured":"Network NCC (2022) Head and neck cancers (version 2.2022). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf. Accessed 1 Mar 2024"},{"key":"5862_CR2","unstructured":"German Cancer Society GCA, AWMF (2021) German guideline program in oncology: oral Cavity cancer"},{"issue":"4","key":"5862_CR3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.5858\/arpa.2018-0411-SA","volume":"143","author":"S M\u00fcller","year":"2019","unstructured":"M\u00fcller S et al (2019) Data set for the reporting of oral cavity carcinomas: explanations and recommendations of the guidelines from the international collaboration of cancer reporting. Arch Pathol Lab Med 143(4):439\u2013446","journal-title":"Arch Pathol Lab Med"},{"issue":"12","key":"5862_CR4","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1001\/jamaoto.2017.0548","volume":"143","author":"KK Tasche","year":"2017","unstructured":"Tasche KK et al (2017) Definition of \u201cClose Margin\u201d in oral cancer surgery and association of margin distance with local recurrence rate. JAMA Otolaryngol Head Neck Surg 143(12):1166\u20131172","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"9","key":"5862_CR5","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.bjoms.2018.06.021","volume":"56","author":"DA Mitchell","year":"2018","unstructured":"Mitchell DA et al (2018) Margins and survival in oral cancer. Br J Oral Maxillofac Surg 56(9):820\u2013829","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"Suppl 1","key":"5862_CR6","first-page":"E2197","volume":"38","author":"RW Smits","year":"2016","unstructured":"Smits RW et al (2016) Resection margins in oral cancer surgery: Room for improvement. Head Neck 38(Suppl 1):E2197\u2013E2203","journal-title":"Head Neck"},{"issue":"8","key":"5862_CR7","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.ejso.2017.04.013","volume":"43","author":"A Mishra","year":"2017","unstructured":"Mishra A et al (2017) Role of microscopic spread beyond gross disease as an adverse prognostic factor in oral squamous cell carcinoma. Eur J Surg Oncol 43(8):1503\u20131508","journal-title":"Eur J Surg Oncol"},{"key":"5862_CR8","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.oraloncology.2019.01.011","volume":"90","author":"A Singh","year":"2019","unstructured":"Singh A et al (2019) Incidence, predictors and impact of positive bony margins in surgically treated T4 stage cancers of the oral cavity. Oral Oncol 90:8\u201312","journal-title":"Oral Oncol"},{"issue":"8","key":"5862_CR9","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.ijom.2018.03.006","volume":"47","author":"RWH Smits","year":"2018","unstructured":"Smits RWH et al (2018) Evaluation of bone resection margins of segmental mandibulectomy for oral squamous cell carcinoma. Int J Oral Maxillofac Surg 47(8):959\u2013964","journal-title":"Int J Oral Maxillofac Surg"},{"key":"5862_CR10","doi-asserted-by":"publisher","first-page":"104579","DOI":"10.1016\/j.oraloncology.2020.104579","volume":"102","author":"M Nieberler","year":"2020","unstructured":"Nieberler M et al (2020) Defining secure surgical bone margins in head and neck squamous cell carcinomas: The diagnostic impact of intraoperative cytological assessment of bone resection margins compared with preoperative imaging. Oral Oncol 102:104579","journal-title":"Oral Oncol"},{"issue":"6","key":"5862_CR11","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.oooo.2019.11.011","volume":"129","author":"CK Sproll","year":"2020","unstructured":"Sproll CK et al (2020) Mandible handling in the surgical treatment of oral squamous cell carcinoma: lessons from clinical results after marginal and segmental mandibulectomy. Oral Surg Oral Med Oral Pathol Oral Radiol 129(6):556\u2013564","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"3","key":"5862_CR12","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.jcms.2015.01.006","volume":"43","author":"H Hanken","year":"2015","unstructured":"Hanken H et al (2015) Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence? J Craniomaxillofac Surg 43(3):373\u2013375","journal-title":"J Craniomaxillofac Surg"},{"issue":"1","key":"5862_CR13","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s00405-016-4219-7","volume":"274","author":"O Camuzard","year":"2017","unstructured":"Camuzard O et al (2017) Primary radical ablative surgery and fibula free-flap reconstruction for T4 oral cavity squamous cell carcinoma with mandibular invasion: oncologic and functional results and their predictive factors. Eur Arch Otorhinolaryngol 274(1):441\u2013449","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"11","key":"5862_CR14","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1245\/s10434-016-5208-1","volume":"23","author":"M Nieberler","year":"2016","unstructured":"Nieberler M et al (2016) Clinical impact of intraoperative cytological assessment of bone resection margins in patients with head and neck carcinoma. Ann Surg Oncol 23(11):3579\u20133586","journal-title":"Ann Surg Oncol"},{"key":"5862_CR15","doi-asserted-by":"publisher","first-page":"628297","DOI":"10.3389\/fonc.2021.628297","volume":"11","author":"EM Barroso","year":"2021","unstructured":"Barroso EM et al (2021) Performance of intraoperative assessment of resection margins in oral cancer surgery: a review of literature. Front Oncol 11:628297","journal-title":"Front Oncol"},{"issue":"12","key":"5862_CR16","doi-asserted-by":"publisher","first-page":"4070","DOI":"10.1245\/s10434-019-07645-9","volume":"26","author":"MM Li","year":"2019","unstructured":"Li MM et al (2019) Margin analysis in head and neck cancer: state of the art and future directions. Ann Surg Oncol 26(12):4070\u20134080","journal-title":"Ann Surg Oncol"},{"key":"5862_CR17","doi-asserted-by":"publisher","first-page":"105453","DOI":"10.1016\/j.oraloncology.2021.105453","volume":"120","author":"A Kouketsu","year":"2021","unstructured":"Kouketsu A et al (2021) Comparison of different diagnostic imaging techniques for the detection of bone invasion in oral cancers. Oral Oncol 120:105453","journal-title":"Oral Oncol"},{"issue":"20","key":"5862_CR18","doi-asserted-by":"publisher","first-page":"5945","DOI":"10.1158\/0008-5472.CAN-16-1227","volume":"76","author":"EM Barroso","year":"2016","unstructured":"Barroso EM et al (2016) Water concentration analysis by raman spectroscopy to determine the location of the tumor border in oral cancer surgery. Cancer Res 76(20):5945\u20135953","journal-title":"Cancer Res"},{"issue":"17","key":"5862_CR19","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1039\/D3AN00650F","volume":"148","author":"Y Aaboubout","year":"2023","unstructured":"Aaboubout Y et al (2023) Intraoperative assessment of resection margins by Raman spectroscopy to guide oral cancer surgery. Analyst 148(17):4116\u20134126","journal-title":"Analyst"},{"key":"5862_CR20","doi-asserted-by":"publisher","first-page":"105787","DOI":"10.1016\/j.sab.2020.105787","volume":"165","author":"G Teng","year":"2020","unstructured":"Teng G et al (2020) Discrimination of infiltrative glioma boundary based on laser-induced breakdown spectroscopy. Spectrochim Acta Part B Atom Spectrosc 165:105787","journal-title":"Spectrochim Acta Part B Atom Spectrosc"},{"key":"5862_CR21","doi-asserted-by":"publisher","first-page":"106200","DOI":"10.1016\/j.sab.2021.106200","volume":"180","author":"X Lin","year":"2021","unstructured":"Lin X et al (2021) Discrimination of lung tumor and boundary tissues based on laser-induced breakdown spectroscopy and machine learning. Spectrochim Acta Part B Atom Spectrosc 180:106200","journal-title":"Spectrochim Acta Part B Atom Spectrosc"},{"key":"5862_CR22","doi-asserted-by":"publisher","first-page":"106090","DOI":"10.1016\/j.sab.2021.106090","volume":"179","author":"J-H Choi","year":"2021","unstructured":"Choi J-H et al (2021) High spatial resolution imaging of melanoma tissue by femtosecond laser-induced breakdown spectroscopy. Spectrochim Acta Part B Atom Spectrosc 179:106090","journal-title":"Spectrochim Acta Part B Atom Spectrosc"},{"issue":"3","key":"5862_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.24.3.031011","volume":"24","author":"Y Moon","year":"2018","unstructured":"Moon Y et al (2018) Mapping of cutaneous melanoma by femtosecond laser-induced breakdown spectroscopy. J Biomed Opt 24(3):1\u20136","journal-title":"J Biomed Opt"},{"issue":"1","key":"5862_CR24","doi-asserted-by":"publisher","first-page":"16391","DOI":"10.1038\/s41598-022-20825-0","volume":"12","author":"P Winnand","year":"2022","unstructured":"Winnand P et al (2022) Evaluation of electrolyte element composition in human tissue by laser-induced breakdown spectroscopy (LIBS). Sci Rep 12(1):16391","journal-title":"Sci Rep"},{"key":"5862_CR25","doi-asserted-by":"publisher","first-page":"106308","DOI":"10.1016\/j.oraloncology.2023.106308","volume":"138","author":"P Winnand","year":"2023","unstructured":"Winnand P et al (2023) Real-time detection of bone-invasive oral cancer with laser-induced breakdown spectroscopy: A proof-of-principle study. Oral Oncol 138:106308","journal-title":"Oral Oncol"},{"issue":"18","key":"5862_CR26","doi-asserted-by":"publisher","first-page":"16635","DOI":"10.1007\/s00432-023-05411-9","volume":"149","author":"P Winnand","year":"2023","unstructured":"Winnand P et al (2023) The role of potassium in depth profiling of the tumor border in bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS): a pilot study. J Cancer Res Clin Oncol 149(18):16635\u201316645","journal-title":"J Cancer Res Clin Oncol"},{"issue":"5","key":"5862_CR27","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.3390\/ijms25052607","volume":"25","author":"P Winnand","year":"2024","unstructured":"Winnand P et al (2024) Assessment of the electrolyte heterogeneity of tissues in mandibular bone-infiltrating head and neck cancer using laser-induced breakdown spectroscopy. Int J Mol Sci 25(5):2607","journal-title":"Int J Mol Sci"},{"key":"5862_CR28","first-page":"Doc08","volume":"3","author":"A Tiemann","year":"2014","unstructured":"Tiemann A et al (2014) Histopathological Osteomyelitis Evaluation Score (HOES) - an innovative approach to histopathological diagnostics and scoring of osteomyelitis. GMS Interdiscip Plast Reconstr Surg DGPW 3:Doc08","journal-title":"GMS Interdiscip Plast Reconstr Surg DGPW"},{"issue":"9","key":"5862_CR29","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","volume":"5","author":"JN Mandrekar","year":"2010","unstructured":"Mandrekar JN (2010) Receiver operating characteristic curve in diagnostic test assessment. J Thorac Oncol 5(9):1315\u20131316","journal-title":"J Thorac Oncol"},{"issue":"1","key":"5862_CR30","doi-asserted-by":"publisher","first-page":"20180060","DOI":"10.1515\/ijb-2018-0060","volume":"15","author":"P Mart\u00ednez-Camblor","year":"2019","unstructured":"Mart\u00ednez-Camblor P, Pardo-Fern\u00e1ndez JC (2019) The youden index in the generalized receiver operating characteristic curve context. Int J Biostat 15(1):20180060","journal-title":"Int J Biostat"},{"issue":"5","key":"5862_CR31","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1039\/D0JA00469C","volume":"36","author":"K Kiss","year":"2021","unstructured":"Kiss K et al (2021) Imaging margins of skin tumors using laser-induced breakdown spectroscopy and machine learning. J Anal At Spectrom 36(5):909\u2013916","journal-title":"J Anal At Spectrom"},{"issue":"5","key":"5862_CR32","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.oraloncology.2015.01.015","volume":"51","author":"CR Anderson","year":"2015","unstructured":"Anderson CR, Sisson K, Moncrieff M (2015) A meta-analysis of margin size and local recurrence in oral squamous cell carcinoma. Oral Oncol 51(5):464\u2013469","journal-title":"Oral Oncol"},{"issue":"2","key":"5862_CR33","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00784-017-2153-8","volume":"22","author":"GD Rabelo","year":"2018","unstructured":"Rabelo GD et al (2018) Evaluation of cortical mandibular bone in patients with oral squamous cell carcinoma. Clin Oral Investig 22(2):783\u2013790","journal-title":"Clin Oral Investig"},{"issue":"9","key":"5862_CR34","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.jcms.2017.04.012","volume":"45","author":"LAA Vaassen","year":"2017","unstructured":"Vaassen LAA, Speel EM, Kessler P (2017) Bone invasion by oral squamous cell carcinoma: Molecular alterations leading to osteoclastogenesis - a review of literature. J Craniomaxillofac Surg 45(9):1464\u20131471","journal-title":"J Craniomaxillofac Surg"},{"issue":"6","key":"5862_CR35","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/bjc.2017.239","volume":"117","author":"AA Elmusrati","year":"2017","unstructured":"Elmusrati AA et al (2017) Cancer-associated fibroblasts promote bone invasion in oral squamous cell carcinoma. Br J Cancer 117(6):867\u2013875","journal-title":"Br J Cancer"},{"issue":"4","key":"5862_CR36","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/0002-9610(86)90304-1","volume":"152","author":"P Scholl","year":"1986","unstructured":"Scholl P et al (1986) Microscopic cut-through of cancer in the surgical treatment of squamous carcinoma of the tongue. Prognostic and therapeutic implications. Am J Surg 152(4):354\u201360","journal-title":"Am J Surg"},{"issue":"1","key":"5862_CR37","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jss.2012.03.019","volume":"178","author":"J Schuld","year":"2012","unstructured":"Schuld J et al (2012) Evidence for tumor cell spread during local hepatic ablation of colorectal liver metastases. J Surg Res 178(1):268\u2013279","journal-title":"J Surg Res"},{"issue":"4","key":"5862_CR38","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3171\/jns.1984.60.4.0819","volume":"60","author":"RM Voorhies","year":"1984","unstructured":"Voorhies RM et al (1984) Does the CO2 laser spread viable brain-tumor cells outside the surgical field? J Neurosurg 60(4):819\u2013820","journal-title":"J Neurosurg"},{"issue":"12","key":"5862_CR39","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1369\/0022155417733708","volume":"65","author":"FM Savi","year":"2017","unstructured":"Savi FM et al (2017) Comparison of different decalcification methods using rat mandibles as a model. J Histochem Cytochem 65(12):705\u2013722","journal-title":"J Histochem Cytochem"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05862-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-05862-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05862-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T11:11:35Z","timestamp":1726744295000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-05862-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["5862"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-05862-5","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"assertion":[{"value":"2 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained from the Medical Faculty of the RWTH Aachen University, Germany (EK 126\/21). All procedures were performed in accordance with the 1964 Helsinki Declaration and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The funding source had no involvement in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Role of the funding source"}},{"value":"KOB was a former employee of Advanced Osteotomy Tools (AOT) AG. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"474"}}