{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:48:12Z","timestamp":1792270092282,"version":"4.4.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-024-05865-2","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T07:02:07Z","timestamp":1722668527000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Remineralization of post-orthodontic white spot lesions with a fluoride varnish and a self-assembling P 11\u2009\u2212\u20094 peptides: a prospective in-vivo-study"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3822-0901","authenticated-orcid":false,"given":"Ecem","family":"G\u00fcven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-0427","authenticated-orcid":false,"given":"Ece","family":"Eden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-7356","authenticated-orcid":false,"given":"Rengin","family":"Attin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-2842","authenticated-orcid":false,"given":"Ezgi Cansu","family":"F\u0131r\u0131nc\u0131o\u011fullar\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"5865_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0002-9416(82)90032-X","volume":"81","author":"L Gorelick","year":"1982","unstructured":"Gorelick L, Geiger AM, Gwinnett AJ (1982) Incidence of white spot formation after bonding and banding. Am J Orthod 81:93\u201398","journal-title":"Am J Orthod"},{"key":"5865_CR2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00056-007-0714-1","volume":"68","author":"S Lovrov","year":"2007","unstructured":"Lovrov S, Hertrich K, Lovrov UH (2007) Enamel demineralization during fixed orthodontic treatment\u2013incidence and correlation to various oral-hygiene parameters. J Orofac Orthopedics\/Fortschritte Der Kieferorthop\u00e4die 68:353\u2013363","journal-title":"J Orofac Orthopedics\/Fortschritte Der Kieferorthop\u00e4die"},{"key":"5865_CR3","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0002-9416(83)90348-2","volume":"84","author":"E Mizrahi","year":"1983","unstructured":"Mizrahi E (1983) Surface distribution of enamel opacities following orthodontic treatment. Am J Orthod 84:323\u2013331. https:\/\/doi.org\/10.1016\/S0002-9416(83)90348-2","journal-title":"Am J Orthod"},{"key":"5865_CR4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/0889-5406(88)90453-2","volume":"94","author":"B \u00d8gaard","year":"1988","unstructured":"\u00d8gaard B, R\u00f8lla G, Arends J (1988) Orthodontic appliances and enamel demineralization. Am J Orthod Dentofac Orthop 94:68\u201373. https:\/\/doi.org\/10.1016\/0889-5406(88)90453-2","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"5865_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0889-5406(91)70046-Y","volume":"100","author":"RG Rosenbloom","year":"1991","unstructured":"Rosenbloom RG, Tinanoff N (1991) Salivary Streptococcus mutans levels in patients before, during, and after orthodontic treatment. Am J Orthod Dentofac Orthop 100:35\u201337","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"5865_CR6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1600-0722.1984.tb00881.x","volume":"92","author":"AA Sche\u0131e","year":"1984","unstructured":"Sche\u0131e AA, Arneberg P, Krogstad O (1984) Effect of orthodontic treatment on prevalence of Streptococcus mutans in plaque and saliva. Eur J Oral Sci 92:211\u2013217. https:\/\/doi.org\/10.1111\/j.1600-0722.1984.tb00881.x","journal-title":"Eur J Oral Sci"},{"key":"5865_CR7","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1159\/000077769","volume":"38","author":"NB Pitts","year":"2004","unstructured":"Pitts NB (2004) Are we ready to move from operative to Non-Operative\/Preventive Treatment of Dental Caries in Clinical Practice? Caries Res 38:294\u2013304. https:\/\/doi.org\/10.1159\/000077769","journal-title":"Caries Res"},{"key":"5865_CR8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1177\/154405910308200208","volume":"82","author":"B Nyvad","year":"2003","unstructured":"Nyvad B, Machiulskiene V, Baelum V (2003) Construct and predictive validity of clinical Caries Diagnostic Criteria assessing lesion activity. J Dent Res 82:117\u2013122. https:\/\/doi.org\/10.1177\/154405910308200208","journal-title":"J Dent Res"},{"key":"5865_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002279.pub2","author":"VC Marinho","year":"2014","unstructured":"Marinho VC, Worthington HV, Walsh T, Clarkson JE (2014) Fluoride varnishes for preventing dental caries in children and adolescents. Cochrane Database Syst. https:\/\/doi.org\/10.1002\/14651858.CD002279.pub2","journal-title":"Cochrane Database Syst"},{"key":"5865_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002280.pub2","author":"VC Marinho","year":"2021","unstructured":"Marinho VC, Worthington HV, Walsh T, Chong LY (2021) Fluoride gels for preventing dental caries in children and adolescents. Cochrane Database Syst Reviews. https:\/\/doi.org\/10.1002\/14651858.CD002280.pub2","journal-title":"Cochrane Database Syst Reviews"},{"key":"5865_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s40496-015-0048-9","volume":"2","author":"BT Amaechi","year":"2015","unstructured":"Amaechi BT (2015) Remineralization therapies for initial caries lesions. Curr Oral Health Rep 2:95\u2013101. https:\/\/doi.org\/10.1007\/s40496-015-0048-9","journal-title":"Curr Oral Health Rep"},{"key":"5865_CR12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/00220345000790010901","volume":"79","author":"GL Vogel","year":"2000","unstructured":"Vogel GL, Zhang Z, Carey CM, Ly A, Chow LC, Proskin HM (2000) Composition of Plaque and Saliva following use of an \u03b1-Tricalcium-phosphate-containing chewing gum and a subsequent sucrose challenge. J Dent Res 79:58\u201362. https:\/\/doi.org\/10.1177\/00220345000790010901","journal-title":"J Dent Res"},{"key":"5865_CR13","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1007\/s10856-010-4064-y","volume":"21","author":"RL Karlinsey","year":"2009","unstructured":"Karlinsey RL, Mackey AC, Walker ER, Frederick KE (2009) Surfactant-modified \u03b2-TCP: structure, properties, and in vitro remineralization of subsurface enamel lesions. J Mater Sci Mater Med 21:2009\u20132020. https:\/\/doi.org\/10.1007\/s10856-010-4064-y","journal-title":"J Mater Sci Mater Med"},{"key":"5865_CR14","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s10853-008-3068-1","volume":"44","author":"RL Karlinsey","year":"2009","unstructured":"Karlinsey RL, Mackey AC (2009) Solid-state preparation and dental application of an organically modified calcium phosphate. J Mater Sci 44:346\u2013349. https:\/\/doi.org\/10.1007\/s10853-008-3068-1","journal-title":"J Mater Sci"},{"key":"5865_CR15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.4103\/0972-0707.108185","volume":"16","author":"S Joshi","year":"2013","unstructured":"Joshi S, Patil N, Choudhari S, Kulkarni S (2013) Comparative evaluation of remineralizing potential of three agents on artificially demineralized human enamel: an in vitro study. J Conservative Dentistry 16:116. https:\/\/doi.org\/10.4103\/0972-0707.108185","journal-title":"J Conservative Dentistry"},{"key":"5865_CR16","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1177\/154405910708600507","volume":"86","author":"Kirkham Jet al","year":"2007","unstructured":"Kirkham Jet al et al (2007) Self-assembling peptide scaffolds promote Enamel Remineralization. J Dent Res 86:426\u2013430. https:\/\/doi.org\/10.1177\/154405910708600507","journal-title":"J Dent Res"},{"key":"5865_CR17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2217\/17435889.1.2.189","volume":"1","author":"A Firth","year":"2006","unstructured":"Firth A, Aggeli A, Burke JL, Yang X, Kirkham J (2006) Biomimetic self-assembling peptides as injectable scaffolds for hard tissue engineering. Nanomedicine 1:189\u2013199. https:\/\/doi.org\/10.2217\/17435889.1.2.189","journal-title":"Nanomedicine"},{"key":"5865_CR18","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1177\/0022034517698419","volume":"96","author":"L Kind","year":"2017","unstructured":"Kind L et al (2017) Biomimetic remineralization of Carious lesions by Self-assembling peptide. J Dent Res 96:790\u2013797. https:\/\/doi.org\/10.1177\/0022034517698419","journal-title":"J Dent Res"},{"issue":"45","key":"5865_CR19","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.1002\/anie.200352207","volume":"42","author":"A Aggeli","year":"2003","unstructured":"Aggeli A, Bell M, Boden N, Carrick LM, Strong AE (2003) Self-assembling peptide polyelectrolyte beta-sheet complexes form nematic hydrogels. Angew Chem Int Ed Engl 42(45):5603\u20135606. https:\/\/doi.org\/10.1002\/anie.200352207","journal-title":"Angew Chem Int Ed Engl"},{"key":"5865_CR20","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3390\/dj3040111","volume":"3","author":"H Deyhle","year":"2015","unstructured":"Deyhle H, Dziadowiec I, Kind L, Thalmann P, Schulz G, M\u00fcller B (2015) Mineralization of early stage Carious Lesions in Vitro\u2014A quantitative Approach. Dent J (Basel) 3:111\u2013122. https:\/\/doi.org\/10.3390\/dj3040111","journal-title":"Dent J (Basel)"},{"issue":"1","key":"5865_CR21","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1186\/s12903-023-03269-4","volume":"23","author":"SM Atteya","year":"2023","unstructured":"Atteya SM, Amer HA, Saleh SM, Safwat Y (2023) Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: randomized controlled clinical trial. BMC Oral Health 23(1):577. https:\/\/doi.org\/10.1186\/s12903-023-03269-4","journal-title":"BMC Oral Health"},{"key":"5865_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-020-00345-1","author":"Y Lena Sezici","year":"2021","unstructured":"Lena Sezici Y, Yetkiner E, Aykut Yetkiner A, Eden E, Attin R (2021) Comparative evaluation of fluoride varnishes, self-assembling peptide-based remineralization agent, and enamel matrix protein derivative on artificial enamel remineralization in vitro. Prog Orthod. https:\/\/doi.org\/10.1186\/s40510-020-00345-1","journal-title":"Prog Orthod"},{"key":"5865_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003809.pub3","author":"PE Benson","year":"2013","unstructured":"Benson PE, Parkin N, Dyer F, Millett DT, Furness S, Germain P (2013) Fluorides for the prevention of early tooth decay (demineralised white lesions) during fixed brace treatment. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD003809.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"5865_CR24","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1177\/0022034512453845","volume":"24","author":"NJ Cochrane","year":"2012","unstructured":"Cochrane NJ, Zero DT, Reynolds EC (2012) Remineralization models. Adv Dent Res 24:129\u2013132. https:\/\/doi.org\/10.1177\/0022034512453845","journal-title":"Adv Dent Res"},{"key":"5865_CR25","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00784-022-04757-7","volume":"27","author":"RAAEG Gohar","year":"2022","unstructured":"Gohar RAAEG, Ibrahim SH, Safwat OM (2022) Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial. Clin Oral Investig 27:613\u2013624. https:\/\/doi.org\/10.1007\/s00784-022-04757-7","journal-title":"Clin Oral Investig"},{"key":"5865_CR26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1034\/j.1600-0722.2001.00997.x","volume":"109","author":"S Tran\u00e6us","year":"2001","unstructured":"Tran\u00e6us S, Al-Khateeb S, Bj\u00f6rkman S, Twetman S, Angmar\u2010M\u00e5nsson B (2001) Application of quantitative light\u2010induced fluorescence to monitor incipient lesions in caries\u2010active children. A comparative study of remineralisation by fluoride varnish and professional cleaning. Eur J Oral Sci 109:71\u201375. https:\/\/doi.org\/10.1034\/j.1600-0722.2001.00997.x","journal-title":"Eur J Oral Sci"},{"issue":"4","key":"5865_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.bdj.2013.741","volume":"215","author":"PA Brunton","year":"2013","unstructured":"Brunton PA et al (2013) Treatment of early caries lesions using biomimetic self-assembling peptides-a clinical safety trial. Br Dent J 215(4):1\u20136. https:\/\/doi.org\/10.1038\/sj.bdj.2013.741","journal-title":"Br Dent J"},{"key":"5865_CR28","doi-asserted-by":"publisher","first-page":"364","DOI":"10.17796\/1053-4628-39.4.364","volume":"39","author":"M Unal","year":"2015","unstructured":"Unal M, Oztas N N (2015) Remineralization capacity of three fissure sealants with and without Gaseous ozone on non-cavitated incipient pit and fissure caries. J Clin Pediatr Dent 39:364\u2013370. https:\/\/doi.org\/10.17796\/1053-4628-39.4.364","journal-title":"J Clin Pediatr Dent"},{"key":"5865_CR29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.17796\/1053-4625-43.3.5","volume":"43","author":"M \u00dcnal","year":"2019","unstructured":"\u00dcnal M, Ko\u00e7kanat A, G\u00fcler S, G\u00fclt\u00fcrk A (2019) Diagnostic performance of different methods in detecting Incipient Non-cavitated Occlusal caries lesions in Permanent Teeth. J Clin Pediatr Dent 43:173\u2013179. https:\/\/doi.org\/10.17796\/1053-4625-43.3.5","journal-title":"J Clin Pediatr Dent"},{"key":"5865_CR30","doi-asserted-by":"publisher","first-page":"99","DOI":"10.23804\/ejpd.2017.18.02.03","volume":"18","author":"A Kockanat","year":"2017","unstructured":"Kockanat A, Unal M (2017) In vivo and in vitro comparison of ICDAS II, DIAGNOdent pen, CarieScan PRO and SoproLife camera for occlusal caries detection in primary molar teeth. Eur J Paediatr Dent 18:99\u2013104. https:\/\/doi.org\/10.23804\/ejpd.2017.18.02.03","journal-title":"Eur J Paediatr Dent"},{"key":"5865_CR31","doi-asserted-by":"publisher","first-page":"136","DOI":"10.2341\/08-54","volume":"34","author":"MA Khalife","year":"2009","unstructured":"Khalife MA, Boynton JR, Dennison JB, Yaman P, Hamilton JC (2009) In vivo evaluation of DIAGNOdent for the Quantification of Occlusal Dental Caries. Oper Dent 34:136\u2013141. https:\/\/doi.org\/10.2341\/08-54","journal-title":"Oper Dent"},{"key":"5865_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.2319\/100107-468.1","volume":"79","author":"O Kronenberg","year":"2009","unstructured":"Kronenberg O, Lussi A, Ruf S (2009) Preventive effect of ozone on the development of White Spot lesions during Multibracket Appliance Therapy. Angle Orthod 79:64\u201369. https:\/\/doi.org\/10.2319\/100107-468.1","journal-title":"Angle Orthod"},{"issue":"11","key":"5865_CR33","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1177\/0022034510376046","volume":"89","author":"NJ Cochrane","year":"2010","unstructured":"Cochrane NJ, Cai F, Huq NL, Burrow MF, Reynolds EC (2010) Critical review in oral biology & medicine: new approaches to enhanced remineralization of tooth enamel. J Dent Res 89(11):1187\u20131197. https:\/\/doi.org\/10.1177\/0022034510376046","journal-title":"J Dent Res"},{"key":"5865_CR34","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1080\/00016350701620644","volume":"65","author":"L Karlsson","year":"2007","unstructured":"Karlsson L, Lindgren LE, Trolls\u00e5s K, Angmar-M\u00e5nsson B, Tranaeus S (2007) Effect of supplementary amine fluoride gel in caries-active adolescents. A clinical QLF study. Acta Odontol Scand 65:284\u2013291. https:\/\/doi.org\/10.1080\/00016350701620644","journal-title":"Acta Odontol Scand"},{"key":"5865_CR35","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/00016350410001793","volume":"62","author":"A Aljehani","year":"2004","unstructured":"Aljehani A, Tranaeus S, Forsberg CM, Angmar-M\u00e5nsson B, Shi XQ (2004) In vitro quantification of white spot enamel lesions adjacent to fixed orthodontic appliances using quantitative light-induced fluorescence and DIAGNOdent. Acta Odontol Scand 62:313\u2013318. https:\/\/doi.org\/10.1080\/00016350410001793","journal-title":"Acta Odontol Scand"},{"key":"5865_CR36","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/sj\/dmfr\/4600644","volume":"30","author":"B Angmar-M\u00e5nsson","year":"2001","unstructured":"Angmar-M\u00e5nsson B, Bosch JJT (2001) Quantitative light-induced fluorescence (QLF): a method for assessment of incipient caries lesions. Dentomaxillofac Radiol 30:298\u2013307. https:\/\/doi.org\/10.1038\/sj\/dmfr\/4600644","journal-title":"Dentomaxillofac Radiol"},{"key":"5865_CR37","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jdent.2004.10.017","volume":"33","author":"IA Pretty","year":"2005","unstructured":"Pretty IA, Edgar WM, Smith PW, Higham SM (2005) Quantification of dental plaque in the research environment. J Dent 33:193\u2013207. https:\/\/doi.org\/10.1016\/j.jdent.2004.10.017","journal-title":"J Dent"},{"key":"5865_CR38","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1159\/000104793","volume":"41","author":"Y Feng","year":"2007","unstructured":"Feng Y, Yin W, Hu D, Zhang YP, Ellwood RP, Pretty IA (2007) Assessment of Autofluorescence to detect the remineralization capabilities of Sodium Fluoride, Monofluorophosphate and Non-fluoride Dentifrices. Caries Res 41:358\u2013364. https:\/\/doi.org\/10.1159\/000104793","journal-title":"Caries Res"},{"key":"5865_CR39","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1600-0722.2005.00255.x","volume":"113","author":"R Heinrich-Weltzien","year":"2005","unstructured":"Heinrich-Weltzien R, K\u00fchnisch J, Ifland S, Tranaeus S, Angmar-M\u00e5nsson B, St\u00f6sser L (2005) Detection of initial caries lesions on smooth surfaces by quantitative light-induced fluorescence and visual examination: an in vivo comparison. Eur J Oral Sci 113:494\u2013498. https:\/\/doi.org\/10.1111\/j.1600-0722.2005.00255.x","journal-title":"Eur J Oral Sci"},{"key":"5865_CR40","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.adaj.2023.03.014","volume":"154","author":"JH Keeper","year":"2023","unstructured":"Keeper JH et al (2023) Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest, cavitation, and progression of initial caries lesions. J Am Dent Association 154:580\u2013591. https:\/\/doi.org\/10.1016\/j.adaj.2023.03.014","journal-title":"J Am Dent Association"},{"key":"5865_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/polym14040792","author":"AA Dawasaz","year":"2022","unstructured":"Dawasaz AA, Togoo RA, Mahmood Z, Azlina A, Thirumulu Ponnuraj K (2022) Effectiveness of self-assembling peptide (P11-4) in Dental Hard tissue conditions: a Comprehensive Review. Polym (Basel). https:\/\/doi.org\/10.3390\/polym14040792","journal-title":"Polym (Basel)"},{"key":"5865_CR42","doi-asserted-by":"publisher","first-page":"857","DOI":"10.61872\/sdj-2017-10-329","volume":"127","author":"T Attin","year":"2017","unstructured":"Attin T, Becker K, Wiedemeier DB, Schmidlin PR, Wegehaupt FJ (2017) Anti-erosive effect of a self-assembling peptide gel. Swiss Dent J 127:857\u2013864","journal-title":"Swiss Dent J"},{"key":"5865_CR43","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05562-0","author":"SM Atteya","year":"2024","unstructured":"Atteya SM, Amer HA, Saleh SM, Safwat Y (2024) The effect of nano silver fluoride, self-assembling peptide and sodium fluoride varnish on salivary cariogenic bacteria: a randomized controlled clinical trial. Clin Oral Investig. https:\/\/doi.org\/10.1007\/s00784-024-05562-0","journal-title":"Clin Oral Investig"},{"key":"5865_CR44","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jobcr.2022.03.012","volume":"12","author":"BK Aparna","year":"2022","unstructured":"Aparna BK, Yoshoda R, Puranik MP (2022) Remineralization of early enamel caries lesions using self-assembling peptides P11-4: systematic review and meta-analysis. J Oral Biol Craniofac Res 12:324\u2013331. https:\/\/doi.org\/10.1016\/j.jobcr.2022.03.012","journal-title":"J Oral Biol Craniofac Res"},{"key":"5865_CR45","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.13126","author":"M Ya\u015far","year":"2023","unstructured":"Ya\u015far M, Bal C, Aksoy M, G\u00fcng\u00f6rm\u00fc\u015f M, Orhan K (2023) In vitro caries-preventive effect of a mineralization-promoting peptide combined with fluoride gel on sound primary teeth. Int J Paediatr Dent. https:\/\/doi.org\/10.1111\/ipd.13126","journal-title":"Int J Paediatr Dent"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05865-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-05865-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05865-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T08:46:53Z","timestamp":1724402813000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-05865-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,3]]},"references-count":45,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["5865"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-05865-2","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,3]]},"assertion":[{"value":"3 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conductedin accordance with the Declaration of Helsinki on medical protocol and ethics and all national ethical standards. Ethical approval was ob-tained from the Research Ethics Committee, Faculty of Dentistry, Ege University (14-11.1\/38\u2009\u2212\u200911\/2014). Signed informed consent was obtained from all patients before participation in the study. For patients less than 18 years, informed consent was obtained from one of theirparents. The trial was prospectively registered on the clinicaltrials.govregistry (NCT02341872).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"464"}}