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While biofilms on the implant surface is considered its etiologic reason, several risk factors determine the pace of progression of peri-implant bone loss. Some risk factors are generally accepted while others are still unconfirmed and a matter of ongoing discussion. Among the latter, tissue macrophage sensitization on TiO<jats:sub>2<\/jats:sub> has gained scientific interest in recent years. The aim of the present case-control study was to test for potential associations between clinically manifest peri-implantitis and MS related parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>In patients with implants affected by peri-implantitis in the test group and healthy implants in the control group clinical parameters (peri-implant pocket depths (PPD) and bleeding on probing (BOP) were measured. Samples of aMMP-8 were taken from the entrance of the peri-implant sulcus and bacterial samples were collected from the sulcus. Blood samples were obtained from the basilic vein to assess MA-related laboratory parameters. Potential correlations between clinical and laboratory parameters were tested by multiple regression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>No statistically significant correlations were found between clinical or bacteriological findings and laboratory parameters were found.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Based on the findings of this study elevated MA-related laboratory parameters do not appear to be linked to peri-implantitis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Sensitization on TiO<jats:sub>2<\/jats:sub> is not associated with clinical symptoms of peri-implantitis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05880-3","type":"journal-article","created":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T07:01:45Z","timestamp":1724569305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of clinical parameters of peri-implantitis and parameters related to tissue macrophage sensitization on TiO2"],"prefix":"10.1007","volume":"28","author":[{"given":"Philipp","family":"Sahrmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Tartsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick R.","family":"Schmidlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"issue":"1","key":"5880_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/joor.12866","volume":"47","author":"L Adler","year":"2020","unstructured":"Adler L, Buhlin K, Jansson L (2020) Survival and complications: a 9- to 15-year retrospective follow-up of dental implant therapy. 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