{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:41:29Z","timestamp":1789630889082,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012681","name":"Universit\u00e4tsklinikum K\u00f6ln","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012681","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This study investigates the relationship between the total volume of oral tongue cancer pre-operatively and the RFFF volume post-operatively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A total of 52 DICOM imaging datasets (CT or MRI) of 26 patients were included in this study. The volume of the desired structure was quantified using semi-automatic segmentation using the software ITK-SNAP. All extracted measurements were validated by two further clinicians at separate instances.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The variation of MeanVolTu can be predicted by MeanVolFlap moderately reliable with 59.1% confidence (R-Qua: 0.591). ANOVA Testing to represent how well the regression line fits the data, resulted in the overall regression model being statistically significant in predicting the MeanVolTu (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The flap volume may be predicted using the following algorithm: MeanVolFlap0\u2009=\u20093241,633\u2009+\u20091, 322 * MeanVolTu.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results of this study show positive correlation between tumor volume and flap volume, highlighting the significance of efficient flap planning with increasing tumor volume. A larger extraction volume of the radial forearm free flap from the donor site compromises the forearm more, thus increasing the probability of post-operative complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Radial forearm free flap design in accordance with its corresponding 3D tumor volume.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05885-y","type":"journal-article","created":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T07:01:45Z","timestamp":1724569305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative analysis of volumetric changes between resection volume of oral tongue cancer and post operative volume of radial forearm flaps"],"prefix":"10.1007","volume":"28","author":[{"given":"Matthias","family":"Zirk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Niknazemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Riekert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kreppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Linz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max-Philipp","family":"Lentzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"5885_CR1","unstructured":"Aum\u00fcller G, Aust G, Conrad A (2006) Duale Reihe Anatomie. Duale Reihe Anatomie. Vol. 1. Auflage Thieme"},{"issue":"5","key":"5885_CR2","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/S1368-8375(97)00029-8","volume":"33","author":"C La Vecchia","year":"1997","unstructured":"La Vecchia C et al (1997) Epidemiology and prevention of oral cancer. Oral Oncol 33(5):302\u2013312","journal-title":"Oral Oncol"},{"issue":"1","key":"5885_CR3","first-page":"14","volume":"9","author":"E Figuero Ruiz","year":"2004","unstructured":"Figuero Ruiz E et al (2004) Effects of the consumption of alcohol in the oral cavity: relationship with oral cancer. Med Oral 9(1):14\u201323","journal-title":"Med Oral"},{"issue":"4","key":"5885_CR4","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.7314\/APJCP.2015.16.4.1371","volume":"16","author":"M Krishnatreya","year":"2015","unstructured":"Krishnatreya M et al (2015) Characteristics of oral tongue and base of the tongue cancer: a hospital cancer registry based analysis. Asian Pac J Cancer Prev 16(4):1371\u20131374","journal-title":"Asian Pac J Cancer Prev"},{"key":"5885_CR5","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.oraloncology.2017.02.019","volume":"67","author":"JE Tota","year":"2017","unstructured":"Tota JE et al (2017) Rising incidence of oral tongue cancer among white men and women in the United States, 1973\u20132012. Oral Oncol 67:146\u2013152","journal-title":"Oral Oncol"},{"issue":"12","key":"5885_CR6","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.oraloncology.2008.02.017","volume":"44","author":"EM Iype","year":"2008","unstructured":"Iype EM et al (2008) The role of selective neck dissection (I-III) in the treatment of node negative (N0) neck in oral cancer. Oral Oncol 44(12):1134\u20131138","journal-title":"Oral Oncol"},{"issue":"8","key":"5885_CR7","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.oraloncology.2014.04.011","volume":"50","author":"A Deganello","year":"2014","unstructured":"Deganello A, Leemans CR (2014) The infrahyoid flap: a comprehensive review of an often overlooked reconstructive method. Oral Oncol 50(8):704\u2013710","journal-title":"Oral Oncol"},{"issue":"8","key":"5885_CR8","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.bjps.2015.04.020","volume":"68","author":"M Baas","year":"2015","unstructured":"Baas M et al (2015) A systematic review on the sensory reinnervation of free flaps for tongue reconstruction: does improved sensibility imply functional benefits? J Plast Reconstr Aesthet Surg 68(8):1025\u20131035","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1","key":"5885_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/cncr.26229","volume":"118","author":"I Ganly","year":"2012","unstructured":"Ganly I, Patel S, Shah J (2012) Early stage squamous cell cancer of the oral tongue\u2013clinicopathologic features affecting outcome. Cancer 118(1):101\u2013111","journal-title":"Cancer"},{"issue":"1","key":"5885_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1054\/ijom.2002.0313","volume":"32","author":"DN Sutton","year":"2003","unstructured":"Sutton DN et al (2003) The prognostic implications of the surgical margin in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 32(1):30\u201334","journal-title":"Int J Oral Maxillofac Surg"},{"key":"5885_CR11","unstructured":"Deutsche Krebsgesellschaft D. K. and AWMF (2019) Leitlinienprogramm Onkologie, in S3-Leitlinie Diagnostik und Therapie des Mundh\u00f6hlenkarzinoms, Langversion 01 (Konsultationsfassung), 2019, AWMF"},{"issue":"2","key":"5885_CR12","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1055\/s-0039-1693504","volume":"52","author":"E Benanti","year":"2019","unstructured":"Benanti E et al (2019) Objective selection criteria between ALT and Radial Forearm flap in oral soft tissues Reconstruction. Indian J Plast Surg 52(2):166\u2013170","journal-title":"Indian J Plast Surg"},{"issue":"11","key":"5885_CR13","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1016\/j.joms.2008.01.018","volume":"66","author":"JC de Vicente","year":"2008","unstructured":"de Vicente JC et al (2008) Microvascular free tissue transfer for tongue reconstruction after hemiglossectomy: a functional assessment of radial forearm versus anterolateral thigh flap. J Oral Maxillofac Surg 66(11):2270\u20132275","journal-title":"J Oral Maxillofac Surg"},{"issue":"5\u20136","key":"5885_CR14","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000502151","volume":"81","author":"YC Cai","year":"2019","unstructured":"Cai YC et al (2019) Comparative Analysis of Radial Forearm Free Flap and Anterolateral Thigh Flap in Tongue Reconstruction after Radical Resection of Tongue Cancer. ORL J Otorhinolaryngol Relat Spec 81(5\u20136):252\u2013264","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"07","key":"5885_CR15","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1055\/s-2006-951313","volume":"22","author":"S Sarukawa","year":"2006","unstructured":"Sarukawa S et al (2006) Volumetric changes in the transferred flap after Anterior Craniofacial Reconstruction. J Reconstr Microsurg 22(07):499\u2013505","journal-title":"J Reconstr Microsurg"},{"issue":"4","key":"5885_CR16","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1002\/lary.22509","volume":"122","author":"KM Higgins","year":"2012","unstructured":"Higgins KM et al (2012) Volumetric changes of the anterolateral thigh free flap following adjuvant radiotherapy in total parotidectomy reconstruction. Laryngoscope 122(4):767\u2013772","journal-title":"Laryngoscope"},{"issue":"4","key":"5885_CR17","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.anl.2020.12.006","volume":"48","author":"KI Kamizono","year":"2021","unstructured":"Kamizono KI et al (2021) Volumetric changes of transferred free anterolateral thigh flaps in head and neck lesions. Auris Nasus Larynx 48(4):751\u2013757","journal-title":"Auris Nasus Larynx"},{"key":"5885_CR18","doi-asserted-by":"crossref","unstructured":"Choi S et al (2004) Radiation Therapy does not Impact Local Complication Rates after Free Flap Reconstruction for Head and Neck Cancer, vol 130. Archives of Otolaryngology\u2013Head & Neck Surgery, pp 1308\u20131312. 11","DOI":"10.1001\/archotol.130.11.1308"},{"issue":"11","key":"5885_CR19","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1007\/s00432-012-1263-6","volume":"138","author":"B Hohlweg-Majert","year":"2012","unstructured":"Hohlweg-Majert B et al (2012) Impact of radiotherapy on microsurgical reconstruction of the head and neck. J Cancer Res Clin Oncol 138(11):1799\u20131811","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"5885_CR20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.oraloncology.2011.11.013","volume":"48","author":"T M\u00fccke","year":"2012","unstructured":"M\u00fccke T et al (2012) Influence of irradiation and oncologic surgery on head and neck microsurgical reconstructions. Oral Oncol 48(4):367\u2013371","journal-title":"Oral Oncol"},{"issue":"6","key":"5885_CR21","doi-asserted-by":"publisher","first-page":"607","DOI":"10.5999\/aps.2021.00808","volume":"48","author":"KH Song","year":"2021","unstructured":"Song KH et al (2021) Volumetric change of the latissimus dorsi muscle after postoperative chemotherapy and radiotherapy in immediate breast reconstruction with an extended latissimus dorsi musculocutaneous flap: final results from serial studies. Arch Plast Surg 48(6):607\u2013613","journal-title":"Arch Plast Surg"},{"issue":"10","key":"5885_CR22","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1002\/hed.21944","volume":"34","author":"K Yamaguchi","year":"2012","unstructured":"Yamaguchi K et al (2012) Quantitative analysis of free flap volume changes in head and neck reconstruction. Head Neck 34(10):1403\u20131407","journal-title":"Head Neck"},{"issue":"6","key":"5885_CR23","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1097\/PRS.0b013e3181f4468b","volume":"126","author":"H Suga","year":"2010","unstructured":"Suga H et al (2010) Adipose tissue remodeling under ischemia: death of adipocytes and activation of stem\/progenitor cells. Plast Reconstr Surg 126(6):1911\u20131923","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"5885_CR24","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.joms.2011.04.014","volume":"70","author":"YS Shin","year":"2012","unstructured":"Shin YS et al (2012) Radiotherapy deteriorates postoperative functional outcome after partial glossectomy with free flap reconstruction. J Oral Maxillofac Surg 70(1):216\u2013220","journal-title":"J Oral Maxillofac Surg"},{"issue":"9","key":"5885_CR25","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.jcms.2016.04.031","volume":"44","author":"A Tarsitano","year":"2016","unstructured":"Tarsitano A et al (2016) Microvascular reconstruction of the tongue using a free anterolateral thigh flap: three-dimensional evaluation of volume loss after radiotherapy. J Craniomaxillofac Surg 44(9):1287\u20131291","journal-title":"J Craniomaxillofac Surg"},{"issue":"2","key":"5885_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/00006534-198408000-00008","volume":"74","author":"PJ Guelinckx","year":"1984","unstructured":"Guelinckx PJ et al (1984) Scanning electron microscopy of irradiated recipient blood vessels in head and neck free flaps. Plast Reconstr Surg 74(2):217\u2013226","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"5885_CR27","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","volume":"31","author":"PA Yushkevich","year":"2006","unstructured":"Yushkevich PA et al (2006) User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. NeuroImage 31(3):1116\u20131128","journal-title":"NeuroImage"},{"key":"5885_CR28","first-page":"3342","volume":"2016","author":"PA Yushkevich","year":"2016","unstructured":"Yushkevich PA, Yang G, Gerig G (2016) ITK-SNAP: an interactive tool for semi-automatic segmentation of multi-modality biomedical images. Annu Int Conf IEEE Eng Med Biol Soc 2016:3342\u20133345","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"issue":"9","key":"5885_CR29","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.joms.2021.05.004","volume":"79","author":"M Riekert","year":"2021","unstructured":"Riekert M et al (2021) Volumetric analysis and clinical outcome in 54 patients with Retrobulbar Hematoma. J Oral Maxillofac Surg 79(9):1914\u20131920","journal-title":"J Oral Maxillofac Surg"},{"issue":"6","key":"5885_CR30","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.jcms.2021.01.014","volume":"49","author":"MP Lentzen","year":"2021","unstructured":"Lentzen MP et al (2021) Bisphosphonate application and volumetric effects on MRONJ lesions. J Craniomaxillofac Surg 49(6):501\u2013507","journal-title":"J Craniomaxillofac Surg"},{"key":"5885_CR31","doi-asserted-by":"crossref","unstructured":"Ngo MT et al (2021) Improving blood Flow visualization of recirculation regions at carotid bulb in 4D Flow MRI using semi-automatic segmentation with ITK-SNAP. Diagnostics (Basel), 11(10)","DOI":"10.3390\/diagnostics11101890"},{"issue":"12","key":"5885_CR32","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s00234-020-02481-1","volume":"62","author":"K Gau","year":"2020","unstructured":"Gau K et al (2020) Accuracy and practical aspects of semi- and fully automatic segmentation methods for resected brain areas. Neuroradiology 62(12):1637\u20131648","journal-title":"Neuroradiology"},{"issue":"6","key":"5885_CR33","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1080\/00016480802369260","volume":"129","author":"A Bozec","year":"2009","unstructured":"Bozec A et al (2009) Radical ablative surgery and radial forearm free flap (RFFF) reconstruction for patients with oral or oropharyngeal cancer: postoperative outcomes and oncologic and functional results. Acta Otolaryngol 129(6):681\u2013687","journal-title":"Acta Otolaryngol"},{"issue":"9","key":"5885_CR34","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.jcms.2020.07.011","volume":"48","author":"LM Ritschl","year":"2020","unstructured":"Ritschl LM et al (2020) Bone volume change following vascularized free bone flap reconstruction of the mandible. J Craniomaxillofac Surg 48(9):859\u2013867","journal-title":"J Craniomaxillofac Surg"},{"issue":"4","key":"5885_CR35","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/MLG.0b013e31816067a3","volume":"118","author":"RW Ng","year":"2008","unstructured":"Ng RW et al (2008) Clinical implications of anterolateral thigh flap shrinkage. Laryngoscope 118(4):585\u2013588","journal-title":"Laryngoscope"},{"key":"5885_CR36","doi-asserted-by":"crossref","unstructured":"Stacey D et al Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Reviews, 2017(4).","DOI":"10.1002\/14651858.CD001431.pub5"},{"key":"5885_CR37","doi-asserted-by":"crossref","unstructured":"Mardinger C et al (2023) Breast Reconstruction decision aids decrease Decisional Conflict and improve decisional satisfaction: a Randomized Controlled Trial, vol 151. Plastic and Reconstructive Surgery, 2","DOI":"10.1097\/PRS.0000000000009830"},{"key":"5885_CR38","doi-asserted-by":"crossref","unstructured":"Iandelli A et al (2024) Donor site scar preference in head and neck free flap reconstruction: the patient point of view. Oral Oncol Rep, 10","DOI":"10.1016\/j.oor.2024.100453"},{"issue":"1","key":"5885_CR39","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000504196","volume":"82","author":"M-S Kim","year":"2020","unstructured":"Kim M-S et al (2020) Assessment of Chronological volume changes in Radial Forearm Free flaps for Tongue Cancer. ORL 82(1):40\u201346","journal-title":"ORL"},{"issue":"4","key":"5885_CR40","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.bjoms.2009.09.004","volume":"48","author":"CM Avery","year":"2010","unstructured":"Avery CM (2010) Review of the radial free flap: is it still evolving, or is it facing extinction? Part one: soft-tissue radial flap. Br J Oral Maxillofac Surg 48(4):245\u2013252","journal-title":"Br J Oral Maxillofac Surg"},{"key":"5885_CR41","first-page":"e9","volume":"12","author":"DJ Loeffelbein","year":"2012","unstructured":"Loeffelbein DJ et al (2012) Reduction of donor site morbidity of free radial forearm flaps: what level of evidence is available? Eplasty 12:e9","journal-title":"Eplasty"},{"key":"5885_CR42","doi-asserted-by":"crossref","unstructured":"Bardsley AF et al (1990) Reducing morbidity in the radial forearm flap donor site. Plast Reconstr Surg, 86(2): p. 287\u2009\u2013\u200992; discussion 293-4.","DOI":"10.1097\/00006534-199008000-00015"},{"issue":"1","key":"5885_CR43","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/00006534-199701000-00017","volume":"99","author":"D Richardson","year":"1997","unstructured":"Richardson D et al (1997) Radial forearm flap donor-site complications and morbidity: a prospective study. Plast Reconstr Surg 99(1):109\u2013115","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"5885_CR44","doi-asserted-by":"publisher","first-page":"631","DOI":"10.5999\/aps.2012.39.6.631","volume":"39","author":"SU Park","year":"2012","unstructured":"Park SU, Shim JS (2012) Assessment of breast volume change after transverse rectus abdominis myocutaneous flap. Arch Plast Surg 39(6):631\u2013635","journal-title":"Arch Plast Surg"},{"key":"5885_CR45","doi-asserted-by":"crossref","unstructured":"Thoenissen P et al (2020) Three-Dimensional magnetic resonance imaging volumetry of Radial Forearm Flap reconstructions after Craniomaxillofacial Tumor Resection. J Craniofac Surg, 31(5)","DOI":"10.1097\/SCS.0000000000006445"},{"issue":"5","key":"5885_CR46","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.bjoms.2021.10.014","volume":"60","author":"Q Xu","year":"2022","unstructured":"Xu Q et al (2022) Comparing donor site morbidity between radial and ulnar forearm free flaps: a meta-analysis. Br J Oral Maxillofac Surg 60(5):547\u2013553","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"4","key":"5885_CR47","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10006-019-00805-x","volume":"23","author":"M Zirk","year":"2019","unstructured":"Zirk M et al (2019) Volumetric analysis of MRONJ lesions by semiautomatic segmentation of CBCT images. Oral Maxillofac Surg 23(4):465\u2013472","journal-title":"Oral Maxillofac Surg"},{"issue":"6","key":"5885_CR48","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.ijom.2023.12.003","volume":"53","author":"PA Younis","year":"2024","unstructured":"Younis PA et al (2024) Volumetric changes in post hemiglossectomy reconstruction with anterolateral thigh free flap versus radial forearm free flap. Int J Oral Maxillofac Surg 53(6):470\u2013474","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05885-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-05885-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05885-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T11:13:35Z","timestamp":1726744415000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-05885-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,25]]},"references-count":48,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["5885"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-05885-y","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,25]]},"assertion":[{"value":"3 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the University Hospital Cologne (No 23-1444-retro). All procedures performed in the study were in accordance with the 1964 Helsinki declaration and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"498"}}