{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:53:14Z","timestamp":1788209594692,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Private Universit\u00e4t Witten\/Herdecke gGmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the efficacy of ribose-crosslinked collagen (RCLC) matrices functionalized by crosslinked hyaluronic acid (xHya) for reconstructive treatment of class I and III (b-c) peri-implantitis lesions in a transmucosal healing mode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Thirteen patients presenting with 15 implants were included in this prospective case series. Upon flap reflection, the implants were thoroughly decontaminated employing glycine powder air polishing and adjunctive sodium hypochlorite. For defect augmentation, xHyA was administered to the bony defect walls, exposed implant surfaces, and the RCLC matrix before defect grafting. The full-thickness flap was readapted and sutured around the implant neck for transmucosal healing. Baseline and respective values at the 12 months post-op evaluation were recorded for the clinical parameters peri-implant probing depth (PPD), buccal soft tissue dehiscence (BSTD) and bleeding on probing (BoP). Furthermore, two independent investigators analyzed radiographic changes in the defect area. The mean changes for all variables were analyzed with a paired t-test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The initial mean PPD was 7.2\u2009\u00b1\u20091.9\u00a0mm, and BoP was present in 63% of sites. After 12 months, PPD at the latest visit was 3.2\u2009\u00b1\u20090.66\u00a0mm, which amounted to a respective 3.9\u2009\u00b1\u20091.85\u00a0mm reduction, while the BoP frequency dropped to 10% at all sites. Radiographic bone fill was accomplished for 62.8% of the former defect area, accompanied by a mean MBL gain of 1.02\u00a0mm around the treated implants (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limits of this case series, we conclude that the proposed treatment sequence substantially improved peri-implant defects and offered a simplified but predictive technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Reconstructive treatment approaches for peri-implantitis are effective but remain non-superior to open flap debridement. Further research on novel biomaterial combinations that may improve reconstructive treatment outcomes are warranted. Ribose-crosslinked collagen matrices biofunctionalized by hyaluronic acid used in this study yield improved clinical and radiographic peri-implant conditions after 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-024-05942-6","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T05:02:03Z","timestamp":1726808523000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Reconstructive surgical therapy of peri-implant defects with ribose cross-linked collagen matrix and crosslinked hyaluronic acid \u2013 a prospective case series"],"prefix":"10.1007","volume":"28","author":[{"given":"Anton","family":"Friedmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rico","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Bilhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Al","family":"Ghawi-Begovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Kauffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"5942_CR1","doi-asserted-by":"publisher","first-page":"S246","DOI":"10.1111\/jcpe.12954","volume":"45","author":"F Schwarz","year":"2018","unstructured":"Schwarz F, Derks J, Monje A, Wang HL (2018) Peri-implantitis. J Clin Periodontol 45:S246\u2013S266","journal-title":"J Clin Periodontol"},{"key":"5942_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jcpe.13823","volume":"50","author":"D Herrera","year":"2023","unstructured":"Herrera D, Berglundh T, Schwarz F et al (2023) Prevention and treatment of peri-implant diseases\u2014the EFP S3 level clinical practice guideline. J Clin Periodontol 50:4\u201376","journal-title":"J Clin Periodontol"},{"key":"5942_CR3","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.1600-051X.2008.01283.x","volume":"35","author":"J Lindhe","year":"2008","unstructured":"Lindhe J, Meyle J, Periodontology, GDotEWo (2008) Peri-implant diseases: consensus report of the sixth European workshop on periodontology. J Clin Periodontol 35:282\u2013285","journal-title":"J Clin Periodontol"},{"issue":"8 Suppl","key":"5942_CR4","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/j.1600-051X.2008.01277.x","volume":"35","author":"N Claffey","year":"2008","unstructured":"Claffey N, Clarke E, Polyzois I, Renvert S (2008) Surgical treatment of peri-implantitis. J Clin Periodontol 35(8 Suppl):316\u2013332","journal-title":"J Clin Periodontol"},{"key":"5942_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.1600-051X.2008.01276.x","volume":"35","author":"S Renvert","year":"2008","unstructured":"Renvert S, Roos-Jans\u00e5ker AM, Claffey N (2008) Non\u2010surgical treatment of Peri\u2010implant mucositis and peri\u2010implantitis: a literature review. J Clin Periodontol 35:305\u2013315","journal-title":"J Clin Periodontol"},{"issue":"5","key":"5942_CR6","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/j.1600-051X.2006.00919.x","volume":"33","author":"S Renvert","year":"2006","unstructured":"Renvert S, Lessem J, Dahlen G, Lindahl C, Svensson M (2006) Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: a randomized clinical trial. J Clin Periodontol 33(5):362\u2013369","journal-title":"J Clin Periodontol"},{"issue":"1","key":"5942_CR7","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/prd.12149","volume":"76","author":"S Renvert","year":"2018","unstructured":"Renvert S, Polyzois I (2018) Treatment of pathologic peri-implant pockets. Periodontol 2000 76(1):180\u2013190","journal-title":"Periodontol 2000"},{"issue":"5","key":"5942_CR8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/j.1600-051X.2010.01540.x","volume":"37","author":"F Schwarz","year":"2010","unstructured":"Schwarz F, Sahm N, Schwarz K, Becker J (2010) Impact of defect configuration on the clinical outcome following surgical regenerative therapy of peri-implantitis. J Clin Periodontol 37(5):449\u2013455","journal-title":"J Clin Periodontol"},{"issue":"10","key":"5942_CR9","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1111\/j.1600-051X.2011.01739.x","volume":"38","author":"F Schwarz","year":"2011","unstructured":"Schwarz F, Sahm N, Mihatovic I, Golubovic V, Becker J (2011) Surgical therapy of advanced ligature-induced peri-implantitis defects: cone-beam computed tomographic and histological analysis. J Clin Periodontol 38(10):939\u2013949","journal-title":"J Clin Periodontol"},{"issue":"6","key":"5942_CR10","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1034\/j.1600-0501.2001.120607.x","volume":"12","author":"LG Persson","year":"2001","unstructured":"Persson LG, Berglundh T, Lindhe J, Sennerby L (2001) Re-osseointegration after treatment of peri-implantitis at different implant surfaces. An experimental study in the dog. Clin Oral Implants Res 12(6):595\u2013603","journal-title":"Clin Oral Implants Res"},{"issue":"1","key":"5942_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/prd.12417","volume":"88","author":"F Schwarz","year":"2022","unstructured":"Schwarz F, Jepsen S, Obreja K, Galarraga-Vinueza ME, Ramanauskaite A (2022) Surgical therapy of peri\u2010implantitis. Periodontol 2000 88(1):145\u2013181","journal-title":"Periodontol 2000"},{"issue":"2","key":"5942_CR12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1563\/aaid-joi-D-18-00168","volume":"45","author":"O Solakoglu","year":"2019","unstructured":"Solakoglu O, Filippi A (2019) Regenerative therapy of Peri-implantitis: clinical and radiologic documentation of 16 consecutive patients with a Mean Follow-Up of 3 years. J Oral Implantol 45(2):145\u2013153","journal-title":"J Oral Implantol"},{"issue":"9","key":"5942_CR13","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/clr.13972","volume":"33","author":"J Derks","year":"2022","unstructured":"Derks J, Ortiz-Vigon A, Guerrero A et al (2022) Reconstructive surgical therapy of peri-implantitis: a multicenter randomized controlled clinical trial. Clin Oral Implants Res 33(9):921\u2013944","journal-title":"Clin Oral Implants Res"},{"issue":"2","key":"5942_CR14","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/ID.0000000000000839","volume":"28","author":"A Ramanauskaite","year":"2019","unstructured":"Ramanauskaite A, Obreja K, Sader R et al (2019) Surgical Treatment of Periimplantitis with augmentative techniques. Implant Dent 28(2):187\u2013209","journal-title":"Implant Dent"},{"issue":"4","key":"5942_CR15","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1111\/cid.13162","volume":"25","author":"A Ramanauskaite","year":"2023","unstructured":"Ramanauskaite A, Cafferata EA, Begic A, Schwarz F (2023) Surgical interventions for the treatment of peri-implantitis. Clin Implant Dent Relat Res 25(4):682\u2013695","journal-title":"Clin Implant Dent Relat Res"},{"issue":"Suppl 21","key":"5942_CR16","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/jcpe.13070","volume":"46","author":"C Tomasi","year":"2019","unstructured":"Tomasi C, Regidor E, Ortiz-Vigon A, Derks J (2019) Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis. J Clin Periodontol 46(Suppl 21):340\u2013356","journal-title":"J Clin Periodontol"},{"issue":"4","key":"5942_CR17","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/cid.12791","volume":"21","author":"A Monje","year":"2019","unstructured":"Monje A, Pons R, Insua A, Nart J, Wang HL, Schwarz F (2019) Morphology and severity of peri-implantitis bone defects. Clin Implant Dent Relat Res 21(4):635\u2013643","journal-title":"Clin Implant Dent Relat Res"},{"issue":"6","key":"5942_CR18","first-page":"546","volume":"16","author":"P Cortellini","year":"1996","unstructured":"Cortellini P, Pini Prato G, Tonetti MS (1996) The modified papilla preservation technique with bioresorbable barrier membranes in the treatment of intrabony defects. Case reports. Int J Periodontics Restor Dent 16(6):546\u2013559","journal-title":"Int J Periodontics Restor Dent"},{"issue":"1","key":"5942_CR19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/prd.12048","volume":"68","author":"P Cortellini","year":"2015","unstructured":"Cortellini P, Tonetti MS (2015) Clinical concepts for regenerative therapy in intrabony defects. Periodontol 2000 68(1):282\u2013307","journal-title":"Periodontol 2000"},{"issue":"6","key":"5942_CR20","doi-asserted-by":"publisher","first-page":"406","DOI":"10.5051\/jpis.2000400020","volume":"50","author":"A Friedmann","year":"2020","unstructured":"Friedmann A, Meskeleviciene V, Yildiz MS, Gotz W, Park JC, Fischer KR (2020) Open healing of contained and non-contained extraction sockets covered with a ribose cross-linked collagen membrane: a pilot study. J Periodontal Implant Sci 50(6):406\u2013417","journal-title":"J Periodontal Implant Sci"},{"key":"5942_CR21","unstructured":"Donos N, Calciolari E, Ghuman M, Baccini M, Sousa V, Nibali L The efficacy of bone reconstructive therapies in the management of peri-implantitis. A systematic review and meta-analysis. J Clin Periodontol"},{"issue":"7","key":"5942_CR22","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1080\/00016357.2023.2243325","volume":"81","author":"M Risolo","year":"2023","unstructured":"Risolo M, Cevik-Aras H, Sayardoust S (2023) The effect of reconstructive techniques as treatment modality for peri-implant osseous defects \u2013 a systematic review and meta-analysis. Acta Odontol Scand 81(7):569\u2013577","journal-title":"Acta Odontol Scand"},{"key":"5942_CR23","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/clr.13840","volume":"32","author":"I Sanz-Mart\u00edn","year":"2021","unstructured":"Sanz-Mart\u00edn I, Cha JK, Sanz\u2010S\u00e1nchez I, Figuero E, Herrera D, Sanz M (2021) Changes in Peri\u2010implant soft tissue levels following surgical treatment of peri\u2010implantitis: a systematic review and meta\u2010analysis. Clin Oral Implants Res 32:230\u2013244","journal-title":"Clin Oral Implants Res"},{"issue":"9","key":"5942_CR24","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/clr.13972","volume":"33","author":"J Derks","year":"2022","unstructured":"Derks J, Ortiz-Vig\u00f3n A, Guerrero A et al (2022) Reconstructive surgical therapy of peri-implantitis: a multicenter randomized controlled clinical trial. Clin Oral Implants Res 33(9):921\u2013944","journal-title":"Clin Oral Implants Res"},{"issue":"6","key":"5942_CR25","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/j.1600-051X.2011.01729.x","volume":"38","author":"AM Roos-Jans\u00e5ker","year":"2011","unstructured":"Roos-Jans\u00e5ker AM, Lindahl C, Persson GR, Renvert S (2011) Long\u2010term stability of surgical bone regenerative procedures of peri\u2010implantitis lesions in a prospective case\u2013control study over 3 years. J Clin Periodontol 38(6):590\u2013597","journal-title":"J Clin Periodontol"},{"issue":"6","key":"5942_CR26","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/clr.13256","volume":"29","author":"F Mercado","year":"2018","unstructured":"Mercado F, Hamlet S, Ivanovski S (2018) Regenerative surgical therapy for peri-implantitis using deproteinized bovine bone mineral with 10% collagen, enamel matrix derivative and Doxycycline\u2014A prospective 3\u2010year cohort study. Clin Oral Implants Res 29(6):583\u2013591","journal-title":"Clin Oral Implants Res"},{"key":"5942_CR27","doi-asserted-by":"publisher","first-page":"238","DOI":"10.61872\/sdj-2022-04-01","volume":"132","author":"D Pilenza","year":"2022","unstructured":"Pilenza D, Filippi A, Walter C, Zitzmann NU, Bornstein MM, K\u00fchl S (2022) Surgical therapy of peri-implantitis with adjunctive hydroxyapatite and enamel matrix derivative: a 1-year retrospective case series. Swiss Dent J 132:238\u2013246","journal-title":"Swiss Dent J"},{"issue":"11","key":"5942_CR28","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1016\/j.bioactmat.2021.03.028","volume":"6","author":"X Cui","year":"2021","unstructured":"Cui X, Huang C, Chen Z et al (2021) Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression. Bioactive Mater 6(11):3801\u20133811","journal-title":"Bioactive Mater"},{"key":"5942_CR29","doi-asserted-by":"crossref","unstructured":"Asparuhova MB, Chappuis V, St\u00e4hli A, Buser D, Sculean A (2020) Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts. Clin Oral Investig :1\u201315","DOI":"10.1007\/s00784-020-03259-8"},{"issue":"4","key":"5942_CR30","doi-asserted-by":"publisher","first-page":"101426","DOI":"10.1016\/j.jormas.2023.101426","volume":"124","author":"B Husseini","year":"2023","unstructured":"Husseini B, Friedmann A, Wak R et al (2023) Clinical and radiographic assessment of cross-linked hyaluronic acid addition in demineralized bovine bone based alveolar ridge preservation: a human randomized split-mouth pilot study. J Stomatol Oral Maxillofac Surg 124(4):101426","journal-title":"J Stomatol Oral Maxillofac Surg"},{"issue":"9","key":"5942_CR31","first-page":"712","volume":"54","author":"F Kauffmann","year":"2023","unstructured":"Kauffmann F, Fickl S, Sculean A, Fischer KR, Friedmann A (2023) Alveolar ridge alterations after lateral guided bone regeneration with and without hyaluronic acid: a prospective randomized trial with morphometric and histomorphometric evaluation. Quintessence Int 54(9):712\u2013722","journal-title":"Quintessence Int"},{"issue":"1","key":"5942_CR32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.5435\/00124635-200501000-00010","volume":"13","author":"SN Khan","year":"2005","unstructured":"Khan SN, Cammisa FP Jr, Sandhu HS, Diwan AD, Girardi FP, Lane JM (2005) The biology of bone grafting. JAAOS-Journal Am Acad Orthop Surg 13(1):77\u201386","journal-title":"JAAOS-Journal Am Acad Orthop Surg"},{"issue":"3","key":"5942_CR33","doi-asserted-by":"publisher","first-page":"786","DOI":"10.3390\/ma13030786","volume":"13","author":"L Sbricoli","year":"2020","unstructured":"Sbricoli L, Guazzo R, Annunziata M, Gobbato L, Bressan E, Nastri L (2020) Selection of collagen membranes for bone regeneration: a literature review. Materials 13(3):786","journal-title":"Materials"},{"issue":"6","key":"5942_CR34","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.3390\/polym12061290","volume":"12","author":"M Toledano","year":"2020","unstructured":"Toledano M, Asady S, Toledano-Osorio M et al (2020) Differential biodegradation kinetics of collagen membranes for bone regeneration. Polymers 12(6):1290","journal-title":"Polymers"},{"key":"5942_CR35","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1007\/s00784-017-2281-1","volume":"22","author":"P-j Chia-Lai","year":"2018","unstructured":"Chia-Lai P-j, Orlowska A, Al-Maawi S et al (2018) Sugar-based collagen membrane cross-linking increases barrier capacity of membranes. Clin Oral Investig 22:1851\u20131863","journal-title":"Clin Oral Investig"},{"key":"5942_CR36","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.bone.2016.04.007","volume":"87","author":"L Cui","year":"2016","unstructured":"Cui L, Houston DA, Farquharson C, MacRae VE (2016) Characterisation of matrix vesicles in skeletal and soft tissue mineralisation. Bone 87:147\u2013158","journal-title":"Bone"},{"issue":"4","key":"5942_CR37","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00418-018-1646-0","volume":"149","author":"T Hasegawa","year":"2018","unstructured":"Hasegawa T (2018) Ultrastructure and biological function of matrix vesicles in bone mineralization. Histochem Cell Biol 149(4):289\u2013304","journal-title":"Histochem Cell Biol"},{"issue":"1","key":"5942_CR38","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1902\/jop.2007.060055","volume":"78","author":"Y Zubery","year":"2007","unstructured":"Zubery Y, Goldlust A, Alves A, Nir E (2007) Ossification of a Novel Cross-linked Porcine Collagen Barrier in guided bone regeneration in Dogs. J Periodontol 78(1):112\u2013121","journal-title":"J Periodontol"},{"key":"5942_CR39","doi-asserted-by":"crossref","unstructured":"Eliezer M, Sculean A, Miron RJ et al (2019) Hyaluronic acid slows down collagen membrane degradation in uncontrolled diabetic rats. J Periodontal Res","DOI":"10.1111\/jre.12665"},{"issue":"3","key":"5942_CR40","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1007\/s00784-021-04206-x","volume":"26","author":"M Eliezer","year":"2022","unstructured":"Eliezer M, Sculean A, Miron RJ et al (2022) Cross-linked hyaluronic acid slows down collagen membrane resorption in diabetic rats through reducing the number of macrophages. Clin Oral Investig 26(3):2401\u20132411","journal-title":"Clin Oral Investig"},{"issue":"1","key":"5942_CR41","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/prd.12049","volume":"66","author":"E Figuero","year":"2014","unstructured":"Figuero E, Graziani F, Sanz I, Herrera D, Sanz M (2014) Management of peri-implant mucositis and peri\u2010implantitis. Periodontol 2000 66(1):255\u2013273","journal-title":"Periodontol 2000"},{"issue":"7","key":"5942_CR42","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1902\/jop.2016.150684","volume":"87","author":"GA Kotsakis","year":"2016","unstructured":"Kotsakis GA, Lan C, Barbosa J et al (2016) Antimicrobial agents used in the treatment of Peri-implantitis alter the Physicochemistry and Cytocompatibility of Titanium surfaces. J Periodontol 87(7):809\u2013819","journal-title":"J Periodontol"},{"issue":"8","key":"5942_CR43","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1007\/s00784-016-1711-9","volume":"20","author":"K Jurczyk","year":"2016","unstructured":"Jurczyk K, Nietzsche S, Ender C, Sculean A, Eick S (2016) In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis. Clin Oral Investig 20(8):2165\u20132173","journal-title":"Clin Oral Investig"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05942-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-05942-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05942-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:21:04Z","timestamp":1729156864000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-05942-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["5942"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-05942-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4455172\/v1","asserted-by":"object"}]},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]},"assertion":[{"value":"21 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval for this study was obtained from the Witten\/Herdecke University ethics committee (S-174\/2022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"536"}}