{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:02:08Z","timestamp":1789387328709,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-024-05978-8","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T01:02:23Z","timestamp":1728522143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cleft lip and palate and periconception COVID-19 infection in five arab countries"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9788-0379","authenticated-orcid":false,"given":"Heba Jafar","family":"Sabbagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0370-8608","authenticated-orcid":false,"given":"Mohammad","family":"Zeinalddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-497X","authenticated-orcid":false,"given":"Ola B.","family":"Al-Batayneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taimoor","family":"Al Bulushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh A.","family":"AboulHassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Koraitim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0956-7965","authenticated-orcid":false,"given":"Lateefa","family":"Alkharafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buthaina","family":"Almuqbali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3053-5885","authenticated-orcid":false,"given":"Sultan Musaad","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Bahdila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-1913","authenticated-orcid":false,"given":"Shaimaa Mohsen","family":"Refahee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-3081","authenticated-orcid":false,"given":"Maryam","family":"Quritum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-6615","authenticated-orcid":false,"given":"Fatemah Fahad","family":"Taqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-3624","authenticated-orcid":false,"given":"Bader","family":"Albassam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-000X","authenticated-orcid":false,"given":"Mariam","family":"Ayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia","family":"Embaireeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raqiya","family":"Alnahdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Talal","family":"AlSharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziza Johar","family":"Aljohar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Dawood","family":"Abdulhameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-7827","authenticated-orcid":false,"given":"Najla Sulaiman","family":"Alrejaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Viswapurna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Al Halasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4989-6584","authenticated-orcid":false,"given":"Maha","family":"El Tantawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama Adel","family":"Basri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana A.","family":"Alamoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"issue":"1","key":"5978_CR1","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41598-021-02159-5","volume":"12","author":"L Slavec","year":"2022","unstructured":"Slavec L, Karas Ku\u017eeli\u010dki N, Locatelli I, Ger\u0161ak K (2022) Genetic markers for non-syndromic orofacial clefts in populations of European ancestry: a meta-analysis. Sci Rep 12(1):1214. https:\/\/doi.org\/10.1038\/s41598-021-02159-5","journal-title":"Sci Rep"},{"issue":"8","key":"5978_CR2","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1177\/10556656211026536","volume":"59","author":"H Allaf","year":"2022","unstructured":"Allaf H, Helal N, Basri O, AlShadwi A, Sabbagh H (2022) Care barriers for patients with nonsyndromic Orofacial clefts in Saudi Arabia: a cross-sectional study. Cleft Palate Craniofac J 59(8):1001\u20131009. https:\/\/doi.org\/10.1177\/10556656211026536","journal-title":"Cleft Palate Craniofac J"},{"issue":"7453","key":"5978_CR3","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1136\/bmj.38106.559120.7C","volume":"328","author":"K Christensen","year":"2004","unstructured":"Christensen K, Juel K, Herskind AM, Murray JC (2004) Long term follow up study of survival associated with cleft lip and palate at birth. BMJ 328(7453):1405. https:\/\/doi.org\/10.1136\/bmj.38106.559120.7C","journal-title":"BMJ"},{"issue":"3","key":"5978_CR4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1080\/14767050500072854","volume":"17","author":"CW Ngai","year":"2005","unstructured":"Ngai CW, Martin WL, Tonks A, Wyldes MP, Kilby MD (2005) Are isolated facial cleft lip and palate associated with increased perinatal mortality? A cohort study from the West Midlands Region, 1995\u20131997. J Matern Fetal Neonatal Med 17(3):203\u2013206. https:\/\/doi.org\/10.1080\/14767050500072854","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"8","key":"5978_CR5","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1001\/archpedi.161.8.753","volume":"161","author":"P Nopoulos","year":"2007","unstructured":"Nopoulos P, Langbehn DR, Canady J, Magnotta V, Richman L (2007) Abnormal brain structure in children with isolated clefts of the lip or palate. Arch Pediatr Adolesc Med 161(8):753\u2013758. https:\/\/doi.org\/10.1001\/archpedi.161.8.753","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"4","key":"5978_CR6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/s0889-5406(99)70258-1","volume":"115","author":"Y Shapira","year":"1999","unstructured":"Shapira Y, Lubit E, Kuftinec MM (1999) Congenitally missing second premolars in cleft lip and cleft palate children. Am J Orthod Dentofac Orthop 115(4):396\u2013400. https:\/\/doi.org\/10.1016\/s0889-5406(99)70258-1","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"1","key":"5978_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/sap.0000000000002187","volume":"85","author":"R Denadai","year":"2020","unstructured":"Denadai R, Chou PY, Pai BCJ, Chen C, Cheng-Hui Lin C, Huang CS et al (2020) Skeletofacial Reconstruction for Cleft-related deformities: four decades of evolving Cleft Care. Ann Plast Surg 85(1):3\u201311. https:\/\/doi.org\/10.1097\/sap.0000000000002187","journal-title":"Ann Plast Surg"},{"issue":"3","key":"5978_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.sdentj.2023.02.004","volume":"35","author":"M Talal AlSharif","year":"2023","unstructured":"Talal AlSharif M, Abdullah Alamoudi R, Jafar Sabbagh H (2023) Maternal stress as a risk factor for non-syndromic orofacial clefts: systematic review and meta-analysis. Saudi Dent J 35(3):207\u2013219. https:\/\/doi.org\/10.1016\/j.sdentj.2023.02.004","journal-title":"Saudi Dent J"},{"issue":"6","key":"5978_CR9","doi-asserted-by":"publisher","first-page":"e1373","DOI":"10.1097\/gox.0000000000001373","volume":"5","author":"AD Glener","year":"2017","unstructured":"Glener AD, Allori AC, Shammas RL, Carlson AR, Pien IJ, Aylsworth AS et al (2017) A Population-Based Exploration of the Social Implications Associated with Cleft lip and\/or palate. Plast Reconstr Surg Glob Open 5(6):e1373. https:\/\/doi.org\/10.1097\/gox.0000000000001373","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"5978_CR10","volume-title":"Craniofacial surgery","author":"G \u015eeyma Ak\u00e7ay","year":"2023","unstructured":"\u015eeyma Ak\u00e7ay G, Belma I\u015fik A, \u015eadiye B-T (2023) Assessment of Psychosocial Functioning among patients with cleft Lip\/Palate and their mothers. In: Belma I\u015fik A, Serhat \u015e (eds) Craniofacial surgery. IntechOpen, Rijeka. Ch. 6."},{"issue":"1","key":"5978_CR11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12903-023-02934-y","volume":"23","author":"HJ Sabbagh","year":"2023","unstructured":"Sabbagh HJ, Alamoudi RA, Zeinalddin M, Al Bulushi T, Al-Batayneh OB, AboulHassan MA et al (2023) COVID-19 related risk factors and their association with non-syndromic orofacial clefts in five arab countries: a case-control study. BMC Oral Health 23(1):246. https:\/\/doi.org\/10.1186\/s12903-023-02934-y","journal-title":"BMC Oral Health"},{"issue":"12","key":"5978_CR12","doi-asserted-by":"publisher","first-page":"e03019","DOI":"10.1016\/j.heliyon.2019.e03019","volume":"5","author":"K Saleem","year":"2019","unstructured":"Saleem K, Zaib T, Sun W, Fu S (2019) Assessment of candidate genes and genetic heterogeneity in human non syndromic orofacial clefts specifically non syndromic cleft lip with or without palate. Heliyon 5(12):e03019. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e03019","journal-title":"Heliyon"},{"issue":"Suppl 4","key":"5978_CR13","first-page":"S25","volume":"96","author":"T Wangsrimongkol","year":"2013","unstructured":"Wangsrimongkol T, Manosudprasit M, Pisek P, Chittiwatanapong N (2013) Prevalence and types of dental anomaly in a Thai non-syndromic oral cleft sample. J Med Assoc Thai 96(Suppl 4):S25\u201335","journal-title":"J Med Assoc Thai"},{"issue":"3","key":"5978_CR14","doi-asserted-by":"publisher","first-page":"e0116963","DOI":"10.1371\/journal.pone.0116963","volume":"10","author":"HJ Sabbagh","year":"2015","unstructured":"Sabbagh HJ, Hassan MH, Innes NP, Elkodary HM, Little J, Mossey PA (2015) Passive smoking in the etiology of non-syndromic orofacial clefts: a systematic review and meta-analysis. PLoS ONE 10(3):e0116963. https:\/\/doi.org\/10.1371\/journal.pone.0116963","journal-title":"PLoS ONE"},{"key":"5978_CR15","unstructured":"World Health Organization Coronavirus disease (COVID-19) pandemic. https:\/\/www.who.int\/europe\/emergencies\/situations\/covid-19. Accessed 12 September 2024"},{"issue":"9","key":"5978_CR16","doi-asserted-by":"publisher","first-page":"e1544","DOI":"10.1002\/hsr2.1544","volume":"6","author":"R Sarker","year":"2023","unstructured":"Sarker R, Roknuzzaman ASM, Nazmunnahar, Shahriar M, Hossain MJ, Islam MR (2023) The WHO has declared the end of pandemic phase of COVID-19: way to come back in the normal life. Health Sci Rep 6(9):e1544. https:\/\/doi.org\/10.1002\/hsr2.1544","journal-title":"Health Sci Rep"},{"issue":"15","key":"5978_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1002\/bdr2.2070","volume":"114","author":"S Hern\u00e1ndez-D\u00edaz","year":"2022","unstructured":"Hern\u00e1ndez-D\u00edaz S, Smith LH, Wyszynski DF, Rasmussen SA (2022) First trimester COVID-19 and the risk of major congenital malformations-International Registry of Coronavirus exposure in pregnancy. Birth Defects Res 114(15):906\u2013914. https:\/\/doi.org\/10.1002\/bdr2.2070","journal-title":"Birth Defects Res"},{"issue":"4","key":"5978_CR18","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/ocr.12241","volume":"21","author":"NV Hermann","year":"2018","unstructured":"Hermann NV, Darvann TA, Munch A, Kreiborg S (2018) Parental age in relation to the severity of cleft lip and\/or palate. Orthod Craniofac Res 21(4):236\u2013241. https:\/\/doi.org\/10.1111\/ocr.12241","journal-title":"Orthod Craniofac Res"},{"issue":"4","key":"5978_CR19","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1597\/14-136","volume":"53","author":"HJ Sabbagh","year":"2016","unstructured":"Sabbagh HJ, Alamoudi NM, Abdulhameed FD, Innes NP, Al-Aama JY, Hummaida T et al (2016) Environmental risk factors in the etiology of nonsyndromic Orofacial clefts in the Western Region of Saudi Arabia. Cleft Palate Craniofac J 53(4):435\u2013443. https:\/\/doi.org\/10.1597\/14-136","journal-title":"Cleft Palate Craniofac J"},{"key":"5978_CR20","doi-asserted-by":"publisher","first-page":"138882","DOI":"10.1016\/j.scitotenv.2020.138882","volume":"728","author":"I Chakraborty","year":"2020","unstructured":"Chakraborty I, Maity P (2020) COVID-19 outbreak: Migration, effects on society, global environment and prevention. Sci Total Environ 728:138882. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.138882","journal-title":"Sci Total Environ"},{"key":"5978_CR21","doi-asserted-by":"publisher","first-page":"353","DOI":"10.26714\/jkj.8.3.2020.353-360","volume":"8","author":"RT Handayani","year":"2020","unstructured":"Handayani RT, Kuntaru S, Darmanyanti AT, Widiyanto A, Atmojo JT (2020) [Factors causing stress in health and community when the COVID-19 pandemic]. Jurnal Keperawatan Jiwa: Persatuan Perawat Nasional Indonesia 8:353\u2013360. https:\/\/doi.org\/10.26714\/jkj.8.3.2020.353-360","journal-title":"Jurnal Keperawatan Jiwa: Persatuan Perawat Nasional Indonesia"},{"issue":"12","key":"5978_CR22","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1007\/s42399-020-00582-9","volume":"2","author":"RJ Nodoushan","year":"2020","unstructured":"Nodoushan RJ, Alimoradi H, Nazari M (2020) Spiritual Health and stress in pregnant women during the Covid-19 pandemic. SN Compr Clin Med 2(12):2528\u20132534. https:\/\/doi.org\/10.1007\/s42399-020-00582-9","journal-title":"SN Compr Clin Med"},{"issue":"1","key":"5978_CR23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.26714\/jkj.9.1.2021.135-142","volume":"9","author":"N Viandika","year":"2021","unstructured":"Viandika N, Septiasari RM (2021) [Anxiety in pregnant women during pandemic COVID-19]. Jurnal Keperawatan Jiwa: Persatuan Perawat Nasional Indonesia 9(1):135\u2013142. https:\/\/doi.org\/10.26714\/jkj.9.1.2021.135-142","journal-title":"Jurnal Keperawatan Jiwa: Persatuan Perawat Nasional Indonesia"},{"issue":"1","key":"5978_CR24","doi-asserted-by":"publisher","first-page":"18062","DOI":"10.1038\/s41598-022-22961-z","volume":"12","author":"NM Aly","year":"2022","unstructured":"Aly NM, Elwan AH, Elzayet RM, Hassanato NMR, Deif M, Abdelaziz WE et al (2022) Association between COVID-19 stress, coping mechanisms and stress-related oral conditions among Egyptian adults: a cross-sectional study. Sci Rep 12(1):18062. https:\/\/doi.org\/10.1038\/s41598-022-22961-z","journal-title":"Sci Rep"},{"key":"5978_CR25","doi-asserted-by":"publisher","first-page":"e13555","DOI":"10.7717\/peerj.13555","volume":"10","author":"M El Tantawi","year":"2022","unstructured":"El Tantawi M, Sabbagh HJ, Alkhateeb NA, Quritum M, Abourdan J, Qureshi N et al (2022) Oral manifestations in young adults infected with COVID-19 and impact of smoking: a multi-country cross-sectional study. PeerJ 10:e13555. https:\/\/doi.org\/10.7717\/peerj.13555","journal-title":"PeerJ"},{"key":"5978_CR26","unstructured":"Statistics Solutions Sample size formula (2022) https:\/\/www.statisticssolutions.com\/dissertation-resources\/sample-size-calculation-and-sample-size-justification\/sample-size-formula\/. Accessed 3"},{"issue":"7641","key":"5978_CR27","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1136\/bmj.39458.563611.AE","volume":"336","author":"A Sivertsen","year":"2008","unstructured":"Sivertsen A, Wilcox AJ, Skjaerven R, Vindenes HA, Abyholm F, Harville E et al (2008) Familial risk of oral clefts by morphological type and severity: population based cohort study of first degree relatives. BMJ 336(7641):432\u2013434. https:\/\/doi.org\/10.1136\/bmj.39458.563611.AE","journal-title":"BMJ"},{"issue":"1","key":"5978_CR28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12992-020-00589-w","volume":"16","author":"N Salari","year":"2020","unstructured":"Salari N, Hosseinian-Far A, Jalali R, Vaisi-Raygani A, Rasoulpoor S, Mohammadi M et al (2020) Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis. Global Health 16(1):57. https:\/\/doi.org\/10.1186\/s12992-020-00589-w","journal-title":"Global Health"},{"key":"5978_CR29","first-page":"15","volume":"46","author":"J Radojicic","year":"2007","unstructured":"Radojicic J, Tani\u0107 T, Andrija R, Aleksandar R, Zorica B (2007) Stress: the risk factor in the lip and palate cleft development. Acta Med Mediterr 46:15\u201319","journal-title":"Acta Med Mediterr"},{"key":"5978_CR30","unstructured":"Kriens O (1989) What is a cleft lip and palate? A multidisciplinary update: proceedings of an advanced workshop, Bremen 1987. Thieme: Stuttgart"},{"issue":"3","key":"5978_CR31","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1007\/s11469-020-00270-8","volume":"20","author":"DK Ahorsu","year":"2022","unstructured":"Ahorsu DK, Lin CY, Imani V, Saffari M, Griffiths MD, Pakpour AH (2022) The fear of COVID-19 scale: development and initial validation. Int J Ment Health Addict 20(3):1537\u20131545. https:\/\/doi.org\/10.1007\/s11469-020-00270-8","journal-title":"Int J Ment Health Addict"},{"issue":"1","key":"5978_CR32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/nur.4770070110","volume":"7","author":"JS Norbeck","year":"1984","unstructured":"Norbeck JS (1984) Modification of life event questionnaires for use with female respondents. Res Nurs Health 7(1):61\u201371. https:\/\/doi.org\/10.1002\/nur.4770070110","journal-title":"Res Nurs Health"},{"key":"5978_CR33","volume-title":"Modification of life events questionnaire for use with arabic-speaking pregnant women","author":"A Qandil","year":"2012","unstructured":"Qandil A (2012) Modification of life events questionnaire for use with arabic-speaking pregnant women. University of Cincinnati: Proquest LLC;, Ann Arbor, MI"},{"key":"5978_CR34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jad.2016.06.058","volume":"205","author":"AM Gariepy","year":"2016","unstructured":"Gariepy AM, Lundsberg LS, Miller D, Stanwood NL, Yonkers KA (2016) Are pregnancy planning and pregnancy timing associated with maternal psychiatric illness, psychological distress and support during pregnancy? J Affect Disord 205:87\u201394. https:\/\/doi.org\/10.1016\/j.jad.2016.06.058","journal-title":"J Affect Disord"},{"key":"5978_CR35","doi-asserted-by":"publisher","unstructured":"Wong YP, Khong TY, Tan GC (2021) The effects of COVID-19 on Placenta and pregnancy: what do we know so far? Diagnostics (Basel) 11(1). https:\/\/doi.org\/10.3390\/diagnostics11010094","DOI":"10.3390\/diagnostics11010094"},{"issue":"1","key":"5978_CR36","first-page":"21","volume":"24","author":"F Bianchi","year":"2000","unstructured":"Bianchi F, Calzolari E, Ciulli L, Cordier S, Gualandi F, Pierini A et al (2000) [Environment and genetics in the etiology of cleft lip and cleft palate with reference to the role of folic acid]. Epidemiol Prev 24(1):21\u201327","journal-title":"Epidemiol Prev"},{"issue":"1","key":"5978_CR37","doi-asserted-by":"publisher","first-page":"e2083","DOI":"10.1097\/gox.0000000000002083","volume":"7","author":"A Campbell","year":"2019","unstructured":"Campbell A, Restrepo C, Park E, Navas G, Deshpande G, Swanson J et al (2019) Influence of severity on aesthetic outcomes of Unilateral Cleft Lip Repair in 1,823 patients. Plast Reconstr Surg Glob Open 7(1):e2083. https:\/\/doi.org\/10.1097\/gox.0000000000002083","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"5978_CR38","doi-asserted-by":"publisher","unstructured":"Adamson O, Oladugba AV, Alade A, Awotoye WO, Busch T, Li M et al (2021) Relationship between parental age and severity of orofacial clefts. https:\/\/doi.org\/10.1101\/2021.02.22.432246v1","DOI":"10.1101\/2021.02.22.432246v1"},{"key":"5978_CR39","doi-asserted-by":"publisher","first-page":"592271","DOI":"10.3389\/fcell.2020.592271","volume":"8","author":"M Martinelli","year":"2020","unstructured":"Martinelli M, Palmieri A, Carinci F, Scapoli L (2020) Non-syndromic cleft palate: an overview on human genetic and environmental risk factors. Front Cell Dev Biol 8:592271. https:\/\/doi.org\/10.3389\/fcell.2020.592271","journal-title":"Front Cell Dev Biol"},{"key":"5978_CR40","doi-asserted-by":"crossref","unstructured":"Uribe LMM, Marazita ML (2023) Epidemiology, etiology, and genetics of orofacial clefting. Cleft and Craniofacial Orthodontics p. 39\u201360","DOI":"10.1002\/9781119778387.ch4"},{"key":"5978_CR41","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14568","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Li H, Cui D, Liu Y, Tian Q, Zheng L et al (2023) Epigenetics in developmental defects of enamel: a scoping review. Oral Dis. https:\/\/doi.org\/10.1111\/odi.14568","journal-title":"Oral Dis"},{"issue":"11","key":"5978_CR42","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1177\/00220345221110196","volume":"101","author":"N Gomaa","year":"2022","unstructured":"Gomaa N (2022) Social Epigenomics: conceptualizations and considerations for oral health. J Dent Res 101(11):1299\u20131306. https:\/\/doi.org\/10.1177\/00220345221110196","journal-title":"J Dent Res"},{"key":"5978_CR43","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3389\/fcimb.2015.00090","volume":"5","author":"A Chandran","year":"2015","unstructured":"Chandran A, Antony C, Jose L, Mundayoor S, Natarajan K, Kumar RA (2015) Mycobacterium tuberculosis infection induces HDAC1-Mediated suppression of IL-12B gene expression in macrophages. Front Cell Infect Microbiol 5:90. https:\/\/doi.org\/10.3389\/fcimb.2015.00090","journal-title":"Front Cell Infect Microbiol"},{"issue":"12","key":"5978_CR44","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1002\/bdra.20195","volume":"73","author":"N Acs","year":"2005","unstructured":"Acs N, B\u00e1nhidy F, Puh\u00f3 E, Czeizel AE (2005) Maternal influenza during pregnancy and risk of congenital abnormalities in offspring. Birth Defects Res Clin Mol Teratol 73(12):989\u2013996. https:\/\/doi.org\/10.1002\/bdra.20195","journal-title":"Birth Defects Res Clin Mol Teratol"},{"key":"5978_CR45","doi-asserted-by":"publisher","unstructured":"Oseghale O, Vlahos R, O\u2019Leary JJ, Brooks RD, Brooks DA, Liong S et al (2022) Influenza virus infection during pregnancy as a trigger of Acute and Chronic complications. Viruses 14(12). https:\/\/doi.org\/10.3390\/v14122729","DOI":"10.3390\/v14122729"},{"issue":"7","key":"5978_CR46","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00784-024-05744-w","volume":"28","author":"RA Alamoudi","year":"2024","unstructured":"Alamoudi RA, Sabbagh HJ, Zeinalddin M, Al-Batayneh OB, Al Bulushi T, AboulHassan MA et al (2024) COVID-19 vaccine and non-syndromic orofacial clefts in five arab countries. A case-control study. Clin Oral Investig 28(7):357. https:\/\/doi.org\/10.1007\/s00784-024-05744-w","journal-title":"Clin Oral Investig"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05978-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-05978-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05978-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T04:15:16Z","timestamp":1731644116000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-05978-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":46,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["5978"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-05978-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3360264\/v1","asserted-by":"object"}]},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"16 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Research Ethics Committee of King Abdulaziz University Faculty of Dentistry (KAUFD) (257-07-21), the Research Ethics Committee of King Fahd Armed Forces Hospital (KFAFH) (REC 391), the Institutional Review Board of the Ministry of National Guard at King Abdullah International Medical Research Center (KAIMRC) (H-01-R-005), the Institutional Review Board of the Ministry of Health in Riyadh (H-01-R012), the Institutional Review Board of the Ministry of Health in Jeddah (H-02-J-002), the Jordan University of Science and Technology (104\/147\/2022) in Jordan, Scientific Ethics Committee of Fayoum University (R446-session 105), and Institutional Review Board\u2013approved protocol (IRB#2017\u2009\u2212\u2009562) in Kuwait.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Prior to participation, parents were provided with an informed consent form to sign that explained the study purpose, confidentiality, and methodology.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"586"}}