{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:27:28Z","timestamp":1786980448835,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Education and Research Support Fund from GC Corporation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Multidisciplinary Research Center for Jaw Disease (MRCJD), Tokyo Dental College","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-024-05979-7","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T03:01:54Z","timestamp":1728270114000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Periodontal regenerative therapy using recombinant human fibroblast growth factor (rhFGF)-2 in combination with carbonate apatite granules or rhFGF-2 alone: 12-month randomized controlled trial"],"prefix":"10.1007","volume":"28","author":[{"given":"Kentaro","family":"Imamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Seshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurie","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuri","family":"Ambiru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Bizenjima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiyo","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"5979_CR1","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1902\/jop.2010.100297","volume":"82","author":"M Silvestri","year":"2011","unstructured":"Silvestri M, Rasperini G, Milani S (2011) 120 infrabony defects treated with regenerative therapy: long-term results. J Periodontol 82:668\u2013675. https:\/\/doi.org\/10.1902\/jop.2010.100297","journal-title":"J Periodontol"},{"key":"5979_CR2","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/prd.12048","volume":"68","author":"P Cortellini","year":"2015","unstructured":"Cortellini P, Tonetti MS (2015) Clinical concepts for regenerative therapy in intrabony defects. Periodontol 2000 68:282\u2013307. https:\/\/doi.org\/10.1111\/prd.12048","journal-title":"Periodontol 2000"},{"key":"5979_CR3","doi-asserted-by":"publisher","first-page":"S134","DOI":"10.1902\/jop.2015.130689","volume":"86","author":"Z Lin","year":"2015","unstructured":"Lin Z, Rios HF, Cochran DL (2015) Emerging regenerative approaches for periodontal reconstruction: a systematic review from the AAP Regeneration Workshop. J Periodontol 86:S134\u2013S152. https:\/\/doi.org\/10.1902\/jop.2015.130689","journal-title":"J Periodontol"},{"key":"5979_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/prd.12246","volume":"79","author":"EA Sallum","year":"2019","unstructured":"Sallum EA, Ribeiro FV, Ruiz KS, Sallum AW (2019) Experimental and clinical studies on regenerative periodontal therapy. Periodontol 2000 79:22\u201355. https:\/\/doi.org\/10.1111\/prd.12246","journal-title":"Periodontol 2000"},{"key":"5979_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1177\/0022034510384616","volume":"90","author":"M Kitamura","year":"2011","unstructured":"Kitamura M, Akamatsu M, Machigashira M, Hara Y, Sakagami R, Hirofuji T et al (2011) FGF-2 stimulates periodontal regeneration: results of a multi-center randomized clinical trial. J Dent Res 90:35\u201340. https:\/\/doi.org\/10.1177\/0022034510384616","journal-title":"J Dent Res"},{"key":"5979_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1902\/cap.2015.140062","volume":"5","author":"MA Reynolds","year":"2015","unstructured":"Reynolds MA, Kao RT, Nares S, Camargo PM, Caton JG, Clem DS, Fiorellini JP, Geisinger ML, Mills MP, Nevins ML, Rosen PS (2015) Periodontal regeneration intrabony defects: practical applications from the AAP regeneration workshop. Clin Adv Periodontics 5:21\u201329. https:\/\/doi.org\/10.1902\/cap.2015.140062","journal-title":"Clin Adv Periodontics"},{"key":"5979_CR7","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1111\/jcpe.13338","volume":"47","author":"SJ Tsai","year":"2020","unstructured":"Tsai SJ, Ding YW, Shih MC, Tu YK (2020) Systematic review and sequential network meta-analysis on the efficacy of periodontal regenerative therapies. J Clin Periodontol 47:1108\u20131120. https:\/\/doi.org\/10.1111\/jcpe.13338","journal-title":"J Clin Periodontol"},{"issue":"6","key":"5979_CR8","doi-asserted-by":"publisher","first-page":"805","DOI":"10.3390\/biom11060805","volume":"11","author":"T Murakami","year":"2021","unstructured":"Murakami T, Matsugami D, Yoshida W, Imamura K, Bizenjima T, Seshima F, Saito A (2021) Healing of experimental periodontal defects following treatment with fibroblast growth factor-2 and deproteinized bovine bone mineral. Biomolecules 11(6):805. https:\/\/doi.org\/10.3390\/biom11060805","journal-title":"Biomolecules"},{"key":"5979_CR9","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/jcpe.13086","volume":"46","author":"A Saito","year":"2019","unstructured":"Saito A, Bizenjima T, Takeuchi T, Suzuki E, Sato M, Yoshikawa K, Kitamura Y, Matsugami D, Aoki H, Kita D, Imamura K, Irokawa D, Seshima F, Tomita S (2019) Treatment of intrabony periodontal defects using rhFGF-2 in combination with deproteinized bovine bone mineral or rhFGF-2 alone: a 6-month randomized controlled trial. J Clin Periodontol 46:332\u2013341. https:\/\/doi.org\/10.1111\/jcpe.13086","journal-title":"J Clin Periodontol"},{"key":"5979_CR10","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/jcpe.13385","volume":"48","author":"H Aoki","year":"2021","unstructured":"Aoki H, Bizenjima T, Seshima F, Sato M, Irokawa D, Yoshikawa K, Yoshida W, Imamura K, Matsugami D, Kitamura Y, Kita D, Sugito H, Tomita S, Saito A (2021) Periodontal surgery using rhFGF-2 with deproteinized bovine bone mineral or rhFGF-2 alone: 2-year follow-up of a randomized controlled trial. J Clin Periodontol 48:92\u2013100. https:\/\/doi.org\/10.1111\/jcpe.13385","journal-title":"J Clin Periodontol"},{"key":"5979_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1597\/1545-1569_2002_039_0197_eocpcb_2.0.co_2","volume":"39","author":"JL Linton","year":"2002","unstructured":"Linton JL, Sohn BW, Yook JI, Le Geros RZ (2002) Effects of calcium phosphate ceramic bone graft materials on permanent teeth eruption in beagles. Cleft Palate Craniofac J 39:197\u2013207. https:\/\/doi.org\/10.1597\/1545-1569_2002_039_0197_eocpcb_2.0.co_2","journal-title":"Cleft Palate Craniofac J"},{"key":"5979_CR12","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/jbm.a.37392","volume":"110","author":"M Fujioka-Kobayashi","year":"2022","unstructured":"Fujioka-Kobayashi M, Miyamoto Y, Ishikawa K, Satomi T, Schaller B (2022) Osteoclast behaviors on the surface of deproteinized bovine bone mineral and carbonate apatite substitutes in vitro. J Biomed Mater Res A 110:1524\u20131532. https:\/\/doi.org\/10.1002\/jbm.a.37392","journal-title":"J Biomed Mater Res A"},{"key":"5979_CR13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.reth.2023.01.002","volume":"22","author":"S Takeuchi","year":"2023","unstructured":"Takeuchi S, Fukuba S, Okada M, Nohara K, Sato R, Yamaki D et al (2023) Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model. Regen Ther 22:128\u2013135. https:\/\/doi.org\/10.1016\/j.reth.2023.01.002","journal-title":"Regen Ther"},{"key":"5979_CR14","doi-asserted-by":"publisher","first-page":"985e1","DOI":"10.1016\/j.joms.2018.11.026","volume":"77","author":"K Kudoh","year":"2019","unstructured":"Kudoh K, Fukuda N, Kasugai S, Tachikawa N, Koyano K, Matsushita Y, Ogino Y, Ishikawa K, Miyamoto Y (2019) Maxillary sinus floor augmentation using low-crystalline carbonate apatite granules with simultaneous implant installation: first-in-human clinical trial. J Oral Maxillofac Surg 77:985e1. https:\/\/doi.org\/10.1016\/j.joms.2018.11.026","journal-title":"J Oral Maxillofac Surg"},{"key":"5979_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40729-021-00303-4","volume":"7","author":"K Nagata","year":"2021","unstructured":"Nagata K, Fuchigami K, Kitami R, Okuhama Y, Wakamori K, Sumitomo H, Kim H, Okubo M, Kawana H (2021) Comparison of the performances of low-crystalline carbonate apatite and Bio-oss in sinus augmentation using three-dimensional image analysis. Int J Implant Dent 7:24. https:\/\/doi.org\/10.1186\/s40729-021-00303-4","journal-title":"Int J Implant Dent"},{"key":"5979_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.reth.2023.08.002","volume":"24","author":"S Fukuba","year":"2023","unstructured":"Fukuba S, Okada M, Iwata T (2023) Clinical outcomes of periodontal regenerative therapy with carbonate apatite granules for treatments of intrabony defects, Class II and Class III furcation involvements: a 9-month prospective pilot clinical study. Regen Ther 24:343\u2013350. https:\/\/doi.org\/10.1016\/j.reth.2023.08.002","journal-title":"Regen Ther"},{"key":"5979_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2209\/tdcpublication.2022-0008","volume":"63","author":"T Murakami","year":"2022","unstructured":"Murakami T, Imamura K, Watanabe-Egawa N, Tomita S, Saito A (2022) Surgical periodontal therapy using recombinant human fibroblast growth factor-2 in combination with carbonate apatite granules for stage III grade B periodontitis: a case report with 1-year follow-up. Bull Tokyo Dent Coll 63:145\u2013153. https:\/\/doi.org\/10.2209\/tdcpublication.2022-0008","journal-title":"Bull Tokyo Dent Coll"},{"key":"5979_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.reth.2022.06.001","volume":"21","author":"M Kitamura","year":"2022","unstructured":"Kitamura M, Yamashita M, Miki K, Ikegami K, Takedachi M, Kashiwagi Y, Nozaki T, Yamanaka K, Masuda H, Ishihara Y, Murakami S (2022) An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH\u00ae and Cytrans\u00ae granules for severe periodontitis with intrabony defects. Regen Ther 21:104\u2013113. https:\/\/doi.org\/10.1016\/j.reth.2022.06.001","journal-title":"Regen Ther"},{"key":"5979_CR19","doi-asserted-by":"publisher","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH et al (2018) Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol 89(Suppl 1):S173\u2013s182. https:\/\/doi.org\/10.1002\/jper.17-0721","DOI":"10.1002\/jper.17-0721"},{"key":"5979_CR20","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","volume":"43","author":"TJ O\u2019Leary","year":"1972","unstructured":"O\u2019Leary TJ, Drake RB, Naylor JE (1972) The plaque control record. J Periodontol 43:38. https:\/\/doi.org\/10.1902\/jop.1972.43.1.38","journal-title":"J Periodontol"},{"key":"5979_CR21","first-page":"24","volume":"56","author":"MCU Garcia","year":"2022","unstructured":"Garcia MCU, Ramos MBG, Tumang BP (2022) Accuracy and reproducibility of UNC-15 and Gram Probe# 2 in measuring probing pocket depths. Acta Med Philippina 56:24\u201330. https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/view\/2749\/2392","journal-title":"Acta Med Philippina"},{"key":"5979_CR22","volume-title":"Textbook of periodontia","author":"SC Miller","year":"1950","unstructured":"Miller SC (1950) Textbook of periodontia. PA:Blakiston., Philadelphia"},{"key":"5979_CR23","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1034\/j.1600-051x.2003.00013.x","volume":"30","author":"H Wachtel","year":"2003","unstructured":"Wachtel H, Schenk G, B\u00f6hm S, Weng D, Zuhr O, H\u00fcrzeler MB (2003) Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: a controlled clinical study. J Clin Periodontol 30:496\u2013504. https:\/\/doi.org\/10.1034\/j.1600-051x.2003.00013.x","journal-title":"J Clin Periodontol"},{"key":"5979_CR24","doi-asserted-by":"publisher","first-page":"393","DOI":"10.11607\/prd.2888","volume":"37","author":"D Irokawa","year":"2017","unstructured":"Irokawa D, Okubo N, Nikaido M, Shimizu H, Konobu H, Matsui T, Fujita T, Goto H, Takeuchi T, Ishii Y, Saito A (2017) Periodontal regenerative therapy of intrabony defects using deproteinized bovine bone mineral in combination with collagen barrier membrane: a multicenter prospective case-series study. Int J Periodontics Restor Dent 37:393\u2013401. https:\/\/doi.org\/10.11607\/prd.2888","journal-title":"Int J Periodontics Restor Dent"},{"key":"5979_CR25","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1902\/jop.2010.090663","volume":"81","author":"A Saito","year":"2010","unstructured":"Saito A, Hosaka Y, Kikuchi M, Akamatsu M, Fukaya C, Matsumoto S, Ueshima F, Hayakawa H, Fujinami K, Nakagawa T (2010) Effect of initial periodontal therapy on oral health-related quality of life in patients with periodontitis in Japan. J Periodontol 81:1001\u20131009. https:\/\/doi.org\/10.1902\/jop.2010.090663","journal-title":"J Periodontol"},{"key":"5979_CR26","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/j.1600-051X.2011.01796.x","volume":"38","author":"A Saito","year":"2011","unstructured":"Saito A, Ota K, Hosaka Y, Akamatsu M, Hayakawa H, Fukaya C, Ida A, Fujinami K, Sugito H, Nakagawa T (2011) Potential impact of surgical periodontal therapy on oral health-related quality of life in patients with periodontitis: a pilot study. J Clin Periodontol 38:1115\u20131121. https:\/\/doi.org\/10.1111\/j.1600-051X.2011.01796.x","journal-title":"J Clin Periodontol"},{"key":"5979_CR27","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1902\/jop.1995.66.4.261","volume":"66","author":"P Cortellini","year":"1995","unstructured":"Cortellini P, Prato GP, Tonetti MS (1995) The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures. J Periodontol 66:261\u2013266. https:\/\/doi.org\/10.1902\/jop.1995.66.4.261","journal-title":"J Periodontol"},{"key":"5979_CR28","unstructured":"Cortellini P, Prato GP, Tonetti MS (1999) The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures. Int J Periodontics Restor Dent 19:589\u2013599"},{"key":"5979_CR29","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/j.1600-051x.1997.tb00199.x","volume":"24","author":"L Trombelli","year":"1997","unstructured":"Trombelli L, Kim CK, Zimmerman GJ, Wikesj\u00f6 UM (1997) Retrospective analysis of factors related to clinical outcome of guided tissue regeneration procedures in intrabony defects. J Clin Periodontol 24:366\u2013371. https:\/\/doi.org\/10.1111\/j.1600-051x.1997.tb00199.x","journal-title":"J Clin Periodontol"},{"key":"5979_CR30","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s00784-021-04134-w","volume":"26","author":"B Liu","year":"2022","unstructured":"Liu B, Ouyang X, Kang J, Zhou S, Suo C, Xu L, Liu J, Liu W (2022) Efficacy of periodontal minimally invasive surgery with and without regenerative materials for treatment of intrabony defect: a randomized clinical trial. Clin Oral Investig 26:1613\u20131623. https:\/\/doi.org\/10.1007\/s00784-021-04134-w","journal-title":"Clin Oral Investig"},{"key":"5979_CR31","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1600-051X.2008.01217.x","volume":"35","author":"S Jepsen","year":"2008","unstructured":"Jepsen S, Topoll H, Rengers H, Heinz B, Teich M, Hoffmann T, Al-Machot E, Meyle J, Jerv\u00f8e-Storm PM (2008) Clinical outcomes after treatment of intra-bony defects with an EMD\/synthetic bone graft or EMD alone: a multicentre randomized-controlled clinical trial. J Clin Periodontol 35:420\u2013428. https:\/\/doi.org\/10.1111\/j.1600-051X.2008.01217.x","journal-title":"J Clin Periodontol"},{"key":"5979_CR32","doi-asserted-by":"publisher","first-page":"18545","DOI":"10.1038\/s41598-020-75584-7","volume":"10","author":"Y Koike","year":"2020","unstructured":"Koike Y, Yozaki M, Utani A, Murota H (2020) Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process. Sci Rep 10:18545. https:\/\/doi.org\/10.1038\/s41598-020-75584-7","journal-title":"Sci Rep"},{"key":"5979_CR33","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1600-0765.1999.tb02277.x","volume":"34","author":"S Murakami","year":"1999","unstructured":"Murakami S, Takayama S, Ikezawa K, Shimabukuro Y, Kitamura M, Nozaki T et al (1999) Regeneration of periodontal tissues by basic fibroblast growth factor. J Periodontal Res 34:425\u2013430. https:\/\/doi.org\/10.1111\/j.1600-0765.1999.tb02277.x","journal-title":"J Periodontal Res"},{"key":"5979_CR34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/0022034513511640","volume":"93","author":"M Yanagita","year":"2014","unstructured":"Yanagita M, Kojima Y, Kubota M, Mori K, Yamashita M, Yamada S et al (2014) Cooperative effects of FGF-2 and VEGF-A in periodontal ligament cells. J Dent Res 93:89\u201395. https:\/\/doi.org\/10.1177\/0022034513511640","journal-title":"J Dent Res"},{"key":"5979_CR35","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/jcpe.13228","volume":"47","author":"A Naji","year":"2020","unstructured":"Naji A, Edman K, Holmlund A (2020) Influence of smoking on periodontal healing one year after active treatment. J Clin Periodontol 47:343\u2013350. https:\/\/doi.org\/10.1111\/jcpe.13228","journal-title":"J Clin Periodontol"},{"key":"5979_CR36","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00784-015-1522-4","volume":"20","author":"T Hoffmann","year":"2016","unstructured":"Hoffmann T, Al-Machot E, Meyle J, Jerv\u00f8e-Storm PM, Jepsen S (2016) Three-year results following regenerative periodontal surgery of advanced intrabony defects with enamel matrix derivative alone or combined with a synthetic bone graft. Clin Oral Investig 20:357\u2013364. https:\/\/doi.org\/10.1007\/s00784-015-1522-4","journal-title":"Clin Oral Investig"},{"key":"5979_CR37","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1111\/jcpe.12742","volume":"44","author":"G Troiano","year":"2017","unstructured":"Troiano G, Laino L, Zhurakivska K, Cicci\u00f9 M, Lo Muzio L, Lo Russo L (2017) Addition of enamel matrix derivatives to bone substitutes for the treatment of intrabony defects: a systematic review, meta-analysis and trial sequential analysis. J Clin Periodontol 44:729\u2013738. https:\/\/doi.org\/10.1111\/jcpe.12742","journal-title":"J Clin Periodontol"},{"issue":"8","key":"5979_CR38","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.3390\/biomedicines12081664","volume":"12","author":"N Miyata","year":"2024","unstructured":"Miyata N, Mori S, Murakami T, Bizenjima T, Seshima F, Imamura K, Saito A (2024) Combined effects of fibroblast growth factor-2 and carbonate apatite granules on periodontal healing: an in vivo and in vitro study. Biomedicines 12(8):1664. https:\/\/doi.org\/10.3390\/biomedicines12081664","journal-title":"Biomedicines"},{"key":"5979_CR39","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1002\/jbmr.2738","volume":"31","author":"M Kitamura","year":"2016","unstructured":"Kitamura M, Akamatsu M, Kawanami M, Furuichi Y, Fujii T, Mori M et al (2016) Randomized placebo-controlled and controlled non-inferiority phase III trials comparing trafermin, a recombinant human fibroblast growth factor 2, and enamel matrix derivative in periodontal regeneration in intrabony defects. J Bone Min Res 31:806\u2013814. https:\/\/doi.org\/10.1002\/jbmr.2738","journal-title":"J Bone Min Res"},{"key":"5979_CR40","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1177\/0022034516632497","volume":"95","author":"DL Cochran","year":"2016","unstructured":"Cochran DL, Oh TJ, Mills MP, Clem DS, McClain PK, Schallhorn RA, McGuire MK, Scheyer ET, Giannobile WV, Reddy MS, Abou-Arraj RV, Vassilopoulos PJ, Genco RJ, Geurs NC, Takemura A (2016) A randomized clinical trial evaluating rh-FGF-2\/\u03b2-TCP in periodontal defects. J Dent Res 95:523\u2013530. https:\/\/doi.org\/10.1177\/0022034516632497","journal-title":"J Dent Res"},{"key":"5979_CR41","doi-asserted-by":"publisher","unstructured":"Seshima F, Bizenjima T, Aoki H, Imamura K, Kita D, Irokawa D, Matsugami D, Kitamura Y, Yamashita K, Sugito H, Tomita S, Saito A (2022) Periodontal regenerative therapy using rhFGF-2 and deproteinized bovine bone mineral versus rhFGF-2 alone: 4-year extended follow-up of a randomized controlled trial. Biomolecules 12(11):1682. https:\/\/doi.org\/10.3390\/biom12111682","DOI":"10.3390\/biom12111682"},{"key":"5979_CR42","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1248\/bpb.19.530","volume":"19","author":"M Okumura","year":"1996","unstructured":"Okumura M, Okuda T, Nakamura T, Yajima M (1996) Acceleration of wound healing in diabetic mice by basic fibroblast growth factor. Biol Pharm Bull 19:530\u2013535. https:\/\/doi.org\/10.1248\/bpb.19.530","journal-title":"Biol Pharm Bull"},{"key":"5979_CR43","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1600-0765.1997.tb00577.x","volume":"32","author":"S Takayama","year":"1997","unstructured":"Takayama S, Murakami S, Miki Y, Ikezawa K, Tasaka S, Terashima A, Asano T, Okada H (1997) Effects of basic fibroblast growth factor on human periodontal ligament cells. J Periodontal Res 32:667\u2013675. https:\/\/doi.org\/10.1111\/j.1600-0765.1997.tb00577.x","journal-title":"J Periodontal Res"},{"key":"5979_CR44","doi-asserted-by":"publisher","unstructured":"Fujisawa K, Akita K, Fukuda N, Kamada K, Kudoh T, Ohe G et al (2018) Compositional and histological comparison of carbonate apatite fabricated by dissolution-precipitation reaction and Bio-Oss\u00ae. J Mater Sci Mater Med 29:121. https:\/\/doi.org\/10.1007\/s10856-018-6129-2","DOI":"10.1007\/s10856-018-6129-2"},{"key":"5979_CR45","doi-asserted-by":"publisher","first-page":"100031","DOI":"10.1016\/j.mtbio.2019.100031","volume":"4","author":"K Hayashi","year":"2019","unstructured":"Hayashi K, Kishida R, Tsuchiya A, Ishikawa K (2019) Honeycomb blocks composed of carbonate apatite, \u03b2-tricalcium phosphate, and hydroxyapatite for bone regeneration: effects of composition on biological responses. Mater Today Bio 4:100031. https:\/\/doi.org\/10.1016\/j.mtbio.2019.100031","journal-title":"Mater Today Bio"},{"key":"5979_CR46","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/j.1708-8208.2012.00445.x","volume":"15","author":"P Galindo-Moreno","year":"2013","unstructured":"Galindo-Moreno P, Hern\u00e1ndez-Cort\u00e9s P, Mesa F, Carranza N, Juodzbalys G, Aguilar M, O\u2019Valle F (2013) Slow resorption of anorganic bovine bone by osteoclasts in maxillary sinus augmentation. Clin Implant Dent Relat Res 15:858\u2013866. https:\/\/doi.org\/10.1111\/j.1708-8208.2012.00445.x","journal-title":"Clin Implant Dent Relat Res"},{"key":"5979_CR47","doi-asserted-by":"publisher","unstructured":"Cortellini P, Tonetti MS (2000) Focus on intrabony defects: guided tissue regeneration. Periodontol 2000 22:104\u2013132. https:\/\/doi.org\/10.1034\/j.1600-0757.2000.2220108.x","DOI":"10.1034\/j.1600-0757.2000.2220108.x"},{"key":"5979_CR48","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/jcpe.13619","volume":"49","author":"Y Shirakata","year":"2022","unstructured":"Shirakata Y, Setoguchi F, Sena K et al (2022) Comparison of periodontal wound healing\/regeneration by recombinant human fibroblast growth factor-2 combined with \u03b2-tricalcium phosphate, carbonate apatite, or deproteinized bovine bone mineral in a canine one\u2010wall intra\u2010bony defect model. J Clin Periodontol 49:599\u2013608. https:\/\/doi.org\/10.1111\/jcpe.13619","journal-title":"J Clin Periodontol"},{"key":"5979_CR49","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1902\/jop.1993.64.4.254","volume":"64","author":"P Cortellini","year":"1993","unstructured":"Cortellini P, Prato GP, Tonetti MS (1993) Periodontal regeneration of human infrabony defects. I. Clinical measures. J Periodontol 64:254\u2013260. https:\/\/doi.org\/10.1902\/jop.1993.64.4.254","journal-title":"J Periodontol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05979-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-05979-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-05979-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T04:14:13Z","timestamp":1731644053000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-05979-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["5979"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-05979-7","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,7]]},"assertion":[{"value":"5 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Tokyo Dental College Ethics Review Committee (No. 997) and was conducted in accordance with the Declaration of Helsinki. All participants joined this study voluntarily and provided oral and written consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"574"}}