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The classification of MIH followed the recommendations of the European Academy of Pediatric Dentistry (EAPD). Statistical analysis included descriptive analysis and mixed-effects logistic regression models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>59.0% of all children had at least one FS; this percentage was 57.8% in the MIH group. The proportions of fully intact sealants and minimal, moderate, or nearly complete loss of retention were 31.7%, 48.3%, 16.8%, and 3.2%, respectively. The mean caries experience was low, at 0.2 DMFT in the whole population. Lower DMFT means were registered in individuals with FSs without MIH (0.1) and with MIH (0.1). The regression analysis revealed a significant caries-protective effect of FSs and MIH in relation to the overall caries burden. In addition, the caries-protective effect was greater in individuals with fully retained sealants (aOR 0.269) than in those with minimal (aOR 0.346), moderate (aOR 0.567) or nearly complete loss of retention (aOR 0.721).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study documented the comparable use, quality, and caries-preventive effects of FSs in individuals and permanent molar with and without MIH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical relevance<\/jats:title>\n            <jats:p>FSs are caries protective in children with and without MIH.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00784-024-06083-6","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:35:17Z","timestamp":1734514517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of fissure sealants in 8- to 10-year-olds with and without molar\u2013incisor hypomineralization (MIH) \u2013 results from a cross-sectional epidemiological study"],"prefix":"10.1007","volume":"29","author":[{"given":"Felicitas","family":"Z\u00f6llner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Ferdinand","family":"Fresen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramy","family":"Gaballah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Schill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Pitchika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Amend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"K\u00fchnisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"6083_CR1","first-page":"179","volume":"5","author":"R Welbury","year":"2004","unstructured":"Welbury R, Raadal M, Lygidakis NA (2004) European Academy of Paediatric Dentistry. 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Eur J Paediatr Dent 6:179\u2013184","journal-title":"Eur J Paediatr Dent"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-06083-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-06083-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-06083-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:00:37Z","timestamp":1738828837000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-06083-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["6083"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-06083-6","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"27 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors confirm that there are no conflicts of interest regarding the authorship or publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This cross-sectional epidemiological study received approval from the Ethics Commission at Justus-Liebig University Gie\u00dfen (AZ 72\/22). All examinations were conducted in compliance with the ethical standards set by the Institutional Review Board (IRB) and the modified Helsinki Declaration []. Before all the examinations, all the included children and their legal guardians provided written consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"20"}}