{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:21Z","timestamp":1790713401239,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-024-06087-2","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T21:28:04Z","timestamp":1733952484000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic potential of farnesoid X receptor agonists for modulating inflammation and periodontal regeneration"],"prefix":"10.1007","volume":"29","author":[{"given":"Jie","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"6087_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230334","volume":"15","author":"A Antezack","year":"2020","unstructured":"Antezack A, Chaudet H, Tissot-Dupont H, Brouqui P, Monnet-Corti V (2020) Rapid diagnosis of periodontitis, a feasibility study using MALDI-TOF mass spectrometry. PLoS ONE 15. https:\/\/doi.org\/10.1371\/journal.pone.0230334","journal-title":"PLoS ONE"},{"key":"6087_CR2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","volume":"7","author":"C Qin","year":"2022","unstructured":"Qin C, Yang S, Chu YH, Zhang H, Pang XW, Chen L, Zhou LQ, Chen M, Tian DS, Wang W (2022) Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 7:215. https:\/\/doi.org\/10.1038\/s41392-022-01064-1","journal-title":"Signal Transduct Target Ther"},{"key":"6087_CR3","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/idj.12630","volume":"71","author":"T Kwon","year":"2021","unstructured":"Kwon T, Lamster IB, Levin L (2021) Current Concepts in the Management of Periodontitis. Int Dent J 71:462\u2013476. https:\/\/doi.org\/10.1111\/idj.12630","journal-title":"Int Dent J"},{"key":"6087_CR4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1902\/jop.2012.120069","volume":"84","author":"F Borges Tde","year":"2013","unstructured":"Borges Tde F, Regalo SC, Taba M Jr, Si\u00e9ssere S, Mestriner W Jr, Semprini M (2013) Changes in masticatory performance and quality of life in individuals with chronic periodontitis. J Periodontol 84:325\u2013331. https:\/\/doi.org\/10.1902\/jop.2012.120069","journal-title":"J Periodontol"},{"key":"6087_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.smim.2016.03.006","volume":"28","author":"G Hajishengallis","year":"2016","unstructured":"Hajishengallis G, Hajishengallis E, Kajikawa T, Wang B, Yancopoulou D, Ricklin D, Lambris JD (2016) Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application. Semin Immunol 28:285\u2013291. https:\/\/doi.org\/10.1016\/j.smim.2016.03.006","journal-title":"Semin Immunol"},{"key":"6087_CR6","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.4103\/jfmpc.jfmpc_438_19","volume":"8","author":"CK Naresh","year":"2019","unstructured":"Naresh CK, Rao SM, Shetty PR, Ranganath V, Patil AS, Anu AJ (2019) Salivary antioxidant enzymes and lipid peroxidation product malondialdehyde and sialic acid levels among smokers and non-smokers with chronic periodontitis-A clinico-biochemical study. Journal of family medicine and primary care 8:2960\u20132964. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_438_19","journal-title":"Journal of family medicine and primary care"},{"key":"6087_CR7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis G (2015) Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 15:30\u201344. https:\/\/doi.org\/10.1038\/nri3785","journal-title":"Nat Rev Immunol"},{"key":"6087_CR8","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.archoralbio.2015.06.017","volume":"60","author":"Y Li","year":"2015","unstructured":"Li Y, Guo H, Wang X, Lu Y, Yang C, Yang P (2015) Coinfection with Fusobacterium nucleatum can enhance the attachment and invasion of Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans to human gingival epithelial cells. Arch Oral Biol 60:1387\u20131393. https:\/\/doi.org\/10.1016\/j.archoralbio.2015.06.017","journal-title":"Arch Oral Biol"},{"key":"6087_CR9","doi-asserted-by":"publisher","first-page":"27956","DOI":"10.1038\/srep27956","volume":"6","author":"B Bor","year":"2016","unstructured":"Bor B, Cen L, Agnello M, Shi W, He X (2016) Morphological and physiological changes induced by contact-dependent interaction between Candida albicans and Fusobacterium nucleatum. Sci Rep 6:27956. https:\/\/doi.org\/10.1038\/srep27956","journal-title":"Sci Rep"},{"key":"6087_CR10","doi-asserted-by":"publisher","first-page":"8915818","DOI":"10.1155\/2019\/8915818","volume":"2019","author":"X Kong","year":"2019","unstructured":"Kong X, Li B, Deng Y, Ma X (2019) FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic \u03b2-Cells. J Diabetes Res 2019:8915818. https:\/\/doi.org\/10.1155\/2019\/8915818","journal-title":"J Diabetes Res"},{"key":"6087_CR11","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41598-017-00698-4","volume":"7","author":"W You","year":"2017","unstructured":"You W, Chen B, Liu X, Xue S, Qin H, Jiang H (2017) Farnesoid X receptor, a novel proto-oncogene in non-small cell lung cancer, promotes tumor growth via directly transactivating CCND1. Sci Rep 7:591. https:\/\/doi.org\/10.1038\/s41598-017-00698-4","journal-title":"Sci Rep"},{"key":"6087_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.632864","volume":"12","author":"S Cao","year":"2021","unstructured":"Cao S, Meng X, Li Y, Sun L, Jiang L, Xuan H, Chen X (2021) Bile Acids Elevated in Chronic Periaortitis Could Activate Farnesoid-X-Receptor to Suppress IL-6 Production by Macrophages. Front Immunol 12. https:\/\/doi.org\/10.3389\/fimmu.2021.632864","journal-title":"Front Immunol"},{"key":"6087_CR13","doi-asserted-by":"publisher","unstructured":"Zheng T, Kim NY and Yim M (2017) Fexaramine Inhibits Receptor Activator of Nuclear Factor-\u03baB Ligand-induced Osteoclast Formation via Nuclear Factor of Activated T Cells Signaling Pathways. Journal of bone metabolism 24:207\u2013215. https:\/\/doi.org\/10.11005\/jbm.2017.24.4.207","DOI":"10.11005\/jbm.2017.24.4.207"},{"key":"6087_CR14","doi-asserted-by":"publisher","first-page":"1538927","DOI":"10.1080\/20002297.2018.1538927","volume":"11","author":"S Elmanfi","year":"2019","unstructured":"Elmanfi S, Zhou J, Sintim HO, K\u00f6n\u00f6nen E, G\u00fcrsoy M, G\u00fcrsoy UK (2019) Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides. J Oral Microbiol 11:1538927. https:\/\/doi.org\/10.1080\/20002297.2018.1538927","journal-title":"J Oral Microbiol"},{"key":"6087_CR15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cbi.2018.09.005","volume":"296","author":"KS Suh","year":"2018","unstructured":"Suh KS, Chon S, Jung WW, Choi EM (2018) Effects of methylglyoxal on RANKL-induced osteoclast differentiation in RAW264.7 cells. Chem Biol Interact 296:18\u201325. https:\/\/doi.org\/10.1016\/j.cbi.2018.09.005","journal-title":"Chem Biol Interact"},{"key":"6087_CR16","doi-asserted-by":"publisher","first-page":"4916971","DOI":"10.1155\/2017\/4916971","volume":"2017","author":"M Nokhbehsaim","year":"2017","unstructured":"Nokhbehsaim M, Damanaki A, Nogueira AVB, Eick S, Memmert S, Zhou X, Nanayakkara S, G\u00f6tz W, Cirelli JA, J\u00e4ger A, Deschner J (2017) Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo. Mediators Inflamm 2017:4916971. https:\/\/doi.org\/10.1155\/2017\/4916971","journal-title":"Mediators Inflamm"},{"key":"6087_CR17","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.ejphar.2017.11.021","volume":"818","author":"F Briand","year":"2018","unstructured":"Briand F, Brousseau E, Quinsat M, Burcelin R, Sulpice T (2018) Obeticholic acid raises LDL-cholesterol and reduces HDL-cholesterol in the Diet-Induced NASH (DIN) hamster model. Eur J Pharmacol 818:449\u2013456. https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.021","journal-title":"Eur J Pharmacol"},{"key":"6087_CR18","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1111\/dom.12681","volume":"18","author":"R Pencek","year":"2016","unstructured":"Pencek R, Marmon T, Roth JD, Liberman A, Hooshmand-Rad R, Young MA (2016) Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers. Diabetes Obes Metab 18:936\u2013940. https:\/\/doi.org\/10.1111\/dom.12681","journal-title":"Diabetes Obes Metab"},{"key":"6087_CR19","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1038\/s41598-020-58732-x","volume":"10","author":"C Kornsuthisopon","year":"2020","unstructured":"Kornsuthisopon C, Pirarat N, Osathanon T, Kalpravidh C (2020) Autologous platelet-rich fibrin stimulates canine periodontal regeneration. Sci Rep 10:1850. https:\/\/doi.org\/10.1038\/s41598-020-58732-x","journal-title":"Sci Rep"},{"key":"6087_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134601","volume":"10","author":"CF Santos","year":"2015","unstructured":"Santos CF, Morandini AC, Dion\u00edsio TJ, Faria FA, Lima MC, Figueiredo CM, Colombini-Ishikiriama BL, Sipert CR, Maciel RP, Akashi AP, Souza GP, Garlet GP, Rodini CO, Amaral SL, Becari C, Salgado MC, Oliveira EB, Matus I, Didier DN, Greene AS (2015) Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue. PLoS ONE 10. https:\/\/doi.org\/10.1371\/journal.pone.0134601","journal-title":"PLoS ONE"},{"key":"6087_CR21","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1002\/jcp.25777","volume":"232","author":"M Nagao","year":"2017","unstructured":"Nagao M, Tanabe N, Manaka S, Naito M, Sekino J, Takayama T, Kawato T, Torigoe G, Kato S, Tsukune N, Maeno M, Suzuki N, Sato S (2017) LIPUS suppressed LPS-induced IL-1\u03b1 through the inhibition of NF-\u03baB nuclear translocation via AT1-PLC\u03b2 pathway in MC3T3-E1 cells. J Cell Physiol 232:3337\u20133346. https:\/\/doi.org\/10.1002\/jcp.25777","journal-title":"J Cell Physiol"},{"key":"6087_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1902\/annals.1998.3.1.51","volume":"3","author":"SG Grossi","year":"1998","unstructured":"Grossi SG, Genco RJ (1998) Periodontal disease and diabetes mellitus: a two-way relationship. Ann Periodontol 3:51\u201361. https:\/\/doi.org\/10.1902\/annals.1998.3.1.51","journal-title":"Ann Periodontol"},{"key":"6087_CR23","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4103\/2230-973x.104394","volume":"2","author":"M Tariq","year":"2012","unstructured":"Tariq M, Iqbal Z, Ali J, Baboota S, Talegaonkar S, Ahmad Z, Sahni JK (2012) Treatment modalities and evaluation models for periodontitis. International journal of pharmaceutical investigation 2:106\u2013122. https:\/\/doi.org\/10.4103\/2230-973x.104394","journal-title":"International journal of pharmaceutical investigation"},{"key":"6087_CR24","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/jre.12269","volume":"50","author":"CM Queiroz-Junior","year":"2015","unstructured":"Queiroz-Junior CM, Silveira KD, de Oliveira CR, Moura AP, Madeira MF, Soriani FM, Ferreira AJ, Fukada SY, Teixeira MM, Souza DG, da Silva TA (2015) Protective effects of the angiotensin type 1 receptor antagonist losartan in infection-induced and arthritis-associated alveolar bone loss. J Periodontal Res 50:814\u2013823. https:\/\/doi.org\/10.1111\/jre.12269","journal-title":"J Periodontal Res"},{"key":"6087_CR25","doi-asserted-by":"publisher","unstructured":"Kim S, Lee JY, Park JY, Kim Y and Kang CH (2022) Lacticaseibacillus rhamnosus MG4706 Suppresses Periodontitis in Osteoclasts, Inflammation-Inducing Cells, and Ligature-Induced Rats. Nutrients 14. https:\/\/doi.org\/10.3390\/nu14224869","DOI":"10.3390\/nu14224869"},{"key":"6087_CR26","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.bbrc.2017.06.129","volume":"490","author":"HM Liu","year":"2017","unstructured":"Liu HM, Liao JF, Lee TY (2017) Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4\/MyD88 pathway related mitochondrial dysfunction in mice. Biochem Biophys Res Commun 490:841\u2013848. https:\/\/doi.org\/10.1016\/j.bbrc.2017.06.129","journal-title":"Biochem Biophys Res Commun"},{"key":"6087_CR27","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/term.1851","volume":"9","author":"R Detsch","year":"2015","unstructured":"Detsch R, Boccaccini AR (2015) The role of osteoclasts in bone tissue engineering. J Tissue Eng Regen Med 9:1133\u20131149. https:\/\/doi.org\/10.1002\/term.1851","journal-title":"J Tissue Eng Regen Med"},{"key":"6087_CR28","doi-asserted-by":"publisher","unstructured":"Omi M and Mishina Y (2022) Roles of osteoclasts in alveolar bone remodeling. Genesis (New York, NY : 2000) 60:e23490. https:\/\/doi.org\/10.1002\/dvg.23490","DOI":"10.1002\/dvg.23490"},{"key":"6087_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","volume":"39","author":"N Udagawa","year":"2021","unstructured":"Udagawa N, Koide M, Nakamura M, Nakamichi Y, Yamashita T, Uehara S, Kobayashi Y, Furuya Y, Yasuda H, Fukuda C, Tsuda E (2021) Osteoclast differentiation by RANKL and OPG signaling pathways. J Bone Miner Metab 39:19\u201326. https:\/\/doi.org\/10.1007\/s00774-020-01162-6","journal-title":"J Bone Miner Metab"},{"key":"6087_CR30","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.archoralbio.2012.06.012","volume":"57","author":"SY Ko","year":"2012","unstructured":"Ko SY (2012) Myricetin suppresses LPS-induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL-induced RAW 264.7 cells. Arch Oral Biol 57:1623\u20131632. https:\/\/doi.org\/10.1016\/j.archoralbio.2012.06.012","journal-title":"Arch Oral Biol"},{"key":"6087_CR31","doi-asserted-by":"publisher","unstructured":"Park KR, Kim S, Cho M and Yun HM (2021) Limonoid Triterpene, Obacunone Increases Runt-Related Transcription Factor 2 to Promote Osteoblast Differentiation and Function. International journal of molecular sciences 22. https:\/\/doi.org\/10.3390\/ijms22052483","DOI":"10.3390\/ijms22052483"},{"key":"6087_CR32","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1177\/00220345211028852","volume":"100","author":"W Ma","year":"2021","unstructured":"Ma W, Lyu H, Pandya M, Gopinathan G, Luan X, Diekwisch TGH (2021) Successful Application of a Galanin-Coated Scaffold for Periodontal Regeneration. J Dent Res 100:1144\u20131152. https:\/\/doi.org\/10.1177\/00220345211028852","journal-title":"J Dent Res"},{"key":"6087_CR33","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/wsbm.1331","volume":"8","author":"S Mitchell","year":"2016","unstructured":"Mitchell S, Vargas J, Hoffmann A (2016) Signaling via the NF\u03baB system. Wiley interdisciplinary reviews Systems biology and medicine 8:227\u2013241. https:\/\/doi.org\/10.1002\/wsbm.1331","journal-title":"Wiley interdisciplinary reviews Systems biology and medicine"},{"key":"6087_CR34","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/jre.13118","volume":"58","author":"H Chen","year":"2023","unstructured":"Chen H, Liu Y, Yu S, Li C, Gao B, Zhou X (2023) Cannabidiol attenuates periodontal inflammation through inhibiting TLR4\/NF-\u03baB pathway. J Periodontal Res 58:697\u2013707. https:\/\/doi.org\/10.1111\/jre.13118","journal-title":"J Periodontal Res"},{"key":"6087_CR35","doi-asserted-by":"publisher","first-page":"12861","DOI":"10.1038\/s41598-023-39853-5","volume":"13","author":"HY Lee","year":"2023","unstructured":"Lee HY, Lee GH, Kim JH, Cheng J, Cho JH, Suh JW, Chae HJ (2023) Ixeris dentata and Lactobacillus gasseri media protect against periodontitis through Nrf2-HO-1 signalling pathway. Sci Rep 13:12861. https:\/\/doi.org\/10.1038\/s41598-023-39853-5","journal-title":"Sci Rep"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-06087-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-06087-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-06087-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:00:21Z","timestamp":1738828821000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-06087-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["6087"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-06087-2","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]},"assertion":[{"value":"15 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal-related procedures were performed with adherence to the Institutional Animal Care and Use Committee. Ethics approval was obtained from the Animal Experimentation Ethics Committee of Zhejiang Eyong Pharmaceutical Research and Development Center (Certificate No. SYXK (Zhe) 2021-0033).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}