{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:19:00Z","timestamp":1778181540727,"version":"3.51.4"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To evaluate the possible additional clinical benefit from autologous platelet concentrate (APC) treatment adjunct to non-surgical periodontal therapy (NSPT).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Electronic (MEDLINE\/Embase\/Cochrane\/MedNar\/CORE) and hand searches were conducted. Following studies selection, evidence tables were formed, and meta-analyses were performed for the following outcomes: probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, and bleeding on probing (BoP) reduction. The protocol for this systematic review was registered in PROSPERO (CRD42023514388).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>After de-duplication, the initial search yielded 194 citations, from which ten papers were eligible for quantitative synthesis. The APC group comprised 270 patients, while the control group included 230. The meta-analysis revealed that a single APC application resulted in a 0.6\u00a0mm greater PPD reduction (MD\u2009=\u2009-0.62; 95% CI: -1.03, -0.22) and 0.8\u00a0mm more CAL gain (MD\u2009=\u2009-0.77; 95% CI: -1.18, -0.37) at the 6\u201312\u00a0weeks follow-up. At six months, the APC group exhibited a 0.6\u00a0mm greater PPD reduction (MD\u2009=\u2009-0.61; 95% CI: -1.13, -0.09) and 1.1\u00a0mm more CAL gain (MD\u2009=\u2009-1.14; 95% CI: -1.94, -0.34) compared to the NSPT only group. In contrast, BoP indices did not reveal a statistically significant difference between the groups after 6\u201312\u00a0weeks (MD\u2009=\u2009-10.54; 95% CI: -25.21, 4.14). High heterogeneity and unclear to high risk of bias were detected.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Over six months, the adjunctive APC use appears to provide additional benefits in PPD reduction and CAL gain compared to NSPT alone.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical relevance<\/jats:title>\n            <jats:p>The adjunctive use of APCs seems to promote further improvements in clinical outcomes following NSPT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00784-024-06128-w","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:29:28Z","timestamp":1737520168000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Autologous platelet concentrates as adjuncts to non-surgical periodontal therapy: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"29","author":[{"given":"Tina","family":"Lipovec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. N.","family":"Antonoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M. C.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M. Fawzy","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Nibali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"6128_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/jcpe.13245","volume":"47","author":"J Suvan","year":"2020","unstructured":"Suvan J, Leira Y, Moreno Sancho FM, Graziani F, Derks J, Tomasi C (2020) Subgingival instrumentation for treatment of periodontitis. A systematic review J Clin Periodontol 47:155\u2013175. https:\/\/doi.org\/10.1111\/jcpe.13245","journal-title":"A systematic review J Clin Periodontol"},{"key":"6128_CR2","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1111\/jcpe.12351","volume":"42","author":"CA Ramseier","year":"2015","unstructured":"Ramseier CA, Suvan JE (2015) Behaviour change counselling for tobacco use cessation and promotion of healthy lifestyles: a systematic review. J Clin Periodontol 42:S47\u2013S58. https:\/\/doi.org\/10.1111\/jcpe.12351","journal-title":"J Clin Periodontol"},{"key":"6128_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jcpe.13290","volume":"47","author":"M Sanz","year":"2020","unstructured":"Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Berglundh T et al (2020) Treatment of stage I-III periodontitis\u2014The EFP S3 level clinical practice guideline. J Clin Periodontol 47:4\u201360. https:\/\/doi.org\/10.1111\/jcpe.13290","journal-title":"J Clin Periodontol"},{"key":"6128_CR4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/jcpe.12351","volume":"20","author":"H Zhao","year":"2020","unstructured":"Zhao H, Hu J, Zhao L (2020) Adjunctive subgingival application of Chlorhexidine gel in nonsurgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis. BMC Oral Health 20:34. https:\/\/doi.org\/10.1111\/jcpe.12351","journal-title":"BMC Oral Health"},{"key":"6128_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1807-3107bor-2021.vol35.0095","volume":"35","author":"AN Haas","year":"2021","unstructured":"Haas AN, Furlaneto F, Gaio EJ, Gomes SC, Palioto DB, Castilho RM et al (2021) New tendencies in non-surgical periodontal therapy. Braz Oral Res 35:1\u201318. https:\/\/doi.org\/10.1590\/1807-3107bor-2021.vol35.0095","journal-title":"Braz Oral Res"},{"key":"6128_CR6","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s10103-018-2441-9","volume":"33","author":"M Giannelli","year":"2018","unstructured":"Giannelli M, Materassi F, Fossi T, Lorenzini L, Bani D (2018) Treatment of severe periodontitis with a laser and light-emitting diode (LED) procedure adjunctive to scaling and root planing: a double-blind, randomized, single-center, split-mouth clinical trial investigating its efficacy and patient-reported outcomes at 1 year. Lasers Med Sci 33:991\u20131002. https:\/\/doi.org\/10.1007\/s10103-018-2441-9","journal-title":"Lasers Med Sci"},{"key":"6128_CR7","doi-asserted-by":"publisher","unstructured":"Donos N, Calciolari E, Brusselaers N, Goldoni M, Bostanci N, Belibasakis GN (2020) The adjunctive use of host modulators in non-surgical periodontal therapy. A systematic review of randomized, placebo-controlled clinical studies. J Clin Periodontol. 47 Suppl 22:199\u2013238. https:\/\/doi.org\/10.1111\/jcpe.13232","DOI":"10.1111\/jcpe.13232"},{"key":"6128_CR8","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/idh.12591","volume":"20","author":"GS Chatzopoulos","year":"2022","unstructured":"Chatzopoulos GS, Anastasopoulos M, Zarenti S, Doufexi A-E, Tsalikis L (2022) Flapless application of enamel matrix derivative in non-surgical periodontal treatment: A systematic review. Int J Dent Hyg 20:422\u2013433. https:\/\/doi.org\/10.1111\/idh.12591","journal-title":"Int J Dent Hyg"},{"key":"6128_CR9","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1902\/jop.1979.50.9.462","volume":"50","author":"JG Caton","year":"1979","unstructured":"Caton JG, Zander HA (1979) The Attachment Between Tooth and Gingival Tissues After Periodic Root Planing and Soft Tissue Curettage. J Periodontol 50:462\u2013466. https:\/\/doi.org\/10.1902\/jop.1979.50.9.462","journal-title":"J Periodontol"},{"key":"6128_CR10","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1902\/jop.2008.080190","volume":"79","author":"TG Wilson","year":"2008","unstructured":"Wilson TG, Carnio J, Schenk R, Myers G (2008) Absence of Histologic Signs of Chronic Inflammation Following Closed Subgingival Scaling and Root Planing Using the Dental Endoscope: Human Biopsies \u2013 A Pilot Study. J Periodontol 79:2036\u20132041. https:\/\/doi.org\/10.1902\/jop.2008.080190","journal-title":"J Periodontol"},{"key":"6128_CR11","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3390\/biology10040317","volume":"10","author":"E Mijiritsky","year":"2021","unstructured":"Mijiritsky E, Assaf HD, Peleg O, Shacham M, Cerroni L, Mangani L (2021) Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation\u2014A Narrative Review. Biology (Basel) 10:317. https:\/\/doi.org\/10.3390\/biology10040317","journal-title":"Biology (Basel)"},{"key":"6128_CR12","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/s0278-2391(97)90187-7","volume":"55","author":"DH Whitman","year":"1997","unstructured":"Whitman DH, Berry RL, Green DM (1997) Platelet gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral and Maxillofac Surg 55:1294\u20131299. https:\/\/doi.org\/10.1016\/s0278-2391(97)90187-7","journal-title":"J Oral and Maxillofac Surg"},{"key":"6128_CR13","first-page":"55","volume":"42","author":"J Choukroun","year":"2001","unstructured":"Choukroun J, Adda F, Schoeffler C, Vervelle A (2001) An opportunity in perio-implantology: The PRF. Implantodontie 42:55\u201362","journal-title":"Implantodontie"},{"key":"6128_CR14","unstructured":"Sacco L (2006) Lecture. International Academy of Implant Prosthesis and Osteoconnection. 12 April; Sersale, Italy."},{"key":"6128_CR15","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1080\/09537104.2016.1267338","volume":"28","author":"J Qiao","year":"2017","unstructured":"Qiao J, An N, Ouyang X (2017) Quantification of growth factors in different platelet concentrates. Platelets 28:774\u2013778. https:\/\/doi.org\/10.1080\/09537104.2016.1267338","journal-title":"Platelets"},{"key":"6128_CR16","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1902\/jop.2009.090531","volume":"81","author":"DM Dohan Ehrenfest","year":"2010","unstructured":"Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier J-B (2010) Three-Dimensional Architecture and Cell Composition of a Choukroun\u2019s Platelet-Rich Fibrin Clot and Membrane. J Periodontol 81:546\u2013555. https:\/\/doi.org\/10.1902\/jop.2009.090531","journal-title":"J Periodontol"},{"key":"6128_CR17","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3389\/fcvm.2019.00126","volume":"6","author":"FS Al-Hamed","year":"2019","unstructured":"Al-Hamed FS, Mahri M, Al-Waeli H, Torres J, Badran Z, Tamimi F (2019) Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration. Front Cardiovasc Med 6:126. https:\/\/doi.org\/10.3389\/fcvm.2019.00126","journal-title":"Front Cardiovasc Med"},{"key":"6128_CR18","doi-asserted-by":"publisher","first-page":"3091619","DOI":"10.1155\/2019\/3091619","volume":"2019","author":"Z Liu","year":"2019","unstructured":"Liu Z, Xiao S, Tao K, Li H, Jin W, Wei Z, Wang D, Deng W (2019) Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model. Stem Cells Int 2019:3091619. https:\/\/doi.org\/10.1155\/2019\/3091619","journal-title":"Stem Cells Int"},{"key":"6128_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1742-4933-10-23","volume":"10","author":"A Albanese","year":"2013","unstructured":"Albanese A, Licata ME, Polizzi B, Campisi G (2013) Platelet-rich plasma (PRP) in dental and oral surgery: From the wound healing to bone regeneration. Immun Ageing 10:23. https:\/\/doi.org\/10.1186\/1742-4933-10-23","journal-title":"Immun Ageing"},{"key":"6128_CR20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1160\/TH03-07-0440","volume":"91","author":"E Anitua","year":"2004","unstructured":"Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT (2004) Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 91:4\u201315. https:\/\/doi.org\/10.1160\/TH03-07-0440","journal-title":"Thromb Haemost"},{"key":"6128_CR21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1600-0765.2011.01446.x","volume":"47","author":"V Lekovic","year":"2012","unstructured":"Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB et al (2012) Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodontal Res 47:409\u2013417. https:\/\/doi.org\/10.1111\/j.1600-0765.2011.01446.x","journal-title":"J Periodontal Res"},{"key":"6128_CR22","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.1016\/j.biomaterials.2009.05.055","volume":"30","author":"G Intini","year":"2009","unstructured":"Intini G (2009) The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials 30:4956\u20134966. https:\/\/doi.org\/10.1016\/j.biomaterials.2009.05.055","journal-title":"Biomaterials"},{"key":"6128_CR23","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1902\/jop.2012.110722","volume":"88","author":"AR Pradeep","year":"2017","unstructured":"Pradeep AR, Bajaj P, Rao NS, Agarwal E, Naik SB (2017) Platelet-Rich Fibrin Combined With a Porous Hydroxyapatite Graft for the Treatment of 3-Wall Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial. J Periodontol 88:1288\u20131296. https:\/\/doi.org\/10.1902\/jop.2012.110722","journal-title":"J Periodontol"},{"key":"6128_CR24","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1563\/AAID-JOI-D-13-00129","volume":"41","author":"N Bolukbasi","year":"2015","unstructured":"Bolukbasi N, Ersanl\u0131 S, Keklikoglu N, Basegmez C, Ozdemir T (2015) Sinus Augmentation With Platelet-Rich Fibrin in Combination With Bovine Bone Graft Versus Bovine Bone Graft in Combination With Collagen Membrane. Journal of Oral Implantology 41:586\u2013595. https:\/\/doi.org\/10.1563\/AAID-JOI-D-13-00129","journal-title":"Journal of Oral Implantology"},{"key":"6128_CR25","doi-asserted-by":"publisher","unstructured":"Thorat MK, Baghele O, Rakhewar PS (2017) Adjunctive Effect of Autologous Platelet-Rich Fibrin in the Treatment of Intrabony Defects in Localized Aggressive Periodontitis Patients: A Randomized Controlled Split-Mouth Clinical Trial. Int J Periodontics Restorative Dent. 37:e302\u2013309. https:\/\/doi.org\/10.11607\/prd.2972","DOI":"10.11607\/prd.2972"},{"key":"6128_CR26","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.oooo.2015.06.035","volume":"120","author":"\u00c0 Rosell\u00f3-Camps","year":"2015","unstructured":"Rosell\u00f3-Camps \u00c0, Monje A, Lin GH, Khoshkam V, Ch\u00e1vez-Gatty M, Wang HL et al (2015) Platelet-rich plasma for periodontal regeneration in the treatment of intrabony defects: a meta-analysis on prospective clinical trials. Oral Surg Oral Med Oral Pathol Oral Radiol 120:562\u2013574. https:\/\/doi.org\/10.1016\/j.oooo.2015.06.035","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"6128_CR27","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3390\/ijms20061347","volume":"20","author":"S Panda","year":"2019","unstructured":"Panda S, Karanxha L, Goker F, Satpathy A, Taschieri S, Francetti L et al (2019) Autologous platelet concentrates in treatment of furcation defects \u2014 A systematic review and meta-analysis. Int J Mol Sci 20:1347. https:\/\/doi.org\/10.3390\/ijms20061347","journal-title":"Int J Mol Sci"},{"key":"6128_CR28","doi-asserted-by":"publisher","unstructured":"\u00d6ncu\u0308 E (2017) The Use of Platelet-Rich Fibrin Versus Subepithelial Connective Tissue Graft in Treatment of Multiple Gingival Recessions: A Randomized Clinical Trial. Int J Periodontics Restorative Dent. 37:265\u2013271. https:\/\/doi.org\/10.11607\/prd.2741","DOI":"10.11607\/prd.2741"},{"key":"6128_CR29","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/jcpe.12444","volume":"42","author":"\u015e Bozkurt Do\u0287an","year":"2015","unstructured":"Bozkurt Do\u0287an \u015e, \u00d6ng\u00f6z Dede F, Balli U, Atalay EN, Durmu\u015flar MC (2015) Concentrated growth factor in the treatment of adjacent multiple gingival recessions: A split-mouth randomized clinical trial. J Clin Periodontol 42:868\u2013875. https:\/\/doi.org\/10.1111\/jcpe.12444","journal-title":"J Clin Periodontol"},{"key":"6128_CR30","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00784-023-05447-8","volume":"28","author":"G Torumtay Cin","year":"2024","unstructured":"Torumtay Cin G, Lektemur Alpan A, \u00c7evik \u00d6 (2024) Efficacy of injectable platelet-rich fibrin on clinical and biochemical parameters in non-surgical periodontal treatment: a split-mouth randomized controlled trial. Clin Oral Investig 28:46. https:\/\/doi.org\/10.1007\/s00784-023-05447-8","journal-title":"Clin Oral Investig"},{"key":"6128_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/cap.10266","author":"PD Shunmuga","year":"2023","unstructured":"Shunmuga PD, Tadepalli A, Parthasarathy H, Ponnaiyan D, Cholan PK, Ramachandran L (2023) Clinical evaluation of the combined efficacy of injectable platelet-rich fibrin along with scaling and root planing in the non-surgical periodontal therapy of stage III and grade C periodontitis patients having type 2 diabetes mellitus: A randomized controlled trial. Clin Adv Periodontics. https:\/\/doi.org\/10.1002\/cap.10266","journal-title":"Clin Adv Periodontics"},{"key":"6128_CR32","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/JPER.20-0713","volume":"92","author":"E \u00d6zcan","year":"2021","unstructured":"\u00d6zcan E, Saygun I, Kantarc\u0131 A, \u00d6zarslant\u00fcrk S, Serdar MA, \u00d6zg\u00fcrta\u015f T (2021) The effects of a novel non-invasive application of platelet-rich fibrin on periodontal clinical parameters and gingival crevicular fluid transforming growth factor-\u03b2 and collagen-1 levels: A randomized, controlled, clinical study. J Periodontol 92:1252\u20131261. https:\/\/doi.org\/10.1002\/JPER.20-0713","journal-title":"J Periodontol"},{"key":"6128_CR33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/jcmm.17675","volume":"27","author":"S Al-Rihaymee","year":"2023","unstructured":"Al-Rihaymee S, Sh. Mahmood M, (2023) The efficacy of non-surgical platelet-rich fibrin application on clinical periodontal parameters and periostin level in periodontitis: Clinical trial. J Cell Mol Med 27:529\u2013537. https:\/\/doi.org\/10.1111\/jcmm.17675","journal-title":"J Cell Mol Med"},{"key":"6128_CR34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.9790\/0853-2009051118","volume":"20","author":"PS Rakhewar","year":"2021","unstructured":"Rakhewar PS, Jannawar P, Chacko NL, Patil S, Saxena S (2021) An evaluation of clinical effects of i-PRF as an adjunctive to non-surgical periodontal therapy versus non-surgical periodontal therapy alone in treatment of chronic periodontitis patients \u2013 a split mouth randomized controlled clinical trial. IOSR-JDMS 20:11\u201318. https:\/\/doi.org\/10.9790\/0853-2009051118","journal-title":"IOSR-JDMS"},{"key":"6128_CR35","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/wrr.12979","volume":"30","author":"N Narendran","year":"2022","unstructured":"Narendran N, Anegundi RV, Shenoy SB, Chandran T (2022) Autologous platelet-rich fibrin as an adjunct to non-surgical periodontal therapy\u2014A follow up clinical pilot study. Wound Repair Regen 30:140\u2013145. https:\/\/doi.org\/10.1111\/wrr.12979","journal-title":"Wound Repair Regen"},{"key":"6128_CR36","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"6128_CR37","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1034\/j.1600-0757.2000.2220102.x","volume":"22","author":"PN Papapanou","year":"2000","unstructured":"Papapanou PN (2000) Tonetti MS (2000) Diagnosis and epidemiology of periodontal osseous lesions. Periodontol 22:8\u201311. https:\/\/doi.org\/10.1034\/j.1600-0757.2000.2220102.x","journal-title":"Periodontol"},{"key":"6128_CR38","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"6128_CR39","unstructured":"Page MJ, Higgins JPT, Sterne JAC (2020) Assessing risk of bias due to missing results in a synthesis. In: Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, Welch VA (ed) Cochrane Handbook for Systematic Reviews of Interventions version 6.1. www.training.cochrane.org\/handbook. Accessed September 2 2024"},{"key":"6128_CR40","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1179\/1465313314Y.0000000111","volume":"41","author":"SN Papageorgiou","year":"2014","unstructured":"Papageorgiou SN (2014) Meta-analysis for orthodontists: Part I - How to choose effect measure and statistical model. J Orthod 41:317\u2013326. https:\/\/doi.org\/10.1179\/1465313314Y.0000000111","journal-title":"J Orthod"},{"key":"6128_CR41","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010247","volume":"6","author":"J IntHout","year":"2016","unstructured":"IntHout J, Ioannidis JPA, Rovers MM, Goeman JJ (2016) Plea for routinely presenting prediction intervals in meta-analysis. BMJ Open 6:e010247. https:\/\/doi.org\/10.1136\/bmjopen-2015-010247","journal-title":"BMJ Open"},{"key":"6128_CR42","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40510-024-00520-8","volume":"25","author":"U Hussain","year":"2024","unstructured":"Hussain U, Campobasso A, Noman M, Alam S, Mujeeb R, Shehzad S, Papageorgiou SN (2024) Influence of elastomeric and steel ligatures on periodontal health during fixed appliance orthodontic treatment: a systematic review and meta-analysis. Prog Orthod 25:24. https:\/\/doi.org\/10.1186\/s40510-024-00520-8","journal-title":"Prog Orthod"},{"key":"6128_CR43","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2020.vol34.0034","volume":"34","author":"S Panda","year":"2020","unstructured":"Panda S, Purkayastha A, Mohanty R, Nayak R, Satpathy A, Das AC et al (2020) Plasma rich in growth factors (PRGF) in non-surgical periodontal therapy: A randomized clinical trial. Braz Oral Res 34:e034. https:\/\/doi.org\/10.1590\/1807-3107bor-2020.vol34.0034","journal-title":"Braz Oral Res"},{"key":"6128_CR44","doi-asserted-by":"publisher","first-page":"676","DOI":"10.3290\/j.qi.b1492019","volume":"52","author":"H Albonni","year":"2021","unstructured":"Albonni H, El Abdelah AAAD, Al Hamwi MOMS, Al Hamoui WB, Sawaf H (2021) Clinical effectiveness of a topical subgingival application of injectable platelet-rich fibrin as adjunctive therapy to scaling and root planing: a double-blind, split-mouth, randomized, prospective, comparative controlled trial. Quintessence Int 52:676\u2013685. https:\/\/doi.org\/10.3290\/j.qi.b1492019","journal-title":"Quintessence Int"},{"key":"6128_CR45","doi-asserted-by":"publisher","unstructured":"Agarwal A, Dev Gupta N (2014) Platelet-rich Plasma with Scaling and Root Planing: A Double-blind Split-mouth Randomized Study. J Periodontol Implant Dent. 6:35\u201339. https:\/\/doi.org\/10.15171\/jpid.2014.007","DOI":"10.15171\/jpid.2014.007"},{"key":"6128_CR46","doi-asserted-by":"publisher","unstructured":"Amin A, Elkady M, El Destawy M (2022) Comparison between PRP vs iPRF as an adjunct therapy in Infra-bony Pocket treatment. Al-Azhar J Den Sci. 25:485\u2013493. https:\/\/doi.org\/10.21608\/ajdsm.2022.121791.1311","DOI":"10.21608\/ajdsm.2022.121791.1311"},{"key":"6128_CR47","doi-asserted-by":"publisher","first-page":"280","DOI":"10.2298\/SARH190925022V","volume":"148","author":"M Vu\u010dkovi\u0107","year":"2020","unstructured":"Vu\u010dkovi\u0107 M, Nikoli\u0107 N, Mila\u0161in J, \u0110or\u0111evi\u0107 V, Milinkovi\u0107 I, Asoti\u0107 J et al (2020) The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. Srp Arh Celok Lek 148:280\u2013285. https:\/\/doi.org\/10.2298\/SARH190925022V","journal-title":"Srp Arh Celok Lek"},{"key":"6128_CR48","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1902\/jop.2008.070436","volume":"79","author":"M Piemontese","year":"2008","unstructured":"Piemontese M, Aspriello SD, Rubini C, Ferrante L, Procaccini M (2008) Treatment of Periodontal Intrabony Defects With Demineralized Freeze-Dried Bone Allograft in Combination With Platelet-Rich Plasma: A Comparative Clinical Trial. J Periodontol 79:802\u2013810. https:\/\/doi.org\/10.1902\/jop.2008.070436","journal-title":"J Periodontol"},{"key":"6128_CR49","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1563\/aaid-joi-D-14-00138","volume":"40","author":"S Ghanaati","year":"2014","unstructured":"Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J et al (2014) Advanced platelet-rich fibrin: A new concept for cell- Based tissue engineering by means of inflammatory cells. J Oral Implantol 40:679\u2013689. https:\/\/doi.org\/10.1563\/aaid-joi-D-14-00138","journal-title":"J Oral Implantol"},{"key":"6128_CR50","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00784-014-1278-2","volume":"19","author":"E Anitua","year":"2015","unstructured":"Anitua E, Murias-Freijo A, Alkhraisat MH, Orive G (2015) Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial. Clin Oral Investig 19:589\u2013600. https:\/\/doi.org\/10.1007\/s00784-014-1278-2","journal-title":"Clin Oral Investig"},{"key":"6128_CR51","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1007\/s00784-017-2063-9","volume":"21","author":"RJ Miron","year":"2017","unstructured":"Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, Choukroun J (2017) Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig 21:2619\u20132627. https:\/\/doi.org\/10.1007\/s00784-017-2063-9","journal-title":"Clin Oral Investig"},{"key":"6128_CR52","first-page":"3","volume":"1","author":"J Choukroun","year":"2014","unstructured":"Choukroun J (2014) Advanced PRF & i-PRF: Platelet Concentrates or Blood Concentrates? J Periodont Med Clin Pr 1:3","journal-title":"J Periodont Med Clin Pr"},{"key":"6128_CR53","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3390\/jfb13040194","volume":"13","author":"JB Tony","year":"2022","unstructured":"Tony JB, Parthasarathy H, Tadepalli A, Ponnaiyan D, Alamoudi A, Kamil MA et al (2022) CBCT Evaluation of Sticky Bone in Horizontal Ridge Augmentation with and without Collagen Membrane\u2014A Randomized Parallel Arm Clinical Trial. J Funct Biomater 13:194. https:\/\/doi.org\/10.3390\/jfb13040194","journal-title":"J Funct Biomater"},{"key":"6128_CR54","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3390\/bioengineering9110602","volume":"9","author":"UP Nair","year":"2022","unstructured":"Nair UP, Shivamurthy R, Nagate RR, Chaturvedi S, Al-Qahtani SM, Magbol MA et al (2022) Effect of Injectable Platelet-Rich Fibrin with a Nano-Hydroxyapatite Bone Graft on the Treatment of a Grade II Furcation Defect. Bioengineering 9:602. https:\/\/doi.org\/10.3390\/bioengineering9110602","journal-title":"Bioengineering"},{"key":"6128_CR55","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/jcpe.13264","volume":"47","author":"W Teughels","year":"2020","unstructured":"Teughels W, Feres M, Oud V, Mart\u00edn C, Matesanz P, Herrera D (2020) Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta-analysis. J Clin Periodontol 47:257\u2013281. https:\/\/doi.org\/10.1111\/jcpe.13264","journal-title":"J Clin Periodontol"},{"key":"6128_CR56","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3109\/09537104.2016.1143921","volume":"27","author":"E Anitua","year":"2016","unstructured":"Anitua E, Prado R, Troya M, Zalduendo M, de la Fuente M, Pino A et al (2016) Implementation of a more physiological plasma rich in growth factor (PRGF) protocol: Anticoagulant removal and reduction in activator concentration. Platelets 27:459\u2013466. https:\/\/doi.org\/10.3109\/09537104.2016.1143921","journal-title":"Platelets"},{"key":"6128_CR57","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.bjoms.2012.08.003","volume":"51","author":"M Tunali","year":"2013","unstructured":"Tunali M, \u00d6zdemir H, K\u00fc\u00e7\u00fckodaci Z, Akman S, Firatli E (2013) In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): A new platelet concentrate. Br J Oral Maxillofac Surg 51:438\u2013443. https:\/\/doi.org\/10.1016\/j.bjoms.2012.08.003","journal-title":"Br J Oral Maxillofac Surg"},{"key":"6128_CR58","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1590\/0100-69912015006013","volume":"42","author":"CF de Mour\u00e3o","year":"2015","unstructured":"de Mour\u00e3o CF, AB, Valiense H, Melo ER, Mour\u00e3o NBMF, Maia MD-C, (2015) Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir 42:421\u2013423. https:\/\/doi.org\/10.1590\/0100-69912015006013","journal-title":"Rev Col Bras Cir"},{"key":"6128_CR59","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1902\/jop.2016.160443","volume":"88","author":"M Fujioka-Kobayashi","year":"2017","unstructured":"Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J (2017) Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response. J Periodontol 88:112\u2013121. https:\/\/doi.org\/10.1902\/jop.2016.160443","journal-title":"J Periodontol"},{"key":"6128_CR60","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","volume":"27","author":"DM Dohan Ehrenfest","year":"2009","unstructured":"Dohan Ehrenfest DM, Rasmusson L, Albrektsson T (2009) Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 27:158\u2013167. https:\/\/doi.org\/10.1016\/j.tibtech.2008.11.009","journal-title":"Trends Biotechnol"},{"key":"6128_CR61","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1007\/s00784-016-1719-1","volume":"20","author":"E Kobayashi","year":"2016","unstructured":"Kobayashi E, Fl\u00fcckiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B et al (2016) Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig 20:2353\u20132360. https:\/\/doi.org\/10.1007\/s00784-016-1719-1","journal-title":"Clin Oral Investig"},{"key":"6128_CR62","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.tripleo.2009.06.044","volume":"108","author":"L He","year":"2009","unstructured":"He L, Lin Y, Hu X, Zhang Y, Wu H (2009) A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Med Oral Pathol Oral Radiol Endod 108:707\u2013713. https:\/\/doi.org\/10.1016\/j.tripleo.2009.06.044","journal-title":"Oral Med Oral Pathol Oral Radiol Endod"},{"key":"6128_CR63","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/jbm.a.36792","volume":"108","author":"J Zhang","year":"2020","unstructured":"Zhang J, Yin C, Zhao Q, Zhao Z, Wang J, Miron RJ, Zhang Y (2020) Anti-inflammation effects of injectable platelet-rich fibrin via macrophages and dendritic cells. J Biomed Mater Res A 108:61\u201368. https:\/\/doi.org\/10.1002\/jbm.a.36792","journal-title":"J Biomed Mater Res A"},{"key":"6128_CR64","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.jclinepi.2010.02.005","volume":"63","author":"Schulz KF, Altman DG, Moher D; CONSORT Group","year":"2010","unstructured":"Schulz KF, Altman DG, Moher D; CONSORT Group (2010) CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol 63:834\u2013840. https:\/\/doi.org\/10.1016\/j.jclinepi.2010.02.005","journal-title":"J Clin Epidemiol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-06128-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-024-06128-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-024-06128-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:01:35Z","timestamp":1738828895000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-024-06128-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["6128"],"URL":"https:\/\/doi.org\/10.1007\/s00784-024-06128-w","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"12 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"74"}}