{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:32:36Z","timestamp":1788229956873,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62003094 and 82003615"],"award-info":[{"award-number":["62003094 and 82003615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["2024SRP163"],"award-info":[{"award-number":["2024SRP163"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-025-06164-0","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T05:09:06Z","timestamp":1737522546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of pain-related long non-coding RNAs for pulpitis prediction"],"prefix":"10.1007","volume":"29","author":[{"given":"Yongjie","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"6164_CR1","doi-asserted-by":"publisher","first-page":"174480692412344","DOI":"10.1177\/17448069241234451","volume":"20","author":"Y Chen","year":"2024","unstructured":"Chen Y, Hu J, Qi F, Kang Y, Zhang T, Wang L (2024) Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK\/NF-kappaB signaling pathway. Mol Pain 20:17448069241234451. https:\/\/doi.org\/10.1177\/17448069241234451","journal-title":"Mol Pain"},{"key":"6164_CR2","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/gene.2016.14","volume":"17","author":"JC Galicia","year":"2016","unstructured":"Galicia JC, Henson BR, Parker JS, Khan AA (2016) Gene expression profile of pulpitis. Genes Immun 17:239\u2013243. https:\/\/doi.org\/10.1038\/gene.2016.14","journal-title":"Genes Immun"},{"key":"6164_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12903-020-01266-5","volume":"20","author":"M Chen","year":"2020","unstructured":"Chen M, Zeng J, Yang Y, Wu B (2020) Diagnostic biomarker candidates for pulpitis revealed by bioinformatics analysis of merged microarray gene expression datasets. BMC Oral Health 20:279. https:\/\/doi.org\/10.1186\/s12903-020-01266-5","journal-title":"BMC Oral Health"},{"key":"6164_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13287-019-1192-2","volume":"10","author":"R Shi","year":"2019","unstructured":"Shi R, Yang H, Lin X, Cao Y, Zhang C, Fan Z, Hou B (2019) Analysis of the characteristics and expression profiles of coding and noncoding RNAs of human dental pulp stem cells in hypoxic conditions. Stem Cell Res Ther 10:89. https:\/\/doi.org\/10.1186\/s13287-019-1192-2","journal-title":"Stem Cell Res Ther"},{"key":"6164_CR5","doi-asserted-by":"publisher","first-page":"e7135","DOI":"10.7717\/peerj.7135","volume":"7","author":"F Lei","year":"2019","unstructured":"Lei F, Zhang H, Xie X (2019) Comprehensive analysis of an lncRNA-miRNA-mRNA competing endogenous RNA network in pulpitis. PeerJ 7:e7135. https:\/\/doi.org\/10.7717\/peerj.7135","journal-title":"PeerJ"},{"key":"6164_CR6","doi-asserted-by":"publisher","first-page":"112495","DOI":"10.1016\/j.yexcr.2021.112495","volume":"400","author":"M Liu","year":"2021","unstructured":"Liu M, Chen L, Wu J, Lin Z, Huang S (2021) Long noncoding RNA MEG3 expressed in human dental pulp regulates LPS-Induced inflammation and odontogenic differentiation in pulpitis. Exp Cell Res 400:112495. https:\/\/doi.org\/10.1016\/j.yexcr.2021.112495","journal-title":"Exp Cell Res"},{"key":"6164_CR7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s13273-022-00264-8","volume":"19","author":"Y Li","year":"2023","unstructured":"Li Y, Li S, Li R, Xu H (2023) LncRNA PVT1 upregulates FBN1 by sponging miR-30b-5p to aggravate pulpitis. Mol Cell Toxicol 19:343\u2013352. https:\/\/doi.org\/10.1007\/s13273-022-00264-8","journal-title":"Mol Cell Toxicol"},{"key":"6164_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.joen.2017.08.022","volume":"44","author":"X Huang","year":"2018","unstructured":"Huang X, Chen K (2018) Differential expression of long noncoding RNAs in normal and Inflamed Human Dental Pulp. J Endod 44:62\u201372. https:\/\/doi.org\/10.1016\/j.joen.2017.08.022","journal-title":"J Endod"},{"key":"6164_CR9","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.joen.2021.07.007","volume":"47","author":"L Liu","year":"2021","unstructured":"Liu L, Wang T, Huang D, Song D (2021) Comprehensive Analysis of differentially expressed genes in clinically diagnosed irreversible pulpitis by Multiplatform Data Integration Using a robust Rank Aggregation Approach. J Endod 47:1365\u20131375. https:\/\/doi.org\/10.1016\/j.joen.2021.07.007","journal-title":"J Endod"},{"key":"6164_CR10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s12864-023-09363-9","volume":"24","author":"Y Wang","year":"2023","unstructured":"Wang Y, Xie Q, Yu H, Zhou B, Guo X, Wu B, Hu J (2023) Establishment and validation of the autophagy-related ceRNA network in irreversible pulpitis. BMC Genomics 24:268. https:\/\/doi.org\/10.1186\/s12864-023-09363-9","journal-title":"BMC Genomics"},{"key":"6164_CR11","doi-asserted-by":"publisher","unstructured":"Gong W, Hong L, Qian Y (2023) Identification and experimental validation of LINC00582 Associated with B Cell Immune and Development of Pulpitis: Bioinformatics and in Vitro Analysis. Diagnostics (Basel) 13. https:\/\/doi.org\/10.3390\/diagnostics13101678","DOI":"10.3390\/diagnostics13101678"},{"key":"6164_CR12","doi-asserted-by":"publisher","first-page":"1198053","DOI":"10.3389\/fimmu.2023.1198053","volume":"14","author":"Q Xie","year":"2023","unstructured":"Xie Q, Yu H, Liu Z, Zhou B, Fang F, Qiu W, Wu H (2023) Identification and characterization of the ferroptosis-related ceRNA network in irreversible pulpitis. Front Immunol 14:1198053. https:\/\/doi.org\/10.3389\/fimmu.2023.1198053","journal-title":"Front Immunol"},{"key":"6164_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/iej.13842","volume":"56","author":"P Huang","year":"2023","unstructured":"Huang P, Wang F, Wang X, Meng X, Qiao W, Meng L (2023) RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells. Int Endod J 56:39\u201352. https:\/\/doi.org\/10.1111\/iej.13842","journal-title":"Int Endod J"},{"key":"6164_CR14","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/iej.13923","volume":"56","author":"Y Jiang","year":"2023","unstructured":"Jiang Y, He Y, Chen Y, Zeng J, Huang W, Huang L, Luo J, Ma Y, Wu L, Yang X (2023) Overexpression of MicroRNA-155 aggravates pulpitis by targeting kinesin superfamily Proteins-5\u00a0C based on Illumina high-throughput sequencing. Int Endod J 56:837\u2013853. https:\/\/doi.org\/10.1111\/iej.13923","journal-title":"Int Endod J"},{"key":"6164_CR15","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim D, Langmead B, Salzberg SL (2015) HISAT: a fast spliced aligner with low memory requirements. Nat Methods 12:357\u2013360. https:\/\/doi.org\/10.1038\/nmeth.3317","journal-title":"Nat Methods"},{"key":"6164_CR16","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders S, Pyl PT, Huber W (2015) HTSeq\u2013a Python framework to work with high-throughput sequencing data. Bioinformatics 31:166\u2013169. https:\/\/doi.org\/10.1093\/bioinformatics\/btu638","journal-title":"Bioinformatics"},{"key":"6164_CR17","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13059-016-1070-5","volume":"17","author":"E Becht","year":"2016","unstructured":"Becht E, Giraldo NA, Lacroix L, Buttard B, Elarouci N, Petitprez F, Selves J, Laurent-Puig P, Sautes-Fridman C, Fridman WH, de Reynies A (2016) Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression. Genome Biol 17:218. https:\/\/doi.org\/10.1186\/s13059-016-1070-5","journal-title":"Genome Biol"},{"key":"6164_CR18","doi-asserted-by":"publisher","first-page":"7222092","DOI":"10.1155\/2022\/7222092","volume":"2022","author":"J Du","year":"2022","unstructured":"Du J, Liu L, Yang F, Leng S, Zhang L, Huang D (2022) Identification of Immune-related lncRNA Regulatory Network in Pulpitis. Dis Markers 2022:7222092. https:\/\/doi.org\/10.1155\/2022\/7222092","journal-title":"Dis Markers"},{"key":"6164_CR19","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.gpb.2019.09.006","volume":"18","author":"Q Zhang","year":"2020","unstructured":"Zhang Q, Liu W, Zhang HM, Xie GY, Miao YR, Xia M, Guo AY (2020) hTFtarget: a comprehensive database for regulations of human transcription factors and their targets. Genomics Proteom Bioinf 18:120\u2013128. https:\/\/doi.org\/10.1016\/j.gpb.2019.09.006","journal-title":"Genomics Proteom Bioinf"},{"key":"6164_CR20","doi-asserted-by":"publisher","first-page":"e23357","DOI":"10.1096\/fj.202301648R","volume":"38","author":"L Zhou","year":"2024","unstructured":"Zhou L, Mao HQ, Li JQ, Chen Z, Zhang L (2024) Fusobacterium nucleatum exacerbates the progression of pulpitis by regulating the STING-dependent pathway. FASEB J 38:e23357. https:\/\/doi.org\/10.1096\/fj.202301648R","journal-title":"FASEB J"},{"key":"6164_CR21","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/s41419-020-03259-2","volume":"11","author":"H Li","year":"2020","unstructured":"Li H, Mu Q, Zhang G, Shen Z, Zhang Y, Bai J, Zhang L, Zhou D, Zheng Q, Shi L, Su W, Yin C, Zhang B (2020) Linc00426 accelerates lung adenocarcinoma progression by regulating mir-455-5p as a molecular sponge. Cell Death Dis 11:1051. https:\/\/doi.org\/10.1038\/s41419-020-03259-2","journal-title":"Cell Death Dis"},{"key":"6164_CR22","doi-asserted-by":"publisher","unstructured":"Wang S, Zheng B, Zhao H, Li Y, Zhang X, Wen J (2021) Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs\/AKT2 axis. Int J Mol Med 47. https:\/\/doi.org\/10.3892\/ijmm.2021.4868","DOI":"10.3892\/ijmm.2021.4868"},{"key":"6164_CR23","doi-asserted-by":"publisher","first-page":"113359","DOI":"10.1016\/j.yexcr.2022.113359","volume":"420","author":"W Zhang","year":"2022","unstructured":"Zhang W, Zhou L, Zhang C (2022) LncRNA Miat promotes neuropathic pain through miR-362-3p\/BAMBI signaling axis. Exp Cell Res 420:113359. https:\/\/doi.org\/10.1016\/j.yexcr.2022.113359","journal-title":"Exp Cell Res"},{"key":"6164_CR24","doi-asserted-by":"publisher","first-page":"16445","DOI":"10.18632\/aging.203166","volume":"13","author":"J Wang","year":"2021","unstructured":"Wang J, Hao JP, Uddin MN, Wu Y, Chen R, Li DF, Xiong DQ, Ding N, Yang JH, Ding XS (2021) Identification and validation of inferior prognostic genes associated with immune signatures and chemotherapy outcome in acute myeloid leukemia. Aging 13:16445\u201316470. https:\/\/doi.org\/10.18632\/aging.203166","journal-title":"Aging"},{"key":"6164_CR25","doi-asserted-by":"publisher","first-page":"1257267","DOI":"10.3389\/fmicb.2023.1257267","volume":"14","author":"G Li","year":"2023","unstructured":"Li G, Feng Z, Song H, Wang Y, Zhu L, Li Y (2023) Long non-coding RNA expression in PBMCs of patients with active pulmonary tuberculosis. Front Microbiol 14:1257267. https:\/\/doi.org\/10.3389\/fmicb.2023.1257267","journal-title":"Front Microbiol"},{"key":"6164_CR26","doi-asserted-by":"publisher","first-page":"1026086","DOI":"10.3389\/fimmu.2023.1026086","volume":"14","author":"Y Cheng","year":"2023","unstructured":"Cheng Y, Xu L, Wang J, Cao X, Chen D, Zhang P, Yang L, Qin L (2023) Analysis of bulk RNA-seq data from sepsis patients reveals sepsis-associated lncRNAs and targeted cell death-related genes contributing to immune microenvironment regulation. Front Immunol 14:1026086. https:\/\/doi.org\/10.3389\/fimmu.2023.1026086","journal-title":"Front Immunol"},{"key":"6164_CR27","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41398-022-01971-5","volume":"12","author":"M Bam","year":"2022","unstructured":"Bam M, Yang X, Ginsberg JP, Aiello AE, Uddin M, Galea S, Nagarkatti PS, Nagarkatti M (2022) Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD. Transl Psychiatry 12:200. https:\/\/doi.org\/10.1038\/s41398-022-01971-5","journal-title":"Transl Psychiatry"},{"key":"6164_CR28","doi-asserted-by":"publisher","first-page":"216463","DOI":"10.1016\/j.canlet.2023.216463","volume":"578","author":"L Du","year":"2023","unstructured":"Du L, Wang B, Wu M, Chen W, Wang W, Diao W, Ding M, Chen W, Cao W, Guo H, Zhang G (2023) LINC00926 promotes progression of renal cell carcinoma via regulating miR-30a-5p\/SOX4 axis and activating IFNgamma-JAK2-STAT1 pathway. Cancer Lett 578:216463. https:\/\/doi.org\/10.1016\/j.canlet.2023.216463","journal-title":"Cancer Lett"},{"key":"6164_CR29","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s12072-020-10101-6","volume":"15","author":"F Fan","year":"2021","unstructured":"Fan F, Chen K, Lu X, Li A, Liu C, Wu B (2021) Dual targeting of PD-L1 and PD-L2 by PCED1B-AS1 via sponging hsa-mir-194-5p induces immunosuppression in hepatocellular carcinoma. Hepatol Int 15:444\u2013458. https:\/\/doi.org\/10.1007\/s12072-020-10101-6","journal-title":"Hepatol Int"},{"key":"6164_CR30","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/iej.14058","volume":"57","author":"OH Nam","year":"2024","unstructured":"Nam OH, Kim JH, Kang SW, Chae YK, Jih MK, You HH, Koh JT, Kim Y (2024) Ginsenoside Rb1 alleviates lipopolysaccharide-induced inflammation in human dental pulp cells via the PI3K\/Akt, NF-kappaB, and MAPK signalling pathways. Int Endod J 57:759\u2013768. https:\/\/doi.org\/10.1111\/iej.14058","journal-title":"Int Endod J"},{"key":"6164_CR31","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1111\/iej.13180","volume":"52","author":"W Qiao","year":"2019","unstructured":"Qiao W, Huang Y, Bian Z, Sun X, Wang X, Gao Q, Peng Y, Meng L (2019) Lipopolysaccharide-induced DNA damage response activates nuclear factor kappaB signalling pathway via GATA4 in dental pulp cells. Int Endod J 52:1704\u20131715. https:\/\/doi.org\/10.1111\/iej.13180","journal-title":"Int Endod J"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-025-06164-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-025-06164-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-025-06164-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:00:19Z","timestamp":1738828819000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-025-06164-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["6164"],"URL":"https:\/\/doi.org\/10.1007\/s00784-025-06164-0","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"26 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"75"}}