{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:16:10Z","timestamp":1787318170145,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-025-06272-x","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T13:28:27Z","timestamp":1742650107000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effects of \u03b2-TCP and\/or xenogeneic bone substitute on alveolar ridge preservation: a randomized clinical trial"],"prefix":"10.1007","volume":"29","author":[{"given":"Liu","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"6272_CR1","doi-asserted-by":"publisher","unstructured":"Tan WL, Wong TLT, Wong MCM, Lang NP (2012) A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans, Clin. Oral Implants Res., vol. 23, no. SUPPL. 5, pp. 1\u201321. https:\/\/doi.org\/10.1111\/j.1600-0501.2011.02375.x","DOI":"10.1111\/j.1600-0501.2011.02375.x"},{"issue":"1","key":"6272_CR2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/prd.12167","volume":"73","author":"V Chappuis","year":"2017","unstructured":"Chappuis V, Ara\u00fajo MG, Buser D (2017) Clinical relevance of dimensional bone and soft tissue alterations post-extraction in esthetic sites. Periodontol 2000 73(1):73\u201383. https:\/\/doi.org\/10.1111\/prd.12167","journal-title":"Periodontol 2000"},{"issue":"6","key":"6272_CR3","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1111\/cid.12364","volume":"18","author":"M Willenbacher","year":"2016","unstructured":"Willenbacher M, Al-Nawas B, Berres M, K\u00e4mmerer PW, Schiegnitz E (2016) The effects of alveolar ridge preservation: A Meta-Analysis. Clin Implant Dent Relat Res 18(6):1248\u20131268. https:\/\/doi.org\/10.1111\/cid.12364","journal-title":"Clin Implant Dent Relat Res"},{"issue":"2","key":"6272_CR4","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/cid.13297","volume":"26","author":"FJ Strauss","year":"2024","unstructured":"Strauss FJ et al (2024) Alveolar ridge changes 1-year after early implant placement, with or without alveolar ridge preservation at single-implant sites in the aesthetic region: A secondary analysis of radiographic and profilometric outcomes from a randomized controlled trial. Clin Implant Dent Relat Res 26(2):356\u2013368. https:\/\/doi.org\/10.1111\/cid.13297","journal-title":"Clin Implant Dent Relat Res"},{"key":"6272_CR5","doi-asserted-by":"publisher","unstructured":"Bone healing (Jan. 2004) And soft tissue contour changes following single-tooth extraction: A clinical and radiographic 12-month prospective study. J Prosthet Dent 91(1):92. https:\/\/doi.org\/10.1016\/j.prosdent.2003.10.022","DOI":"10.1016\/j.prosdent.2003.10.022"},{"issue":"7","key":"6272_CR6","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1111\/clr.12170","volume":"25","author":"J Lindhe","year":"2014","unstructured":"Lindhe J, Cecchinato D, Donati M, Tomasi C, Liljenberg B (2014) Ridge preservation with the use of deproteinized bovine bone mineral. Clin Oral Implants Res 25(7):786\u2013790. https:\/\/doi.org\/10.1111\/clr.12170","journal-title":"Clin Oral Implants Res"},{"issue":"3","key":"6272_CR7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1757-7861.2012.00189.x","volume":"4","author":"B Liu","year":"2012","unstructured":"Liu B, Lun Dxing (2012) Current application of \u03b2-tricalcium phosphate composites in orthopaedics. Orthop Surg 4(3):139\u2013144. https:\/\/doi.org\/10.1111\/j.1757-7861.2012.00189.x","journal-title":"Orthop Surg"},{"key":"6272_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.actbio.2020.06.022","volume":"113","author":"M Bohner","year":"2020","unstructured":"Bohner M, Santoni BLG, D\u00f6belin N (2020) \u03b2-tricalcium phosphate for bone substitution: synthesis and properties. Acta Biomater 113:23\u201341. https:\/\/doi.org\/10.1016\/j.actbio.2020.06.022","journal-title":"Acta Biomater"},{"issue":"16","key":"6272_CR9","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1016\/j.biomaterials.2007.01.040","volume":"28","author":"T Okuda","year":"2007","unstructured":"Okuda T et al (2007) The effect of the microstructure of \u03b2-tricalcium phosphate on the metabolism of subsequently formed bone tissue. Biomaterials 28(16):2612\u20132621. https:\/\/doi.org\/10.1016\/j.biomaterials.2007.01.040","journal-title":"Biomaterials"},{"issue":"13","key":"6272_CR10","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1016\/j.biomaterials.2003.09.035","volume":"25","author":"C Wang","year":"2004","unstructured":"Wang C et al (2004) Phenotypic expression of bone-related genes in osteoblasts grown on calcium phosphate ceramics with different phase compositions. Biomaterials 25(13):2507\u20132514. https:\/\/doi.org\/10.1016\/j.biomaterials.2003.09.035","journal-title":"Biomaterials"},{"issue":"3","key":"6272_CR11","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s10856-011-4530-1","volume":"23","author":"R De Oliveira","year":"2012","unstructured":"De Oliveira R (2012) The association of human primary bone cells with biphasic calcium phosphate (\u03b2TCP\/HA 70:30) granules increases bone repair. J Mater Sci Mater Med 23(3):781\u2013788. https:\/\/doi.org\/10.1007\/s10856-011-4530-1","journal-title":"J Mater Sci Mater Med"},{"key":"6272_CR12","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S0142-9612(97)00036-7","volume":"18","author":"S Yamada","year":"1997","unstructured":"Yamada S, Heymann D, Bouler JM, Daculsi G (1997) Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite\/\u03b2-tricalcium phosphate ratios. Biomaterials 18:1037\u20131041. https:\/\/doi.org\/10.1016\/S0142-9612(97)00036-7","journal-title":"Biomaterials"},{"issue":"5","key":"6272_CR13","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1034\/j.1600-0501.2003.00970.x","volume":"14","author":"G Serino","year":"2003","unstructured":"Serino G, Biancu S, Iezzi G, Piattelli A (2003) Ridge preservation following tooth extraction using a polylactide and polyglycolide sponge as space filler: A clinical and histological study in humans. Clin Oral Implants Res 14(5):651\u2013658. https:\/\/doi.org\/10.1034\/j.1600-0501.2003.00970.x","journal-title":"Clin Oral Implants Res"},{"issue":"2","key":"6272_CR14","doi-asserted-by":"publisher","first-page":"485","DOI":"10.11607\/jomi.3408","volume":"29","author":"N Geurs","year":"2014","unstructured":"Geurs N, Ntounis A, Vassilopoulos P, Van der Velden U, Loos BG, Reddy M (2014) Using growth factors in human extraction sockets: A histologic and histomorphometric evaluation of Short-Term healing. Int J Oral Maxillofac Implants 29(2):485\u2013496. https:\/\/doi.org\/10.11607\/jomi.3408","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"2","key":"6272_CR15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s11706-016-0333-0","volume":"10","author":"T Wang","year":"2016","unstructured":"Wang T et al (2016) Comparative evaluation of a biomimic collagen\/hydroxyapatite\/\u03b2-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss collagen. Front Mater Sci 10(2):122\u2013133. https:\/\/doi.org\/10.1007\/s11706-016-0333-0","journal-title":"Front Mater Sci"},{"issue":"5","key":"6272_CR16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1600-0501.2009.01705.x","volume":"20","author":"MG Ara\u00fajo","year":"2009","unstructured":"Ara\u00fajo MG, Lindhe J (2009) Ridge preservation with the use of Bio-Oss\u00ae collagen: A 6-month study in the dog. Clin Oral Implants Res 20(5):433\u2013440. https:\/\/doi.org\/10.1111\/j.1600-0501.2009.01705.x","journal-title":"Clin Oral Implants Res"},{"issue":"2","key":"6272_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1034\/j.1600-0501.2003.140201.x","volume":"14","author":"D Carmagnola","year":"2003","unstructured":"Carmagnola D, Adriaens P, Berglundh T (2003) Healing of human extraction sockets filled with Bio-Oss\u00ae. Clin Oral Implants Res 14(2):137\u2013143. https:\/\/doi.org\/10.1034\/j.1600-0501.2003.140201.x","journal-title":"Clin Oral Implants Res"},{"key":"6272_CR18","doi-asserted-by":"publisher","unstructured":"Canellas JV et al (2021) What grafting materials produce greater alveolar ridge preservation after tooth extraction? A systematic review and network meta-analysis, J. Cranio-Maxillofac. Surg., vol. 49, no. 11, pp. 1064\u20131071. https:\/\/doi.org\/10.1016\/j.jcms.2021.06.005","DOI":"10.1016\/j.jcms.2021.06.005"},{"issue":"2","key":"6272_CR19","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/jbm.b.30540","volume":"79","author":"H Kihara","year":"2006","unstructured":"Kihara H, Shiota M, Yamashita Y, Kasugai S (2006) Biodegradation process of \u03b1-TCP particles and new bone formation in a rabbit cranial defect model. J Biomed Mater Res - Part B Appl Biomater 79(2):284\u2013291. https:\/\/doi.org\/10.1002\/jbm.b.30540","journal-title":"J Biomed Mater Res - Part B Appl Biomater"},{"issue":"1","key":"6272_CR20","doi-asserted-by":"publisher","first-page":"5627","DOI":"10.2147\/IJN.S66852","volume":"9","author":"AK Macmillan","year":"2014","unstructured":"Macmillan AK, Lamberti FV, Moulton JN, Geilich BM, Webster TJ (2014) Similar healthy osteoclast and osteoblast activity on nanocrystalline hydroxyapatite and nanoparticles of tri-calcium phosphate compared to natural bone. Int J Nanomed 9(1):5627\u20135637. https:\/\/doi.org\/10.2147\/IJN.S66852","journal-title":"Int J Nanomed"},{"issue":"12","key":"6272_CR21","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/jcpe.12623","volume":"43","author":"ET Scheyer","year":"2016","unstructured":"Scheyer ET et al (2016) A randomized, controlled, multicentre clinical trial of post-extraction alveolar ridge preservation. J Clin Periodontol 43(12):1188\u20131199. https:\/\/doi.org\/10.1111\/jcpe.12623","journal-title":"J Clin Periodontol"},{"key":"6272_CR22","unstructured":"Horowitz RA, Mazor Z, Miller RJ, Krauser J, Prasad HS, Rohrer MD (1995) Clinical evaluation alveolar ridge preservation with a beta-tricalcium phosphate socket graft., Compend. Contin. Educ. Dent. Jamesburg NJ vol. 30, no. 9, 2009"},{"issue":"4","key":"6272_CR23","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/jre.12735","volume":"55","author":"T Ikawa","year":"2020","unstructured":"Ikawa T et al (2020) Ridge reconstruction in damaged extraction sockets using tunnel \u03b2-tricalcium phosphate blocks: A 6-month histological study in beagle dogs. J Periodontal Res 55(4):496\u2013502. https:\/\/doi.org\/10.1111\/jre.12735","journal-title":"J Periodontal Res"},{"key":"6272_CR24","doi-asserted-by":"crossref","unstructured":"Leventis MD et al (2016) Minimally Invasive Alveolar Ridge Preservation Utilizing an In Situ Hardening??-Tricalcium Phosphate Bone Substitute: A Multicenter Case Series, Int. J. OfDentistry, vol. 2016","DOI":"10.1155\/2016\/5406736"},{"issue":"1","key":"6272_CR25","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/jcpe.12027","volume":"40","author":"RE Jung","year":"2013","unstructured":"Jung RE et al (2013) Radiographic evaluation of different techniques for ridge preservation after tooth extraction: A randomized controlled clinical trial. J Clin Periodontol 40(1):90\u201398. https:\/\/doi.org\/10.1111\/jcpe.12027","journal-title":"J Clin Periodontol"},{"key":"6272_CR26","doi-asserted-by":"publisher","unstructured":"Mardas N, Chadha V, Donos N (2010) Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomized, controlled clinical trial, Clin. Oral Implants Res., vol. 21, no. 7, pp. 688\u2013698, Jul. https:\/\/doi.org\/10.1111\/j.1600-0501.2010.01918.x","DOI":"10.1111\/j.1600-0501.2010.01918.x"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-025-06272-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-025-06272-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-025-06272-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:49:13Z","timestamp":1744678153000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-025-06272-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["6272"],"URL":"https:\/\/doi.org\/10.1007\/s00784-025-06272-x","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"16 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No competing financial interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"200"}}