{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:53:05Z","timestamp":1785851585825,"version":"3.56.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-025-06291-8","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T22:20:14Z","timestamp":1743373214000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Does the early loss of primary teeth impact the oral health-related quality of life of children? A systematic review and meta-analysis"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9308-2118","authenticated-orcid":false,"given":"Aur\u00e9lio","family":"de Oliveira Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-0696","authenticated-orcid":false,"given":"Michely Cristina","family":"Goebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3535-6937","authenticated-orcid":false,"given":"Karina","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-0789","authenticated-orcid":false,"given":"Lucas Menezes","family":"dos Anjos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-7942","authenticated-orcid":false,"given":"Mariane","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-9169","authenticated-orcid":false,"given":"Filipe Colombo","family":"Vitali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9310-5642","authenticated-orcid":false,"given":"Pablo Silveira","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"issue":"1","key":"6291_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41407-023-1709-5","volume":"10","author":"R Rughani","year":"2023","unstructured":"Rughani R, Ondhia A (2023) They\u2019re not \u2018just baby teeth\u2019. BDJ Team 10(1):10\u201313. https:\/\/doi.org\/10.1038\/s41407-023-1709-5","journal-title":"BDJ Team"},{"key":"6291_CR2","doi-asserted-by":"publisher","first-page":"7322","DOI":"10.3389\/fpubh.2019.00322","volume":"7","author":"OB Al-Batayneh","year":"2019","unstructured":"Al-Batayneh OB, Al-Khateeb HO, Ibrahim WM, Khader YS (2019) Parental knowledge and acceptance of different treatment options for primary teeth provided by dental practitioners. Front Public Health 7:7322. https:\/\/doi.org\/10.3389\/fpubh.2019.00322","journal-title":"Front Public Health"},{"issue":"3","key":"6291_CR3","first-page":"108","volume":"85","author":"D Feu","year":"2018","unstructured":"Feu D, Rosetti Lessa FC, Awad Barcellos L, Grillo CB, Freitas LA (2018) Factors associated with premature loss of primary teeth in Brazilian children. J Dent Child (Chic) 85(3):108\u2013113","journal-title":"J Dent Child (Chic)"},{"key":"6291_CR4","doi-asserted-by":"publisher","first-page":"e092","DOI":"10.1590\/1807-3107bor-2021.vol35.0092","volume":"35","author":"P Nadelman","year":"2021","unstructured":"Nadelman P, Magno MB, Pithon MM, Castro ACR, Maia LC (2021) Does the premature loss of primary anterior teeth cause morphological, functional and psychosocial consequences? Braz Oral Res 35:e092","journal-title":"Braz Oral Res"},{"issue":"19","key":"6291_CR5","doi-asserted-by":"publisher","first-page":"12163","DOI":"10.3390\/ijerph191912163","volume":"19","author":"MC Gomes","year":"2022","unstructured":"Gomes MC, Perazzo MF, Neves ETB, Siqueira MBLD, Paiva SM, Granville-Garcia AF (2022) Premature primary tooth loss and oral Health-Related quality of life in preschool children. Int J Environ Res Public Health 19(19):12163. https:\/\/doi.org\/10.3390\/ijerph191912163","journal-title":"Int J Environ Res Public Health"},{"key":"6291_CR6","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/ipd.12644","volume":"30","author":"P Nadelman","year":"2020","unstructured":"Nadelman P, Bedran N, Magno MB, Masterson D, Castro ACR, Maia LC (2020) Premature loss of primary anterior teeth and its consequences to primary dental arch and speech pattern: A systematic review and meta-analysis. Int J Paediatr Dent 30:687\u2013712. https:\/\/doi.org\/10.1111\/ipd.12644","journal-title":"Int J Paediatr Dent"},{"issue":"6","key":"6291_CR7","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.3390\/ijerph19063386","volume":"19","author":"K Spodzieja","year":"2022","unstructured":"Spodzieja K, Olczak-Kowalczyk D (2022) Premature loss of deciduous teeth as a symptom of systemic disease: A narrative literature review. Int J Environ Res Public Health 19(6):3386. https:\/\/doi.org\/10.3390\/ijerph19063386","journal-title":"Int J Environ Res Public Health"},{"issue":"6","key":"6291_CR8","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s40368-022-00736-4","volume":"23","author":"ME Evangelista","year":"2022","unstructured":"Evangelista ME, Brancher GP, Borgatto AF, Bolan M, Santana CM, Cardoso M (2022) Premature loss of primary molars: impact on the oral health-related quality of life of schoolchildren. Eur Arch Paediatr Dent 23(6):911\u2013918. https:\/\/doi.org\/10.1007\/s40368-022-00736-4","journal-title":"Eur Arch Paediatr Dent"},{"issue":"6","key":"6291_CR9","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/ipd.12416","volume":"28","author":"AS Monte-Santo","year":"2018","unstructured":"Monte-Santo AS, Viana SVC, Moreira KMS, Imparato JCP, Mendes FM, Bonini GAVC (2018) Prevalence of early loss of primary molar and its impact in schoolchildren\u2019s quality of life. Int J Paediatr Dent 28(6):595\u2013601. https:\/\/doi.org\/10.1111\/ipd.12416","journal-title":"Int J Paediatr Dent"},{"issue":"4","key":"6291_CR10","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/edt.12576","volume":"36","author":"PF Day","year":"2020","unstructured":"Day PF, Flores MT, O\u2019Connell AC, Abbott PV, Tsilingaridis G, Fouad AF et al (2020) International association of dental traumatology guidelines for the management of traumatic dental injuries: 3. Injuries in the primary dentition. Dent Traumatol 36(4):343\u2013359. https:\/\/doi.org\/10.1111\/edt.12576","journal-title":"Dent Traumatol"},{"key":"6291_CR11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/cdoe.12022","volume":"41","author":"AC Scarpelli","year":"2013","unstructured":"Scarpelli AC, Paiva SM, Viegas CM, Carvalho AC, Ferreira FM, Pordeus IA (2013) Oral health-related quality of life among Brazilian preschool children. Community Dent Oral Epidemiol 41:336\u2013344. https:\/\/doi.org\/10.1111\/cdoe.12022","journal-title":"Community Dent Oral Epidemiol"},{"issue":"5","key":"6291_CR12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s40368-018-0357-5","volume":"19","author":"AJ Ahmad","year":"2018","unstructured":"Ahmad AJ, Parekh S, Ashley PF (2018) Methods of space maintenance for premature loss of a primary molar: a review. Eur Arch Paediatr Dent 19(5):311\u2013320. https:\/\/doi.org\/10.1007\/s40368-018-0357-5","journal-title":"Eur Arch Paediatr Dent"},{"issue":"3","key":"6291_CR13","first-page":"23","volume":"23","author":"PA Martins-J\u00fanior","year":"2012","unstructured":"Martins-J\u00fanior PA, Marques LS (2012) Clinical implications of early loss of a lower deciduous canine. Int J Orthod Milwaukee 23(3):23\u201327","journal-title":"Int J Orthod Milwaukee"},{"key":"6291_CR14","doi-asserted-by":"publisher","first-page":"e044","DOI":"10.1590\/1807-3107bor-2021.vol35.0044","volume":"35","author":"FV Bitencourt","year":"2021","unstructured":"Bitencourt FV, Rodrigues JA, Toassi RFC (2021) Narratives about a stigma: attributing meaning to the early loss of deciduous teeth on children\u2019s caregivers. Braz Oral Res 35:e044. https:\/\/doi.org\/10.1590\/1807-3107bor-2021.vol35.0044","journal-title":"Braz Oral Res"},{"issue":"4","key":"6291_CR15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1600-0528.2010.00543.x","volume":"38","author":"GH Lee","year":"2010","unstructured":"Lee GH, McGrath C, Yiu CK, King NM (2010) A comparison of a generic and oral health-specific measure in assessing the impact of early childhood caries on quality of life. Community Dent Oral Epidemiol 38(4):333\u2013339. https:\/\/doi.org\/10.1111\/j.1600-0528.2010.00543.x","journal-title":"Community Dent Oral Epidemiol"},{"issue":"4","key":"6291_CR16","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1159\/000330231","volume":"45","author":"HM Wong","year":"2011","unstructured":"Wong HM, McGrath CP, King NM, Lo EC (2011) Oral health-related quality of life in Hong Kong preschool children. Caries Res 45(4):370\u2013376. https:\/\/doi.org\/10.1159\/000330231","journal-title":"Caries Res"},{"issue":"2","key":"6291_CR17","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1177\/2380084419855636","volume":"5","author":"C Yang","year":"2020","unstructured":"Yang C, Crystal YO, Ruff RR, Veitz-Keenan A, McGowan RC, Niederman R (2020) Quality appraisal of child oral Health-Related quality of life measures: A scoping review. JDR Clin Trans Res 5(2):109\u2013117. https:\/\/doi.org\/10.1177\/2380084419855636","journal-title":"JDR Clin Trans Res"},{"key":"6291_CR18","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"issue":"1","key":"6291_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","volume":"4","author":"D Moher","year":"2015","unstructured":"Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4(1):1. https:\/\/doi.org\/10.1186\/2046-4053-4-1","journal-title":"Syst Rev"},{"issue":"1","key":"6291_CR20","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"M Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan-a web and mobile app for systematic reviews. Syst Rev 5(1):210. https:\/\/doi.org\/10.1186\/s13643-016-0384-4","journal-title":"Syst Rev"},{"key":"6291_CR21","doi-asserted-by":"crossref","unstructured":"Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, Currie M, Qureshi R, Mattis P, Lisy K, Mu PF (2020) Chapter 7: Systematic reviews of etiology and risk. In: Aromataris E, Munn Z (Editors). JBI Manual for Evidence Synthesis. JBI, Available from https:\/\/synthesismanual.jbi.global","DOI":"10.46658\/JBIRM-17-06"},{"key":"6291_CR22","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898","journal-title":"BMJ"},{"key":"6291_CR23","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (2024) Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated August 2024). Cochrane. Available from www.training.cochrane.org\/handbook"},{"key":"6291_CR24","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/jrsm.1313","volume":"10","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Akl EA, Schunemann HJ (2018) Using systematic reviews in guideline development: the GRADE approach. Res Synth Methods 10:312\u2013329. https:\/\/doi.org\/10.1002\/jrsm.1313","journal-title":"Res Synth Methods"},{"issue":"4","key":"6291_CR25","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/idh.12568","volume":"20","author":"D Feu","year":"2022","unstructured":"Feu D, Lessa FCR, Barcellos LA, Goulart MA, Grillo CB, Freitas LA (2022) The impact on the quality of life caused by the early loss of primary molars. Int J Dent Hyg 20(4):620\u2013626. https:\/\/doi.org\/10.1111\/idh.12568","journal-title":"Int J Dent Hyg"},{"issue":"1","key":"6291_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/cdoe.12895","volume":"52","author":"J Abanto","year":"2024","unstructured":"Abanto J, Tsakos G, Oleg\u00e1rio IC, Paiva SM, Mendes FM, Ardenghi TM, B\u00f6necker M (2024) Impact of pulpectomy versus tooth extraction in children\u2019s oral health-related quality of life: A randomized clinical trial. Community Dent Oral Epidemiol 52(1):13\u201323. https:\/\/doi.org\/10.1111\/cdoe.12895","journal-title":"Community Dent Oral Epidemiol"},{"key":"6291_CR27","doi-asserted-by":"publisher","unstructured":"Perazzo MF, Serra-Negra JM, Firmino RT, Pordeus IA, Martins-J\u00fanior PA, Paiva SM (2020) Patient-centered assessments: how can they be used in dental clinical trials? Braz Oral Res 34 Suppl 2e075. https:\/\/doi.org\/10.1590\/1807-3107bor-2020.vol34.0075","DOI":"10.1590\/1807-3107bor-2020.vol34.0075"},{"issue":"3","key":"6291_CR28","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/ipd.12465","volume":"29","author":"MB Magno","year":"2019","unstructured":"Magno MB, Silva LPD, Ferreira DM, Barja-Fidalgo F, Fonseca-Gon\u00e7alves A (2019) Aesthetic perception, acceptability and satisfaction in the treatment of caries lesions with silver Diamine fluoride: A scoping review. Int J Paediatr Dent 29(3):257\u2013266. https:\/\/doi.org\/10.1111\/ipd.12465","journal-title":"Int J Paediatr Dent"},{"issue":"6","key":"6291_CR29","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1590\/0103-6440202003871","volume":"31","author":"MF Perazzo","year":"2020","unstructured":"Perazzo MF, Martins-J\u00fanior PA, Abreu LG, Mattos FF, Pordeus IA, Paiva SM (2020) Oral Health-Related quality of life of Pre-School children: review and perspectives for new instruments. Braz Dent J 31(6):568\u2013581. https:\/\/doi.org\/10.1590\/0103-6440202003871","journal-title":"Braz Dent J"},{"key":"6291_CR30","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/1477-7525-8-126","volume":"8","author":"AE Gerritsen","year":"2010","unstructured":"Gerritsen AE, Allen PF, Witter DJ, Bronkhorst EM, Creugers NH (2010) Tooth loss and oral health-related quality of life: a systematic review and meta-analysis. Health Qual Life Outcomes 8:126. https:\/\/doi.org\/10.1186\/1477-7525-8-126","journal-title":"Health Qual Life Outcomes"},{"issue":"10","key":"6291_CR31","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1590\/s1413-81232011001100013","volume":"16","author":"T Barbosa","year":"2011","unstructured":"Barbosa T, de Vicentin S, Gavi\u00e3o MD MB (2011) Qualidade de Vida e Sa\u00fade bucal Em crian\u00e7as - Parte I: Vers\u00e3o Brasileira do child perceptions questionnaire 8\u201310 [Quality of life and oral health in children - Part I: Brazilian version of the child perceptions questionnaire 8\u201310]. Cien Saude Colet 16(10):4077\u20134085. https:\/\/doi.org\/10.1590\/s1413-81232011001100013","journal-title":"Cien Saude Colet"},{"issue":"1","key":"6291_CR32","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10654-019-00576-5","volume":"35","author":"T Muka","year":"2020","unstructured":"Muka T, Glisic M, Milic J, Verhoog S, Bohlius J, Bramer W, Chowdhury R, Franco OH (2020) A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. Eur J Epidemiol 35(1):49\u201360. https:\/\/doi.org\/10.1007\/s10654-019-00576-5","journal-title":"Eur J Epidemiol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-025-06291-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-025-06291-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-025-06291-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T17:04:09Z","timestamp":1744736649000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-025-06291-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["6291"],"URL":"https:\/\/doi.org\/10.1007\/s00784-025-06291-8","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"11 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study did not require ethical approval or consent to participate as it was not carried out with humans or animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"213"}}