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Each defect was unilaterally and randomly assigned to one of five treatment groups: (1) no treatment (control), (2) guided tissue regeneration (GTR) with a collagenated bone substitute and a collagen membrane, (3) GTR with an enamel matrix derivative (GTR\/EMD), (4) GTR with 2\u00a0mg\/ml SCPT (GTR\/SCPT2), or (5) GTR with 4\u00a0mg\/ml SCPT (GTR\/SCPT4). Six weeks after initial surgery, identical procedures were performed on the contralateral area. Healing outcomes were assessed at 6 and 12 weeks through radiographic and histomorphometric analyses. The primary outcome was the length of the root surface covered by new cementum assessed histologically and the secondary outcome included other histomorphometric and radiographic healing outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Radiographically, the GTR\/SCPT groups showed significantly greater new bone volume than the control group at both 6- and 12-week timepoints (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Histologically, specimens treated with both formulations of SCPT displayed better-organized periodontal ligaments and improved cementum formation, similar to those treated with EMD. The group with the highest concentration of SCPT (GTR\/SCPT4) exhibited the greatest amount of new cementum formation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Within the limitations of this study, both formulations of SCPT demonstrated significant regenerative potential in periodontal tissues, with outcomes comparable to those of EMD treatment, suggesting SCPT\u2019s viability as an alternative bioactive agent for periodontal regeneration in class II furcation defects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical relevance<\/jats:title>\n            <jats:p>This study suggests that SCPT could serve as a viable alternative bioactive agent for periodontal regeneration in class II furcation defect in clinical settings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00784-025-06334-0","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:19:35Z","timestamp":1745482775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of selcopintide on periodontal regeneration in a class II furcation defect model: a radiographic and histomorphometric analysis"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7851-4936","authenticated-orcid":false,"given":"Jungwoo","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-442X","authenticated-orcid":false,"given":"Jungwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4567-3982","authenticated-orcid":false,"given":"Seunghee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-2630","authenticated-orcid":false,"given":"Ki-Tae","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-5452","authenticated-orcid":false,"given":"Yang-Jo","family":"Seol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Cheol","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Min","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Seok","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5619-3847","authenticated-orcid":false,"given":"Yong-Moo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"6334_CR1","doi-asserted-by":"publisher","first-page":"S105","DOI":"10.1902\/jop.2015.140378","volume":"86","author":"MA Reynolds","year":"2015","unstructured":"Reynolds MA, Kao RT, Camargo PM, Caton JG, Clem DS, Fiorellini JP, Geisinger ML, Mills MP, Nares S, Nevins ML (2015) Periodontal regeneration - intrabony defects: a consensus report from the AAP regeneration workshop. 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Joo-Cheol Park is the founder of HysensBio Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors have stated that there are no conflicts of interest with regard to this study. A grant was provided by HysensBio (Gyeonggi-do, Korea, Republic of Korea). However, the company did not play any role in the design of the study; the collection, analysis, and interpretation of data; the writing of the manuscript; or the decision to publish the results.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"265"}}