{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:00:14Z","timestamp":1781614814860,"version":"3.54.5"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006393","name":"Universidad de Granada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006393","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to, first, determine the prevalence of periodontitis in patients diagnosed with colorectal cancer (CRC) through a comprehensive clinical periodontal evaluation, and second, to analyze the relationship between periodontitis and different tumor severity variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In a cross-sectional and analytical study in patients with CRC, we divided the patients into two groups, periodontitis and non-periodontitis, based on a complete periodontal assessment (clinical attachment loss, probing pocket depth, bleeding on probing, plaque index, number of present teeth, and a periodontal severity index). In both groups, in addition to sociodemographic variables, 12 histopathological tumor severity variables were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 59 patients diagnosed with CRC, 41 (69.5%, 95% CI: 56.1\u201380.8) were diagnosed with periodontitis. The mean values in ng\/mL of baseline and peak carcinoembryonic antigen (CEA) in the periodontitis patient group, mean\u2009\u00b1\u2009SD (0.44\u2009\u00b1\u20090.39, 0.69\u2009\u00b1\u20090.49), were much higher compared to the non-periodontitis group (0.11\u2009\u00b1\u20090.29, 0.35\u2009\u00b1\u20090.45), 95% CI: 0.12\u20130.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and 95% CI: 0.06\u20130.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005, respectively. The rest of the comparisons between the different characteristics and histopathological variables of the tumor showed very similar results between both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 69.5% prevalence of periodontitis in patients with colorectal cancer highlights the relationship between both diseases. Furthermore, the association between periodontitis and elevated CEA levels suggests a possible role of chronic inflammation in tumor susceptibility. However, the absence of an association with other histopathological variables suggests that periodontitis is not related to cancer severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Recognizing periodontitis as a potential field cancerization highlights the importance of periodontal management as a possible strategy to reduce CRC susceptibility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-025-06399-x","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T21:23:29Z","timestamp":1748813009000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Periodontitis as a field of cancerization: association with carcinoembryonic antigen in colorectal cancer patients"],"prefix":"10.1007","volume":"29","author":[{"given":"Mar\u00eda Jos\u00e9","family":"Mesa-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Egea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"El-Amrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alberca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"6399_CR1","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.ejca.2021.07.039","volume":"157","author":"T Dyba","year":"2021","unstructured":"Dyba T, Randi G, Bray F, Martos C, Giusti F, Nicholson N et al (2021) The European cancer burden in 2020: incidence and mortality estimates for 40 countries and 25 major cancers. 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