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Moreover, this study aimed to investigate their diagnostic potential in distinguishing different periodontal diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      73 systemically healthy non-smoking individuals were divided into H (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925), G (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) and P (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) groups. Clinical periodontal parameters were recorded, and GCF samples were collected at baseline in all groups, and 3rd month after NSPT in the G and P groups. GCF levels of CTRP-1, TNF-\u03b1, and IL-10 were analyzed using ELISA. The area under the curve (AUC) was assessed using the receiver operating characteristic curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CTRP-1 levels were significantly elevated in the G and P group compared to the H group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while there was no significant difference between the G and P groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.095). TNF-\u03b1 and IL-10 levels were significantly higher in the P group compared to the other groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). GCF CTRP-1 demonstrated an excellent diagnostic performance to discriminate periodontitis and gingivitis from periodontal health (AUC value of 0.998 and 0.974 with 100% and 91.3% sensitivity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CTRP-1 could serve as a potential biomarker for periodontal diseases. CTRP-1 demonstrated excellent diagnostic performance in distinguishing stage III grade B periodontitis and gingivitis from periodontal health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>GCF CTRP-1 levels may serve as a valuable marker for diagnosing periodontal diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-025-06420-3","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:41:36Z","timestamp":1750466496000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of non-surgical periodontal therapy on gingival crevicular fluid CTRP-1, TNF-\u03b1, and IL-10 levels"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4770-9837","authenticated-orcid":false,"given":"Asena","family":"Kaday\u0131f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1008-2428","authenticated-orcid":false,"given":"\u00d6zge Elif","family":"Ta\u015f\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-3896","authenticated-orcid":false,"given":"Burcu","family":"Karaduman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"issue":"Suppl 20","key":"6420_CR1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1111\/jcpe.12935","volume":"45","author":"JG Caton","year":"2018","unstructured":"Caton JG, Armitage G, Berglundh T et al (2018) A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. 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