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Participants were randomly assigned to early closure (Group A: 6\u20138 months) or late closure (Group B: 10\u201312 months). Chewing function was evaluated at 9, 13, and 17 months of age using the Mastication Observation and Evaluation (MOE) instrument, which scores eight components of mastication.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>No statistically significant differences were found in total MOE scores between groups at any time point. However, at 17 months, Group B showed significantly better lateral tongue movement than Group A (mean\u2009=\u20092.72, SD\u2009=\u20090.53 vs. mean\u2009=\u20092.45, SD\u2009=\u20090.51; <jats:italic>p<\/jats:italic>\u2009=\u2009.047).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Early palatal closure (6\u20138 months) does not improve overall mastication compared to late closure (10\u201312 months) in the first 17 months of life.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Relevance<\/jats:title>\n            <jats:p>Research on mastication in children with CL\/P is limited. This study provides novel insights into functional outcomes of palatal surgery, supporting evidence-based refinement of cleft treatment protocols.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial Registration Number<\/jats:title>\n            <jats:p>The CLEFED study was approved by the Medical Ethics Committee of the University Medical Center Utrecht, The Netherlands (registration no: NTR3275). Date of registration: November 2011. Trial Register: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.trialregister.nl\/trial\/3125\" ext-link-type=\"uri\">https:\/\/www.trialregister.nl\/trial\/3125<\/jats:ext-link> (trial number: NTR3275)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00784-025-06467-2","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:04:19Z","timestamp":1756796659000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chewing with a cleft palate: a randomized controlled trial. Effect of timing of surgical closure of the palate on mastication in infants with clefts"],"prefix":"10.1007","volume":"29","author":[{"given":"C. H. A. L.","family":"Guillaume","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M. 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