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Swelling was measured with a flexible ruler using the diagonals joining Trago and Pogonion, Gonion and labial cleft. The swelling was calculated as the sum of these diagonals before surgery, on day 3 and 7. Pain was assessed by VAS scale until the 7th postoperative day. Surgical wound healing was evaluated by the Healing Index by Landry on 3, 7 ,14 and 21st day postosperatively. The relation between duration of intervention and total swelling was also evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>56 patients were enrolled in this study (28 for the test group and 28 for the control group). Randomization resulted in groups with similar baseline characteristics. No patients were lost during the follow-up and no adverse events were noted. On day 3 the total swelling was 12.7\u2009\u00b1\u20090.92\u00a0mm for control group and 12.1\u2009\u00b1\u20090.75\u00a0mm for test group; on day 7 it was 12.3\u2009\u00b1\u20090.88\u00a0mm for control group and 11.7\u2009\u00b1\u20090.73\u00a0mm for test group. A statistically significant difference was found on day 3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and on day 7 (<jats:italic>p<\/jats:italic>\u2009=\u20090.018). The relation between total swelling and duration of intervention was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.276). A significant reduction in pain scores was observed in the i-PRF group on days 1 and 3 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Surgical wound healing also showed statistically significant improvement in the i-PRF group at all time points (days 3, 7, 14, and 21; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Within the limit of our study, this randomized controlled clinical trial suggests that submucosal infiltration of i-PRF after the extraction of impacted lower third molars effectively reduces postoperative swelling and pain, while also promoting faster wound healing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Relevance<\/jats:title>\n            <jats:p>The adjunctive use of injectable platelet-rich fibrin (i\u2011PRF) after surgical removal of impacted mandibular third molars may contribute to improve early postoperative outcomes by attenuating soft tissue inflammation, reducing pain intensity, and accelerating wound healing. By potentially lowering the need for nonsteroidal anti-inflammatory drugs (NSAIDs) and minimizing associated adverse effects, i\u2011PRF represents a minimally invasive, autologous approach that could enhance patient comfort, reduce recovery time, and support faster return to daily activities.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00784-025-06563-3","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:34:58Z","timestamp":1758267298000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Using injectable Platelet-Rich fibrin to improve recovery after impacted lower third molar extraction: a randomized controlled clinical trial"],"prefix":"10.1007","volume":"29","author":[{"given":"Angelo","family":"Aliberti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Mariniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bergaminelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Dolce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Sammartino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianrico","family":"Spagnuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Gasparro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"6563_CR1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1834-7819.2008.00073.x","volume":"53","author":"O Breik","year":"2008","unstructured":"Breik O, Grubor D (2008) The incidence of mandibular third molar impactions in different skeletal face types. 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