{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:08:41Z","timestamp":1787756921002,"version":"build-2784847793"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Supported by the Fundamental Research Funds for the Central Universities","award":["31920230187"],"award-info":[{"award-number":["31920230187"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]},{"name":"Gansu Province Science and Technology Plan Project (23JRRA721) awarded to Tianzhu Song.","award":["23JRRA721"],"award-info":[{"award-number":["23JRRA721"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-025-06564-2","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T07:31:59Z","timestamp":1760340719000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of subgingival microbial community structure in MAFLD patients with periodontitis"],"prefix":"10.1007","volume":"29","author":[{"given":"Hai","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisheng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"issue":"9","key":"6564_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095142","volume":"23","author":"M Di Stefano","year":"2022","unstructured":"Di Stefano M, Polizzi A, Santonocito S, Romano A, Lombardi T, Isola G (2022) Impact of oral microbiome in periodontal health and periodontitis: a critical review on prevention and treatment. Int J Mol Sci 23(9):5142. https:\/\/doi.org\/10.3390\/ijms23095142","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6564_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/prd.12430","volume":"89","author":"G Hajishengallis","year":"2022","unstructured":"Hajishengallis G (2022) Interconnection of periodontal disease and comorbidities: evidence, mechanisms, and implications. Periodontol 2000 89(1):9\u201318. https:\/\/doi.org\/10.1111\/prd.12430","journal-title":"Periodontol 2000"},{"issue":"7","key":"6564_CR3","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","volume":"158","author":"M Eslam","year":"2020","unstructured":"Eslam M, Sanyal AJ, George J, International Consensus Panel (2020) MAFLD: A Consensus-Driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology 158(7):1999\u20132014. https:\/\/doi.org\/10.1053\/j.gastro.2019.11.312","journal-title":"Gastroenterology"},{"key":"6564_CR4","doi-asserted-by":"publisher","unstructured":"Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez,M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J. F., Schattenberg, J. M., Kawaguchi,T., Arrese, M., Valenti, L., Shiha, G., Tiribelli, C., Yki-J\u00e4rvinen, H., Fan, J. G.,Gr\u00f8nb\u00e6k, H., Yilmaz, Y., Cortez-Pinto, H., \u2026 George, J. (2020). A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement. Journal of hepatology, 73(1),202\u2013209. https:\/\/doi.org\/10.1016\/j.jhep.2020.03.039","DOI":"10.1016\/j.jhep.2020.03.039"},{"issue":"6","key":"6564_CR5","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","volume":"14","author":"M Eslam","year":"2020","unstructured":"Eslam M, Sarin SK, Wong VW, Fan JG, Kawaguchi T, Ahn SH, Zheng MH, Shiha G, Yilmaz Y, Gani R, Alam S, Dan YY, Kao JH, Hamid S, Cua IH, Chan WK, Payawal D, Tan SS, Tanwandee T, Adams LA, Wong Vincent Wai-Sun, Kumar Manoj, Omata Masao, George J (2020) The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease. Hepatol Int 14(6):889\u2013919","journal-title":"Hepatol Int"},{"key":"6564_CR6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.redox.2018.01.009","volume":"15","author":"A Borrelli","year":"2018","unstructured":"Borrelli A, Bonelli P, Tuccillo FM, Goldfine ID, Evans JL, Buonaguro FM, Mancini A (2018) Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: current and innovative therapeutic approaches. Redox Biol 15:467\u2013479. https:\/\/doi.org\/10.1016\/j.redox.2018.01.009","journal-title":"Redox Biol"},{"issue":"22","key":"6564_CR7","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1001\/jama.2015.5370","volume":"313","author":"ME Rinella","year":"2015","unstructured":"Rinella ME (2015) Nonalcoholic fatty liver disease: a systematic review. JAMA 313(22):2263\u20132273. https:\/\/doi.org\/10.1001\/jama.2015.5370","journal-title":"JAMA"},{"issue":"4","key":"6564_CR8","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/hep.30702","volume":"70","author":"F Zhou","year":"2019","unstructured":"Zhou F, Zhou J, Wang W, Zhang XJ, Ji YX, Zhang P, She ZG, Zhu L, Cai J, Li H (2019) Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: a systematic review and meta-analysis. Hepatology (Baltimore MD) 70(4):1119\u20131133. https:\/\/doi.org\/10.1002\/hep.30702","journal-title":"Hepatology (Baltimore MD)"},{"issue":"5","key":"6564_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S2468-1253(19)30039-1","volume":"4","author":"J Li","year":"2019","unstructured":"Li J, Zou B, Yeo YH, Feng Y, Xie X, Lee DH, Fujii H, Wu Y, Kam LY, Ji F, Li X, Chien N, Wei M, Ogawa E, Zhao C, Wu X, Stave CD, Henry L, Barnett S, Takahashi H, Furusyo Norihiro, Eguchi Yuichiro, Hsu Yao-Chun, Lee Teng-Yu, Ren Wanhua, Qin Chengyong, Jun Dae Won, Toyoda Hidenori, Wong Vincent Wai-Sun, Cheung Ramsey, Zhu Qiang, Nguyen MH (2019) Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999\u20132019: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 4(5):389\u2013398. https:\/\/doi.org\/10.1016\/S2468-1253(19)30039-1","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"8","key":"6564_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084156","volume":"22","author":"Y Sakurai","year":"2021","unstructured":"Sakurai Y, Kubota N, Yamauchi T, Kadowaki T (2021) Role of insulin resistance in MAFLD. Int J Mol Sci 22(8):4156. https:\/\/doi.org\/10.3390\/ijms22084156","journal-title":"Int J Mol Sci"},{"issue":"Suppl","key":"6564_CR11","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.3350\/cmh.2022.0367","volume":"29","author":"C Gofton","year":"2023","unstructured":"Gofton C, Upendran Y, Zheng MH, George J (2023) MAFLD: how is it different from NAFLD? Clin Mol Hepatol 29(Suppl):S17\u2013S31. https:\/\/doi.org\/10.3350\/cmh.2022.0367","journal-title":"Clin Mol Hepatol"},{"key":"6564_CR12","doi-asserted-by":"publisher","DOI":"10.1177\/20420188221145549","volume":"14","author":"RM Pipitone","year":"2023","unstructured":"Pipitone RM, Ciccioli C, Infantino G, La Mantia C, Parisi S, Tulone A, Pennisi G, Grimaudo S, Petta S (2023) MAFLD: a multisystem disease. Ther Adv Endocrinol Metab 14:20420188221145549. https:\/\/doi.org\/10.1177\/20420188221145549","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"4","key":"6564_CR13","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s13105-023-00954-4","volume":"79","author":"P Sangro","year":"2023","unstructured":"Sangro P, de la Torre Al\u00e1ez M, Sangro B, D\u2019Avola D (2023) Metabolic dysfunction-associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment. J Physiol Biochem 79(4):869\u2013879. https:\/\/doi.org\/10.1007\/s13105-023-00954-4","journal-title":"J Physiol Biochem"},{"issue":"7","key":"6564_CR14","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1007\/s00204-021-03069-1","volume":"95","author":"J Boeckmans","year":"2021","unstructured":"Boeckmans J, Rombaut M, Demuyser T, Declerck B, Pi\u00e9rard D, Rogiers V, De Kock J, Waumans L, Magerman K, Cartuyvels R, Rummens JL, Rodrigues RM, Vanhaecke T (2021) Infections at the nexus of metabolic-associated fatty liver disease. Arch Toxicol 95(7):2235\u20132253. https:\/\/doi.org\/10.1007\/s00204-021-03069-1","journal-title":"Arch Toxicol"},{"issue":"4","key":"6564_CR15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3233\/DMA-2012-0926","volume":"33","author":"AR Pradeep","year":"2012","unstructured":"Pradeep AR, Priyanka N, Prasad MV, Kalra N, Kumari M (2012) Association of progranulin and high sensitivity CRP concentrations in gingival crevicular fluid and serum in chronic periodontitis subjects with and without obesity. Dis Markers 33(4):207\u2013213. https:\/\/doi.org\/10.3233\/DMA-2012-0926","journal-title":"Dis Markers"},{"issue":"5","key":"6564_CR16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1902\/jop.2015.150583","volume":"87","author":"S Thanakun","year":"2016","unstructured":"Thanakun S, Izumi Y (2016) Effect of periodontitis on adiponectin, C-reactive protein, and immunoglobulin G against Porphyromonas gingivalis in Thai people with overweight or obese status. J Periodontol 87(5):566\u2013576. https:\/\/doi.org\/10.1902\/jop.2015.150583","journal-title":"J Periodontol"},{"issue":"9","key":"6564_CR17","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1007\/s00784-018-2726-1","volume":"22","author":"MS Alakhali","year":"2018","unstructured":"Alakhali MS, Al-Maweri SA, Al-Shamiri HM, Al-Haddad K, Halboub E (2018) The potential association between periodontitis and non-alcoholic fatty liver disease: a systematic review. Clin Oral Invest 22(9):2965\u20132974. https:\/\/doi.org\/10.1007\/s00784-018-2726-1","journal-title":"Clin Oral Invest"},{"key":"6564_CR18","doi-asserted-by":"publisher","first-page":"706432","DOI":"10.3389\/fimmu.2021.706432","volume":"12","author":"V Machado","year":"2021","unstructured":"Machado V, Botelho J, Escalda C, Hussain SB, Luthra S, Mascarenhas P, Orlandi M, Mendes JJ, D\u2019Aiuto F (2021) Serum C-reactive protein and periodontitis: a systematic review and meta-analysis. Front Immunol 12:706432. https:\/\/doi.org\/10.3389\/fimmu.2021.706432","journal-title":"Front Immunol"},{"issue":"6","key":"6564_CR19","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.3390\/biomedicines13061346","volume":"13","author":"M Juzba\u0161i\u0107","year":"2025","unstructured":"Juzba\u0161i\u0107 M, Tomas M, Petrovi\u0107 A, Hefer M, Sikora R, Ma\u010dkovi\u0107 A, Siber S, Smoli\u0107 M (2025) Interaction between periodontitis and MASLD: pathophysiological associations and possibilities of prevention and therapy. Biomedicines 13(6):1346. https:\/\/doi.org\/10.3390\/biomedicines13061346","journal-title":"Biomedicines"},{"issue":"1","key":"6564_CR20","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1186\/s12903-025-05959-7","volume":"25","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Zheng Q, Liu Y, Chen G, Li Y (2025) Association between periodontitis and mortality in participants with metabolic dysfunction-associated steatotic liver disease: results from NHANES. BMC Oral Health 25(1):567. https:\/\/doi.org\/10.1186\/s12903-025-05959-7","journal-title":"BMC Oral Health"},{"issue":"7","key":"6564_CR21","doi-asserted-by":"publisher","first-page":"e63775","DOI":"10.7759\/cureus.63775","volume":"16","author":"HS Vegda","year":"2024","unstructured":"Vegda HS, Patel B, Girdhar GA, Pathan MSH, Ahmad R, Haque M, Sinha S, Kumar S (2024) Role of nonalcoholic fatty liver disease in periodontitis: a bidirectional relationship. Cureus 16(7):e63775. https:\/\/doi.org\/10.7759\/cureus.63775","journal-title":"Cureus"},{"issue":"5","key":"6564_CR22","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.1111\/odi.14785","volume":"30","author":"F Qiao","year":"2024","unstructured":"Qiao F, Li X, Liu Y, Zhang S, Liu D, Li C (2024) Periodontitis and NAFLD-related diseases: a bidirectional two-sample Mendelian randomization study. Oral Dis 30(5):3452\u20133461. https:\/\/doi.org\/10.1111\/odi.14785","journal-title":"Oral Dis"},{"issue":"1","key":"6564_CR23","doi-asserted-by":"publisher","first-page":"10718","DOI":"10.1038\/s41598-018-28905-w","volume":"8","author":"A Jensen","year":"2018","unstructured":"Jensen A, Ladegaard Gr\u00f8nkj\u00e6r L, Holmstrup P, Vilstrup H, Kilian M (2018) Unique subgingival microbiota associated with periodontitis in cirrhosis patients. Sci Rep 8(1):10718. https:\/\/doi.org\/10.1038\/s41598-018-28905-w","journal-title":"Sci Rep"},{"key":"6564_CR24","doi-asserted-by":"publisher","first-page":"939608","DOI":"10.3389\/fmicb.2022.939608","volume":"13","author":"L Jiang","year":"2022","unstructured":"Jiang L, Zhang J, Fang M, Qin Y, Huang Y, Tao R (2022) Analysis of subgingival micro-organisms based on multi-omics and Treg\/Th17 balance in type 2 diabetes with\/without periodontitis. Front Microbiol 13:939608. https:\/\/doi.org\/10.3389\/fmicb.2022.939608","journal-title":"Front Microbiol"},{"issue":"10","key":"6564_CR25","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.3969\/j.issn.10015256.2023.10.025","volume":"39","author":"ZB Chen","year":"2023","unstructured":"Chen ZB, Huang LY, Wang BY et al (2023) Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity[J]. J Clin Hepatol 39(10):2454\u20132459. https:\/\/doi.org\/10.3969\/j.issn.10015256.2023.10.025","journal-title":"J Clin Hepatol"},{"issue":"1","key":"6564_CR26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12916-024-03315-0","volume":"22","author":"L Cao","year":"2024","unstructured":"Cao L, An Y, Liu H, Jiang J, Liu W, Zhou Y, Shi M, Dai W, Lv Y, Zhao Y, Lu Y, Chen L, Xia Y (2024) Global epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis. BMC Med 22(1):101. https:\/\/doi.org\/10.1186\/s12916-024-03315-0","journal-title":"BMC Med"},{"key":"6564_CR27","doi-asserted-by":"publisher","unstructured":"Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., Flemmig,T. F., Garcia, R., Giannobile, W. V., Graziani, F., Greenwell, H., Herrera, D., Kao,R. T., Kebschull, M., Kinane, D. F., Kirkwood, K. L., Kocher, T., Kornman, K. S.,Kumar, P. S., Loos, B. G., \u2026 Tonetti, M. S. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of clinical periodontology, 45 Suppl 20, S162\u2013S170. https:\/\/doi.org\/10.1111\/jcpe.12946","DOI":"10.1111\/jcpe.12946"},{"issue":"Suppl 20","key":"6564_CR28","doi-asserted-by":"publisher","first-page":"S149","DOI":"10.1111\/jcpe.12945","volume":"45","author":"MS Tonetti","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS (2018) Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Clin Periodontol 45(Suppl 20):S149\u2013S161. https:\/\/doi.org\/10.1111\/jcpe.12945","journal-title":"J Clin Periodontol"},{"issue":"17","key":"6564_CR29","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","volume":"34","author":"S Chen","year":"2018","unstructured":"Chen S, Zhou Y, Chen Y, Gu J (2018) Fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34(17):i884\u2013i890. https:\/\/doi.org\/10.1093\/bioinformatics\/bty560","journal-title":"Bioinformatics"},{"issue":"21","key":"6564_CR30","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","volume":"27","author":"T Mago\u010d","year":"2011","unstructured":"Mago\u010d T, Salzberg SL (2011) Flash: fast length adjustment of short reads to improve genome assemblies. Bioinformatics 27(21):2957\u20132963. https:\/\/doi.org\/10.1093\/bioinformatics\/btr507","journal-title":"Bioinformatics"},{"issue":"10","key":"6564_CR31","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","volume":"10","author":"RC Edgar","year":"2013","unstructured":"Edgar RC (2013) Uparse: highly accurate OTU sequences from microbial amplicon reads. Nat Methods 10(10):996\u2013998. https:\/\/doi.org\/10.1038\/nmeth.2604","journal-title":"Nat Methods"},{"issue":"4","key":"6564_CR32","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1099\/00207713-44-4-846","volume":"44","author":"E Stackebrandt","year":"1994","unstructured":"Stackebrandt E, Goebel BM (1994) Taxonomic note: a place for DNA-DNA reassociation and 16S rRNA sequence analysis in the present species definition in bacteriology. Int J Syst Evol Microbiol 44(4):846\u2013849. https:\/\/doi.org\/10.1099\/00207713-44-4-846","journal-title":"Int J Syst Evol Microbiol"},{"issue":"16","key":"6564_CR33","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1128\/AEM.00062-07","volume":"73","author":"Q Wang","year":"2007","unstructured":"Wang Q, Garrity GM, Tiedje JM, Cole JR (2007) Naive bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol 73(16):5261\u20135267. https:\/\/doi.org\/10.1128\/AEM.00062-07","journal-title":"Appl Environ Microbiol"},{"issue":"6","key":"6564_CR34","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","volume":"38","author":"GM Douglas","year":"2020","unstructured":"Douglas GM, Maffei VJ, Zaneveld JR, Yurgel SN, Brown JR, Taylor CM, Huttenhower C, Langille MGI (2020) PICRUSt2 for prediction of metagenome functions. Nat Biotechnol 38(6):685\u2013688. https:\/\/doi.org\/10.1038\/s41587-020-0548-6","journal-title":"Nat Biotechnol"},{"key":"6564_CR35","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12427","author":"E Albuquerque-Souza","year":"2022","unstructured":"Albuquerque-Souza E, Sahingur SE (2022) Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis. Periodontol 2000. https:\/\/doi.org\/10.1111\/prd.12427","journal-title":"Periodontol 2000"},{"issue":"1","key":"6564_CR36","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1600-0765.2012.01498.x","volume":"48","author":"RC Casarin","year":"2013","unstructured":"Casarin RC, Barbagallo A, Meulman T, Santos VR, Sallum EA, Nociti FH, Duarte PM, Casati MZ, Gon\u00e7alves RB (2013) Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis. J Periodontal Res 48(1):30\u201336. https:\/\/doi.org\/10.1111\/j.1600-0765.2012.01498.x","journal-title":"J Periodontal Res"},{"key":"6564_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-025-01114-y","author":"D Accili","year":"2025","unstructured":"Accili D, Deng Z, Liu Q (2025) Insulin resistance in type 2 diabetes mellitus. Nat Rev Endocrinol. https:\/\/doi.org\/10.1038\/s41574-025-01114-yAdvance online publication","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"6564_CR38","doi-asserted-by":"publisher","first-page":"e00782","DOI":"10.1128\/mBio.00782-16","volume":"7","author":"A Stacy","year":"2016","unstructured":"Stacy A, Fleming D, Lamont RJ, Rumbaugh KP, Whiteley M (2016) A commensal bacterium promotes virulence of an opportunistic pathogen via cross-respiration. mBio 7(3):e00782\u2013e00716. https:\/\/doi.org\/10.1128\/mBio.00782-16","journal-title":"mBio"},{"issue":"17","key":"6564_CR39","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.3390\/cells11172718","volume":"11","author":"N Lanthier","year":"2022","unstructured":"Lanthier N, Delzenne N (2022) Targeting the gut Microbiome to treat metabolic Dysfunction-Associated fatty liver disease: ready for prime time?? Cells 11(17):2718. https:\/\/doi.org\/10.3390\/cells11172718","journal-title":"Cells"},{"issue":"1","key":"6564_CR40","first-page":"1","volume":"29","author":"H Yaghmaei","year":"2025","unstructured":"Yaghmaei H, Taromiha A, Nojoumi SA, Soltanipur M, Shahshenas S, Rezaei M, Mirhosseini SM, Hosseini SM, Siadat SD (2025) Role of gut-liver axis in non-alcoholic fatty liver disease. Iran Biomed J 29(1):1\u20138","journal-title":"Iran Biomed J"},{"key":"6564_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2023.1210200","author":"A Basic","year":"2023","unstructured":"Basic A, Dahl\u00e9n G (2023) Microbial metabolites in the pathogenesis of periodontal diseases: a narrative review. Front Oral Health. https:\/\/doi.org\/10.3389\/froh.2023.1210200","journal-title":"Front Oral Health"},{"issue":"9","key":"6564_CR42","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1177\/0022034512453589","volume":"91","author":"RP Darveau","year":"2012","unstructured":"Darveau RP, Hajishengallis G, Curtis MA (2012) Porphyromonas gingivalis as a potential community activist for disease. J Dent Res 91(9):816\u2013820. https:\/\/doi.org\/10.1177\/0022034512453589","journal-title":"J Dent Res"},{"issue":"5","key":"6564_CR43","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","volume":"10","author":"G Hajishengallis","year":"2011","unstructured":"Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA (2011) Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe 10(5):497\u2013506. https:\/\/doi.org\/10.1016\/j.chom.2011.10.006","journal-title":"Cell Host Microbe"},{"issue":"18","key":"6564_CR44","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1042\/CS20220572","volume":"136","author":"OO Badmus","year":"2022","unstructured":"Badmus OO, Hillhouse SA, Anderson CD, Hinds TD, Stec DE (2022) Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways. Clin Sci 136(18):1347\u20131366. https:\/\/doi.org\/10.1042\/CS20220572","journal-title":"Clin Sci"},{"issue":"1","key":"6564_CR45","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/prd.12387","volume":"87","author":"R Kuraji","year":"2021","unstructured":"Kuraji R, Sekino S, Kapila Y, Numabe Y (2021) Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an emerging concept of oral-liver axis. Periodontol 2000 87(1):204\u2013240. https:\/\/doi.org\/10.1111\/prd.12387","journal-title":"Periodontol 2000"},{"issue":"8","key":"6564_CR46","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.3969\/j.issn.1001-5256.2023.08.026","volume":"39","author":"AQ LI","year":"2023","unstructured":"LI AQ, ZHAO YQ, ZHAO PR et al (2023) Research advances in the association between microcirculation disturbance and microvascular system in metabolic associated fatty liver disease [J]. J Clin Hepatol 39(8):1939\u20131945. https:\/\/doi.org\/10.3969\/j.issn.1001-5256.2023.08.026","journal-title":"J Clin Hepatol"},{"key":"6564_CR47","doi-asserted-by":"publisher","unstructured":"Shabalala SC, Dludla PV, Mabasa L, Kappo AP, Basson AK, Pheiffer C, Johnson R (2020) The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling, vol 131. Biomedicine & pharmacotherapy\u2009=\u2009Biomedecine & pharmacotherapie, p 110785. https:\/\/doi.org\/10.1016\/j.biopha.2020.110785","DOI":"10.1016\/j.biopha.2020.110785"},{"issue":"1","key":"6564_CR48","doi-asserted-by":"publisher","first-page":"25","DOI":"10.17925\/EE.2024.20.1.7","volume":"20","author":"A Checa-Ros","year":"2024","unstructured":"Checa-Ros A, Hsueh WC, Merck B, Gonz\u00e1lez-Torres H, Berm\u00fadez V, D\u2019Marco L (2024) Obesity and oral health: the link between adipokines and periodontitis. touchREVIEWS in Endocrinology 20(1):25\u201331. https:\/\/doi.org\/10.17925\/EE.2024.20.1.7","journal-title":"touchREVIEWS in Endocrinology"},{"issue":"20","key":"6564_CR49","doi-asserted-by":"publisher","first-page":"15123","DOI":"10.3390\/ijms242015123","volume":"24","author":"S L\u00ea","year":"2023","unstructured":"L\u00ea S, Laurencin-Dalicieux S, Minty M, Assoulant-Anduze J, Vinel A, Yanat N, Loubieres P, Azalbert V, Diemer S, Burcelin R, Canceill T, Thomas C, Blasco-Baque V (2023) Obesity is associated with the severity of periodontal inflammation due to a specific signature of subgingival microbiota. Int J Mol Sci 24(20):15123. https:\/\/doi.org\/10.3390\/ijms242015123","journal-title":"Int J Mol Sci"},{"issue":"8","key":"6564_CR50","doi-asserted-by":"publisher","first-page":"e105181","DOI":"10.1371\/journal.pone.0105181","volume":"9","author":"VM Barnes","year":"2014","unstructured":"Barnes VM, Kennedy AD, Panagakos F, Devizio W, Trivedi HM, J\u00f6nsson T, Guo L, Cervi S, Scannapieco FA (2014) Global metabolomic analysis of human saliva and plasma from healthy and diabetic subjects, with and without periodontal disease. PLoS ONE 9(8):e105181. https:\/\/doi.org\/10.1371\/journal.pone.0105181","journal-title":"PLoS ONE"},{"issue":"10","key":"6564_CR51","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/s41580-018-0044-8","volume":"19","author":"Q Yang","year":"2018","unstructured":"Yang Q, Vijayakumar A, Kahn BB (2018) Metabolites as regulators of insulin sensitivity and metabolism. Nat Rev Mol Cell Biol 19(10):654\u2013672. https:\/\/doi.org\/10.1038\/s41580-018-0044-8","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"6564_CR52","doi-asserted-by":"publisher","first-page":"344","DOI":"10.11569\/wcjd.v33.i5.344","volume":"33","author":"Y Liu","year":"2025","unstructured":"Liu Y, Hu Y, Shan ZL (2025) Mitochondrial DNA release mediates metabolic-associated steatohepatitis via activation of inflammatory pathways. Shijie Huaren Xiaohua Zazhi 33(5):344\u2013360. https:\/\/doi.org\/10.11569\/wcjd.v33.i5.344","journal-title":"Shijie Huaren Xiaohua Zazhi"},{"issue":"6","key":"6564_CR53","doi-asserted-by":"publisher","first-page":"4707","DOI":"10.3390\/ijerph20064707","volume":"20","author":"N Said-Sadier","year":"2023","unstructured":"Said-Sadier N, Sayegh B, Farah R, Abbas LA, Dweik R, Tang N, Ojcius DM (2023) Association between periodontal disease and cognitive impairment in adults. Int J Environ Res Public Health 20(6):4707. https:\/\/doi.org\/10.3390\/ijerph20064707","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"6564_CR54","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12915-020-00830-3","volume":"18","author":"B He","year":"2020","unstructured":"He B, Shi J, Wang X, Jiang H, Zhu HJ (2020) Genome-wide pQTL analysis of protein expression regulatory networks in the human liver. BMC Biol 18(1):97. https:\/\/doi.org\/10.1186\/s12915-020-00830-3","journal-title":"BMC Biol"},{"issue":"1","key":"6564_CR55","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1753-4887.1970.tb06149.x","volume":"28","author":"LC Fillios","year":"1970","unstructured":"Fillios LC (1970) Protein synthesis in the liver. Nutr Rev 28(1):26\u201327. https:\/\/doi.org\/10.1111\/j.1753-4887.1970.tb06149.x","journal-title":"Nutr Rev"},{"issue":"3","key":"6564_CR56","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3892\/ijmm.2021.4999","volume":"48","author":"S Yao","year":"2021","unstructured":"Yao S, Yang X, An J, Jin H, Wen G, Wang H, Tuo B (2021) Role of the S100 protein family in liver disease (Review). Int J Mol Med 48(3):166. https:\/\/doi.org\/10.3892\/ijmm.2021.4999","journal-title":"Int J Mol Med"},{"issue":"4","key":"6564_CR57","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1002\/hep.31582","volume":"73","author":"Z Song","year":"2021","unstructured":"Song Z, Chen W, Athavale D, Ge X, Desert R, Das S, Han H, Nieto N (2021) Osteopontin takes center stage in chronic liver disease. Hepatology 73(4):1594\u20131608. https:\/\/doi.org\/10.1002\/hep.31582","journal-title":"Hepatology"},{"key":"6564_CR58","doi-asserted-by":"publisher","unstructured":"Katayama K (2020) Zinc and protein metabolism in chronic liver diseases. Nutrition research, vol 74. New York, pp 1\u20139. https:\/\/doi.org\/10.1016\/j.nutres.2019.11.009","DOI":"10.1016\/j.nutres.2019.11.009"},{"issue":"3","key":"6564_CR59","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s100240010146","volume":"4","author":"PA Russo","year":"2001","unstructured":"Russo PA, Mitchell GA, Tanguay RM (2001) Tyrosinemia: a review. Pediatr Dev Pathology: Official J Soc Pediatr Pathol Pediatr Pathol Soc 4(3):212\u2013221. https:\/\/doi.org\/10.1007\/s100240010146","journal-title":"Pediatr Dev Pathology: Official J Soc Pediatr Pathol Pediatr Pathol Soc"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-025-06564-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-025-06564-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-025-06564-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T08:48:17Z","timestamp":1763542097000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-025-06564-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":59,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["6564"],"URL":"https:\/\/doi.org\/10.1007\/s00784-025-06564-2","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"19 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Research Ethics Committee of Northwest Minzu University granted approval for this study (Approval No: XBMZ-YX-20230018). Each participant executed an informed consent form in accordance with the Declaration of Helsinki\u2019s principles after being apprised of the study\u2019s objectives.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"The participants were provided with written informed consent to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"504"}}