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The study aimed to estimate and compare the diagnostic accuracy of aMMP-8 expression in oral rinse, saliva, and GCF (gingival crevicular fluid) among patients with periodontitis and those with and without MetS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      A pilot sample of 77 participants was categorized into three groups based on the 2018 AAP\/EFP periodontitis classification and the 2006 IDF metabolic syndrome criteria: MetS with periodontitis (MetS-PD;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934), systemically healthy with periodontitis (SH-PD;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), and healthy controls (SH-PH;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922). Active metalloproteinase-8 (aMMP-8) levels in oral biofluids were quantified using an enzyme-linked immunosorbent assay. ANOVA and ROC curve analysis were done to assess diagnostic accuracy across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      aMMP-8 levels varied by group but remained consistent across biofluids, with lower levels in SH-PH and higher levels in SH-PD and MetS-PD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). aMMP-8 levels were significantly elevated in MetS-PD (25.86\u2009\u00b1\u20094.48 ng\/ml) and SH-PD (24.72\u2009\u00b1\u20092.13 ng\/ml) compared to controls (11.99\u2009\u00b1\u20093.46 ng\/ml) in oral rinse samples (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Oral rinse demonstrated superior diagnostic accuracy (AUC\u2009=\u20090.89) compared to saliva (AUC\u2009=\u20090.85) and GCF (AUC\u2009=\u20090.82) in distinguishing MetS-PD from healthy controls, with an optimal cut-off value of 20 ng\/ml.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral rinse may be a preferable matrix for diagnosing periodontal disease, particularly in patients with systemic conditions, compared to saliva and GCF. Prospective longitudinal studies are required to evaluate its utility for monitoring over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>This study highlights the potential of aMMP-8 as a reliable biomarker for assessing periodontal disease severity in patients with MetS, utilizing non-invasive oral fluids. With oral rinses demonstrating high diagnostic accuracy, they may be an effective and accessible tool for screening and case-finding in medical and dental settings in patients with MetS, facilitating early detection and tailored management strategies. aMMP-8 immunoassay chair-side kit offers a practical alternative to traditional methods for screening patients in non-dental settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-025-06584-y","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:03:32Z","timestamp":1760166212000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic accuracy of aMMP-8 levels in oral biofluids for monitoring periodontitis in patients with metabolic syndrome"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-2621","authenticated-orcid":false,"given":"Julie Toby","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismo T.","family":"R\u00e4is\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukumaran","family":"Anil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Waltimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"6584_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1186\/s12903-023-03133-5","volume":"23","author":"A Nilsen","year":"2023","unstructured":"Nilsen A, Thorsnes A, Lie SA, Methlie P, Bunaes DF, Reinholtsen KK, Leknes KN (2023) Periodontitis in obese adults with and without metabolic syndrome: a cross-sectional study. 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