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Current predictive models often lack comprehensive predictors and robust statistical methodologies, limiting their clinical applicability. To overcome these challenges, a predictive model of head and neck oncology patients\u2019 maximum voluntary bite force was developed by analyzing key anatomical and physiological factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data were collected from 41 head and neck cancer patients, with 109 bite force observations analyzed using a linear mixed-effects model. The identified key predictors include body weight, superficial masseter muscle volume, bite force measurement region, and maxilla and\/or mandibular teeth mobility. Superficial masseter muscle volume showed a positive association with bite force, while increased mobility of the teeth in the maxilla or mandible impacted bite force negatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The model demonstrated strong explanatory performance (conditional R\u00b2 = 0.777).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>This model enables patient-specific treatment planning and implant design for head and neck reconstructive surgery by implementing the bite forces in a finite element software used for computer aided designs. For instance, by tailoring mandibular reconstruction plates to individual bite forces using novel materials or designs, the model allows for a balance between sufficiently strong designs while preventing stress shielding seen with excessively strong designs. This study provides valuable insights into the multifactorial nature of bite force and its implications for patient care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-025-06626-5","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T02:13:59Z","timestamp":1761617639000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictive bite force modelling of head and neck oncology patients for clinical mandibular reconstruction applications"],"prefix":"10.1007","volume":"29","author":[{"given":"Jorn-Ids","family":"Heins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barzi","family":"Gareb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier","family":"ten Brink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Vosselman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy B.","family":"Halmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiia O.","family":"Krushynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram B. 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