{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:48:54Z","timestamp":1793047734528,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Periodontitis, a chronic inflammatory condition of tooth-supporting tissues, is associated with adverse systemic health outcomes, including cardiovascular disease, malignancies and premature mortality. Large-scale assessments remain limited. We analyzed real-world data of approximately 100,000 matched patients to clarify the broader health impact of periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>In this retrospective study, we identified two cohorts \u2212\u200947,498 patients each with and without periodontitis (ICD-10-CM: K05.6) - from the TriNetX database, matched by age and gender. We evaluated outcomes over 19 years, including heart inflammations, heart disease, head and neck cancer, C-reactive protein (CRP) levels and overall mortality. Propensity score matching, risk analyses and Kaplan\u2013Meier survival statistics were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to controls, patients with periodontitis exhibited higher risks of heart inflammations (OR: 3.06; 95% CI: 2.79\u20133.35), heart disease (OR: 2.40; 95% CI: 2.33\u20132.47), overall cancer (OR: 1.64; 95% CI: 1.58\u20131.71), head and neck cancer (OR: 1.60; 95% CI: 1.31\u20131.96) and premature mortality (OR: 1.42; 95% CI: 1.36\u20131.48). Median CRP levels were higher in the periodontitis group (39.30 vs. 35.79;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Periodontitis is associated with significantly increased adverse systemic health outcomes and higher mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>These findings underscore the importance of preventive oral care and enhanced patient surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-025-06710-w","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T04:33:59Z","timestamp":1766205239000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The systemic impact of periodontitis in about 100,000 patients: associations with heart diseases, cancer, and mortality"],"prefix":"10.1007","volume":"30","author":[{"given":"Friederike","family":"Weinbecker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Nahles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Preissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Heiland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kernen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Preissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"issue":"1","key":"6710_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/0022034520952401","volume":"100","author":"M Romandini","year":"2021","unstructured":"Romandini M, Baima G, Antonoglou G, Bueno J, Figuero E, Sanz M (2021) Periodontitis, Edentulism, and risk of mortality: A systematic review with Meta-analyses. 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