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We examined the association between anterior malocclusions and tooth loss\u2013related outcomes in a large-scale, community-based sample of Japanese adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      This cross-sectional study targeted 17,349 participants aged\u2009\u2265\u200940 years from the Tohoku Medical Megabank Cohort Study (2013\u20132017). Based on overjet and overbite, participants were classified into normal occlusion (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916,790), anterior open bite (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009177), anterior crossbite (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009348), and combined malocclusion (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934). Outcomes included\u2009\u2264\u200919 remaining natural teeth and posterior tooth loss. Adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using modified Poisson regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The crossbite group demonstrated a higher prevalence of \u2264\u200919 remaining teeth (PR, 1.48; 95% CI, 1.04\u20132.10) and posterior tooth loss (PR, 1.14; 95% CI, 1.07\u20131.20) than the normal group; the open bite group exhibited a lower prevalence of posterior tooth loss (PR, 0.79; 95% CI, 0.69\u20130.90). Heatmap analysis revealed lower molar tooth retention in the crossbite group and higher retention in the open bite group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anterior crossbite is associated with increased posterior tooth loss, whereas open bite shows a weaker association. These findings suggest that specific anterior malocclusions may be linked to reduced tooth retention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Identification of anterior malocclusion types, particularly anterior crossbite, may help identify individuals at higher risk for tooth loss. Orthodontic management of anterior crossbite might support posterior dentition preservation and long-term oral function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-025-06715-5","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:58:10Z","timestamp":1767837490000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of anterior crossbite and open bite with the number of remaining teeth: A cross-sectional study from the Tohoku medical megabank cohort"],"prefix":"10.1007","volume":"30","author":[{"given":"Kento","family":"Numazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Tamahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamasa","family":"Komiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Numazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Kanetaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"6715_CR1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1177\/14653125211042891","volume":"49","author":"R Leck","year":"2022","unstructured":"Leck R, Paul N, Rolland S, Birnie D (2022) The consequences of living with a severe malocclusion: A review of the literature. 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