{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:38:56Z","timestamp":1788781136535,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-026-06752-8","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:12:03Z","timestamp":1771395123000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Probiotic supplementation and dental caries prevention in children and adolescents: a systematic review of strain-specific and context-dependent effects"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-3592","authenticated-orcid":false,"given":"Gonzalo","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-4648","authenticated-orcid":false,"given":"Eduardo","family":"Fern\u00e1ndez Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-4429","authenticated-orcid":false,"given":"Alain","family":"Chaple Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-2569","authenticated-orcid":false,"given":"Rafael","family":"Contador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-8308","authenticated-orcid":false,"given":"Cristian","family":"Bersezio Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1868-0318","authenticated-orcid":false,"given":"Rodrigo","family":"Cabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"6752_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fped.2017.00157","volume":"5","author":"S Anil","year":"2017","unstructured":"Anil S, Anand PS (2017) Early childhood caries: Prevalence, risk Factors, and prevention. Front Pead 5:157. https:\/\/doi.org\/10.3389\/fped.2017.00157","journal-title":"Front Pead"},{"key":"6752_CR2","first-page":"289","volume":"30","author":"AI Ismail","year":"2008","unstructured":"Ismail AI, Lim S, Sohn W, Willem JM (2008) Determinants of early childhood caries in low-income African American young children. Pediatr Dent 30:289\u2013296","journal-title":"Pediatr Dent"},{"key":"6752_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41368-022-00186-0","volume":"14","author":"J Zou","year":"2022","unstructured":"Zou J, Du Q, Ge L, Wang J, Wang X, Li Y, Song G, Zhao W, Chen X, Jiang B, Mei Y, Huang Y, Deng S, Zhang H, Li Y, Zhou X (2022) Expert consensus on early childhood caries management. Int J Oral Sci 14:35. https:\/\/doi.org\/10.1038\/s41368-022-00186-0","journal-title":"Int J Oral Sci"},{"key":"6752_CR4","doi-asserted-by":"publisher","unstructured":"Han SY, Chang CL, Wang YL, Wang CS, Lee WJ, Vo TTT, Chen YL, Cheng CY, Lee IT (2025) A narrative review on advancing pediatric oral health: Comprehensive strategies for the prevention and management of dental challenges in children. Children (Basel, Switzerland) 12. https:\/\/doi.org\/10.3390\/children12030286","DOI":"10.3390\/children12030286"},{"key":"6752_CR5","doi-asserted-by":"publisher","first-page":"8651","DOI":"10.1002\/fsn3.4473","volume":"12","author":"M Banakar","year":"2024","unstructured":"Banakar M, Fernandes GVO, Etemad-Moghadam S, Frankenberger R, Pourhajibagher M, Mehran M, Yazdi MH, Haghgoo R, Alaeddini M (2024) The strategic role of biotics in dental caries prevention: A scoping review. Food Sci Nutr 12:8651\u20138674. https:\/\/doi.org\/10.1002\/fsn3.4473","journal-title":"Food Sci Nutr"},{"key":"6752_CR6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41522-024-00488-7","volume":"10","author":"SC Luo","year":"2024","unstructured":"Luo SC, Wei SM, Luo XT, Yang QQ, Wong KH, Cheung PCK, Zhang BB (2024) How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: an oral microbiota perspective. NPJ Biofilms Microbiomes 10:14. https:\/\/doi.org\/10.1038\/s41522-024-00488-7","journal-title":"NPJ Biofilms Microbiomes"},{"key":"6752_CR7","doi-asserted-by":"publisher","first-page":"e12980","DOI":"10.1111\/eos.12980","volume":"132","author":"A Feldmann","year":"2024","unstructured":"Feldmann A, Eidt G, Henz SL, Arthur RA (2024) Probiotics-containing beverages and dental caries: A systematic review and meta-analysis. Eur J Oral Sci 132:e12980. https:\/\/doi.org\/10.1111\/eos.12980","journal-title":"Eur J Oral Sci"},{"key":"6752_CR8","doi-asserted-by":"publisher","unstructured":"Maftei NM, Raileanu CR, Balta AA, Ambrose L, Boev M, Marin DB, Lisa EL (2024) The potential impact of probiotics on human health: An update on their health-promoting properties. Microorganisms 12. https:\/\/doi.org\/10.3390\/microorganisms12020234","DOI":"10.3390\/microorganisms12020234"},{"key":"6752_CR9","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1007\/s12602-020-09652-9","volume":"12","author":"BS Sivamaruthi","year":"2020","unstructured":"Sivamaruthi BS, Kesika P, Chaiyasut C (2020) A review of the role of probiotic supplementation in dental caries. Probiotics Antimicrob Proteins 12:1300\u20131309. https:\/\/doi.org\/10.1007\/s12602-020-09652-9","journal-title":"Probiotics Antimicrob Proteins"},{"key":"6752_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41432-024-01068-1","volume":"25","author":"M Robertson","year":"2024","unstructured":"Robertson M (2024) PRO-biotics? Are pre- and probiotics a valuable adjunct to fluoridated toothpaste in the battle against dental decay? Evid-Based Dent 25:39\u201340. https:\/\/doi.org\/10.1038\/s41432-024-01068-1","journal-title":"Evid-Based Dent"},{"key":"6752_CR11","doi-asserted-by":"publisher","unstructured":"Mathipa-Mdakane MG, Thantsha MS (2022) Lacticaseibacillus rhamnosus: A suitable candidate for the construction of novel bioengineered probiotic strains for targeted pathogen Control. Foods (Basel, Switzerland) 11. https:\/\/doi.org\/10.3390\/foods11060785","DOI":"10.3390\/foods11060785"},{"key":"6752_CR12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/microorganisms13010045","volume":"13","author":"Z Liu","year":"2025","unstructured":"Liu Z, Cao Q, Wang W, Wang B, Yang Y, Xian CJ, Li T, Zhai Y (2025) The impact of Lactobacillus reuteri on oral and systemic health: A comprehensive review of recent research. Microorganisms 13:45","journal-title":"Microorganisms"},{"key":"6752_CR13","doi-asserted-by":"publisher","first-page":"259","DOI":"10.5005\/jp-journals-10005-2527","volume":"16","author":"HP Salim","year":"2023","unstructured":"Salim HP, Mallikarjun SB, Raju S, Surendranath AR (2023) Randomized clinical trial of oral probiotic Streptococcus salivarius M18 on salivary Streptococcus mutans in preprimary children. Int J Clin Pediatr Dentistry 16:259\u2013263. https:\/\/doi.org\/10.5005\/jp-journals-10005-2527","journal-title":"Int J Clin Pediatr Dentistry"},{"key":"6752_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1159\/000504164","volume":"54","author":"A Zare Javid","year":"2020","unstructured":"Zare Javid A, Amerian E, Basir L, Ekrami A, Haghighizadeh MH, Maghsoumi-Norouzabad L (2020) Effects of the consumption of probiotic yogurt containing bifidobacterium lactis Bb12 on the levels of Streptococcus mutans and lactobacilli in saliva of students with initial stages of dental caries: a double-blind randomized controlled trial. Caries Res 54:68\u201374. https:\/\/doi.org\/10.1159\/000504164","journal-title":"Caries Res"},{"key":"6752_CR15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12903-024-03893-8","volume":"24","author":"PC Lopes","year":"2024","unstructured":"Lopes PC, Gomes A, Mendes K, Blanco L, Correia MJ (2024) Unlocking the potential of probiotic administration in caries management: a systematic review. BMC Oral Health 24:216. https:\/\/doi.org\/10.1186\/s12903-024-03893-8","journal-title":"BMC Oral Health"},{"key":"6752_CR16","doi-asserted-by":"publisher","first-page":"9977","DOI":"10.1080\/10408398.2022.2077693","volume":"63","author":"J Shi","year":"2023","unstructured":"Shi J, Wang Q, Ruan G, Chen Y, Zhao M, Shi D, Pan B, Xu Z, Zhang T, Wang F, Xu C (2023) Efficacy of probiotics against dental caries in children: a systematic review and meta-analysis. Crit Rev Food Sci Nutr 63:9977\u20139994. https:\/\/doi.org\/10.1080\/10408398.2022.2077693","journal-title":"Crit Rev Food Sci Nutr"},{"key":"6752_CR17","doi-asserted-by":"publisher","first-page":"e0322027","DOI":"10.1371\/journal.pone.0322027","volume":"20","author":"J Lim","year":"2025","unstructured":"Lim J, Carle AC, Carpiano RM, Chi DL (2025) Topical fluoride hesitancy and opposition are significantly and positively associated: A cross-sectional study. PLoS ONE 20:e0322027. https:\/\/doi.org\/10.1371\/journal.pone.0322027","journal-title":"PLoS ONE"},{"key":"6752_CR18","doi-asserted-by":"publisher","first-page":"e0282834","DOI":"10.1371\/journal.pone.0282834","volume":"18","author":"DL Chi","year":"2023","unstructured":"Chi DL, Kerr D, Pati\u00f1o Nguyen D, Shands ME, Cruz S, Edwards T, Carle A, Carpiano R, Lewis F (2023) A conceptual model on caregivers\u2019 hesitancy of topical fluoride for their children. PLoS ONE 18:e0282834. https:\/\/doi.org\/10.1371\/journal.pone.0282834","journal-title":"PLoS ONE"},{"key":"6752_CR19","doi-asserted-by":"publisher","first-page":"228080002513764","DOI":"10.1177\/22808000251376427","volume":"23","author":"MZI Nizami","year":"2025","unstructured":"Nizami MZI, Chu S, Chu S, Chu CH (2025) Probiotics for caries prevention: A narrative review. J Appl Biomater Funct Mater 23:22808000251376427. https:\/\/doi.org\/10.1177\/22808000251376427","journal-title":"J Appl Biomater Funct Mater"},{"key":"6752_CR20","doi-asserted-by":"publisher","unstructured":"Nasser M, Kumbargere S, Uhm S, Eachempati P, Bhaumik S (2025) Do we need systematic reviews of research priority setting? A proposal for a new concept on conducting systematic reviews of research priority setting exercises. Authorea March 01, 2025. https:\/\/doi.org\/10.22541\/au.174081962.27718420\/v1","DOI":"10.22541\/au.174081962.27718420\/v1"},{"key":"6752_CR21","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hr\u00f3bjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"6752_CR22","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.11124\/jbies-23-00139","volume":"21","author":"K Kolaski","year":"2023","unstructured":"Kolaski K, Logan LR, Ioannidis JPA (2023) Guidance to best tools and practices for systematic reviews. JBI Evid Synthesis 21:1699\u20131731. https:\/\/doi.org\/10.11124\/jbies-23-00139","journal-title":"JBI Evid Synthesis"},{"key":"6752_CR23","doi-asserted-by":"publisher","first-page":"e2165","DOI":"10.1002\/hsr2.2165","volume":"7","author":"SA Nejadghaderi","year":"2024","unstructured":"Nejadghaderi SA, Balibegloo M, Rezaei N (2024) The Cochrane risk of bias assessment tool 2 (RoB 2) versus the original rob: A perspective on the pros and cons. Health Sci Rep 7:e2165. https:\/\/doi.org\/10.1002\/hsr2.2165","journal-title":"Health Sci Rep"},{"key":"6752_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1177\/0022034515623935","volume":"95","author":"G Rodr\u00edguez","year":"2016","unstructured":"Rodr\u00edguez G, Ruiz B, Faleiros S, Vistoso A, Marr\u00f3 ML, S\u00e1nchez J, Urz\u00faa I, Cabello R (2016) Probiotic compared with standard milk for high-caries children: a cluster randomized trial. J Dent Res 95:402\u2013407. https:\/\/doi.org\/10.1177\/0022034515623935","journal-title":"J Dent Res"},{"key":"6752_CR25","doi-asserted-by":"publisher","first-page":"3823","DOI":"10.1007\/s00784-020-03712-8","volume":"25","author":"F Sandoval","year":"2021","unstructured":"Sandoval F, Faleiros S, Cabello R, D\u00edaz-Dosque M, Rodr\u00edguez G, Escobar A (2021) The consumption of milk supplemented with probiotics decreases the occurrence of caries and the salivary concentration of h\u03b2D-3 in children. Clin Oral Invest 25:3823\u20133830. https:\/\/doi.org\/10.1007\/s00784-020-03712-8","journal-title":"Clin Oral Invest"},{"key":"6752_CR26","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1007\/s00784-019-03095-5","volume":"24","author":"C Manmontri","year":"2020","unstructured":"Manmontri C, Nirunsittirat A, Piwat S, Wattanarat O, Pahumunto N, Makeudom A, Sastraruji T, Krisanaprakornkit S, Teanpaisan R (2020) Reduction of Streptococcus mutans by probiotic milk: a multicenter randomized controlled trial. Clin Oral Invest 24:2363\u20132374. https:\/\/doi.org\/10.1007\/s00784-019-03095-5","journal-title":"Clin Oral Invest"},{"key":"6752_CR27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12903-015-0096-5","volume":"15","author":"T Hedayati-Hajikand","year":"2015","unstructured":"Hedayati-Hajikand T, Lundberg U, Eldh C, Twetman S (2015) Effect of probiotic chewing tablets on early childhood caries: a randomized controlled trial. BMC Oral Health 15:112. https:\/\/doi.org\/10.1186\/s12903-015-0096-5","journal-title":"BMC Oral Health"},{"key":"6752_CR28","doi-asserted-by":"publisher","DOI":"10.1159\/000354412","author":"M Stensson","year":"2014","unstructured":"Stensson M, Koch G, Coric S, Abrahamsson TR, Jenmalm MC, Birkhed D, Wendt LK (2014) Oral administration of Lactobacillus reuteri during the first year of life reduces caries prevalence in the primary dentition at 9 years of age. Caries Res. https:\/\/doi.org\/10.1159\/000354412","journal-title":"Caries Res"},{"key":"6752_CR29","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/171895","author":"D Olczak-Kowalczyk","year":"2024","unstructured":"Olczak-Kowalczyk D, Turska-Szybka A, Twetman S, Gozdowski D, Piekoszewska-Zietek P, Gora J, Wroblewska M (2024) Effect of tablets containing a paraprobiotic strain and the cranberry extract on caries incidence in preschool children: A randomized controlled trial. Dent Med Probl. https:\/\/doi.org\/10.17219\/dmp\/171895EA JUL 2024","journal-title":"Dent Med Probl"},{"issue":"19","key":"6752_CR30","doi-asserted-by":"publisher","first-page":"12447","DOI":"10.3390\/ijerph191912447","volume":"19","author":"M Staszczyk","year":"2022","unstructured":"Staszczyk M, Jamka-Kasprzyk M, Ko\u015bcielniak D, Cienkosz-Stepa\u0144czak B, Krzy\u015bciak W, Jurczak A (2022) Effect of a short-term intervention with Lactobacillus salivarius probiotic on early childhood caries: an open-label randomized controlled trial. Int J Environ Res Public Health 19(19):12447. https:\/\/doi.org\/10.3390\/ijerph191912447","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"6752_CR31","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s12602-022-09913-9","volume":"14","author":"P Hassl\u00f6f","year":"2022","unstructured":"Hassl\u00f6f P, Granqvist L, Stecks\u00e9n-Blicks C, Twetman S (2022) Prevention of recurrent childhood caries with probiotic supplements: a randomized controlled trial with a 12-month follow-up. Probiotics Antimicrob Proteins 14(2):384\u2013390. https:\/\/doi.org\/10.1007\/s12602-022-09913-9","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"5","key":"6752_CR32","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1159\/000348424","volume":"47","author":"T Taipale","year":"2013","unstructured":"Taipale T, Pienih\u00e4kkinen K, Alanen P, Jokela J, S\u00f6derling E (2013) Administration of bifidobacterium animalis subsp. Lactis BB-12 in early childhood: a post-trial effect on caries occurrence at four years of age. Caries Res 47(5):364\u2013372. https:\/\/doi.org\/10.1159\/000348424","journal-title":"Caries Res"},{"key":"6752_CR33","doi-asserted-by":"publisher","first-page":"104670","DOI":"10.1016\/j.jdent.2023.104670","volume":"137","author":"CJ P\u00f8rksen","year":"2023","unstructured":"P\u00f8rksen CJ, Ekstrand KR, Markvart M, Larsen T, Garrido LE, Bakhshandeh A (2023) The efficacy of combined arginine and probiotics as an add-on to 1450 Ppm fluoride toothpaste to prevent and control dental caries in children: a randomized controlled trial. J Dent 137:104670. https:\/\/doi.org\/10.1016\/j.jdent.2023.104670","journal-title":"J Dent"},{"issue":"1","key":"6752_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/ejo\/cjv015","volume":"38","author":"S Gizani","year":"2016","unstructured":"Gizani S, Petsi G, Twetman S, Caroni C, Makou M, Papagianoulis L (2016) Effect of the probiotic bacterium Lactobacillus reuteri on white spot lesion development in orthodontic patients. Eur J Orthod 38(1):85\u201389. https:\/\/doi.org\/10.1093\/ejo\/cjv015","journal-title":"Eur J Orthod"},{"key":"6752_CR35","doi-asserted-by":"publisher","unstructured":"Cabello R, Faleiros S, D\u00edaz-Dosque M, Ruiz B, Contador R, Moreno B Godoy EF and Mart\u00ednez GR effect of probiotic supplementation on the progression of non-cavitated carious lesions in children: A 12-month randomized controlled trial. Eur J Oral Sci n\/a e70061. https:\/\/doi.org\/10.1111\/eos.70061","DOI":"10.1111\/eos.70061"},{"issue":"5\u20136","key":"6752_CR36","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1159\/000509926","volume":"54","author":"S Piwat","year":"2020","unstructured":"Piwat S, Teanpaisan R, Manmontri C, Wattanarat O, Pahumunto N, Makeudom A, Krisanaprakornkit S, Nirunsittirat A (2020) Efficacy of probiotic milk for caries regression in preschool children: a multicenter randomized controlled trial. Caries Res 54(5\u20136):491\u2013501. https:\/\/doi.org\/10.1159\/000509926","journal-title":"Caries Res"},{"key":"6752_CR37","doi-asserted-by":"publisher","first-page":"38","DOI":"10.2174\/1874285800802010038","volume":"2","author":"C Badet","year":"2008","unstructured":"Badet C, Thebaud NB (2008) Ecology of lactobacilli in the oral cavity: a review of literature. Open Microbiol J 2:38\u201348. https:\/\/doi.org\/10.2174\/1874285800802010038","journal-title":"Open Microbiol J"},{"issue":"6","key":"6752_CR38","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1159\/000350524","volume":"47","author":"P Hassl\u00f6f","year":"2013","unstructured":"Hassl\u00f6f P, West CE, Karlsson Videhult F, Brandelius C, Stecks\u00e9n-Blicks C (2013) Early intervention with probiotic Lactobacillus paracasei F19 has no long-term effect on caries experience. Caries Res 47(6):559\u2013565. https:\/\/doi.org\/10.1159\/000350524","journal-title":"Caries Res"},{"key":"6752_CR39","doi-asserted-by":"publisher","unstructured":"Ebrahim F, Malek S, James K, MacDonald K, Cadieux P, Burton J, Cioffi I, Levesque C, Gong S, Ebrahim F, Malek S, James K, MacDonald K, Cadieux P, Burton J, Cioffi I, Levesque C, Gong S-G (2022) Effectiveness of the Lorodent probiotic lozenge in reducing plaque and <\u2009i\u2009>\u2009Streptococcus mutans\u2009Levels in orthodontic patients: A Double-Blind randomized control trial. Front Oral Health 3. https:\/\/doi.org\/10.3389\/froh.2022.884683","DOI":"10.3389\/froh.2022.884683"},{"key":"6752_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-025-10646-8","author":"Y Yang","year":"2025","unstructured":"Yang Y, Sui J, Liao W, Wang S, Pan D, Sun G, Gao P, Xiang X, Xia H (2025) Clinical evidence on the health benefits and safety of probiotic Lacticaseibacillus rhamnosus: A systematic review. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-025-10646-8","journal-title":"Probiotics Antimicrob Proteins"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06752-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-026-06752-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06752-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T21:01:59Z","timestamp":1772485319000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-026-06752-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["6752"],"URL":"https:\/\/doi.org\/10.1007\/s00784-026-06752-8","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"assertion":[{"value":"1 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"N\/A","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"N\/A","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"82"}}