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Participants received three protocols:\n                      <jats:bold>GLU<\/jats:bold>\n                      : 3% potassium nitrate\u2009+\u2009glutaraldehyde\/HEMA desensitizer (control);\n                      <jats:bold>GAS<\/jats:bold>\n                      : 3% potassium nitrate\u2009+\u2009glutaraldehyde\/HEMA desensitizer\u2009+\u2009universal adhesive; and\n                      <jats:bold>GAR<\/jats:bold>\n                      : 3% potassium nitrate\u2009+\u2009glutaraldehyde\/HEMA desensitizer\u2009+\u2009universal adhesive\u2009+\u2009bulk-fill flowable resin. Pain intensity was recorded using the Numeric Rating Scale (NRS; 0\u201310) after standardized air-blast and tactile stimuli at baseline, immediately after intervention, and at 7, 30, 90, and 180 days. OHRQoL was assessed using OHIP-14 at baseline, 90, and 180 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NRS scores decreased over time for both stimuli (air-blast:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; tactile:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No differences were observed among protocols (air-blast:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.910; tactile:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.681) and no time \u00d7 protocol interaction was detected (air-blast:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.341; tactile:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.738). OHIP-14 scores improved at 90 and 180 days versus baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The three protocols produced comparable patient-centered outcomes, indicating that adding adhesive and resin steps to potassium nitrate\u2009+\u2009glutaraldehyde\/HEMA does not enhance DH pain control or OHRQoL up to 180 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Increasing complexity with adhesive and resin steps was not associated with superior patient-centered outcomes within 180 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration number<\/jats:title>\n                    <jats:p>RBR-109h3wcv.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-06776-0","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:48:37Z","timestamp":1772246917000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of different material protocols on the control of dentin hypersensitivity: a split-mouth randomized controlled clinical trial"],"prefix":"10.1007","volume":"30","author":[{"given":"J\u00falia Marques","family":"Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda Ferreira","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Jos\u00e9 Pimentel Lopes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Coelho","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo C\u00e9sar","family":"de Freitas Santos Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Lemes","family":"Carlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Jos\u00e9","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele Rodrigues","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"6776_CR1","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1111\/j.1600-051x.1997.tb01194.x","volume":"24","author":"GR Holland","year":"1997","unstructured":"Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R (1997) Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. 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