{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:59:39Z","timestamp":1781647179338,"version":"3.54.5"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the oral health status and dental treatment needs in a cohort of children and adults with different types of Epidermolysis Bullosa (EB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional study was designed. 101 participants with EB (EB Simplex\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926, Junctional EB\u2009=\u20096, Dominant Dystrophic EB (DDEB)\u2009=\u200920, Recessive Dystrophic EB (RDEB)\u2009=\u200947, Kindler EB\u2009=\u20092) were assessed including simplified debris index (DI-S), Basic Periodontal Examination (BPE), Decay\/Missing\/Filled Teeth index (DMFT\/deft index) and Orthodontic index of complexity, outcome and need (ICON). Treatment needs were classified into preventive, periodontics, restorative, endodontics, orthodontics, prosthodontics, oral surgery, oral pathology, oral radiology, speech therapy and others. Descriptive and statistical analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sample showed a Debris Index of 2.04\u2009\u00b1\u20090.8, with higher levels in participants with recessive dystrophic EB (2.34\u2009\u00b1\u20090.7). 15.1% of the total sample (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) showed a BPE value of 3 or 4. DMFT was 11.2\u2009\u00b1\u20090.1, while 30.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928\/93) showed an ICON value of 43 or higher. Treatment needs were high, with a median of 3 referrals per patient, with the highest needs in restorative dentistry (\n                      <jats:italic>n<\/jats:italic>\n                      =55, 54.5%), prosthodontics (\n                      <jats:italic>n<\/jats:italic>\n                      =52, 51.5%), and speech\/oral function therapy (\n                      <jats:italic>n<\/jats:italic>\n                      =43, 42.6%). By EB type, junctional EB (3.67\u00b10.52) and recessive dystrophic EB (3.34\u00b11.03) showed the highest need for referrals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral health status among people living with EB differed across major types. Patients with recessive dystrophic EB were associated with poorer oral hygiene, a higher caries experience and more missing teeth, whereas those with junctional EB were associated with a higher number of restored teeth. On the opposite, those with simplex EB and dominant dystrophic EB were associated with more favourable oral health indicator. The greatest referral needs were for restorative dentistry, prosthodontics and speech therapy, with higher referral needs observed among EB subtypes with high risk of oral disease (recessive dystrophic EB, junctional EB and Kindler EB). Older age was associated with periodontics and prosthodontics referral needs, while male participants were associated with a higher need for speech therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>This research seems to indicate that patients with recessive dystrophic EB and junctional EB are at high risk of oral disease, requiring referrals to at least 3 different dental specialities. In addition to paediatric dentists, special care dentists and orthodontists, dental teams caring for patients with EB should include specialists in restorative dentistry and prosthodontics, with access to consultants in speech and language therapy, endodontics and periodontics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-06779-x","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:59:51Z","timestamp":1775786391000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral status and dental treatment needs in patients with Epidermolysis Bullosa - a cross-sectional study"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1893-3007","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"V\u00e9liz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1483-401X","authenticated-orcid":false,"given":"Pedro","family":"Diz-Dios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7966-2707","authenticated-orcid":false,"given":"Colomba","family":"Besa-Witto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8510-4022","authenticated-orcid":false,"given":"Susanne","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"6779_CR1","doi-asserted-by":"publisher","unstructured":"Has C, Bauer JW, Bodemer C et al (2020) Consensus reclassification of inherited epidermolysis bullosa and other disorders with skin fragility. Br J Dermatol bjd 18921. https:\/\/doi.org\/10.1111\/bjd.18921","DOI":"10.1111\/bjd.18921"},{"key":"6779_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41572-020-0210-0","volume":"6","author":"A Bardhan","year":"2020","unstructured":"Bardhan A, Bruckner-Tuderman L, Chapple ILC et al (2020) Epidermolysis bullosa. Nat Rev Dis Primer 6:78. https:\/\/doi.org\/10.1038\/s41572-020-0210-0","journal-title":"Nat Rev Dis Primer"},{"key":"6779_CR3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/00005792-199205000-00002","volume":"71","author":"GA Ergun","year":"1992","unstructured":"Ergun GA, Lin AN, Dannenberg AJ, Carter DM (1992) Gastrointestinal manifestations of epidermolysis bullosa. A study of 101 patients. Med (Baltim) 71:121\u2013127. https:\/\/doi.org\/10.1097\/00005792-199205000-00002","journal-title":"Med (Baltim)"},{"key":"6779_CR4","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.bjps.2021.05.056","volume":"75","author":"L Abboud","year":"2022","unstructured":"Abboud L, Leclerc-Mercier S, Bodemer C, Gu\u00e9ro S (2022) Hand surgery in recessive dystrophic epidermolysis bullosa: Our experience with dermal substitutes. J Plast Reconstr Aesthet Surg 75:314\u2013324. https:\/\/doi.org\/10.1016\/j.bjps.2021.05.056","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"6779_CR5","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12916-014-0178-2","volume":"12","author":"KR Goldschneider","year":"2014","unstructured":"Goldschneider KR, Good J, Harrop E et al (2014) Pain care for patients with epidermolysis bullosa: best care practice guidelines. BMC Med 12:178. https:\/\/doi.org\/10.1186\/s12916-014-0178-2","journal-title":"BMC Med"},{"key":"6779_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/scd.12511","volume":"40","author":"S Kr\u00e4mer","year":"2020","unstructured":"Kr\u00e4mer S, Lucas J, Gamboa F et al (2020) Clinical practice guidelines: Oral health care for children and adults living with epidermolysis bullosa. Spec Care Dentist 40:3\u201381. https:\/\/doi.org\/10.1111\/scd.12511","journal-title":"Spec Care Dentist"},{"key":"6779_CR7","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/j.jaad.2020.03.117","volume":"83","author":"S Kr\u00e4mer","year":"2020","unstructured":"Kr\u00e4mer S, Fuentes I, Yubero MJ et al (2020) Absence of tongue papillae as a clinical criterion for the diagnosis of generalized recessive dystrophic epidermolysis bullosa types. J Am Acad Dermatol 83:1815\u20131816. https:\/\/doi.org\/10.1016\/j.jaad.2020.03.117","journal-title":"J Am Acad Dermatol"},{"key":"6779_CR8","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1034\/j.1601-0825.2003.03971.x","volume":"9","author":"MC Serrano-Mart\u00ednez","year":"2003","unstructured":"Serrano-Mart\u00ednez MC, Bag\u00e1n JV, Silvestre FJ, Viguer MT (2003) Oral lesions in recessive dystrophic epidermolysis bullosa. Oral Dis 9:264\u2013268","journal-title":"Oral Dis"},{"key":"6779_CR9","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1684\/ejd.2011.1356","volume":"21","author":"C Stellingsma","year":"2011","unstructured":"Stellingsma C, Dijkstra PU, Dijkstra J et al (2011) Restrictions in oral functions caused by oral manifestations of epidermolysis bullosa. Eur J Dermatol 21:405\u2013409. https:\/\/doi.org\/10.1684\/ejd.2011.1356","journal-title":"Eur J Dermatol"},{"key":"6779_CR10","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/0003-9969(93)90107-W","volume":"38","author":"JT Wright","year":"1993","unstructured":"Wright JT, Johnson LB, Fine JD (1993) Development defects of enamel in humans with hereditary epidermolysis bullosa. Arch Oral Biol 38:945\u2013955","journal-title":"Arch Oral Biol"},{"key":"6779_CR11","doi-asserted-by":"publisher","unstructured":"Urz\u00faa B, Kr\u00e4mer S, Morales-Bozo I et al (2021) Case report: Crown resorption in a patient with junctional epidermolysis bullosa and amelogenesis imperfecta with LAMB3 gene mutations. https:\/\/doi.org\/10.3389\/fdmed.2021.704423. Front Dent Med 2:","DOI":"10.3389\/fdmed.2021.704423"},{"key":"6779_CR12","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1001\/jamadermatol.2024.0065","volume":"160","author":"S Kr\u00e4mer","year":"2024","unstructured":"Kr\u00e4mer S, Hillebrecht AL, Wang Y et al (2024) Orofacial Anomalies in Kindler Epidermolysis Bullosa. JAMA Dermatol 160:544\u2013549. https:\/\/doi.org\/10.1001\/jamadermatol.2024.0065","journal-title":"JAMA Dermatol"},{"key":"6779_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1902\/jop.2003.74.1.25","volume":"74","author":"CB Wiebe","year":"2003","unstructured":"Wiebe CB, Penagos H, Luong N et al (2003) Clinical and Microbiologic Study of Periodontitis Associated With Kindler Syndrome. J Periodontol 74:25\u201331. https:\/\/doi.org\/10.1902\/jop.2003.74.1.25","journal-title":"J Periodontol"},{"key":"6779_CR14","doi-asserted-by":"publisher","unstructured":"Kr\u00e4mer S, Hillebrecht AL, Bekes K et al (2024) Oral health care pathways for patients with epidermolysis bullosa: A position statement from the European reference network for rare skin diseases. J Eur Acad Dermatol Venereol jdv 20498. https:\/\/doi.org\/10.1111\/jdv.20498","DOI":"10.1111\/jdv.20498"},{"key":"6779_CR15","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/scd.12515","volume":"40","author":"S V\u00e9liz","year":"2020","unstructured":"V\u00e9liz S, Huber H, Yubero MJ et al (2020) Early teeth extraction in patients with generalized recessive dystrophic epidermolysis bullosa: A case series. Spec Care Dentist 40:561\u2013565. https:\/\/doi.org\/10.1111\/scd.12515","journal-title":"Spec Care Dentist"},{"key":"6779_CR16","doi-asserted-by":"publisher","unstructured":"V\u00e9liz S, Olivares A, Kr\u00e4mer S (2024) Mini-implant assisted palate expansion and digital design in junctional epidermolysis bullosa and amelogenesis imperfecta: Case report. Spec Care Dentist n\/a. https:\/\/doi.org\/10.1111\/scd.13044","DOI":"10.1111\/scd.13044"},{"key":"6779_CR17","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12808","author":"S V\u00e9liz M\u00e9ndez","year":"2022","unstructured":"V\u00e9liz M\u00e9ndez S, Baeza M, Kr\u00e4mer Strenger S (2022) Impression technique modification and oral contracture release surgery for orthodontic treatment in a patient with severe microstomia due to recessive dystrophic epidermolysis bullosa. Spec Care Dentist. https:\/\/doi.org\/10.1111\/scd.12808","journal-title":"Spec Care Dentist"},{"key":"6779_CR18","doi-asserted-by":"publisher","unstructured":"V\u00e9lizM\u00e9ndez S, Baeza Paredes M, Olivares A et al (2023) Comprehensive orthodontic treatment using miniscrews and digital rehabilitation in a patient with severe recessive dystrophic epidermolysis bullosa. Spec Care Dent Off Publ Am Assoc Hosp Dent Acad Dent Handicap Am Soc Geriatr Dent. https:\/\/doi.org\/10.1111\/scd.12947","DOI":"10.1111\/scd.12947"},{"key":"6779_CR19","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1754-4505.2008.00028.x","volume":"28","author":"W Pacheco","year":"2008","unstructured":"Pacheco W, Marques de Sousa Araugio R (2008) Orthodontic treatment of a patient with recessive dystrophic epidermolysis bullosa: a case report. Spec Care Dentist 28:136\u2013139. https:\/\/doi.org\/10.1111\/j.1754-4505.2008.00028.x","journal-title":"Spec Care Dentist"},{"key":"6779_CR20","first-page":"48","volume":"6","author":"C Serrano Mart\u00ednez","year":"2001","unstructured":"Serrano Mart\u00ednez C, Silvestre Donat FJ, Bag\u00e1n Sebasti\u00e1n JV et al (2001) Epiderm\u00f3lisis ampollosa hereditaria a prop\u00f3sito del manejo odontol\u00f3gico de tres casos cl\u00ednicos. Med Oral 6:48\u201356","journal-title":"Med Oral"},{"key":"6779_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.17796\/1053-4625-45.1.8","volume":"45","author":"I Blanchet","year":"2021","unstructured":"Blanchet I, Tardieu C, Casazza E (2021) Oral Care in Kindler Syndrome: 7-Year Follow-up of 2 Brothers. J Clin Pediatr Dent 45:41\u201347. https:\/\/doi.org\/10.17796\/1053-4625-45.1.8","journal-title":"J Clin Pediatr Dent"},{"key":"6779_CR22","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1902\/jop.1999.70.11.1392","volume":"70","author":"JH Brain","year":"1999","unstructured":"Brain JH, Paul BF, Assad DA (1999) Periodontal Plastic Surgery in a Dystrophic Epidermolysis Bullosa Patient: Review and Case Report. J Periodontol 70:1392\u20131396. https:\/\/doi.org\/10.1902\/jop.1999.70.11.1392","journal-title":"J Periodontol"},{"issue":"4","key":"6779_CR23","first-page":"651","volume":"22","author":"M Pe\u00f1arrocha","year":"2007","unstructured":"Pe\u00f1arrocha M, Larraz\u00e1bal C, Balaguer J et al (2007) Restoration with implants in patients with recessive dystrophic epidermolysis bullosa and patient satisfaction with the implant-supported superstructure. Int J Oral Maxillofac Implants 22(4):651\u2013655","journal-title":"Int J Oral Maxillofac Implants"},{"key":"6779_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.prosdent.2006.12.010","volume":"97","author":"H Lee","year":"2007","unstructured":"Lee H, Al Mardini M, Ercoli C, Smith MN (2007) Oral rehabilitation of a completely edentulous epidermolysis bullosa patient with an implant-supported prosthesis: a clinical report. J Prosthet Dent 97:65\u201369. https:\/\/doi.org\/10.1016\/j.prosdent.2006.12.010","journal-title":"J Prosthet Dent"},{"key":"6779_CR25","doi-asserted-by":"publisher","first-page":"383","DOI":"10.2340\/00015555-2512","volume":"97","author":"E Sindici","year":"2017","unstructured":"Sindici E, Astesano S, Fazio L et al (2017) Treatment of Oral Lesions in Dystrophic Epidermolysis Bullosa: A Case Series of Cord Blood Platelet Gel and Low-level Laser Therapy. Acta Derm Venereol 97:383\u2013384. https:\/\/doi.org\/10.2340\/00015555-2512","journal-title":"Acta Derm Venereol"},{"key":"6779_CR26","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1186\/s12903-024-04861-y","volume":"24","author":"Z Smith","year":"2024","unstructured":"Smith Z, Nath S, Javanmard M, Salamon Y (2024) The dental needs of children with Epidermolysis Bullosa and service delivery: a scoping review. BMC Oral Health 24:1131. https:\/\/doi.org\/10.1186\/s12903-024-04861-y","journal-title":"BMC Oral Health"},{"key":"6779_CR27","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1093\/bjd\/ljae245","volume":"191","author":"F Palisson","year":"2024","unstructured":"Palisson F, Yubero MJ, Lecaros C et al (2024) Epidemiology of epidermolysis bullosa in Chile. Br J Dermatol 191:835\u2013837. https:\/\/doi.org\/10.1093\/bjd\/ljae245","journal-title":"Br J Dermatol"},{"key":"6779_CR28","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M et al (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453\u20131457. https:\/\/doi.org\/10.1016\/S0140-6736(07)61602-X","journal-title":"Lancet"},{"key":"6779_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.14219\/JADA.ARCHIVE.1964.0034","volume":"68","author":"JC Greene","year":"1964","unstructured":"Greene JC, Vermillion JR (1964) The simplified oral hygiene index. J Am Dent Assoc 1939 68:7\u201313. https:\/\/doi.org\/10.14219\/JADA.ARCHIVE.1964.0034","journal-title":"J Am Dent Assoc 1939"},{"key":"6779_CR30","unstructured":"British Society of Periodontology (2019) Basic Periodontal Examination (BPE). Available at https:\/\/www.bsperio.org.uk\/assets\/downloads\/BSP_BPE_Guidelines_2019.pdf. Accessed: 1 Sept 2025"},{"key":"6779_CR31","doi-asserted-by":"publisher","unstructured":"Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M, Tonetti MS (2018) A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J Periodontol. 89:Suppl 1:S1-S8. https:\/\/doi.org\/10.1002\/JPER.18-0157","DOI":"10.1002\/JPER.18-0157"},{"key":"6779_CR32","unstructured":"World Health Organization (2013) Oral Health Surveys - Basic Methods 5th edition. In: WHO"},{"key":"6779_CR33","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/ortho\/27.2.149","volume":"27","author":"C Daniels","year":"2000","unstructured":"Daniels C, Richmond S (2000) The development of the index of complexity, outcome and need (ICON). J Orthod 27:149\u2013162. https:\/\/doi.org\/10.1093\/ortho\/27.2.149","journal-title":"J Orthod"},{"key":"6779_CR34","doi-asserted-by":"publisher","first-page":"211","DOI":"10.5005\/jp-journals-10024-1829","volume":"17","author":"SC Leal","year":"2016","unstructured":"Leal SC, Lia EN, Amorim R et al (2016) Higher dental caries prevalence and its association with dietary habits and physical limitation in Epidermolysis Bullosa patients: a case control study. J Contemp Dent Pract 17:211\u2013216","journal-title":"J Contemp Dent Pract"},{"issue":"5","key":"6779_CR35","first-page":"313","volume":"42","author":"D Puliyel","year":"2014","unstructured":"Puliyel D, Chiu C, Habibian M (2014) Restorative and periodontal challenges in adults with dystrophic epidermolysis bullosa. J Calif Dent Assoc 42(5):313\u2013318","journal-title":"J Calif Dent Assoc"},{"key":"6779_CR36","doi-asserted-by":"publisher","first-page":"e70084","DOI":"10.1111\/scd.70084","volume":"45","author":"S V\u00e9liz","year":"2025","unstructured":"V\u00e9liz S, Abeleira MT, Serrano MC et al (2025) Orthodontic Treatment in Patients With Epidermolysis Bullosa (EB)-Clinical Practice Guidelines (CPG). Spec Care Dent Off Publ Am Assoc Hosp Dent Acad Dent Handicap. Am Soc Geriatr Dent 45:e70084. https:\/\/doi.org\/10.1111\/scd.70084","journal-title":"Am Soc Geriatr Dent"},{"key":"6779_CR37","first-page":"438","volume":"23","author":"JC Harris","year":"2001","unstructured":"Harris JC, Bryan RA, Lucas VS, Roberts GJ (2001) Dental disease and caries related microflora in children with dystrophic epidermolysis bullosa. Pediatr Dent 23:438\u2013443","journal-title":"Pediatr Dent"},{"key":"6779_CR38","doi-asserted-by":"publisher","first-page":"100140","DOI":"10.1016\/j.dentre.2024.100140","volume":"4","author":"T Iwashimizu","year":"2024","unstructured":"Iwashimizu T, Tabata H, Otsuka H et al (2024) The relationship between periodontal disease and age-related disease. Dent Rev 4:100140. https:\/\/doi.org\/10.1016\/j.dentre.2024.100140","journal-title":"Dent Rev"},{"key":"6779_CR39","unstructured":"Wright JT (1999) Oral Manifestations of Epidermolysis Bullosa. Epidermolysis Bullosa. Clinical, Epidemiologic, and Laboratory Advances and the Findings of the National Epidermolysis Bullosa Registry. Johns Hopkins University, Baltimore, pp 236\u2013256"},{"key":"6779_CR40","doi-asserted-by":"publisher","unstructured":"Besa-WittoC, Ortega\u2010Pinto A, V\u00e9liz S et al (2025) Prevalence of Crown Resorption in Amelogenesis Imperfecta due to Junctional Epidermolysis Bullosa. Oral Dis. https:\/\/doi.org\/10.1111\/odi.15250","DOI":"10.1111\/odi.15250"},{"key":"6779_CR41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.17116\/stomat201594234-36","volume":"94","author":"MV Korolenkova","year":"2015","unstructured":"Korolenkova MV (2015) [Dental treatment in children with dystrophic form of epidermolysis bullosa]. Stomatologiia (Sofiia) 94:34\u201336","journal-title":"Stomatologiia (Sofiia)"},{"key":"6779_CR42","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1093\/ejo\/25.3.279","volume":"25","author":"A Liepa","year":"2003","unstructured":"Liepa A (2003) Orthodontic treatment need in Latvia. Eur J Orthod 25:279\u2013284. https:\/\/doi.org\/10.1093\/ejo\/25.3.279","journal-title":"Eur J Orthod"},{"key":"6779_CR43","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.3390\/healthcare11152202","volume":"11","author":"ID Z\u00fa\u00f1iga-Herrera","year":"2023","unstructured":"Z\u00fa\u00f1iga-Herrera ID, Aguilar-P\u00e9rez FJ, Escoffi\u00e9-Ram\u00edrez M, Herrera-Atoche JR (2023) Malocclusion Complexity in Patients with Disc Displacement Disorders: A Case\u2013Control Study. Healthcare 11:2202. https:\/\/doi.org\/10.3390\/healthcare11152202","journal-title":"Healthcare"},{"key":"6779_CR44","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1186\/s12903-024-04524-y","volume":"24","author":"F Farzanegan","year":"2024","unstructured":"Farzanegan F, Shadmehri SA, Shooshtari Z et al (2024) Evaluating malocclusion patterns in children with autism spectrum disorder using the index of complexity, outcome and need: a cross-sectional study. BMC Oral Health 24:759. https:\/\/doi.org\/10.1186\/s12903-024-04524-y","journal-title":"BMC Oral Health"},{"key":"6779_CR45","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/ejo\/24.1.53","volume":"24","author":"O Hunt","year":"2002","unstructured":"Hunt O (2002) The Aesthetic Component of the Index of Orthodontic Treatment Need validated against lay opinion. Eur J Orthod 24:53\u201359. https:\/\/doi.org\/10.1093\/ejo\/24.1.53","journal-title":"Eur J Orthod"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06779-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-026-06779-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06779-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:43:52Z","timestamp":1781646232000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-026-06779-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["6779"],"URL":"https:\/\/doi.org\/10.1007\/s00784-026-06779-x","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"26 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained at the Ethics Committee of the North Metropolitan Health Service, Chile (002\/2023).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"All participants were asked to sign a consent form to participate. In the case of minors, both the patient and their guardians were asked to sign a consent to participate.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"169"}}