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Oral mucosal biopsies were performed using a standardized protocol. Group allocation was carried out using simple randomization. Participants were assigned to two groups: active PBM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931) and simulated (sham) PBM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931). A single intraoral PBM session (wavelength 940\u00a0nm, output power 0.5\u00a0W) was applied immediately after the biopsy procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences were observed between the groups with respect to pain or inflammation reduction during the 7-day follow-up period. Both variables decreased over time in both groups, with no significant group effect or group\u2013time interaction effect (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.279 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.220, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single session of PBM applied immediately after a soft tissue oral biopsy did not demonstrate additional benefits compared with sham treatment in reducing postoperative pain or inflammation over a 7-day period. Further studies using optimized PBM protocols are needed to better define its potential role in this clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-06791-1","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:13:15Z","timestamp":1771909995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of immediate photobiomodulation on pain and inflammation after oral biopsy: A randomized clinical study"],"prefix":"10.1007","volume":"30","author":[{"given":"Yolanda","family":"Collado-Murcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Parra-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"L\u00f3pez-Jornet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"7","key":"6791_CR1","first-page":"E504","volume":"12","author":"A Mota-Ram\u00edrez","year":"2007","unstructured":"Mota-Ram\u00edrez A, Silvestre FJ, Sim\u00f3 JM (2007) Oral biopsy in dental practice. 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