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After undergoing surgery, participants were randomly assigned to receive either GT\/HA gel or chlorhexidine gel three times daily for 14 days. Clinical parameters (plaque index, probing depth, bleeding on probing, and clinical attachment level) were evaluated at baseline and 60 days postoperatively. Subgingival biofilm samples were collected at baseline and after 14 and 30 days and analyzed using checkerboard DNA\u2013DNA hybridization for 40 bacterial species. Patient-reported outcomes included postoperative pain, analgesic consumption, and quality of life assessed by the OHIP-14 questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both groups showed statistically significant clinical improvements from baseline to 60 days, with no significant differences between treatments. Temporary reductions in some bacterial species were observed during the 14-day gel application period in both groups, followed by regrowth after discontinuation. GT\/HA gel was associated with fewer adverse effects, particularly regarding taste alteration and tooth or tissue staining. A reduction in OHIP-14 scores was observed in both groups, with statistically significant differences between baseline and 30 days after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GT\/HA gel was noninferior to chlorhexidine gel in terms of clinical and microbiological outcomes and showed greater patient tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>GT\/HA gel may represent a safe and effective alternative to chlorhexidine in postoperative care in periodontal surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-06792-0","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T03:28:09Z","timestamp":1771903689000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the effects of a gel containing green tea and hyaluronic acid on clinical and Microbiological outcomes following periodontal surgery. A randomized, controlled, double-blinded, noninferiority trial"],"prefix":"10.1007","volume":"30","author":[{"given":"Laura Sanches","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9ffany Souza","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Jos\u00e9 Pimentel Lopes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Jos\u00e9 Barbosa","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Aparecida Chaves","family":"Furlaneto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Lu\u00eds Scombatti","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"6792_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1600-0765.2006.00883.x","volume":"41","author":"H-K Lu","year":"2006","unstructured":"Lu H-K, Chen Y-L, Chang H-C et al (2006) Identification of the osteoprotegerin\/receptor activator of nuclear factor-kappa B ligand system in gingival crevicular fluid and tissue of patients with chronic periodontitis. 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Furthermore, the study was registered in the Brazilian Clinical Trials Registry (ReBEC - number RBR-475mc4q).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all participants prior to their inclusion in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Fabio Jose Barbosa Bezerra is the Chief Executive Officer (CEO) of New Dental Care, a company that operates in the oral care industry. This professional position is unrelated to the conduct of the research described in the manuscript; however, it is disclosed here in the interest of full transparency.All other authors have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"91"}}