{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:18:54Z","timestamp":1787159934786,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100031447","name":"Solventum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This prospective, randomized, post-market, paired-comparison controlled trial compared the 2-year clinical performance of a new universal adhesive, Scotchbond Universal Plus Adhesive (SBU+), with that of Scotchbond Universal Adhesive (SBU). Both were applied as self-etch (SE) adhesives for composite resin restoration of Class I and Class II preparations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Two posterior teeth in each of 51 subjects were randomized in a 1:1 ratio to a restoration with SBU\u2009+\u2009or to a restoration with SBU (control) applied with the SE strategy. Class I and\/or Class II preparations were restored with Filtek Universal Restorative. Two calibrated and blinded examiners evaluated the restorations at baseline, 6 months, 1 year, and 2 years, using the modified FDI criteria. The Wilcoxon signed-rank test was used to compare the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the 2-year evaluation, retention was 100% for both the SBU\u2009+\u2009and SBU groups. Regarding fracture and retention, 36 of the 37 SBU+ restorations (97%) were graded \u201cClinically Excellent\/Very Good,\u201d while 1\/37 (3%) was graded \u201cClinically Satisfactory.\u201d All 38 SBU restorations (100%) were graded \u201cClinically Excellent\/Very Good\u201d. Marginal adaptation was clinically acceptable for all restorations at 2 years, with no statistically significant difference between the two adhesive materials. Furthermore, no recurrent caries lesions were observed at 2 years, and no restorations received a \u201cClinically Insufficient\/Unsatisfactory\u201d or \u201cClinically Poor\u201d grade for any FDI criteria during any evaluation visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>At 2 years, SBU+ exhibited clinical efficacy similar to its predecessor, SBU, in Class I and Class II restorations in adult patients when using the self-etch (SE) technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Mildly acidic universal dental adhesives may be used for posterior composite restorations without prior phosphoric acid etching.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-06799-7","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:24:29Z","timestamp":1773033869000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prospective, randomized, paired-comparison clinical trial of a new universal adhesive in posterior composite restorations: A 2-year evaluation"],"prefix":"10.1007","volume":"30","author":[{"given":"Jorge","family":"Perdig\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli A.","family":"Trauger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla I.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hooi Pin","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignatius K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacie","family":"Woodis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"6799_CR1","doi-asserted-by":"publisher","first-page":"666379","DOI":"10.3389\/fdmed.2021.666379","volume":"2","author":"T Sato","year":"2021","unstructured":"Sato T, Takagaki T, Hatayama T, Nikaido T, Tagami J (2021) Update on enamel bonding strategies. Front Dent Med 2:666379. https:\/\/doi.org\/10.3389\/fdmed.2021.666379","journal-title":"Front Dent Med"},{"key":"6799_CR2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jdent.2017.05.010","volume":"62","author":"R Wang","year":"2017","unstructured":"Wang R, Shi Y, Li T, Pan Y, Cui Y, Xia W (2017) Adhesive interfacial characteristics and the related bonding performance of four self-etching adhesives with different functional monomers applied to dentin. J Dent 62:72\u201380. https:\/\/doi.org\/10.1016\/j.jdent.2017.05.010","journal-title":"J Dent"},{"issue":"6","key":"6799_CR3","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1177\/154405910408300604","volume":"83","author":"Y Yoshida","year":"2004","unstructured":"Yoshida Y, Nagakane K, Fukuda R, Nakayama Y et al (2004) Comparative study on adhesive performance of functional monomers. J Dent Res 83(6):454\u2013458. https:\/\/doi.org\/10.1177\/154405910408300604","journal-title":"J Dent Res"},{"issue":"4","key":"6799_CR4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1177\/0022034512437375","volume":"91","author":"Y Yoshida","year":"2012","unstructured":"Yoshida Y, Yoshihara K, Nagaoka N, Hayakawa S, Torii Y, Ogawa T, Osaka A, Meerbeek BV (2012) Self-assembled Nano-layering at the Adhesive interface. J Dent Res 91(4):376\u2013381. https:\/\/doi.org\/10.1177\/0022034512437375","journal-title":"J Dent Res"},{"issue":"8","key":"6799_CR5","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.1016\/j.actbio.2011.04.026","volume":"7","author":"K Yoshihara","year":"2011","unstructured":"Yoshihara K, Yoshida Y, Hayakawa S, Nagaoka N et al (2011) Nano-layering of phosphoric-acid ester monomer at enamel and dentin. Acta Biomater 7(8):3187\u20133195. https:\/\/doi.org\/10.1016\/j.actbio.2011.04.026","journal-title":"Acta Biomater"},{"issue":"9","key":"6799_CR6","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1177\/0022034518763606","volume":"97","author":"K Yoshihara","year":"2018","unstructured":"Yoshihara K, Hayakawa S, Nagaoka N, Okihara T, Yoshida Y, Van Meerbeek B (2018) Etching Efficacy of Self-Etching Functional Monomers. J Dent Res 97(9):1010\u20131016. https:\/\/doi.org\/10.1177\/0022034518763606","journal-title":"J Dent Res"},{"issue":"5","key":"6799_CR7","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1177\/0022034520979133","volume":"100","author":"K Yoshihara","year":"2023","unstructured":"Yoshihara K, Nagaoka N, Nakamura A, Hara T, Yoshida Y, Van Meerbeek B (2023) Nano-Layering Adds Strength to the Adhesive Interface. J Dent Res 100(5):515\u2013521. https:\/\/doi.org\/10.1177\/0022034520979133","journal-title":"J Dent Res"},{"issue":"11","key":"6799_CR8","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1016\/j.dental.2020.08.007","volume":"36","author":"T de Paris Matos","year":"2020","unstructured":"de Paris Matos T, Perdig\u00e3o J, de Paula E, Coppla F, Hass V, Scheffer RF, Reis A, Loguercio AD (2020) Five-year clinical evaluation of a universal adhesive: A randomized double-blind trial. Dent Mater 36(11):1474\u20131485. https:\/\/doi.org\/10.1016\/j.dental.2020.08.007","journal-title":"Dent Mater"},{"issue":"10","key":"6799_CR9","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.jdent.2015.07.009","volume":"43","author":"NC Lawson","year":"2015","unstructured":"Lawson NC, Robles A, Fu CC, Lin CP, Sawlani K, Burgess JO (2015) Two-year clinical trial of a universal adhesive in total-etch and self-etch mode in non-carious cervical lesions. J Dent 43(10):1229\u20131234. https:\/\/doi.org\/10.1016\/j.jdent.2015.07.009","journal-title":"J Dent"},{"issue":"7","key":"6799_CR10","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s00784-025-06427-w","volume":"29","author":"M Polesso Patias","year":"2025","unstructured":"Polesso Patias M, Fernandes-E-Silva P, Carre\u00f1o NLV, Lund RG, Piva E, da Silva AF, De Oliveira Da Rosa WL (2025) Comparative clinical performance of universal adhesives versus etch-and-rinse and self-etch adhesives: a meta-analysis. Clin Oral Investig 29(7):352. https:\/\/doi.org\/10.1007\/s00784-025-06427-w","journal-title":"Clin Oral Investig"},{"issue":"11","key":"6799_CR11","doi-asserted-by":"publisher","first-page":"e503","DOI":"10.1016\/j.dental.2021.08.017","volume":"37","author":"U Josic","year":"2021","unstructured":"Josic U, Maravic T, Mazzitelli C, Radovic I et al (2021) Is clinical behavior of composite restorations placed in non-carious cervical lesions influenced by the application mode of universal adhesives? A systematic review and meta-analysis. Dent Mater 37(11):e503\u2013e521. https:\/\/doi.org\/10.1016\/j.dental.2021.08.017","journal-title":"Dent Mater"},{"key":"6799_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3290\/j.jad.b4186751","volume":"25","author":"M Peumans","year":"2023","unstructured":"Peumans M, Vandormael S, De Coster I (2023) Three-year Clinical Performance of a Universal Adhesive in Non-Carious Cervical Lesions. J Adhes Dent 25:133\u2013146. https:\/\/doi.org\/10.3290\/j.jad.b4186751","journal-title":"J Adhes Dent"},{"issue":"4","key":"6799_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/adj.12975","volume":"68","author":"H Tepe","year":"2023","unstructured":"Tepe H, Irmak \u00d6 (2023) Clinical performance of non-carious cervical lesions restored with using self-etch mode of adhesives according to the FDI criteria. Aust Dent J 68(4):255\u2013264. https:\/\/doi.org\/10.1111\/adj.12975","journal-title":"Aust Dent J"},{"issue":"5","key":"6799_CR14","doi-asserted-by":"publisher","first-page":"476","DOI":"10.2341\/18-049-c","volume":"44","author":"RF Zanatta","year":"2019","unstructured":"Zanatta RF, Silva TM, Esper M, Bresciani E, Gon\u00e7alves S, Caneppele T (2019) Bonding Performance of Simplified Adhesive Systems in Noncarious Cervical Lesions at 2-year Follow-up: A Double-blind Randomized Clinical Trial. Oper Dent 44(5):476\u2013487. https:\/\/doi.org\/10.2341\/18-049-c","journal-title":"Oper Dent"},{"issue":"6","key":"6799_CR15","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1007\/s00784-018-2708-3","volume":"23","author":"NN \u00c7ak\u0131r","year":"2019","unstructured":"\u00c7ak\u0131r NN, Demirbuga S (2019) The effect of five different universal adhesives on the clinical success of class I restorations: 24-month clinical follow-up. Clin Oral Investig 23(6):2767\u20132776. https:\/\/doi.org\/10.1007\/s00784-018-2708-3","journal-title":"Clin Oral Investig"},{"issue":"1","key":"6799_CR16","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12903-019-0913-3","volume":"19","author":"AA Carvalho","year":"2019","unstructured":"Carvalho AA, Leite MM, Zago JKM, Nunes CABCM et al (2019) Influence of different application protocols of universal adhesive system on the clinical behavior of Class I and II restorations of composite resin - a randomized and double-blind controlled clinical trial. BMC Oral Health 19(1):252. https:\/\/doi.org\/10.1186\/s12903-019-0913-3","journal-title":"BMC Oral Health"},{"issue":"2","key":"6799_CR17","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/jerd.13285","volume":"37","author":"G \u00d6zden","year":"2025","unstructured":"\u00d6zden G, Karadas M (2025) Clinical performance of different composite materials in class II cavities bonded with universal adhesives. J Esthet Restor Dent 37(2):314\u2013325. https:\/\/doi.org\/10.1111\/jerd.13285","journal-title":"J Esthet Restor Dent"},{"issue":"4","key":"6799_CR18","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3290\/j.jad.a38867","volume":"19","author":"JW van Dijken","year":"2017","unstructured":"van Dijken JW, Pallesen U (2017) Three-year Randomized Clinical Study of a One-step Universal Adhesive and a Two-step Self-etch Adhesive in Class II Composite Restorations. J Adhes Dent 19(4):287\u2013294. https:\/\/doi.org\/10.3290\/j.jad.a38867","journal-title":"J Adhes Dent"},{"issue":"3","key":"6799_CR19","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.jds.2023.12.004","volume":"19","author":"A Alam","year":"2024","unstructured":"Alam A, Yamauti M, Chowdhury AFMA, Wang X et al (2024) Evaluating the advancements in a recently introduced universal adhesive compared to its predecessor. J Dent Sci 19(3):1609\u20131619. https:\/\/doi.org\/10.1016\/j.jds.2023.12.004","journal-title":"J Dent Sci"},{"key":"6799_CR20","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3290\/j.jad.b3559035","volume":"24","author":"K Iwase","year":"2022","unstructured":"Iwase K, Takamizawa T, Sai K, Shibasaki S et al (2022) Early Phase Enamel Bond Performance of a Two-step Adhesive Containing a Primer Derived from a Universal Adhesive. J Adhes Dent 24:407\u2013420. https:\/\/doi.org\/10.3290\/j.jad.b3559035","journal-title":"J Adhes Dent"},{"issue":"5","key":"6799_CR21","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1111\/jerd.13204","volume":"36","author":"M J\u00e4ggi","year":"2024","unstructured":"J\u00e4ggi M, Karlin S, Zitzmann NU, Rohr N (2024) Shear bond strength of universal adhesives to human enamel and dentin. J Esthet Restor Dent 36(5):804\u2013812. https:\/\/doi.org\/10.1111\/jerd.13204","journal-title":"J Esthet Restor Dent"},{"key":"6799_CR22","doi-asserted-by":"publisher","first-page":"103698","DOI":"10.1016\/j.ijadhadh.2024.103698","volume":"132","author":"R Muto","year":"2024","unstructured":"Muto R, Takamizawa T, Shoji M, Hirokane E, Shibasaki S, Barkmeier WW, Latta MA, Miyazaki M (2024) Effect of different pretreatment agents on intact or ground enamel bond performance of different types of adhesive systems. Int J Adhes Adhes 132:103698. https:\/\/doi.org\/10.1016\/j.ijadhadh.2024.103698","journal-title":"Int J Adhes Adhes"},{"key":"6799_CR23","doi-asserted-by":"publisher","unstructured":"Dawoud B, Abou-Auf E, Shaalan O (2025) 24-Month clinical evaluation of cervical restorations bonded using radio-opaque universal adhesive compared to conventional universal adhesive in carious cervical lesions: A randomized clinical trial. Sci Rep 15(1):5505. https:\/\/doi.org\/10.1038\/s41598-025-88201-2. Erratum in: Sci Rep 2025;15(1):10072","DOI":"10.1038\/s41598-025-88201-2"},{"key":"6799_CR24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00784-010-0432-8","volume":"12","author":"R Hickel","year":"2010","unstructured":"Hickel R, Peschke A, Tyas M et al (2010) FDI World Dental Federation - clinical criteria for the evaluation of direct and indirect restorations. Update and clinical examples. J Adhes Dent 12:259\u2013272. https:\/\/doi.org\/10.1007\/s00784-010-0432-8","journal-title":"J Adhes Dent"},{"key":"6799_CR25","doi-asserted-by":"publisher","first-page":"c332","DOI":"10.1136\/bmj.c332","volume":"340","author":"KF Schulz","year":"2010","unstructured":"Schulz KF, Altman DG, Moher D, CONSORT Group (2010) CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 340:c332. https:\/\/doi.org\/10.1136\/bmj.c332","journal-title":"BMJ"},{"key":"6799_CR26","doi-asserted-by":"publisher","first-page":"j2835","DOI":"10.1136\/bmj.j2835","volume":"357","author":"N Pandis","year":"2017","unstructured":"Pandis N, Chung B, Scherer RW, Elbourne D, Altman DG (2017) CONSORT 2010 statement: extension checklist for reporting within person randomised trials. BMJ 357:j2835. https:\/\/doi.org\/10.1136\/bmj.j2835","journal-title":"BMJ"},{"issue":"1","key":"6799_CR27","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1590\/1807-3107bor-2017.vol31.0056","volume":"31","author":"FF Demarco","year":"2017","unstructured":"Demarco FF, Collares K, Correa MB, Cenci MS, Moraes RR, Opdam NJ (2017) Should my composite restorations last forever? Why are they failing. Braz Oral Res 31(1):e56. https:\/\/doi.org\/10.1590\/1807-3107bor-2017.vol31.0056","journal-title":"Braz Oral Res"},{"issue":"5","key":"6799_CR28","doi-asserted-by":"publisher","first-page":"e109","DOI":"10.1016\/j.dental.2021.10.018","volume":"38","author":"SD Heintze","year":"2022","unstructured":"Heintze SD, Loguercio AD, Hanzen TA, Reis A, Rousson V (2022) Clinical efficacy of resin-based direct posterior restorations and glass-ionomer restorations - An updated meta-analysis of clinical outcome parameters. Dent Mater 38(5):e109\u2013e135. https:\/\/doi.org\/10.1016\/j.dental.2021.10.018","journal-title":"Dent Mater"},{"issue":"9","key":"6799_CR29","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.jdent.2015.06.005","volume":"43","author":"V Moraschini","year":"2015","unstructured":"Moraschini V, Fai CK, Alto RM, Dos Santos GO (2015) Amalgam and resin composite longevity of posterior restorations: a systematic review and meta-analysis. J Dent 43(9):1043\u20131050. https:\/\/doi.org\/10.1016\/j.jdent.2015.06.005","journal-title":"J Dent"},{"key":"6799_CR30","doi-asserted-by":"publisher","unstructured":"Rasines Alcaraz MG, Veitz-Keenan A, Sahrmann P, Schmidlin PR, Davis D, Iheozor-Ejiofor Z (2014) Direct composite resin fillings versus amalgam fillings for permanent or adult posterior teeth. Cochrane Database Syst Rev 3CD005620. https:\/\/doi.org\/10.1002\/14651858.cd005620.pub2","DOI":"10.1002\/14651858.cd005620.pub2"},{"issue":"8","key":"6799_CR31","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.dental.2020.04.024","volume":"36","author":"C Kaiser","year":"2020","unstructured":"Kaiser C, Price RB (2020) Effect of time on the post-irradiation curing of six resin-based composites. Dent Mater 36(8):1019\u20131027. https:\/\/doi.org\/10.1016\/j.dental.2020.04.024","journal-title":"Dent Mater"},{"issue":"8","key":"6799_CR32","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.dental.2013.05.006","volume":"29","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara K, Yoshida Y, Nagaoka N et al (2013) Adhesive interfacial interaction affected by different carbon-chain monomers. Dent Mater 29(8):888\u2013897. https:\/\/doi.org\/10.1016\/j.dental.2013.05.006","journal-title":"Dent Mater"},{"issue":"10","key":"6799_CR33","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.dental.2021.08.014","volume":"37","author":"J Fehrenbach","year":"2021","unstructured":"Fehrenbach J, Isolan CP, M\u00fcnchow EA (2021) Is the presence of 10-MDP associated to higher bonding performance for self-etching adhesive systems? A meta-analysis of in vitro studies. Dent Mater 37(10):1463\u20131485. https:\/\/doi.org\/10.1016\/j.dental.2021.08.014","journal-title":"Dent Mater"},{"key":"6799_CR34","unstructured":"Scotchbond Universal Safety Data Sheet https:\/\/multimedia.3m.com\/mws\/mediawebserver?mwsId=SSSSSuUn_zu8l00xMY_eN8mGov70k17zHvu9lxtD7SSSSSS--, accessed December 2 2025."},{"key":"6799_CR35","unstructured":"Scotchbond Universal Plus Safety Data Sheet https:\/\/multimediahttps:\/\/multimedia.3m.com\/mws\/mediawebservermwsId=SSSSSuUn_zu8l00xNx_Bnx_vMv70k17zHvu9lxtD7SSSSSS--, accessed December 2 2025."},{"issue":"4","key":"6799_CR36","doi-asserted-by":"publisher","first-page":"364","DOI":"10.2341\/21-132-c","volume":"48","author":"VC Ruschel","year":"2023","unstructured":"Ruschel VC, Stolf SC, da Luz Baratieri C, Chung Y, Boushell LW, Baratieri LN, Walter R (2023) Five-year Clinical Evaluation of Universal Adhesives in Noncarious Cervical Lesions. Oper Dent 48(4):364\u2013372. https:\/\/doi.org\/10.2341\/21-132-c","journal-title":"Oper Dent"},{"key":"6799_CR37","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3290\/j.jad.a43994","volume":"22","author":"B Van Meerbeek","year":"2020","unstructured":"Van Meerbeek B, Yoshihara K, Van Landuyt K, Yoshida Y, Peumans M (2020) From Buonocore\u2019s Pioneering Acid-Etch Technique to Self-Adhering Restoratives. A Status Perspective of Rapidly Advancing Dental Adhesive Technology. J Adhes Dent 22:7\u201334. https:\/\/doi.org\/10.3290\/j.jad.a43994","journal-title":"J Adhes Dent"},{"key":"6799_CR38","doi-asserted-by":"publisher","first-page":"e20250402","DOI":"10.1590\/1678-7757-2025-0402","volume":"33","author":"TS Mendon\u00e7a","year":"2025","unstructured":"Mendon\u00e7a TS, Carvalho AA, Zago JKM, Barata TJE, Torres \u00c9M, Freitas GC, Lopes LG (2025) Clinical performance of posterior resin composite restorations bonded with universal adhesive system using three different application modes: a 26-month randomized clinical trial. J Appl Oral Sci 33:e20250402. https:\/\/doi.org\/10.1590\/1678-7757-2025-0402","journal-title":"J Appl Oral Sci"},{"issue":"23","key":"6799_CR39","doi-asserted-by":"publisher","first-page":"6910","DOI":"10.3390\/jcm11236910","volume":"11","author":"R Haak","year":"2022","unstructured":"Haak R, Werner MS, Schneider H, H\u00e4fer M, Schulz-Kornas E (2022) Clinical Outcomes and Quantitative Margin Analysis of a Universal Adhesive Using a Randomized Clinical Trial over Three Years. J Clin Med 11(23):6910. https:\/\/doi.org\/10.3390\/jcm11236910","journal-title":"J Clin Med"},{"issue":"1","key":"6799_CR40","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s00784-024-06121-3","volume":"29","author":"J Perdig\u00e3o","year":"2024","unstructured":"Perdig\u00e3o J, Chew HP, Lee IK, Woodis K, Hatch B (2024) Prospective, randomized clinical trial evaluating the clinical performance of a new universal adhesive in Class I and Class II restorations at 1 year. Clin Oral Investig 29(1):38. https:\/\/doi.org\/10.1007\/s00784-024-06121-3","journal-title":"Clin Oral Investig"},{"issue":"6","key":"6799_CR41","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.1007\/s00784-022-04397-x","volume":"26","author":"MO Barceleiro","year":"2022","unstructured":"Barceleiro MO, Lopes LS, Tardem C et al (2022) Thirty-six-month follow-up of cervical composite restorations placed with an MDP-free universal adhesive system using different adhesive protocols: a randomized clinical trial. Clin Oral Investig 26(6):4337\u20134350. https:\/\/doi.org\/10.1007\/s00784-022-04397-x","journal-title":"Clin Oral Investig"},{"issue":"1","key":"6799_CR42","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jdsr.2020.08.004","volume":"56","author":"J Perdig\u00e3o","year":"2020","unstructured":"Perdig\u00e3o J (2020) Current perspectives on dental adhesion: (1) Dentin adhesion - not there yet. Jpn Dent Sci Rev 56(1):190\u2013207. https:\/\/doi.org\/10.1016\/j.jdsr.2020.08.004","journal-title":"Jpn Dent Sci Rev"},{"issue":"2","key":"6799_CR43","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1177\/00220345000790020301","volume":"79","author":"Y Yoshida","year":"2020","unstructured":"Yoshida Y, Van Meerbeek B, Nakayama Y et al (2020) Evidence of chemical bonding at biomaterial-hard tissue interfaces. J Dent Res 79(2):709\u2013714. https:\/\/doi.org\/10.1177\/00220345000790020301","journal-title":"J Dent Res"},{"issue":"4","key":"6799_CR44","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.dental.2008.09.008","volume":"25","author":"SB Mitra","year":"2009","unstructured":"Mitra SB, Lee CY, Bui HT, Tantbirojn D, Rusin RP (2009) Long-term adhesion and mechanism of bonding of a paste-liquid resin-modified glass-ionomer. Dent Mater 25(4):459\u2013466. https:\/\/doi.org\/10.1016\/j.dental.2008.09.008","journal-title":"Dent Mater"},{"issue":"1","key":"6799_CR45","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1177\/00220345910700011201","volume":"70","author":"SB Mitra","year":"1991","unstructured":"Mitra SB (1991) Adhesion to dentin and physical properties of a light-cured glass-ionomer liner\/base. J Dent Res 70(1):72\u201374. https:\/\/doi.org\/10.1177\/00220345910700011201","journal-title":"J Dent Res"},{"key":"6799_CR46","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3290\/j.jad.a36222","volume":"18","author":"A Sezinando","year":"2016","unstructured":"Sezinando A, Serrano ML, P\u00e9rez VM (2016) Chemical Adhesion of Polyalkenoate-based Adhesives to Hydroxyapatite. J Adhes Dent 18:257\u2013265. https:\/\/doi.org\/10.3290\/j.jad.a36222","journal-title":"J Adhes Dent"},{"issue":"6","key":"6799_CR47","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1177\/00220345010800061701","volume":"80","author":"Y Yoshida","year":"2001","unstructured":"Yoshida Y, Van Meerbeek B, Nakayama Y, Yoshioka M et al (2001) Adhesion to and decalcification of hydroxyapatite by carboxylic acids. J Dent Res 80(6):1565\u20131569. https:\/\/doi.org\/10.1177\/00220345010800061701","journal-title":"J Dent Res"},{"issue":"1","key":"6799_CR48","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2341\/11-222-c","volume":"37","author":"J Perdig\u00e3o","year":"2012","unstructured":"Perdig\u00e3o J, Dutra-Corr\u00eaa M, Saraceni CH, Ciaramicoli MT, Kiyan VH, Queiroz CS (2012) Randomized clinical trial of four adhesion strategies: 18-month results. Oper Dent 37(1):3\u201311. https:\/\/doi.org\/10.2341\/11-222-c","journal-title":"Oper Dent"},{"issue":"2","key":"6799_CR49","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jdent.2005.04.003","volume":"34","author":"S Kubo","year":"2006","unstructured":"Kubo S, Kawasaki K, Yokota H, Hayashi Y (2006) Five-year clinical evaluation of two adhesive systems in non-carious cervical lesions. J Dent 34(2):97\u2013105. https:\/\/doi.org\/10.1016\/j.jdent.2005.04.003","journal-title":"J Dent"},{"issue":"10","key":"6799_CR50","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.dental.2014.07.007","volume":"30","author":"M Peumans","year":"2014","unstructured":"Peumans M, De Munck J, Mine A, Van Meerbeek B (2014) Clinical effectiveness of contemporary adhesives for the restoration of non-carious cervical lesions. A systematic review. Dent Mater 30(10):1089\u20131103. https:\/\/doi.org\/10.1016\/j.dental.2014.07.007","journal-title":"Dent Mater"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06799-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-026-06799-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06799-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:36:16Z","timestamp":1781638576000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-026-06799-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["6799"],"URL":"https:\/\/doi.org\/10.1007\/s00784-026-06799-7","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"31 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval - This study was approved and continuously monitored by the University of Minnesota IRB committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This study was sponsored by Solventum LLC.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was supported by Solventum US LLC (previously known as 3\u00a0M Healthcare).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Competing interests"}},{"value":"Written informed consent was obtained from all subjects prior to their inclusion in the study. All details that might disclose the identity of the subjects under study were omitted.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"113"}}