{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:52:33Z","timestamp":1781650353201,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009827","name":"Alexandria University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009827","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The stimulatory effects of laser Biostimulation on immediate implant clinical wound healing and radiographic bone quality analysis is with insufficient evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effect of low-level diode laser as a biostimulatory bolster for immediate implants in maxillary premolars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The study was conducted as a double-blinded randomized clinical trial on 20 patients with unrestorable maxillary premolars with a Type I socket. Patients were divided into two groups, where those who received immediate implant with laser biostimulation were assigned to the study group, while a sham laser application was used in the control group. Implant stability was appraised using radiofrequency analysis. Radiographic evaluation was conducted using an immediate post-operative and after 4-months tomographic scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Implant stability analysis showed a significant difference in the reported secondary stability values in the irradiated group. The healing index quantitative assessment of wound healing, reported significantly higher scores compared to the control group at all follow-up points. Radiographic bone density and labial plate thickness showed statistically insignificant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The overall success rate, secondary implant stability, and radiographic performance were comparable to those of the control group. These findings suggest that the biostimulatory effects of the laser are limited in the long term, offering no significant additional benefits over conventional methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-06847-2","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:55:11Z","timestamp":1776156911000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of diode laser biostimulation on implant stability, post-surgical inflammation, and bone healing in immediate implant in the maxillary premolars. A randomized double-blind trial"],"prefix":"10.1007","volume":"30","author":[{"given":"Basma Ashraf","family":"Kassem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeeda Mahmoud","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehia","family":"El-Mahallawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"6847_CR1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/cid.13275","volume":"26","author":"A Elaskary","year":"2024","unstructured":"Elaskary A, Ghallab N, Thabet A, Shemais N (2024) The bone shielding versus dual-zone concept in treating thin-walled fresh extraction sockets with immediate implant placement: Soft and hard tissue changes. A randomized clinical trial. Clin Implant Dent Relat Res 26:66\u201377. https:\/\/doi.org\/10.1111\/cid.13275","journal-title":"Clin Implant Dent Relat Res"},{"key":"6847_CR2","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1902\/jop.2014.130722","volume":"85","author":"BM Kinaia","year":"2014","unstructured":"Kinaia BM, Shah M, Neely AL, Goodis HE (2014) Crestal bone level changes around immediately placed implants: a systematic review and meta-analyses with at least 12 months\u2019 follow-up after functional loading. J Periodontol 85:1537\u20131548. https:\/\/doi.org\/10.1902\/jop.2014.130722","journal-title":"J Periodontol"},{"issue":"Suppl 1","key":"6847_CR3","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/cid.12098","volume":"17","author":"BR Chrcanovic","year":"2015","unstructured":"Chrcanovic BR, Martins MD, Wennerberg A (2015) Immediate placement of implants into infected sites: a systematic review. Clin Implant Dent Relat Res 17(Suppl 1):e1\u2013e16. https:\/\/doi.org\/10.1111\/cid.12098","journal-title":"Clin Implant Dent Relat Res"},{"key":"6847_CR4","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.3390\/jcm14072462","volume":"14","author":"A Ickroth","year":"2025","unstructured":"Ickroth A, Christiaens V, Pitman J, Cosyn J (2025) A Systematic Review on Immediate Implant Placement in Intact Versus Non-Intact Alveolar Sockets. J Clin Med 14:2462","journal-title":"J Clin Med"},{"key":"6847_CR5","doi-asserted-by":"publisher","unstructured":"Heimes D, Schiegnitz E, Kuchen R, K\u00e4mmerer PW, Al-Nawas B (2021) Buccal Bone Thickness in Anterior and Posterior Teeth-A Systematic Review. Healthc (Basel) 9. https:\/\/doi.org\/10.3390\/healthcare9121663","DOI":"10.3390\/healthcare9121663"},{"key":"6847_CR6","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jds.2011.03.004","volume":"6","author":"J-H Zhao","year":"2011","unstructured":"Zhao J-H, Tsai C-H, Chang Y-C (2011) Clinical and histologic evaluation of extraction socket healing filled with platelet rich fibrin. J Dent Sci - J DENT SCI 6:116\u2013122. https:\/\/doi.org\/10.1016\/j.jds.2011.03.004","journal-title":"J Dent Sci - J DENT SCI"},{"key":"6847_CR7","unstructured":"Khadra M (2005) The effect of low level laser irradiation on implant-tissue interaction. In vivo and in vitro studies. Swed Dent J Suppl. :1\u201363"},{"key":"6847_CR8","doi-asserted-by":"publisher","first-page":"128001","DOI":"10.1117\/1.Jbo.18.12.128001","volume":"18","author":"MM Jawad","year":"2013","unstructured":"Jawad MM, Husein A, Azlina A, Alam MK, Hassan R, Shaari R (2013) Effect of 940 nm low-level laser therapy on osteogenesis in vitro. J Biomed Opt 18:128001. https:\/\/doi.org\/10.1117\/1.Jbo.18.12.128001","journal-title":"J Biomed Opt"},{"key":"6847_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s40729-020-00257-z","volume":"6","author":"M Karakaya","year":"2020","unstructured":"Karakaya M, Demirba\u015f AE (2020) Effect of low-level laser therapy on osseointegration of titanium dental implants in ovariectomized rabbits: biomechanics and micro-CT analysis. Int J Implant Dent 6:61. https:\/\/doi.org\/10.1186\/s40729-020-00257-z","journal-title":"Int J Implant Dent"},{"key":"6847_CR10","volume-title":"Fundamentals of biostatistics: Seventh edition","author":"B Rosner","year":"2011","unstructured":"Rosner B (2011) Fundamentals of biostatistics: Seventh edition. Brooks\/Cole, Cengage Learning, [2011] \u00a92011, Boston"},{"key":"6847_CR11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang A-G, Buchner A (2007) G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175\u2013191. https:\/\/doi.org\/10.3758\/BF03193146","journal-title":"Behav Res Methods"},{"key":"6847_CR12","doi-asserted-by":"publisher","unstructured":"Fahim A, Shehab A, El-Beialy W, Abozekry A (2022) Effect of Low-Level Diode Laser Bio-Stimulation on Implant Stability Before, During and After Immediate Implants in Mandibular Molars. (A Randomized Clinical Study). Future Dent J 87\u201394. https:\/\/doi.org\/10.54623\/fdj.8023","DOI":"10.54623\/fdj.8023"},{"key":"6847_CR13","doi-asserted-by":"publisher","first-page":"Zc66","DOI":"10.7860\/jcdr\/2015\/13759.5956","volume":"9","author":"RG Manjunath","year":"2015","unstructured":"Manjunath RG, Rana A, Sarkar A (2015) Gingival Biotype Assessment in a Healthy Periodontium: Transgingival Probing Method. J Clin Diagn Res 9:Zc66\u2013Zc69. https:\/\/doi.org\/10.7860\/jcdr\/2015\/13759.5956","journal-title":"J Clin Diagn Res"},{"key":"6847_CR14","first-page":"99","volume":"19","author":"N Elian","year":"2007","unstructured":"Elian N, Cho SC, Froum S, Smith RB, Tarnow DP (2007) A simplified socket classification and repair technique. Pract Proced Aesthet Dent 19:99\u2013104 quiz 6","journal-title":"Pract Proced Aesthet Dent"},{"key":"6847_CR15","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3390\/app11030970","volume":"11","author":"L-C Chang","year":"2021","unstructured":"Chang L-C, Cheng Y-M (2021) The Effect of Different Socket Types on Implant Therapy While Using Flapless Ridge Preservation. Appl Sci 11:970","journal-title":"Appl Sci"},{"key":"6847_CR16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s10103-011-0944-8","volume":"27","author":"JJ Park","year":"2012","unstructured":"Park JJ, Kang KL (2012) Effect of 980-nm GaAlAs diode laser irradiation on healing of extraction sockets in streptozotocin-induced diabetic rats: a pilot study. Lasers Med Sci 27:223\u2013230. https:\/\/doi.org\/10.1007\/s10103-011-0944-8","journal-title":"Lasers Med Sci"},{"key":"6847_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/clr.14026","volume":"34","author":"GCV Camolesi","year":"2023","unstructured":"Camolesi GCV, Somoza-Mart\u00edn JM, Reboiras-L\u00f3pez MD, Camacho-Alonso F, Blanco-Carri\u00f3n A, P\u00e9rez-Say\u00e1ns M (2023) Photobiomodulation in dental implant stability and post-surgical healing and inflammation. A randomised double-blind study. Clin Oral Implants Res 34:137\u2013147. https:\/\/doi.org\/10.1111\/clr.14026","journal-title":"Clin Oral Implants Res"},{"key":"6847_CR18","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.52783\/jes.3906","volume":"20","author":"S Hegde","year":"2024","unstructured":"Hegde S (2024) A Review of Laser Threat and Safety Measures in Dental Practices. J Electr Syst 20:1897\u20131901. https:\/\/doi.org\/10.52783\/jes.3906","journal-title":"J Electr Syst"},{"key":"6847_CR19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/clr.59_13508","volume":"30","author":"C Berti","year":"2019","unstructured":"Berti C, Barausse C, Breschi L, Felice P (2019) Immediate, early (6 weeks) and delayed (4 months) post-extractive single implants- a 3-year RCT. Clin Oral Implants Res 30:36. https:\/\/doi.org\/10.1111\/clr.59_13508","journal-title":"Clin Oral Implants Res"},{"key":"6847_CR20","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.jds.2023.04.029","volume":"18","author":"P-S Fu","year":"2023","unstructured":"Fu P-S, Tseng F-C, Lan T-H, Lai P-L, Chen C-H, Chen J-H et al (2023) Immediate implant placement with and without provisionalization: A comparison of a one-year longitudinal study. J Dent Sci 18:1361\u20131367. https:\/\/doi.org\/10.1016\/j.jds.2023.04.029","journal-title":"J Dent Sci"},{"key":"6847_CR21","doi-asserted-by":"publisher","first-page":"e0290050","DOI":"10.1371\/journal.pone.0290050","volume":"19","author":"AB Rodriguez","year":"2024","unstructured":"Rodriguez AB, Alhachache S, Velasquez D, Chan HL (2024) A systematic review of oral wound healing indices. PLoS ONE 19:e0290050. https:\/\/doi.org\/10.1371\/journal.pone.0290050","journal-title":"PLoS ONE"},{"key":"6847_CR22","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/j.1600-0501.2005.01193.x","volume":"16","author":"R F\u00fcrhauser","year":"2006","unstructured":"F\u00fcrhauser R, Florescu D, Benesch T, Haas R, Mailath G, Watzek G (2006) Evaluation of soft tissue around single-tooth implant crowns: the Pink Esthetic Score. Clin Oral Implants Res 16:639\u2013644. https:\/\/doi.org\/10.1111\/j.1600-0501.2005.01193.x","journal-title":"Clin Oral Implants Res"},{"key":"6847_CR23","doi-asserted-by":"publisher","first-page":"953","DOI":"10.5005\/jp-journals-10024-1961","volume":"17","author":"A Chopra","year":"2016","unstructured":"Chopra A, Mhapuskar AA, Marathe S, Nisa SU, Thopte S, Saddiwal R (2016) Evaluation of Osseointegration in Implants using Digital Orthopantomogram and Cone Beam Computed Tomography. J Contemp Dent Pract 17:953\u2013957. https:\/\/doi.org\/10.5005\/jp-journals-10024-1961","journal-title":"J Contemp Dent Pract"},{"key":"6847_CR24","doi-asserted-by":"publisher","first-page":"499","DOI":"10.11607\/prd.5709","volume":"41","author":"SJ Chu","year":"2021","unstructured":"Chu SJ, Saito H, Levin BP, Baumgarten H, Egbert N, Wills MJ et al (2021) Outcomes of a 1-Year Prospective Single-Arm Cohort Study Using a Novel Macro-Hybrid Implant Design in Extraction Sockets: Part 1. Int J Periodontics Restor Dent 41:499\u2013508. https:\/\/doi.org\/10.11607\/prd.5709","journal-title":"Int J Periodontics Restor Dent"},{"key":"6847_CR25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12903-019-0779-4","volume":"19","author":"Y Chen","year":"2019","unstructured":"Chen Y, Liu C, Chen X, Mo A (2019) Clinical evidence of photobiomodulation therapy (PBMT) on implant stability and success: a systematic review and meta-analysis. BMC Oral Health 19:77. https:\/\/doi.org\/10.1186\/s12903-019-0779-4","journal-title":"BMC Oral Health"},{"key":"6847_CR26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s10103-017-2365-9","volume":"33","author":"P Torkzaban","year":"2018","unstructured":"Torkzaban P, Kasraei S, Torabi S, Farhadian M (2018) Low-level laser therapy with 940 nm diode laser on stability of dental implants: a randomized controlled clinical trial. Lasers Med Sci 33:287\u2013293. https:\/\/doi.org\/10.1007\/s10103-017-2365-9","journal-title":"Lasers Med Sci"},{"key":"6847_CR27","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/cid.12904","volume":"22","author":"RPB Lobato","year":"2020","unstructured":"Lobato RPB, Kinalski MA, Martins TM, Agostini BA, Bergoli CD, Dos Santos MBF (2020) Influence of low-level laser therapy on implant stability in implants placed in fresh extraction sockets: A randomized clinical trial. Clin Implant Dent Relat Res 22:261\u2013269. https:\/\/doi.org\/10.1111\/cid.12904","journal-title":"Clin Implant Dent Relat Res"},{"key":"6847_CR28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s40729-021-00331-0","volume":"7","author":"MA Kinalski","year":"2021","unstructured":"Kinalski MA, Agostini BA, Bergoli CD, Dos Santos MBF (2021) Influence of low-level laser therapy on implant stability in implants placed in healed sites: a randomized controlled trial. Int J Implant Dent 7:49. https:\/\/doi.org\/10.1186\/s40729-021-00331-0","journal-title":"Int J Implant Dent"},{"key":"6847_CR29","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10103-017-2381-9","volume":"33","author":"J Matys","year":"2018","unstructured":"Matys J, Flieger R, Tenore G, Grzech-Le\u015bniak K, Romeo U, Dominiak M (2018) Er:YAG laser, piezosurgery, and surgical drill for bone decortication during orthodontic mini-implant insertion: primary stability analysis-an animal study. Lasers Med Sci 33:489\u2013495. https:\/\/doi.org\/10.1007\/s10103-017-2381-9","journal-title":"Lasers Med Sci"},{"key":"6847_CR30","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1186\/s12903-024-04430-3","volume":"24","author":"AA Hamouda","year":"2024","unstructured":"Hamouda AA, El-Habashy LM, Khalil A (2024) The use of laser photobiomodulation as pre-anesthetic tissue management technique in reducing injection pain in children. BMC Oral Health 24:717. https:\/\/doi.org\/10.1186\/s12903-024-04430-3","journal-title":"BMC Oral Health"},{"key":"6847_CR31","doi-asserted-by":"publisher","unstructured":"Suphangul S, Rokaya D, Kanchanasobhana C, Rungsiyakull P, Chaijareenont P (2022) PEEK Biomaterial in Long-Term Provisional Implant Restorations: A Review. J Funct Biomater 13. https:\/\/doi.org\/10.3390\/jfb13020033","DOI":"10.3390\/jfb13020033"},{"key":"6847_CR32","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/cid.12957","volume":"22","author":"P Gulati","year":"2020","unstructured":"Gulati P, Kumar M, Issar G, Thakral A (2020) Effect of low level laser therapy on crestal bone levels around dental implants-A pilot study. Clin Implant Dent Relat Res 22:739\u2013746. https:\/\/doi.org\/10.1111\/cid.12957","journal-title":"Clin Implant Dent Relat Res"},{"key":"6847_CR33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.5125\/jkaoms.2016.42.1.2","volume":"42","author":"JR Kim","year":"2016","unstructured":"Kim JR, Kim SH, Kim IR, Park BS, Kim YD (2016) Low-level laser therapy affects osseointegration in titanium implants: resonance frequency, removal torque, and histomorphometric analysis in rabbits. J Korean Assoc Oral Maxillofac Surg 42:2\u20138. https:\/\/doi.org\/10.5125\/jkaoms.2016.42.1.2","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"6847_CR34","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.ijom.2015.08.989","volume":"44","author":"MM Rom\u00e3o","year":"2015","unstructured":"Rom\u00e3o MM, Marques MM, Cortes AR, Horliana AC, Moreira MS, Lascala CA (2015) Micro-computed tomography and histomorphometric analysis of human alveolar bone repair induced by laser phototherapy: a pilot study. Int J Oral Maxillofac Surg 44:1521\u20131528. https:\/\/doi.org\/10.1016\/j.ijom.2015.08.989","journal-title":"Int J Oral Maxillofac Surg"},{"key":"6847_CR35","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1089\/pho.2006.2030","volume":"25","author":"CB Lopes","year":"2007","unstructured":"Lopes CB, Pinheiro AL, Sathaiah S, Da Silva NS, Salgado MA (2007) Infrared laser photobiomodulation (lambda 830 nm) on bone tissue around dental implants: a Raman spectroscopy and scanning electronic microscopy study in rabbits. Photomed Laser Surg 25:96\u2013101. https:\/\/doi.org\/10.1089\/pho.2006.2030","journal-title":"Photomed Laser Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06847-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-026-06847-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06847-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:00:17Z","timestamp":1781647217000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-026-06847-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["6847"],"URL":"https:\/\/doi.org\/10.1007\/s00784-026-06847-2","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"19 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"An ethical approval statement is added in the body of the manuscript. The study was conducted based on the recommendations of the Helsinki Guidelines (IRB:0811\u2009\u2212\u2009012\/2023\/IORG:0008839) (ClinicalTrials.gov\/NCT07044245\/2025-6-27).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All of the enrolled subjects have given a full written informed consent for study participation and the utilization of their clinical and photographic data for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"175"}}