{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:46:23Z","timestamp":1782456383914,"version":"3.54.5"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-026-06921-9","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:28:03Z","timestamp":1780565283000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydroxyapatite composite sodium hyaluronate for alveolar ridge preservation: a prospective, randomized, parallel-controlled, single-blind, non-inferiority multicenter clinical trial"],"prefix":"10.1007","volume":"30","author":[{"given":"Yang","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2019ao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"6921_CR1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/jcpe.13390","volume":"48","author":"E Couso-Queiruga","year":"2021","unstructured":"Couso-Queiruga E, Stuhr S, Tattan M, Chambrone L, Avila-Ortiz G (2021) Post-extraction dimensional changes: A systematic review and meta-analysis. J Clin Periodontol 48:126\u2013144. https:\/\/doi.org\/10.1111\/jcpe.13390","journal-title":"J Clin Periodontol"},{"key":"6921_CR2","doi-asserted-by":"publisher","first-page":"187S","DOI":"10.1177\/0022034515592869","volume":"94","author":"V Chappuis","year":"2015","unstructured":"Chappuis V, Engel O, Shahim K, Reyes M, Katsaros C, Buser D (2015) Soft Tissue Alterations in Esthetic Postextraction Sites: A 3-Dimensional Analysis. J Dent Res 94:187S\u201393S","journal-title":"J Dent Res"},{"key":"6921_CR3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/prd.12082","volume":"68","author":"MG Ara\u00fajo","year":"2015","unstructured":"Ara\u00fajo MG, Silva CO, Misawa M, Sukekava F (2015) Alveolar socket healing: what can we learn? Periodontol 2000 68:122\u2013134. https:\/\/doi.org\/10.1111\/prd.12082","journal-title":"Periodontol 2000"},{"key":"6921_CR4","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.ijom.2017.03.008","volume":"46","author":"HC Aludden","year":"2017","unstructured":"Aludden HC, Mordenfeld A, Hallman M, Dahlin C, Jensen T (2017) Lateral ridge augmentation with Bio-Oss alone or Bio-Oss mixed with particulate autogenous bone graft: a systematic review. Int J Oral Maxillofac Surg 46:1030\u20131038","journal-title":"Int J Oral Maxillofac Surg"},{"key":"6921_CR5","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/0022-3913(71)90069-2","volume":"26","author":"DA Atwood","year":"1971","unstructured":"Atwood DA (1971) Reduction of residual ridges: a major oral disease entity. J Prosthet Dent 26:266\u2013279","journal-title":"J Prosthet Dent"},{"key":"6921_CR6","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.prosdent.2022.02.021","volume":"131","author":"GS Chatzopoulos","year":"2024","unstructured":"Chatzopoulos GS, Koidou VP, Sonnenberger M, Johnson D, Chu H, Wolff LF (2024) Postextraction ridge preservation by using dense PTFE membranes: A systematic review and meta-analysis. J Prosthet Dent 131:410\u2013419","journal-title":"J Prosthet Dent"},{"key":"6921_CR7","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0022-3913(03)00158-6","volume":"89","author":"A Tallgren","year":"2003","unstructured":"Tallgren A (2003) The continuing reduction of the residual alveolar ridges in complete denture wearers: a mixed-longitudinal study covering 25 years. 1972. J Prosthet Dent 89:427\u2013435","journal-title":"J Prosthet Dent"},{"key":"6921_CR8","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/jcpe.13057","volume":"46","author":"G Avila-Ortiz","year":"2019","unstructured":"Avila-Ortiz G, Chambrone L, Vignoletti F (2019) Effect of alveolar ridge preservation interventions following tooth extraction: A systematic review and meta-analysis. J Clin Periodontol 46:195\u2013223. https:\/\/doi.org\/10.1111\/jcpe.13057","journal-title":"J Clin Periodontol"},{"key":"6921_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/jcpe.12027","volume":"40","author":"RE Jung","year":"2013","unstructured":"Jung RE, Philipp A, Annen BM, Signorelli L, Thoma DS, H\u00e4mmerle CH, Attin T, Schmidlin P (2013) Radiographic evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial. J Clin Periodontol 40:90\u201398. https:\/\/doi.org\/10.1111\/jcpe.12027","journal-title":"J Clin Periodontol"},{"key":"6921_CR10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2334\/josnusd.57.195","volume":"57","author":"TP Loveless","year":"2015","unstructured":"Loveless TP, Kilinc Y, Altay MA, Flores-Hidalgo A, Baur DA, Quereshy FA (2015) Hounsfield unit comparison of grafted versus non-grafted extraction sockets. J Oral Sci 57:195\u2013200. https:\/\/doi.org\/10.2334\/josnusd.57.195","journal-title":"J Oral Sci"},{"key":"6921_CR11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1563\/aaid-joi-D-17-00053","volume":"44","author":"S Chavda","year":"2018","unstructured":"Chavda S, Levin L (2018) Human Studies of Vertical and Horizontal Alveolar Ridge Augmentation Comparing Different Types of Bone Graft Materials: A Systematic Review. J Oral Implantol 44:74\u201384. https:\/\/doi.org\/10.1563\/aaid-joi-D-17-00053","journal-title":"J Oral Implantol"},{"key":"6921_CR12","first-page":"120","volume":"6","author":"G Nazirkar","year":"2014","unstructured":"Nazirkar G, Singh S, Dole V, Nikam A (2014) Effortless effort in bone regeneration: a review. J Int Oral Health 6:120\u2013124","journal-title":"J Int Oral Health"},{"key":"6921_CR13","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1007\/s00784-023-05068-1","volume":"27","author":"I El-Sioufi","year":"2023","unstructured":"El-Sioufi I, Oikonomou I, Koletsi D, Bobetsis YA, Madianos PN, Vassilopoulos S (2023) Clinical evaluation of different alveolar ridge preservation techniques after tooth extraction: a randomized clinical trial. Clin Oral Investig 27:4471\u20134480. https:\/\/doi.org\/10.1007\/s00784-023-05068-1","journal-title":"Clin Oral Investig"},{"key":"6921_CR14","doi-asserted-by":"publisher","unstructured":"Kao ST, Scott DD (2007) A review of bone substitutes. Oral Maxillofac Surg Clin North Am 19 513\u2009\u2013\u200921, vi. https:\/\/doi.org\/10.1016\/j.coms.2007.06.002","DOI":"10.1016\/j.coms.2007.06.002"},{"issue":"3","key":"6921_CR15","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1016\/j.injury.2005.07.029","volume":"36","author":"PV Giannoudis","year":"2005","unstructured":"Giannoudis PV, Dinopoulos H, Tsiridis E (2005) Bone substitutes: an update. Injury 36(3):S20\u2013S27","journal-title":"Injury"},{"key":"6921_CR16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1902\/jop.2007.060238","volume":"78","author":"L Levin","year":"2007","unstructured":"Levin L, Nitzan D, Schwartz-Arad D (2007) Success of dental implants placed in intraoral block bone grafts. J Periodontol 78:18\u201321. https:\/\/doi.org\/10.1902\/jop.2007.060238","journal-title":"J Periodontol"},{"issue":"2","key":"6921_CR17","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1016\/j.injury.2011.06.199","volume":"42","author":"G Zimmermann","year":"2011","unstructured":"Zimmermann G, Moghaddam A (2011) Allograft bone matrix versus synthetic bone graft substitutes. Injury 42(2):S16\u201321","journal-title":"Injury"},{"key":"6921_CR18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/sj\/dmfr\/4600601","volume":"30","author":"B Johansson","year":"2001","unstructured":"Johansson B, Grepe A, Wannfors K, Hirsch JM (2001) A clinical study of changes in the volume of bone grafts in the atrophic maxilla. Dentomaxillofac Radiol 30:157\u2013161","journal-title":"Dentomaxillofac Radiol"},{"key":"6921_CR19","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.1016\/j.oooo.2012.04.018","volume":"117","author":"YK Kim","year":"2014","unstructured":"Kim YK, Kim SG, Yun PY, Yeo IS, Jin SC, Oh JS, Kim HJ, Yu SK, Lee SY, Kim JS, Um IW, Jeong MA, Kim GW (2014) Autogenous teeth used for bone grafting: a comparison with traditional grafting materials. Oral Surg Oral Med Oral Pathol Oral Radiol 117:e39\u201345","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"6921_CR20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40729-024-00544-z","volume":"10","author":"A Pabst","year":"2024","unstructured":"Pabst A, Becker P, G\u00f6tz W, Heimes D, Thiem DGE, Blatt S, K\u00e4mmerer PW (2024) A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review. Int J Implant Dent 10:26. https:\/\/doi.org\/10.1186\/s40729-024-00544-z","journal-title":"Int J Implant Dent"},{"key":"6921_CR21","doi-asserted-by":"publisher","first-page":"5539","DOI":"10.3390\/ijms24065539","volume":"24","author":"M Tomas","year":"2023","unstructured":"Tomas M, Karl M, \u010candrli\u0107 M, Matijevi\u0107 M, Juzba\u0161i\u0107 M, Peloza OC, Radeti\u0107 ATJ, Kui\u0161 D, Vidakovi\u0107 B, Ivani\u0161evi\u0107 Z, Ka\u010darevi\u0107 \u017dP (2023) A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial. Int J Mol Sci 24:5539. https:\/\/doi.org\/10.3390\/ijms24065539","journal-title":"Int J Mol Sci"},{"key":"6921_CR22","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.jcms.2012.01.002","volume":"40","author":"A Kolk","year":"2012","unstructured":"Kolk A, Handschel J, Drescher W, Rothamel D, Kloss F, Blessmann M, Heiland M, Wolff KD, Smeets R (2012) Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials. J Craniomaxillofac Surg 40:706\u2013718. https:\/\/doi.org\/10.1016\/j.jcms.2012.01.002","journal-title":"J Craniomaxillofac Surg"},{"key":"6921_CR23","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.3390\/molecules26103007","volume":"26","author":"R Zhao","year":"2021","unstructured":"Zhao R, Yang R, Cooper PR, Khurshid Z, Shavandi A, Ratnayake J (2021) Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules 26:3007. https:\/\/doi.org\/10.3390\/molecules26103007","journal-title":"Molecules"},{"key":"6921_CR24","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3109\/21691401.2014.893521","volume":"43","author":"W Zhu","year":"2015","unstructured":"Zhu W, Wang D, Xiong J, Liu J, You W, Huang J, Duan L, Chen J, Zeng Y (2015) Study on clinical application of nano-hydroxyapatite bone in bone defect repair. Artif Cells Nanomed Biotechnol 43:361\u2013365. https:\/\/doi.org\/10.3109\/21691401.2014.893521","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"6921_CR25","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/j.ijbiomac.2019.10.169","volume":"151","author":"P Zhai","year":"2020","unstructured":"Zhai P, Peng X, Li B, Liu Y, Sun H, Li X (2020) The application of hyaluronic acid in bone regeneration. Int J Biol Macromol 151:1224\u20131239. https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.10.169","journal-title":"Int J Biol Macromol"},{"key":"6921_CR26","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/jcpe.12623","volume":"43","author":"ET Scheyer","year":"2016","unstructured":"Scheyer ET, Heard R, Janakievski J, Mandelaris G, Nevins ML, Pickering SR, Richardson CR, Pope B, Toback G, Vel\u00e1squez D, Heiner Nagursky (2016) A randomized, controlled, multicentre clinical trial of post-extraction alveolar ridge preservation. J Clin Periodontol 43:1188\u20131199. https:\/\/doi.org\/10.1111\/jcpe.12623","journal-title":"J Clin Periodontol"},{"key":"6921_CR27","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.3390\/ma14112885","volume":"14","author":"S Kyyak","year":"2021","unstructured":"Kyyak S, Pabst A, Heimes D, K\u00e4mmerer PW (2021) The Influence of Hyaluronic Acid Biofunctionalization of a Bovine Bone Substitute on Osteoblast Activity In Vitro. Mater (Basel) 14:2885. https:\/\/doi.org\/10.3390\/ma14112885","journal-title":"Mater (Basel)"},{"key":"6921_CR28","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1002\/jbm.b.30755","volume":"82","author":"MW Laschke","year":"2007","unstructured":"Laschke MW, Witt K, Pohlemann T, Menger MD (2007) Injectable nanocrystalline hydroxyapatite paste for bone substitution: in vivo analysis of biocompatibility and vascularization. J Biomed Mater Res B Appl Biomater 82:494\u2013505. https:\/\/doi.org\/10.1002\/jbm.b.30755","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"6921_CR29","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/S0901-5027(87)80048-6","volume":"16","author":"JW Frame","year":"1987","unstructured":"Frame JW (1987) Hydroxyapatite as a biomaterial for alveolar ridge augmentation. Int J Oral Maxillofac Surg 16:642\u2013655","journal-title":"Int J Oral Maxillofac Surg"},{"key":"6921_CR30","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1021\/acsbiomaterials.2c00140","volume":"8","author":"SM George","year":"2022","unstructured":"George SM, Nayak C, Singh I, Balani K (2022) Multifunctional Hydroxyapatite Composites for Orthopedic Applications: A Review. ACS Biomater Sci Eng 8:3162\u20133186. https:\/\/doi.org\/10.1021\/acsbiomaterials.2c00140","journal-title":"ACS Biomater Sci Eng"},{"key":"6921_CR31","doi-asserted-by":"publisher","unstructured":"Kyyak S, Blatt S, Wiesmann N, Smeets R, Kaemmerer PW (2022) Hyaluronic Acid with Bone Substitutes Enhance Angiogenesis In Vivo. Materials (Basel) 15:3839. https:\/\/doi.org\/10.3390\/ma15113839","DOI":"10.3390\/ma15113839"},{"key":"6921_CR32","doi-asserted-by":"publisher","unstructured":"Seigo Ohba Y, Sumita Y, Nakatani S, Noda I Asahina (2019) Alveolar bone preservation by a hydroxyapatite\/collagen composite material after tooth extraction. Clinical oral investigations 23:2413\u20132419. https:\/\/doi.org\/10.1007\/s00784-018-2705-6","DOI":"10.1007\/s00784-018-2705-6"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06921-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-026-06921-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-026-06921-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:52:28Z","timestamp":1782453148000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-026-06921-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["6921"],"URL":"https:\/\/doi.org\/10.1007\/s00784-026-06921-9","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"13 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This trial adhered to the Declaration of Helsinki and was conducted at five centers in China: School of Stomatology, Fourth Military Medical University, Xi\u2019an; Nanjing First Hospital, Nanjing Medical University, Nanjing; Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing; Hospital of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an; and Xuzhou Municipal Central Hospital, Xuzhou. The study protocol was approved by the Ethics Committees of each center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"276"}}