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Human dentin specimens (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009180) were subjected to an initial erosive challenge and randomly allocated into six experimental groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930). Treatments were applied prior to a 7-day erosive\u2013abrasive cycling model. Dentin surface loss (dSL), collagen degradation (dCol), and calcium release (CaR) were quantitatively assessed, and surface morphology was qualitatively evaluated using scanning electron microscopy (SEM). Data were analyzed using one-way ANOVA followed by Tukey\u2019s test (\u03b1\u2009=\u20090.05). Exploratory linear regression analyses were performed to assess the association between total polyphenol content and dentin outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>P. cupana<\/jats:italic>\n                      and\n                      <jats:italic>E. oleracea<\/jats:italic>\n                      exhibited the highest polyphenol content and antioxidant capacity and were associated with significantly reduced dSL, dCol, and CaR compared with the untreated control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Qualitative analysis suggested a more compact surface with reduced dentinal tubule exposure in these groups.\n                      <jats:italic>B. crassifolia<\/jats:italic>\n                      demonstrated moderate protective effects, whereas\n                      <jats:italic>B. gasipaes<\/jats:italic>\n                      showed limited efficacy. Exploratory regression analyses indicated a negative association between total polyphenol content and dentin outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Polyphenol-rich extracts derived from tropical fruit seeds\u2014particularly\n                      <jats:italic>P. cupana<\/jats:italic>\n                      and\n                      <jats:italic>E. oleracea<\/jats:italic>\n                      \u2014were associated with protective effects on dentin under erosive\u2013abrasive conditions, reducing mineral loss and collagen degradation. However, the underlying mechanisms remain unclear and should be further investigated in future studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical significance<\/jats:title>\n                    <jats:p>Plant-derived polyphenol-rich extracts may represent a promising adjunctive approach in preventive strategies for erosive tooth wear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-06961-1","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:25:49Z","timestamp":1781940349000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Do polyphenol-rich solutions derived from tropical fruit seeds protect dentin against erosive\u2013abrasive challenges?"],"prefix":"10.1007","volume":"30","author":[{"given":"Eveline Lassance Cunha","family":"de Alencar Camacho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Mendes Acatauassu","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro Cordeiro","family":"Loretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Pimentel","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryvelto Miranda","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Felipe","family":"Besegato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfredo Gustavo Escalante","family":"Ot\u00e1rola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"de Melo Alencar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"6961_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000360380","volume":"25","author":"A Lussi","year":"2014","unstructured":"Lussi A, Carvalho TS (2014) Erosive tooth wear: a multifactorial condition of growing concern and increasing knowledge. 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