{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:12:55Z","timestamp":1792782775048,"version":"4.5.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Klinikum der Universit\u00e4t M\u00fcnchen","id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this German S3-level guideline project was to develop evidence-based recommendations to support professionals in the diagnosis and management of individuals with rare dental disorders. The research question was which form of dental care should be part of an age-related, long-term treatment for individuals affected by amelogenesis imperfecta, dentinogenesis imperfecta, ectodermal dysplasia, X-linked hypophosphatemia, hypophosphatasia or rare periodontal disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The guideline development combines a systematic search of the literature, expert input from multiple disciplines and a structured consensus process. In addition to phrasing recommendations on clinical, radiological and genetic diagnostics, much emphasis has been placed on the development of disease-specific treatment recommendations. This article presents a summary of the German guideline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 41 evidence- and consensus-based recommendations covering interdisciplinary collaboration, diagnostics, preventive care, restorative and prosthetic treatment, and orthodontic and surgical interventions were developed. The recommendations emphasise the importance of tailoring dental care to the individual patient\u2019s needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For the first time, an evidence-based guideline is available for the dental management of individuals affected by rare dental disorders. The guideline provides practical guidance and highlights the need for interdisciplinary management approaches. Furthermore, the guideline establishes a foundation for standardised, evidence-based dental care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>This guideline is expected to improve oral health outcomes and quality of life in this vulnerable patient group. Although developed in Germany, it may inform adoption or adaptation internationally, thereby fostering harmonised standards of care in different healthcare systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-07142-w","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:00:25Z","timestamp":1790064025000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The German S3-level guideline for the diagnosis and management of rare dental disorders"],"prefix":"10.1007","volume":"30","author":[{"given":"Helena","family":"Dujic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"B\u00fccher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina Manuela","family":"Sch\u00fcler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Hertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Timpel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Jablonski-Momeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Schilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Kapferer-Seebacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Zschocke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Liebermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Frederik","family":"G\u00fcth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Edelhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswitha","family":"Heinrich-Weltzien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-2291","authenticated-orcid":false,"given":"Jan","family":"K\u00fchnisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"10","key":"7142_CR1","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1002\/ajmg.a.61316","volume":"179","author":"M de La Dure-Molla","year":"2019","unstructured":"de La Dure-Molla M, Fournier BP, Manzanares MC, Acevedo AC, Hennekam RC, Friedlander L, Boy-Lefevre ML, Kerner S, Toupenay S, Garrec P, Vi-Fane B, Felizardo R, Berteretche MV, Jordan L, Ferre F, Clauss F, Jung S, de Chalendar M, Troester S, Kawczynski M, Chaloyard J, N. International Group of Dental, Maniere MC, Berdal A, Bloch-Zupan A (2019) Elements of morphology: standard terminology for the teeth and classifying genetic dental disorders. Am J Med Genet A 179(10):1913\u20131981","journal-title":"Am J Med Genet A"},{"issue":"1","key":"7142_CR2","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s13023-019-1109-2","volume":"14","author":"L Friedlander","year":"2019","unstructured":"Friedlander L, Berdal A, Boizeau P, Licht BA, Maniere MC, Picard A, Azzis O, Vazquez MP, Alberti C, Molla MD (2019) Oral health related quality of life of children and adolescents affected by rare orofacial diseases: a questionnaire-based cohort study. 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R.S. claims to have received benefits from Alexion and Kyowa Kirin.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Statement of ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The guideline was coordinated by the German Society for Paediatric Dentistry (DGKiZ, Ina Sch\u00fcler), the German Society for Prosthetic Dentistry and Biomaterials (DGPro, Daniel Edelhoff), the German Society for Computer-Aided Dentistry (DGCZ, Jan-Frederik Gueth), the German Society for Human Genetics (GfH, Johannes Zschocke), and the German Society for Dental, Oral and Maxillofacial Medicine (DGZMK, Julia Winter).The authors gratefully acknowledge the following professional societies, organisations, and their representatives for their contributions:, which participated in the guideline development process: Working Group on Paediatric Immunology (API, Fabian Hauck); German Society of Implantology (DGI, Henrik Terheyden); German Society of Orthodontics (DGKFO, Callin Jacobs); German Society of Paediatrics and Adolescent Medicine (DGKJ, Helge Hebestreit); German Society of Oral and Maxillofacial Surgery (DGMKG, Sven Otto); German Society of Osteology (DGO, Ralf Oheim); Society of Paediatric Radiology (GPR, Hans-Joachim Mentzel); German Society of Periodontology (DG PARO, Peter Eikholz); German Society of Dental Implantology (DGZI, Arzu Tuna); German Society of Conservative Dentistry (DGZ, Reinhard Schilke); Society of Neuropaediatrics (GNP, Heike K\u00f6lbel, Regina Trollmann); German Society of Dentistry for Individuals with Disabilities or Special Medical Needs (DGZMB, Peter Schmidt); Working Group on Oral and Maxillofacial Surgery (AGOKi, Andreas Sch\u00f6n); Professional Association of German Oral Surgeons (BDO, Frank Strietzel); Federal Association of Implantologists in Germany (BDIZ EDI, J\u00f6rg Neugebauer); Federal Association of Paediatric Dentists (BuKiZ, Monika Prinz-Kattinger); Professional Association of Paediatricians (BVKJ, Burkhard Lawrenz); Federal Association of Dentists in Public Health Services (BZ\u00d6G, Silke Riemer); German Society of Aesthetic Dentistry (DG\u00c4Z, Robert Sader); German Society of Endodontology and Dental Traumatology (DGET, Anahita Jablonski-Momeni); German Society of Laser Dentistry (DGL, Gabriele Schindler-Hultzsch); German Society of Preventive Dentistry (DGPZM, Jochen Jackowski); German Society of Restorative and Regenerative Dentistry (DGR\n                      2\n                      Z, Matthias Widbiller); European Reference Network on Rare Craniofacial Anomalies and ENT Disorders (ERN Cranio, Sigmar Reinert); Free Association of German Dentists (FVDZ, Thomas Wolf); Association of Medical Professions (VMF, Marion Schellmann, Sylvia Gabel).The following patient advocacy organisations were represented in the guideline development process: German Osteogenesis Imperfecta Society (Deutsche Gesellschaft f\u00fcr Osteogenesis imperfecta Betroffene e.V., Claudia Finis); Ectodermal Dysplasia Society Germany (Ektodermale Dysplasie e.V., Andrea Burk); Parent Initiative for Apert Syndrome and Related Malformations (Elterninitiative Apert-Syndrom und verwandte Fehlbildungen e.V., Sandra M\u00f6sche); Hypophosphatasia Germany (Hypophosphatasie Deutschland e.V., Gerald Brandt); X-linked Hypophosphatemia Germany (Phosphatdiabetes e.V., Jana Bombosch, Martha Kirchhoff).We would like to express our gratitude to Dr. Monika Nothacker (AMWF) for providing invaluable methodological advice during the development of this guideline project. Her expertise and guidance were instrumental in the development of the guideline. The working group thanks Dr. Anke Weber (DGZMK) and Dr. Birgit Marr\u00e9 (DGZMK) for their organisational and methodological support.","order":3,"name":"Ethics","label":"Participating organisations and their representatives","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"459"}}