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Blocks were treated twice\/day and subjected to four daily erosive challenges for five days (0.05\u00a0M citric acid, pH 3.2, 90\u00a0s), either erosion only (ERO) or erosion plus abrasion by brushing (ERO\u2009+\u2009ABR). The samples were analyzed by profilometry and computed X-ray microtomography, and the data were analyzed by 2-way ANOVA followed by Fisher\u2019s LSD\n                      <jats:italic>post hoc<\/jats:italic>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Under both conditions, a dose-response relationship was observed between F concentration and all variables, with the lowest values for 5000F and EXP. Under ERO, only 5000F showed lower DEW than 1100F; under ERO\u2009+\u2009ABR, all TMP and\/or QC-containing solutions reduced DEW compared with 1100F, with a similar trend for mineral loss and depth of mineral loss, most notably for 5000F and EXP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adding QC or TMP to 1100F produced modest additional protection, while their combination yielded a significant additive effect comparable to that of a solution with a five-fold higher F concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Possibility of reducing fluoride concentration in preventive formulations with an effect similar to that of high-concentration formulations against DEW.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-07177-z","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:23:30Z","timestamp":1791005010000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coadministration of fluoride, trimetaphosphate, and quercetin reduces dentin erosive wear in vitro"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8734-4556","authenticated-orcid":false,"given":"Isabela Maria Passarela","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-4853","authenticated-orcid":false,"given":"Alberto Carlos Botazzo","family":"Delbem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-1548","authenticated-orcid":false,"given":"Tamires Passadori","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5760-1337","authenticated-orcid":false,"given":"Isabela Ferreira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-9262","authenticated-orcid":false,"given":"Lucas Fernando Oliveira Tom\u00e1z","family":"Ferraresso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2775-9263","authenticated-orcid":false,"given":"Let\u00edcia Cabrera","family":"Capalbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-3951","authenticated-orcid":false,"given":"Mar\u00edlia Afonso Rabelo","family":"Buzalaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-5259","authenticated-orcid":false,"given":"Douglas Roberto","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-3933","authenticated-orcid":false,"given":"Juliano Pelim","family":"Pessan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"7177_CR1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/ipd.13250","volume":"35","author":"F Marschner","year":"2025","unstructured":"Marschner F, Kanzow P, Wiegand A (2025) Systematic review and meta-analysis on prevalence and anamnestic risk factors for erosive tooth wear in the primary dentition. 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