{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:39:00Z","timestamp":1792579140961,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Suomen Naishammasl\u00e4\u00e4k\u00e4rit ry"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Oral autoimmune blistering diseases (AIBDs) are a group of rare, chronic disorders causing different symptoms on the oral mucosa. The most common oral AIBDs are mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). The aim of this study was to describe the demographic and clinical characteristics, as well as comorbidities, of patients with oral AIBDs in Southern and Western Finland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This retrospective two-center study included patients diagnosed with AIBD with oral symptoms treated at Helsinki University Hospital and Turku University Hospital between the years 2000 and 2022. Statistical analyses included descriptive statistics, t-tests, Chi-square tests, Fisher\u2019s exact tests, and likelihood ratio tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 115 patients (65.2% women, mean age at diagnosis 66 years) analyzed, 86.1% were diagnosed with MMP. Patients with PV were significantly younger than patients with MMP. Most of the patients who had available lifestyle information reported being non-smokers and non-alcohol users. Approximately one third of the patients had an autoimmune or neurological comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      There is a female predominance in oral AIBDs. Patients with MMP were older at diagnosis than patients with PV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Comorbidity comparisons between diagnostic groups were limited by the small PV subgroup and should be interpreted as descriptive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>MMP and PV are rare chronic AIBDs that can cause painful oral symptoms and thus impair quality of life. With an aging population and increasing immigration, the prevalence of these rare diseases in Western countries including Finland may rise. Therefore, early recognition and diagnosis with proper treatment and follow-up is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-026-07228-5","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:48:33Z","timestamp":1792576113000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Demographic characteristics and comorbidities in patients with oral mucous membrane pemphigoid and pemphigus"],"prefix":"10.1007","volume":"30","author":[{"given":"Lili","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Willberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Uittamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auli","family":"Suominen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna K.","family":"Laine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"6","key":"7228_CR1","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s40257-019-00461-7","volume":"20","author":"H Rashid","year":"2019","unstructured":"Rashid H, Lamberts A, Diercks GFH, Pas HH, Meijer JM, Bolling MC, Horv\u00e1th B (2019) Oral lesions in autoimmune bullous diseases: an overview of clinical characteristics and diagnostic algorithm. 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All procedures performed in this study were in accordance with Helsinki declaration.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this type of study, formal consent is not required.","order":2,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"541"}}