{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:16:31Z","timestamp":1773872191886,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T00:00:00Z","timestamp":1246320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s00787-009-0043-6","type":"journal-article","created":{"date-parts":[[2009,6,29]],"date-time":"2009-06-29T12:40:15Z","timestamp":1246279215000},"page":"67-74","source":"Crossref","is-referenced-by-count":69,"title":["Adenosine A2A receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder"],"prefix":"10.1007","volume":"19","author":[{"given":"Christine M.","family":"Freitag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Agelopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Huy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Rothermundt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Krakowitzky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jobst","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"von Gontard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Hohoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,6,30]]},"reference":[{"key":"43_CR1","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1038\/sj.npp.1300232","volume":"28","author":"K Alsene","year":"2003","unstructured":"Alsene K, Deckert J, Sand P, de Wit H (2003) Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 28:1694\u20131702","journal-title":"Neuropsychopharmacology"},{"key":"43_CR2","unstructured":"American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders (DSM-IV), 4th edn. American Psychiatric Association, Washington, DC"},{"key":"43_CR3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0140-6736(06)69041-7","volume":"368","author":"G Baird","year":"2006","unstructured":"Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, Charman T (2006) Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the special needs and autism project (SNAP). Lancet 368:210\u2013215","journal-title":"Lancet"},{"key":"43_CR4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1024\/1422-4917.32.1.45","volume":"32","author":"S Bolte","year":"2004","unstructured":"Bolte S, Poustka F (2004) The German form of the autism diagnostic observation schedule (ADOS): first results on reliability and validity. Zeitschrift fur Kinder-und Jugendpsychiatrie und Psychotherapie 32:45\u201350","journal-title":"Zeitschrift fur Kinder-und Jugendpsychiatrie und Psychotherapie"},{"key":"43_CR5","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1073\/pnas.98.4.1970","volume":"98","author":"JF Chen","year":"2001","unstructured":"Chen JF, Moratalla R, Impagnatiello F, Grandy DK, Cuellar B, Rubinstein M, Beilstein MA, Hackett E, Fink JS, Low MJ, Ongini E, Schwarzschild MA (2001) The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proc Natl Acad Sci USA 98:1970\u20131975","journal-title":"Proc Natl Acad Sci USA"},{"key":"43_CR6","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1038\/npp.2008.17","volume":"33","author":"E Childs","year":"2008","unstructured":"Childs E, Hohoff C, Deckert J, Xu K, Badner J, de Wit H (2008) Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 33:2791\u20132800","journal-title":"Neuropsychopharmacology"},{"key":"43_CR7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/sj.mp.4000345","volume":"3","author":"J Deckert","year":"1998","unstructured":"Deckert J, Nothen MM, Franke P, Delmo C, Fritze J, Knapp M, Maier W, Beckmann H, Propping P (1998) Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease. Mol Psychiatry 3:81\u201385","journal-title":"Mol Psychiatry"},{"key":"43_CR8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.mp.4001896","volume":"12","author":"CM Freitag","year":"2007","unstructured":"Freitag CM (2007) The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry 12:2\u201322","journal-title":"Mol Psychiatry"},{"key":"43_CR9","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/sj.npp.1300311","volume":"29","author":"SP Hamilton","year":"2004","unstructured":"Hamilton SP, Slager SL, De Leon AB, Heiman GA, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA (2004) Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder. Neuropsychopharmacology 29:558\u2013565","journal-title":"Neuropsychopharmacology"},{"key":"43_CR10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1468-2982.2007.01254.x","volume":"27","author":"C Hohoff","year":"2007","unstructured":"Hohoff C, Marziniak M, Lesch KP, Deckert J, Sommer C, Mossner R (2007) An adenosine A2A receptor gene haplotype is associated with migraine with aura. Cephalalgia 27:177\u2013181","journal-title":"Cephalalgia"},{"key":"43_CR11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ajmg.b.30228","volume":"139","author":"C Hohoff","year":"2005","unstructured":"Hohoff C, McDonald JM, Baune BT, Cook EH, Deckert J, de Wit H (2005) Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants. Am J Med Genet B Neuropsychiatr Genet 139:42\u201344","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"43_CR12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1023\/A:1012380416876","volume":"26","author":"L Koles","year":"2001","unstructured":"Koles L, Wirkner K, Illes P (2001) Modulation of ionotropic glutamate receptor channels. Neurochem Res 26:925\u2013932","journal-title":"Neurochem Res"},{"key":"43_CR13","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10803-006-0123-0","volume":"36","author":"OT Leyfer","year":"2006","unstructured":"Leyfer OT, Folstein SE, Bacalman S, Davis NO, Dinh E, Morgan J, Tager-Flusberg H, Lainhart JE (2006) Comorbid psychiatric disorders in children with autism: interview development and rates of disorders. J Autism Dev Disord 36:849\u2013861","journal-title":"J Autism Dev Disord"},{"key":"43_CR14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/A:1005592401947","volume":"30","author":"C Lord","year":"2000","unstructured":"Lord C, Risi S, Lambrecht L, Cook E H Jr, Leventhal BL, DiLavore PC, Pickles A, Rutter M (2000) The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 30:205\u2013223","journal-title":"J Autism Dev Disord"},{"key":"43_CR15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF02172145","volume":"24","author":"C Lord","year":"1994","unstructured":"Lord C, Rutter M, Le Couteur A (1994) Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24:659\u2013685","journal-title":"J Autism Dev Disord"},{"key":"43_CR16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ajhg.2007.12.009","volume":"82","author":"CR Marshall","year":"2008","unstructured":"Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L, Skaug J, Shago M, Moessner R, Pinto D, Ren Y, Thiruvahindrapduram B, Fiebig A, Schreiber S, Friedman J, Ketelaars CE, Vos YJ, Ficicioglu C, Kirkpatrick S, Nicolson R, Sloman L, Summers A, Gibbons CA, Teebi A, Chitayat D, Weksberg R, Thompson A, Vardy C, Crosbie V, Luscombe S, Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B, Szatmari P, Scherer SW (2008) Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet 82:477\u2013488","journal-title":"Am J Hum Genet"},{"key":"43_CR17","unstructured":"Melchers, P., Preu\u00df, U. (2001) Kaufman assessment battery for children, German version, 6th edn. Hogrefe, G\u00f6ttingen"},{"key":"43_CR18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-0173(99)00059-4","volume":"31","author":"JL Moreau","year":"1999","unstructured":"Moreau JL, Huber G (1999) Central adenosine A(2A) receptors: an overview. Brain Res Brain Res Rev 31:65\u201382","journal-title":"Brain Res Brain Res Rev"},{"key":"43_CR19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1750-3639.2007.00102.x","volume":"17","author":"CA Pardo","year":"2007","unstructured":"Pardo CA, Eberhart CG (2007) The neurobiology of autism. Brain Pathol 17:434\u2013447","journal-title":"Brain Pathol"},{"key":"43_CR20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000284984","volume":"29","author":"F Poustka","year":"1996","unstructured":"Poustka F, Lisch S, Ruhl D, Sacher A, Schmotzer G, Werner K (1996) The standardized diagnosis of autism, autism diagnostic interview-revised: interrater reliability of the German form of the interview. Psychopathology 29:145\u2013153","journal-title":"Psychopathology"},{"key":"43_CR21","doi-asserted-by":"crossref","first-page":"15676","DOI":"10.1073\/pnas.0505414102","volume":"102","author":"JV Retey","year":"2005","unstructured":"Retey JV, Adam M, Honegger E, Khatami R, Luhmann UF, Jung HH, Berger W, Landolt HP (2005) A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci USA 102:15676\u201315681","journal-title":"Proc Natl Acad Sci USA"},{"key":"43_CR22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pneurobio.2007.05.001","volume":"83","author":"SN Schiffmann","year":"2007","unstructured":"Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferre S (2007) Adenosine A(2A) receptors and basal ganglia physiology. Prog Neurobiol 83:277\u2013292","journal-title":"Prog Neurobiol"},{"key":"43_CR23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00213-007-0795-y","volume":"193","author":"T Schneider","year":"2007","unstructured":"Schneider T, Ziolkowska B, Gieryk A, Tyminska A, Przewlocki R (2007) Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism. Psychopharmacology (Berl) 193:547\u2013555","journal-title":"Psychopharmacology (Berl)"},{"key":"43_CR24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1126\/science.1138659","volume":"316","author":"J Sebat","year":"2007","unstructured":"Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, Spence SJ, Lee AT, Puura K, Lehtimaki T, Ledbetter D, Gregersen PK, Bregman J, Sutcliffe JS, Jobanputra V, Chung W, Warburton D, King MC, Skuse D, Geschwind DH, Gilliam TC, Ye K, Wigler M (2007) Strong association of de novo copy number mutations with autism. Science 316:445\u2013449","journal-title":"Science"},{"key":"43_CR25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.eurpsy.2007.05.006","volume":"23","author":"AC Stanfield","year":"2008","unstructured":"Stanfield AC, McIntosh AM, Spencer MD, Philip R, Gaur S, Lawrie SM (2008) Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies. Eur Psychiatry 23:289\u2013299","journal-title":"Eur Psychiatry"},{"key":"43_CR26","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/379378","volume":"73","author":"M Stephens","year":"2003","unstructured":"Stephens M, Donnelly P (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162\u20131169","journal-title":"Am J Hum Genet"},{"key":"43_CR27","unstructured":"Tellegen PJ, Winkel M, Laros JA (1998) SON-R 2 1\/2-7. Non-verbaler Intelligenztest"},{"key":"43_CR28","unstructured":"Tewes U, Neubauer A, von Aster M (2006) WIE. Wechsler Intelligenztest f\u00fcr Erwachsene"},{"key":"43_CR29","unstructured":"Tewes U, Rossmann P, Schallberger U (2000) HAWIK-III. Hamburg-Wechsler-Intelligenztest f\u00fcr Kinder III"},{"key":"43_CR30","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/chi.0b013e3180303b7d","volume":"46","author":"JA Vorstman","year":"2007","unstructured":"Vorstman JA, Morcus ME, van Engeland H (2007) Autism in children with 22q11.2 deletion syndrome. J Am Acad Child Adolesc Psychiatry 46:434\u2013435","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"43_CR31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2003.11.072","volume":"1000","author":"L Yu","year":"2004","unstructured":"Yu L, Frith MC, Suzuki Y, Peterfreund RA, Gearan T, Sugano S, Schwarzschild MA, Weng Z, Fink JS, Chen JF (2004) Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses. Brain Res 1000:156\u2013173","journal-title":"Brain Res"}],"container-title":["European Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-009-0043-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00787-009-0043-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-009-0043-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T02:33:25Z","timestamp":1559097205000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00787-009-0043-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,30]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["43"],"URL":"https:\/\/doi.org\/10.1007\/s00787-009-0043-6","relation":{},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"value":"1018-8827","type":"print"},{"value":"1435-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,30]]}}}