{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:57:10Z","timestamp":1780984630099,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s00787-013-0451-5","type":"journal-article","created":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T03:29:22Z","timestamp":1374031762000},"page":"225-233","source":"Crossref","is-referenced-by-count":14,"title":["Subthreshold traits of the broad autistic spectrum are distributed across different subgroups in parents, but not siblings, of probands with autism"],"prefix":"10.1007","volume":"23","author":[{"given":"Laurence","family":"Robel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Rousselot-Pailley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Levy-Rueff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Golse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Falissard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"451_CR1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S0033291700028099","volume":"25","author":"A Bailey","year":"1995","unstructured":"Bailey A, Le Couteur A, Gottesman I et al (1995) Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 25:63\u201378","journal-title":"Psychol Med"},{"key":"451_CR2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrg2346","volume":"9","author":"BS Abraham","year":"2008","unstructured":"Abraham BS, Geschwind DH (2008) Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev 9:341\u2013355","journal-title":"Nat Rev"},{"issue":"1","key":"451_CR3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2040-2392-2-12","volume":"2","author":"RF Gillis","year":"2011","unstructured":"Gillis RF, Rouleau GA (2011) The ongoing dissection of the genetic architecture of autistic spectrum disorder. Mol Autism 2(1):12","journal-title":"Mol Autism"},{"issue":"12","key":"451_CR4","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrg2670","volume":"10","author":"R Plomin","year":"2009","unstructured":"Plomin R, Haworth CMA, Davis OSP (2009) Common disorders are quantitative traits. Nat Rev Genet 10(12):872\u2013878","journal-title":"Nat Rev Genet"},{"key":"451_CR5","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/archpsyc.60.5.524","volume":"60","author":"JN Constantino","year":"2003","unstructured":"Constantino JN, Todd R (2003) Autistic traits in the general population. Arch Gen Psychiatry 60:524\u2013530","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"451_CR6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1176\/appi.ajp.163.2.294","volume":"163","author":"JN Constantino","year":"2006","unstructured":"Constantino JN, Lajonchere C, Lutz M, Gray T, Abbacchi A, McKenna K, Singh D, Todd RD (2006) Autistic social impairment in the siblings of children with pervasive developmental disorders. Am J Psychiatry 163(2):294\u2013296","journal-title":"Am J Psychiatry"},{"issue":"5","key":"451_CR7","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/1469-7610.00644","volume":"41","author":"P Szatmari","year":"2000","unstructured":"Szatmari P, MacLean JE, Jones MB, Bryson SE, Zwaigenbaum L, Bartolucci G, Mahoney WJ, Tuff L (2000) The familial aggregation of the lesser variant in biological and non-biological relatives of PDD probands: a family history study. J Child Psychol Psychiatry 41(5):579\u2013586","journal-title":"J Child Psychol Psychiatry"},{"issue":"9","key":"451_CR8","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/j.1469-7610.2010.02267.x","volume":"51","author":"AJ Schwichtenberg","year":"2010","unstructured":"Schwichtenberg AJ, Young GS, Sigman M, Hutman T, Ozonoff S (2010) Can family affectedness inform infant sibling outcomes of autism spectrum disorders? J Child Psychol Psychiatry 51(9):1021\u20131030","journal-title":"J Child Psychol Psychiatry"},{"issue":"3","key":"451_CR9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ajmg.b.30810","volume":"150B","author":"YV Virkud","year":"2009","unstructured":"Virkud YV, Todd RD, Abbacchi AM, Zhang Y, Constantino JN (2009) Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. Am J Med Genet B Neuropsychiatr Genet 150B(3):328\u2013334","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"451_CR10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1126\/science.1138659","volume":"316","author":"J Sebat","year":"2007","unstructured":"Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, Spence SJ, Lee AT, Puura K, Lehtim\u00e4ki T, Ledbetter D, Gregerse PK, Bregman J, Sutcliffe JS, Jobanputr V, Chung W, Warburton D, King MC, Skuse D, Geschwind DH, Gilliam TC, Ye K, Wigler M (2007) Strong association of de novo copy number mutations with autism. Science 316:445\u2013449","journal-title":"Science"},{"issue":"4","key":"451_CR11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1023\/A:1025014929212","volume":"33","author":"JN Constantino","year":"2003","unstructured":"Constantino JN, Davis SA, Todd RD, Schindler MK, Gross MM, Brophy SL, Metzger LM, Shoushtari CS, Spintler R, Reich W (2003) Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. J Autism Dev Disord 33(4):427\u2013433","journal-title":"J Autism Dev Disord"},{"key":"451_CR12","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1176\/appi.ajp.157.12.2043","volume":"157","author":"JN Constantino","year":"2000","unstructured":"Constantino JN, Todd RD (2000) Genetic structure of reciprocal social behavior. Am J Psychiatry 157:2043\u20132045","journal-title":"Am J Psychiatry"},{"key":"451_CR13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1005653411471","volume":"31","author":"S Baron-Cohen","year":"1995","unstructured":"Baron-Cohen S, Wheelwright S, Skinner R et al (1995) The autism spectrum quotient (AQ): evidence from Asperger syndrome\/high functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord 31:5\u201317","journal-title":"J Autism Dev Disord"},{"issue":"3","key":"451_CR14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10803-005-3300-7","volume":"35","author":"MR Woodbury-Smith","year":"2005","unstructured":"Woodbury-Smith MR, Robinson J, Wheelwright S, Baron-Cohen S (2005) Screening adults for Asperger Syndrome using the AQ: a preliminary study of its diagnostic validity in clinical practice. J Autism Dev Disord 35(3):331\u2013335","journal-title":"J Autism Dev Disord"},{"key":"451_CR15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10803-010-1073-0","volume":"41","author":"RA Hoekstra","year":"2011","unstructured":"Hoekstra RA, Vinkhuyzen AAE, Wheelwright S, Bartels M, Boomsma DI, Baron-Cohen S, Posthuma D, Van der Sluis S (2011) The construction and validation of an abridged version of the Autism-Spectrum Quotient (AQ-short). J Autism Dev Disord 41:589\u2013596","journal-title":"J Autism Dev Disord"},{"key":"451_CR16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0013-7006(07)92041-2","volume":"33","author":"H Piana","year":"2007","unstructured":"Piana H, Fortin C, Noulhiane M, Golse B, Robel L (2007) Investigation of the behavioural phenotype of parents of child with autism through the new FAQ self-report. Encephale 33:285\u2013292","journal-title":"Encephale"},{"issue":"6","key":"451_CR17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/YPG.0b013e3283060fa5","volume":"18","author":"F Laroche","year":"2008","unstructured":"Laroche F, Ramoz N, Leroy S, Fortin C, Rousselot-Pailley B, Philippe A, Colleaux L, Golse B, Mouren-Simeoni M-C, Gorwood P, Galli T, Simonneau M, Krebs M-O, Robel L (2008) Polymorphism of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders. Psychiatry Genetics 18(6):295\u2013301","journal-title":"Psychiatry Genetics"},{"key":"451_CR18","volume-title":"Diagnostic and statistical manual of mental disorders, fourth edition, text revision (DSM IV-TR)","author":"American Psychiatric Association","year":"1994","unstructured":"American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, fourth edition, text revision (DSM IV-TR). American Psychiatric Press, Washington, DC"},{"key":"451_CR19","unstructured":"The ICD-10 Classification of Mental and Behavioral disorders (1993) Clinical descriptions and diagnostic guidelines, WHO, Geneva"},{"key":"451_CR20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF02172145","volume":"24","author":"C Lord","year":"1994","unstructured":"Lord C, Rutter M, LeCouteur A (1994) Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24:659\u2013685","journal-title":"J Autism Dev Disord"},{"issue":"1","key":"451_CR21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF02408436","volume":"10","author":"E Schopler","year":"1980","unstructured":"Schopler E, Reichler RJ, DeVellis RF, Daly K (1980) Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord 10(1):91\u2013103","journal-title":"J Autism Dev Disord"},{"key":"451_CR22","volume-title":"Psychoeducational profile-revised (PEP-R), vol I","author":"E Schopler","year":"1979","unstructured":"Schopler E, Reichler RJ, Bashford A, Lansing MD, Marcus LM (1979) Psychoeducational profile-revised (PEP-R), vol I. University Park Press, Baltimore"},{"key":"451_CR23","volume-title":"Assessment of children: WISC-IV and WPPSI-III supplement","author":"JM Sattler","year":"2004","unstructured":"Sattler JM, Dumont R (2004) Assessment of children: WISC-IV and WPPSI-III supplement. J.M. Sattler Publisher, San Diego"},{"issue":"3","key":"451_CR24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.encep.2010.08.014","volume":"37","author":"B Rousselot-Pailley","year":"2011","unstructured":"Rousselot-Pailley B, Fortin C, Golse B, Falissard B, Robel L (2011) The FAQ self-report is a valid instrument to characterize endophenotypes of the autistic spectrum in parents of children with autism. Encephale 37(3):191\u2013198","journal-title":"Encephale"},{"key":"451_CR25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1198\/016214502760047131","volume":"97","author":"C Fraley","year":"2002","unstructured":"Fraley C, Raftery AE (2002) Model-based clustering, discriminant analysis, and density estimation. J Am Stat Assoc 97:611\u2013631","journal-title":"J Am Stat Assoc"},{"issue":"8","key":"451_CR26","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/j.1469-7610.2004.00325.x","volume":"45","author":"DV Bishop","year":"2004","unstructured":"Bishop DV, Maybery M, Maley A et al (2004) Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: a study using the Autism-Spectrum Quotient. J Child Psychol Psychiatry 45(8):1431\u20131436","journal-title":"J Child Psychol Psychiatry"},{"key":"451_CR27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2040-2392-1-10","volume":"1","author":"S Wheelwright","year":"2010","unstructured":"Wheelwright S, Auyeung B, Allison C, Baron-Cohen S (2010) Defining the broader, medium and narrow autism phenotype among parents using the Autism Spectrum Quotient (AQ) Molecular. Autism 1:10","journal-title":"Autism"},{"issue":"11","key":"451_CR28","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1176\/appi.ajp.2010.09101470","volume":"167","author":"JN Constantino","year":"2010","unstructured":"Constantino JN, Zhang YI, Frazier T, Abbachini AM, Law P (2010) Sibling recurrence and the genetic epidemiology of autism. Am J Psychiatry 167(11):1349\u20131356","journal-title":"Am J Psychiatry"},{"key":"451_CR29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/adc.2005.075846","volume":"91","author":"S Baron-Cohen","year":"2006","unstructured":"Baron-Cohen S (2006) Two new theories of autism: hypersystemizing and assortative mating. Arch Dis Child 91:2\u20135","journal-title":"Arch Dis Child"},{"key":"451_CR30","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1176\/appi.ajp.164.4.656","volume":"164","author":"JA Duvall","year":"2007","unstructured":"Duvall JA, Ake L, Cantor RM, Todd RD, Constantino JN, Geschwind DH (2007) A quantitative trait locus analysis of social responsiveness in multiplex autism families. Am J Psychiatry 164:656\u2013662","journal-title":"Am J Psychiatry"},{"issue":"5","key":"451_CR31","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1086\/659629","volume":"177","author":"BP Zietsch","year":"2011","unstructured":"Zietsch BP, Verweij KJ, Heath AC, Martin NG (2011) Variation in human mate choice: simultaneously investigating heritability, parental influence, sexual imprinting, and assortative mating. Am Nat 177(5):605\u2013616","journal-title":"Am Nat"},{"issue":"5","key":"451_CR32","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1073\/pnas.1011687108","volume":"108","author":"JH Fowler","year":"2010","unstructured":"Fowler JH, Settle J, Christakis N (2010) Correlated genotypes in friendship networks. Proc Natl Acad Sci 108(5):1993\u20131997","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"451_CR33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/1362361307076857","volume":"11","author":"RP Goin-Kochel","year":"2007","unstructured":"Goin-Kochel RP, Abbachi N, Constantino JN, AGRE Consortium (2007) Lack of evidence for increased genetic loading for autism among families of affected females: a replication from family history data in two large samples. Autism 11(3):279\u2013286","journal-title":"Autism"}],"container-title":["European Child & Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-013-0451-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00787-013-0451-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-013-0451-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T06:36:22Z","timestamp":1559111782000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00787-013-0451-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,18]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["451"],"URL":"https:\/\/doi.org\/10.1007\/s00787-013-0451-5","relation":{},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"value":"1018-8827","type":"print"},{"value":"1435-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,18]]}}}