{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:45:18Z","timestamp":1789854318290,"version":"4.0.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T00:00:00Z","timestamp":1463788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria, Instituto de Salud Carlos III, Ministry of Health, Spain","award":["PI04\/0455"],"award-info":[{"award-number":["PI04\/0455"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s00787-016-0866-x","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T14:53:32Z","timestamp":1464015212000},"page":"35-46","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The effects of antipsychotics on weight gain, weight-related hormones and homocysteine in children and adolescents: a 1-year follow-up study"],"prefix":"10.1007","volume":"26","author":[{"given":"Inmaculada","family":"Baeza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Vigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"de la Serna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Calvo-Escalona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Merch\u00e1n-Naranjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Rodr\u00edguez-Latorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso","family":"Arango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Castro-Fornieles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,21]]},"reference":[{"key":"866_CR1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/JCP.0000000000000190","volume":"5","author":"I Baeza","year":"2014","unstructured":"Baeza I, De la Serna E, Calvo-Escalona R, Morer A, Merch\u00e1n-Naranjo J, Tapia C, Mart\u00ednez-Cantarero MC, Andr\u00e9s P, Alda JA, S\u00e1nchez B, Arango C, Castro-Fornieles J (2014) Antipsychotic use in children and adolescents. A 1-year follow-up study. J Clin Psychopharmacol 5:613\u2013619","journal-title":"J Clin Psychopharmacol"},{"key":"866_CR2","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/archgenpsychiatry.2012.647","volume":"69","author":"M Olfson","year":"2012","unstructured":"Olfson M, Blanco C, Liu SM, Wang S, Correll CU (2012) National trends in the office-based treatment of children, adolescents, and adults with antipsychotics. Arch Gen Psychiatry 69:1247\u20131256","journal-title":"Arch Gen Psychiatry"},{"key":"866_CR3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.euroneuro.2010.07.002","volume":"21","author":"D Fraguas","year":"2011","unstructured":"Fraguas D, Correll CU, Merch\u00e1n-Naranjo J, Rapado-Castro M, Parellada M, Moreno C, Arango C (2011) Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons. Eur Neuropsychopharmacol 21:621\u2013645","journal-title":"Eur Neuropsychopharmacol"},{"key":"866_CR4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.euroneuro.2014.11.003","volume":"25","author":"C Arango","year":"2015","unstructured":"Arango C (2015) Present and future of developmental neuropsychopharmacology. Eur Neuropsychopharmacol 25:703\u2013712","journal-title":"Eur Neuropsychopharmacol"},{"key":"866_CR5","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1001\/jama.2009.1549","volume":"302","author":"CU Correll","year":"2009","unstructured":"Correll CU, Manu P, Olshanskiy V, Napolitano B, Kane JM, Malhotra AK (2009) Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents. JAMA 302:1765\u20131773","journal-title":"JAMA"},{"key":"866_CR6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/cap.2006.16.308","volume":"16","author":"C Fleischhaker","year":"2006","unstructured":"Fleischhaker C, Heiser P, Hennighausen K, Herpertz-Dahlmann B, Holtkamp K, Mehler-Wex C, Rauh R, Remschmidt H, Schulz E, Warnke A (2006) Clinical drug monitoring in child and adolescent psychiatry: side effects of atypical neuroleptics. J Child Adolesc Psychopharmacol 16:308\u2013316","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"866_CR7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/01.jcp.0000130558.86125.5b","volume":"24","author":"DJ Safer","year":"2004","unstructured":"Safer DJ (2004) A comparison of risperidone-induced weight gain across the age span. J Clin Psychopharmacol 24:429\u2013436","journal-title":"J Clin Psychopharmacol"},{"key":"866_CR8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00787-013-0399-5","volume":"22","author":"JM Mart\u00ednez-Ortega","year":"2013","unstructured":"Mart\u00ednez-Ortega JM, Funes-Godoy S, D\u00edaz-Atienza F, Guti\u00e9rrez-Rojas L, P\u00e9rez-Costillas L, Gurpegui M (2013) Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review. Eur Child Adolesc Psychiatry 22:457\u2013479","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"866_CR9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/070674370605100804","volume":"51","author":"TA Cohn","year":"2006","unstructured":"Cohn TA, Sernyak MJ (2006) Metabolic monitoring for patients treated with antipsychotic medications. Can J Psychiatry 51:492\u2013501","journal-title":"Can J Psychiatry"},{"key":"866_CR10","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","volume":"156","author":"DB Allison","year":"1999","unstructured":"Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC (1999) Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156:1686\u20131696","journal-title":"Am J Psychiatry"},{"key":"866_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnpbp.2009.11.009","volume":"34","author":"C Deng","year":"2010","unstructured":"Deng C, Weston-Green K, Huang X (2010) The role of histaminergic H1 and H3 receptors in food intake: a mechanism for atypical antipsychotic-induced weight gain? Prog Neuropsychopharmacol Biol Psychiatry 34:1\u20134","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"866_CR12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0447.1999.tb10908.x","volume":"100","author":"T Baptista","year":"1999","unstructured":"Baptista T (1999) Body weight gain induced by antipsychotic drugs: mechanisms and management. Acta Psychiatr Scand 100:3\u201316","journal-title":"Acta Psychiatr Scand"},{"key":"866_CR13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/ejcn.2013.253","volume":"68","author":"C Cuerda","year":"2014","unstructured":"Cuerda C, Velasco C, Merch\u00e1n-Naranjo J, Garc\u00eda-Peris P, Arango C (2014) The effects of second-generation antipsychotics on food intake, resting energy expenditure and physical activity. Eur J Clin Nutr 68:146\u2013152","journal-title":"Eur J Clin Nutr"},{"key":"866_CR14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1177\/153537020122601102","volume":"226","author":"PJ Havel","year":"2001","unstructured":"Havel PJ (2001) Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med (Maywood). 226:963\u2013977","journal-title":"Exp Biol Med (Maywood)."},{"key":"866_CR15","doi-asserted-by":"crossref","unstructured":"Friedman JM (2002) The function of leptin in nutrition, weight, and physiology. Nutr Rev 60:S1\u201314 (discussion S68\u201384, 85\u201387)","DOI":"10.1301\/002966402320634878"},{"key":"866_CR16","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/schbul\/sbm141","volume":"34","author":"O Sentissi","year":"2008","unstructured":"Sentissi O, Epelbaum J, Oli\u00e9 JP, Poirier MF (2008) Leptin and ghrelin levels in patients with schizophrenia during different antipsychotics treatment: a review. Schiz Bull 34:1189\u20131199","journal-title":"Schiz Bull"},{"key":"866_CR17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrg862","volume":"3","author":"GS Barsh","year":"2002","unstructured":"Barsh GS, Schwartz MW (2002) Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet 3:589\u2013600","journal-title":"Nat Rev Genet"},{"key":"866_CR18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","volume":"409","author":"M Nakazato","year":"2001","unstructured":"Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S (2001) A role for ghrelin in the central regulation of feeding. Nature 409:194\u2013198","journal-title":"Nature"},{"key":"866_CR19","doi-asserted-by":"crossref","unstructured":"Lucidi P, Murdolo G, Di Loreto C, Parlanti N, De Cicco A, Ranchelli A, Fatone C, Taglioni C, Fanelli C, Santeusanio F, De Feo P (2004) Meal intake similarly reduces circulating concentrations of octanoyl and total ghrelin in humans. J Endocrinol Invest 27:RC12\u20135","DOI":"10.1007\/BF03345282"},{"key":"866_CR20","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.2174\/1381612033454766","volume":"9","author":"LK Heilbronn","year":"2003","unstructured":"Heilbronn LK, Smith SR, Ravussin E (2003) The insulin-sensitizing role of the fat derived hormone adiponectin. Curr Pharm Des 9:1411\u20131418","journal-title":"Curr Pharm Des"},{"key":"866_CR21","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","volume":"86","author":"C Weyer","year":"2001","unstructured":"Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinmia. J Clin Endocrinol Metab 86:1930\u20131935","journal-title":"J Clin Endocrinol Metab"},{"key":"866_CR22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.mce.2009.06.005","volume":"316","author":"T Reinehr","year":"2010","unstructured":"Reinehr T (2010) Obesity and thyroid function. Mol Cel Endocrinol 316:165\u2013171","journal-title":"Mol Cel Endocrinol"},{"key":"866_CR23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/MOP.0b013e328344c393","volume":"23","author":"T Reinehr","year":"2011","unstructured":"Reinehr T (2011) Thyroid function in the nutritionally obese child and adolescent. Curr Opin Pediatrics 23:415\u2013420","journal-title":"Curr Opin Pediatrics"},{"key":"866_CR24","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1515\/jpem-2012-0384","volume":"26","author":"C Aypak","year":"2013","unstructured":"Aypak C, T\u00fcredi O, Y\u00fcce A, G\u00f6rpelio\u011flu S (2013) Thyroid-stimulating hormone (TSH) level in nutritionally obese children and metabolic co-morbidity. J Pediatr Endocrinol Metab 26:703\u2013708","journal-title":"J Pediatr Endocrinol Metab"},{"key":"866_CR25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2265.2005.02247.x","volume":"62","author":"G Jacobellis","year":"2005","unstructured":"Jacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F (2005) Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin Endocrinol 62:487\u2013491","journal-title":"Clin Endocrinol"},{"key":"866_CR26","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1530\/EJE-12-0447","volume":"167","author":"G Roef","year":"2012","unstructured":"Roef G, Lapauw B, Goemaere S, Zmierczak HG, Toye K, Kaufman JM, Taes Y (2012) Body composition and metabolic parameters are associated with variation in thyroid hormone levels among euthyroid young men. Eur J Endocrinol 167:719\u2013726","journal-title":"Eur J Endocrinol"},{"key":"866_CR27","doi-asserted-by":"publisher","unstructured":"Mart\u00ed-Carvajal AJ, Sol\u00e0 I, Lathyris D, Karakitsiou DE, Simancas-Racines D (2013) Homocysteine-lowering interventions for preventing\u00a0cardiovascular\u00a0events. Cochrane Database Syst Rev 1:CD006612. doi: 10.1002\/14651858.CD006612.pub3","DOI":"10.1002\/14651858.CD006612.pub3"},{"key":"866_CR28","first-page":"156","volume":"61","author":"RA Karatela","year":"2009","unstructured":"Karatela RA, Sainani GS (2009) Plasma homocysteine in obese, overweight and hypertensive subjects in Mumbai. Indian Heart 61:156\u2013159","journal-title":"Indian Heart"},{"key":"866_CR29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/CH-2010-1366","volume":"47","author":"A Vay\u00e1","year":"2011","unstructured":"Vay\u00e1 A, Carmona P, Badia N, P\u00e9rez R, Hernandez Mijares A, Corella D (2011) Homocysteine levels and the metabolic syndrome in a Mediterranean population: a case-control study. Clin Hemorheol Microcirc 47:59\u201366","journal-title":"Clin Hemorheol Microcirc"},{"key":"866_CR30","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3390\/nu6041649","volume":"6","author":"M Yakub","year":"2014","unstructured":"Yakub M, Schulze KJ, Khatry SK, Stewart CP, Christian P, West KP Jr (2014) High Plasma Homocysteine increases risk of metabolic syndrome in 6\u20138\u00a0year old children in rural Nepal. Nutrients 6:1649\u20131661","journal-title":"Nutrients"},{"key":"866_CR31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.schres.2007.11.026","volume":"100","author":"H Jin","year":"2008","unstructured":"Jin H, Meyer JM, Mudaliar S, Jeste DV (2008) Impact of atypical antipsychotic therapy on leptin, ghrelin and adiponectin. Schiz Res 100:70\u201385","journal-title":"Schiz Res"},{"issue":"suppl 1","key":"866_CR32","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.diabres.2005.03.008","volume":"68","author":"E Palik","year":"2005","unstructured":"Palik E, Birkas KD, Faludi G, Kar\u00e1di I, Cseh K (2005) Correlation of serum ghrelin levels with body mass index and carbohydrate metabolism in patients treated with atypical antipsychotics. Diabetes Res Clin Pract 68(suppl 1):S60\u2013S64","journal-title":"Diabetes Res Clin Pract"},{"key":"866_CR33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/JCP.0b013e318172b8e6","volume":"28","author":"R Perez-Iglesias","year":"2008","unstructured":"Perez-Iglesias R, Vazquez-Barquero JL, Amado JA, Berja A, Garcia-Unzueta MT, Pelayo-Ter\u00e1n JM, Carrasco-Mar\u00edn E, Mata I, Crespo-Facorro B (2008) Effect of antipsychotics on peptides involved in energy balance in drug-naive psychotic patients after 1\u00a0year of treatment. J Clin Psychopharmacol 28:289\u2013295","journal-title":"J Clin Psychopharmacol"},{"key":"866_CR34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/YIC.0b013e3283377850","volume":"25","author":"C Basoglu","year":"2010","unstructured":"Basoglu C, Oner O, Gunes C, Semiz UB, Ates AM, Algul A, Ebrinc S, Cetin M, Ozcan O, Ipcioglu O (2010) Plasma orexin A, ghrelin, cholecistokinin, visfasin, leptin and agouti-related protein levels during 6-week olanzapine treatment in first-episode male patients with psychosis. Int Clin Psychopharmacol 25:165\u2013171","journal-title":"Int Clin Psychopharmacol"},{"key":"866_CR35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/01.jcp.0000218404.64619.52","volume":"26","author":"AA Richards","year":"2006","unstructured":"Richards AA, Hickman IJ, Wang AY, Jones AL, Newell F, Mowry BJ, Whitehead JP, Prins JB, Macdonald GA (2006) Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum: a potential mechanism for olanzapine-induced insulin resistance in patients with schizophrenia. J Clin Psychopharmacol 26:232\u2013237","journal-title":"J Clin Psychopharmacol"},{"key":"866_CR36","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1097\/01.chi.0000170552.15798.dd","volume":"44","author":"AL Sporn","year":"2005","unstructured":"Sporn AL, Bobb AJ, Gogtay N, Stevens H, Greenstein DK, Clasen LS, Tossell JW, Nugent T, Gochman PA, Sharp WS, Mattai A, Lenane MC, Yanovski JA, Rapoport JL (2005) Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory study. J Am Acad Child Adolesc Psychiatry 44:925\u2013933","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"866_CR37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hup.1097","volume":"25","author":"LA Maayan","year":"2010","unstructured":"Maayan LA, Vakhrusheva J (2010) Risperidone associated weight, leptin, and anthropometric changes in children and adolescents with psychotic disorders in early treatment. Human Psychopharmacol 25:133\u2013138","journal-title":"Human Psychopharmacol"},{"key":"866_CR38","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1176\/appi.ajp.161.6.1125","volume":"161","author":"A Martin","year":"2004","unstructured":"Martin A, Scahill L, Anderson G, Aman M, Arnold LE, McCracken J, McDougle CJ, Tierney E, Chuang S, Vitiello B (2004) Weight and leptin changes among risperidone-treated youths with autism: 6-month prospective data. Am J Psychiatry 161:1125\u20131127","journal-title":"Am J Psychiatry"},{"key":"866_CR39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/cap.2008.007","volume":"19","author":"CA Calarge","year":"2009","unstructured":"Calarge CA, Acion L, Kuperman S, Tansey M, Schlechte JA (2009) Weight gain and metabolic abnormalities during extended risperidone treatment in children and adolescents. J Child Adol Psychopharmacol 19:101\u2013109","journal-title":"J Child Adol Psychopharmacol"},{"key":"866_CR40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.rpsm.2012.03.006","volume":"5","author":"J Merchan-Naranjo","year":"2012","unstructured":"Merchan-Naranjo J, Tapia C, Bail\u00f3n C, Moreno C, Baeza I, Calvo-Escalona R, Morer A, Mart\u00ednez-Cantarero C, Nestares PA, Alda J\u00c1, Mu\u00f1oz D, Arango C (2012) Secondary effects of antipsychotic treatment in na\u00efve or quasi-na\u00efve children and adolescents: design of a follow-up protocol and baseline results. Rev Psiquiatr Salud Ment 5:217\u2013228","journal-title":"Rev Psiquiatr Salud Ment"},{"key":"866_CR41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.biopsych.2009.08.040","volume":"67","author":"NC Andreasen","year":"2010","unstructured":"Andreasen NC, Pressler M, Nopoulos P, Miller D, Ho BC (2010) Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs. Biol Psychiatry 67:255\u2013262","journal-title":"Biol Psychiatry"},{"key":"866_CR42","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412\u2013419","journal-title":"Diabetologia"},{"key":"866_CR43","volume-title":"Curvas y tablas de crecimiento: estudios longitudinal y transversal","author":"B Sobradillo","year":"2004","unstructured":"Sobradillo B, Aguirre A, Aresti U, Bilbao C, Fern\u00e1ndez-Ramos A, Lizarraga H, Lorenzo L, Madariaga I, Rica I, Ruiz E, S\u00e1nchez C Santamar\u00eda, Serrano JM, Zabala A, Zurimendi B, Hern\u00e1ndez M (2004) Curvas y tablas de crecimiento: estudios longitudinal y transversal. Fundaci\u00f3n Faustino Orbegozo Eizaguirre, Bilbao"},{"key":"866_CR44","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/sj.ijo.0802787","volume":"28","author":"CE Flodmark","year":"2004","unstructured":"Flodmark CE, Lissau I, Moreno LA, Pietrobelli A, Widhalm K (2004) New insights into the field of children and adolescents\u2019 obesity: the European perspective. Int J Obes Relat Metab Disord 28:1189\u20131196","journal-title":"Int J Obes Relat Metab Disord"},{"key":"866_CR45","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jaac.2014.08.009","volume":"53","author":"C Arango","year":"2014","unstructured":"Arango C, Gir\u00e1ldez M, Merch\u00e1n-Naranjo J, Baeza I, Castro-Fornieles J, Alda JA, Mart\u00ednez-Cantarero C, Moreno C, de Andr\u00e9s P, Cuerda C, de la Serna E, Correll CU, Fraguas D, Parellada M (2014) Second-generation antipsychotic use in children and adolescents; a 6-month prospective cohort study in drug-na\u00efve patients. J Am Acad Child Adol Psychiatry 53:1179\u20131190","journal-title":"J Am Acad Child Adol Psychiatry"},{"key":"866_CR46","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/archpedi.162.10.929","volume":"162","author":"RS McIntyre","year":"2008","unstructured":"McIntyre RS, Jerrell JM (2008) Metabolic and cardiovascular adverse events associated with antipsychotic treatment in children and adolescents. Arch Pediatr Adolesc Med 162:929\u2013935","journal-title":"Arch Pediatr Adolesc Med"},{"key":"866_CR47","first-page":"994","volume":"47","author":"SV Faraone","year":"2008","unstructured":"Faraone SV, Biederman J, Morley CP, Spencer TJ (2008) Effect of stimulants on height and weight: a review of the literature. J Am Acad Child Adolesc Psychiatry 47:994\u20131009","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"866_CR48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/cap.2009.0051","volume":"19","author":"JB Penzner","year":"2009","unstructured":"Penzner JB, Dudas M, Saito E, Olshanskiy V, Parikh UH, Kapoor S, Chekuri R, Gadaleta D, Avedon J, Sheridan EM, Randell J, Malhotra AK, Kane JM, Correll CU (2009) Lack of effect of stimulant combination with second-generation antipsychotics on weight gain, metabolic changes, prolactin levels, and sedation in youth with clinically relevant aggression or oppositionality. J Child Adolesc Psychopharmacol. 19:563\u2013573","journal-title":"J Child Adolesc Psychopharmacol."},{"key":"866_CR49","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1467-789X.2009.00589.x","volume":"10","author":"S Gentile","year":"2009","unstructured":"Gentile S (2009) Contributing factors to weight gain during long-term treatment with second-generation antipsychotics. A systematic appraisal and clinical implications. Obes Rev 10:527\u2013542","journal-title":"Obes Rev"},{"key":"866_CR50","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/jpc.12610","volume":"50","author":"NC Gonzaga","year":"2014","unstructured":"Gonzaga NC, Medeiros CC, de Carvalho DF, Alves JG (2014) Leptin and cardiometabolic risk factors in obese children and adolescents. J Paediatr Child Health 50:707\u2013712","journal-title":"J Paediatr Child Health"},{"key":"866_CR51","doi-asserted-by":"crossref","first-page":"505","DOI":"10.7705\/biomedica.v27i4.119","volume":"27","author":"E Poveda","year":"2007","unstructured":"Poveda E, Callas NE, Baracaldo CM, Castillo C, Hern\u00e1ndez P (2007) Leptin levels in school age children associated with antropometric measurements and lipid profiles. Biomedica 27:505\u2013514","journal-title":"Biomedica"},{"key":"866_CR52","first-page":"1047","volume":"39","author":"AA Venner","year":"2006","unstructured":"Venner AA, Lyon ME, Doyle-Baker PK (2006) Leptin: a potencial biomarker for childhood obesity? Clin. Biochem 39:1047\u20131056","journal-title":"Biochem"},{"key":"866_CR53","doi-asserted-by":"publisher","unstructured":"Karavani G, Strich D, Edri S, Gillis D (2014) Increases in thyrotropin within the near-normal range are associated with increased triiodothyronine but not increased thyroxine in the pediatric age. J Clin Endocrinol Metab 99(8):E1471\u20135. doi: 10.1210\/jc.2014-1441 (Epub 2014 May 30)","DOI":"10.1210\/jc.2014-1441"},{"key":"866_CR54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000284361","volume":"73","author":"V Marras","year":"2010","unstructured":"Marras V, Casini MR, Pilia S, Carta D, Civolani P, Porcu M, Uccheddu AP, Loche S (2010) Thyroid function in obese children and adolescents. Horm Res Paediatr 73:193\u2013197","journal-title":"Horm Res Paediatr"},{"key":"866_CR55","first-page":"177","volume":"28","author":"L Margari","year":"2013","unstructured":"Margari L, Matera E, Craig F, Petruzzelli MG, Palmieri VO, Pastore A, Margari F (2013) Tolerability and safety profile of risperidone in a sample of children and adolescents. Int Clin Psychopharmacol 28:177\u2013183","journal-title":"Int Clin Psychopharmacol"},{"key":"866_CR56","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1762-2","author":"B Misiak","year":"2014","unstructured":"Misiak B, Frydecka D, Laczmanski L, Slezak R, Kiejna A (2014) Effects of second-generation antipsychotics on selected markers of one-carbon metabolism and metabolic syndrome components in first-episode schizophrenia patients. Eur J Clin Pharmacol. doi: 10.1007\/s00228-014-1762-2","journal-title":"Eur J Clin Pharmacol"},{"key":"866_CR57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/sj.mp.4002066","volume":"13","author":"HA Nasrallah","year":"2008","unstructured":"Nasrallah HA (2008) Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 13:27\u201335","journal-title":"Mol Psychiatry."},{"key":"866_CR58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.peptides.2014.03.015","volume":"56","author":"G Catli","year":"2014","unstructured":"Catli G, Anik A, Tuhan H\u00dc, Kume T, Bober E, Abaci A (2014) The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children. Peptides 56:72\u201376","journal-title":"Peptides"},{"key":"866_CR59","doi-asserted-by":"publisher","unstructured":"Friedemann C,\u00a0Heneghan C,\u00a0Mahtani K,\u00a0Thompson M,\u00a0Perera R,\u00a0Ward AM (2012) Cardiovascular disease risk in healthy\u00a0children\u00a0and its association with body mass index: systematic\u00a0review\u00a0and meta-analysis. BMJ 345:e4759. doi: 10.1136\/bmj.e4759","DOI":"10.1136\/bmj.e4759"},{"key":"866_CR60","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00004583-200203000-00014","volume":"41","author":"G Ratzoni","year":"2002","unstructured":"Ratzoni G, Gothelf D, Brand-Gothelf A, Reidman J, Kikinzon L, Gal G, Phillip M, Apter A, Weizman R (2002) Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study. J Am Acad Child Adol Psychiatry 41:337\u2013343","journal-title":"J Am Acad Child Adol Psychiatry"}],"container-title":["European Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-016-0866-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00787-016-0866-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-016-0866-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-016-0866-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T11:14:04Z","timestamp":1692357244000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00787-016-0866-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,21]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["866"],"URL":"https:\/\/doi.org\/10.1007\/s00787-016-0866-x","relation":{},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"value":"1018-8827","type":"print"},{"value":"1435-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,21]]}}}