{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:41:29Z","timestamp":1790667689988,"version":"4.1.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2009\/09949-8"],"award-info":[{"award-number":["2009\/09949-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08531-5"],"award-info":[{"award-number":["2013\/08531-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/50917-0"],"award-info":[{"award-number":["2014\/50917-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["465550\/2014-2"],"award-info":[{"award-number":["465550\/2014-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s00787-019-01320-w","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T18:07:20Z","timestamp":1554919640000},"page":"1607-1617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Caudate volume differences among treatment responders, non-responders and controls in children with obsessive\u2013compulsive disorder"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-8041","authenticated-orcid":false,"given":"Edoardo F. Q.","family":"Vattimo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian B.","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guaraci","family":"Requena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o R.","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euripedes C.","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseli G.","family":"Shavitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Q.","family":"Hoexter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo C.","family":"Batistuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"issue":"6","key":"1320_CR1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0887-6185(00)00048-7","volume":"14","author":"JL Rapoport","year":"2000","unstructured":"Rapoport JL, Inoff-Germain G, Weissman MM, Greenwald S, Narrow WE, Jensen PS et al (2000) Childhood obsessive\u2013compulsive disorder in the NIMH MECA Study: parent versus child identification of cases. J Anxiety Disord 14(6):535\u2013548","journal-title":"J Anxiety Disord"},{"issue":"2","key":"1320_CR2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1590\/1516-4446-2014-1606","volume":"37","author":"CS Paula","year":"2015","unstructured":"Paula CS, Coutinho ES, Mari JJ, Rohde LA, Miguel EC, Bordin IA (2015) Prevalence of psychiatric disorders among children and adolescents from four Brazilian regions. Rev Bras Psiquiatr 37(2):178\u2013179","journal-title":"Rev Bras Psiquiatr"},{"issue":"7","key":"1320_CR3","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cpr.2011.06.007","volume":"31","author":"S Taylor","year":"2011","unstructured":"Taylor S (2011) Early versus late onset obsessive\u2013compulsive disorder: evidence for distinct subtypes. Clin Psychol Rev 31(7):1083\u20131100","journal-title":"Clin Psychol Rev"},{"issue":"1","key":"1320_CR4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0005-7894(05)80054-1","volume":"36","author":"JS Abramowitz","year":"2006","unstructured":"Abramowitz JS, Whiteside SP, Deacon BJ (2006) The effectiveness of treatment for pediatric obsessive\u2013compulsive disorder: a meta-analysis. Behav Ther 36(1):55\u201363","journal-title":"Behav Ther"},{"issue":"5","key":"1320_CR5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1469-7610.2007.01875.x","volume":"49","author":"HJ Watson","year":"2008","unstructured":"Watson HJ, Rees CS (2008) Meta-analysis of randomized, controlled treatment trials for pediatric obsessive\u2013compulsive disorder. J Child Psychol Psychiatry 49(5):489\u2013498","journal-title":"J Child Psychol Psychiatry"},{"issue":"16","key":"1320_CR6","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1001\/jama.292.16.1969","volume":"292","author":"The POTS Team","year":"2004","unstructured":"The POTS Team (2004) Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive\u2013compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial. JAMA 292(16):1969","journal-title":"JAMA"},{"issue":"8","key":"1320_CR7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/da.22389","volume":"32","author":"JF McGuire","year":"2015","unstructured":"McGuire JF, Piacentini J, Lewin AB, Brennan EA, Murphy TK, Storch EA (2015) A meta-analysis of cognitive behavior therapy and medication for child obsessive\u2013compulsive disorder: moderators of treatment efficacy, response, and remission. Depress Anxiety 32(8):580\u2013593","journal-title":"Depress Anxiety"},{"issue":"1","key":"1320_CR8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cpr.2005.06.010","volume":"26","author":"L Friedlander","year":"2006","unstructured":"Friedlander L, Desrocher M (2006) Neuroimaging studies of obsessive\u2013compulsive disorder in adults and children. Clin Psychol Rev 26(1):32\u201349","journal-title":"Clin Psychol Rev"},{"issue":"4","key":"1320_CR9","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1172\/JCI37563","volume":"119","author":"SK Kalra","year":"2009","unstructured":"Kalra SK, Swedo SE (2009) Children with obsessive\u2013compulsive disorder: are they just \u201clittle adults\u201d? J Clin Invest 119(4):737","journal-title":"J Clin Invest"},{"issue":"5","key":"1320_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1176\/appi.ajp.2017.17050485","volume":"175","author":"PS Boedhoe","year":"2017","unstructured":"Boedhoe PS, Schmaal L, Abe Y, Alonso P, Ameis SH, Anticevic A et al (2017) Cortical abnormalities associated with pediatric and adult obsessive\u2013compulsive disorder: findings from the ENIGMA obsessive\u2013compulsive disorder working group. Am J Psychiatry 175(5):453\u2013462. \nhttps:\/\/doi.org\/10.1176\/appi.ajp.2017.17050485","journal-title":"Am J Psychiatry"},{"issue":"1","key":"1320_CR11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1176\/appi.ajp.2016.16020201","volume":"174","author":"PS Boedhoe","year":"2016","unstructured":"Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC et al (2016) Distinct subcortical volume alterations in pediatric and adult OCD: a worldwide meta-and mega-analysis. Am J Psychiatry 174(1):60\u201369","journal-title":"Am J Psychiatry"},{"issue":"11","key":"1320_CR12","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archgenpsychiatry.2009.152","volume":"66","author":"BJ Harrison","year":"2009","unstructured":"Harrison BJ, Soriano-Mas C, Pujol J, Ortiz H, L\u00f3pez-Sol\u00e0 M, Hern\u00e1ndez-Ribas R et al (2009) Altered corticostriatal functional connectivity in obsessive\u2013compulsive disorder. Arch Gen Psychiatry 66(11):1189\u20131200","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"1320_CR13","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1001\/archpsyc.1990.01810210048007","volume":"47","author":"C Benkelfat","year":"1990","unstructured":"Benkelfat C, Nordahl TE, Semple WE, King AC, Murphy DL, Cohen RM (1990) Local cerebral glucose metabolic rates in obsessive\u2013compulsive disorder: patients treated with clomipramine. Arch Gen Psychiatry 47(9):840\u2013848","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"1320_CR14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0893-133X(99)00082-2","volume":"21","author":"S Saxena","year":"1999","unstructured":"Saxena S, Brody AL, Maidment KM, Dunkin JJ, Colgan M, Alborzian S et al (1999) Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive\u2013compulsive disorder. Neuropsychopharmacology 21(6):683\u2013693","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"1320_CR15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archpsyc.1996.01830020023004","volume":"53","author":"JM Schwartz","year":"1996","unstructured":"Schwartz JM, Stoessel PW, Baxter LR, Martin KM, Phelps ME (1996) Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive\u2013compulsive disorder. Arch Gen Psychiatry 53(2):109\u2013113","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"1320_CR16","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/archpsyc.1992.01820090009002","volume":"49","author":"LR Baxter Jr","year":"1992","unstructured":"Baxter LR Jr, Schwartz JM, Bergman KS et al (1992) Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive\u2013compulsive disorder. Arch Gen Psychiatry 49(9):681\u2013689","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"1320_CR17","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/00004583-200009000-00008","volume":"39","author":"DR Rosenberg","year":"2000","unstructured":"Rosenberg DR, MacMaster FP, Keshavan MS, Fitzgerald KD, Stewart CM, Moore GJ (2000) Decrease in caudate glutamatergic concentrations in pediatric obsessive\u2013compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry 39(9):1096\u20131103","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"5","key":"1320_CR18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/archpsyc.57.5.449","volume":"57","author":"AR Gilbert","year":"2000","unstructured":"Gilbert AR, Moore GJ, Keshavan MS, Paulson LAD, Narula V, Mac Master FP et al (2000) Decrease in thalamic volumes of pediatric patients with obsessive\u2013compulsive disorder who are taking paroxetine. Arch Gen Psychiatry 57(5):449\u2013456","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"1320_CR19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pnpbp.2011.09.007","volume":"36","author":"J O\u2019Neill","year":"2012","unstructured":"O\u2019Neill J, Piacentini JC, Chang S, Levitt JG, Rozenman M, Bergman L et al (2012) MRSI correlates of cognitive\u2013behavioral therapy in pediatric obsessive\u2013compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 36(1):161\u2013168","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"6","key":"1320_CR20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/15622975.2013.819122","volume":"15","author":"C Huyser","year":"2014","unstructured":"Huyser C, van den Heuvel OA, Wolters L, de Haan E, Lindauer R, Veltman DJ (2014) A longitudinal VBM study in paediatric obsessive\u2013compulsive disorder at 2-year follow-up after cognitive behavioural therapy. World J Biol Psychiatry 15(6):443\u2013452","journal-title":"World J Biol Psychiatry"},{"issue":"4","key":"1320_CR21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/15622975.2012.674215","volume":"14","author":"C Huyser","year":"2013","unstructured":"Huyser C, van den Heuvel OA, Wolters LH, de Haan E, Boer F, Veltman DJ (2013) Increased orbital frontal gray matter volume after cognitive behavioural therapy in paediatric obsessive compulsive disorder. World J Biol Psychiatry 14(4):319\u2013331","journal-title":"World J Biol Psychiatry"},{"issue":"12","key":"1320_CR22","first-page":"1238","volume":"49","author":"C Huyser","year":"2010","unstructured":"Huyser C, Veltman DJ, Wolters LH, de Haan E, Boer F (2010) Functional magnetic resonance imaging during planning before and after cognitive-behavioral therapy in pediatric obsessive\u2013compulsive disorder. J Am Acad Child Adolesc Psychiatry 49(12):1238\u20131248","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"6","key":"1320_CR23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1001\/archpsyc.1989.01810060038007","volume":"46","author":"SE Swedo","year":"1989","unstructured":"Swedo SE, Schapiro MB, Grady CL, Cheslow DL, Leonard HL, Kumar A et al (1989) Cerebral glucose metabolism in childhood-onset obsessive\u2013compulsive disorder. Arch Gen Psychiatry 46(6):518\u2013523","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"1320_CR24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0925-4927(03)00091-X","volume":"124","author":"T Hendler","year":"2003","unstructured":"Hendler T, Goshen E, Zwas ST, Sasson Y, Gal G, Zohar J (2003) Brain reactivity to specific symptom provocation indicates prospective therapeutic outcome in OCD. Psychiatry Res Neuroimaging 124(2):87\u2013103","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"2","key":"1320_CR25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pscychresns.2004.12.003","volume":"138","author":"KLH Pian","year":"2005","unstructured":"Pian KLH, van Megen HJ, Ramsey NF, Mandl R, van Rijk PP, Wynne H et al (2005) Decreased thalamic blood flow in obsessive\u2013compulsive disorder patients responding to fluvoxamine. Psychiatry Res Neuroimaging 138(2):89\u201397","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"12","key":"1320_CR26","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/da.22380","volume":"32","author":"MQ Hoexter","year":"2015","unstructured":"Hoexter MQ, Diniz JB, Lopes AC, Batistuzzo MC, Shavitt RG, Dougherty DD et al (2015) Orbitofrontal thickness as a measure for treatment response prediction in obsessive\u2013compulsive disorder. Depress Anxiety 32(12):900\u2013908","journal-title":"Depress Anxiety"},{"issue":"04","key":"1320_CR27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1017\/S0033291713001128","volume":"44","author":"M Fullana","year":"2014","unstructured":"Fullana M, Cardoner N, Alonso P, Subir\u00e0 M, L\u00f3pez-Sol\u00e0 C, Pujol J et al (2014) Brain regions related to fear extinction in obsessive\u2013compulsive disorder and its relation to exposure therapy outcome: a morphometric study. Psychol Med 44(04):845\u2013856","journal-title":"Psychol Med"},{"issue":"3","key":"1320_CR28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1176\/appi.ajp.160.3.522","volume":"160","author":"S Saxena","year":"2003","unstructured":"Saxena S, Brody AL, Ho ML, Zohrabi N, Maidment KM, Baxter LR Jr (2003) Differential brain metabolic predictors of response to paroxetine in obsessive\u2013compulsive disorder versus major depression. Am J Psychiatry 160(3):522\u2013532","journal-title":"Am J Psychiatry"},{"issue":"5","key":"1320_CR29","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0893-133X(02)00351-2","volume":"27","author":"SL Rauch","year":"2002","unstructured":"Rauch SL, Shin LM, Dougherty DD, Alpert NM, Fischman AJ, Jenike MA (2002) Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study. Neuropsychopharmacology 27(5):782\u2013791","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"1320_CR30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jpsychires.2009.08.007","volume":"44","author":"H Sanematsu","year":"2010","unstructured":"Sanematsu H, Nakao T, Yoshiura T, Nabeyama M, Togao O, Tomita M et al (2010) Predictors of treatment response to fluvoxamine in obsessive\u2013compulsive disorder: an fMRI study. J Psychiatr Res 44(4):193\u2013200","journal-title":"J Psychiatr Res"},{"issue":"1","key":"1320_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0925-4927(98)00041-9","volume":"84","author":"AL Brody","year":"1998","unstructured":"Brody AL, Saxena S, Schwartz JM, Stoessel PW, Maidment K, Phelps ME et al (1998) FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder. Psychiatry Res Neuroimaging 84(1):1\u20136","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"7","key":"1320_CR32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.euroneuro.2012.06.014","volume":"23","author":"MQ Hoexter","year":"2013","unstructured":"Hoexter MQ, Dougherty DD, Shavitt RG, D\u2019Alcante CC, Duran FL, Lopes AC et al (2013) Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive\u2013compulsive disorder. Eur Neuropsychopharmacol 23(7):569\u2013580","journal-title":"Eur Neuropsychopharmacol"},{"issue":"4","key":"1320_CR33","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jpsychires.2012.11.010","volume":"47","author":"J O\u2019Neill","year":"2013","unstructured":"O\u2019Neill J, Gorbis E, Feusner JD, Yip JC, Chang S, Maidment KM et al (2013) Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive\u2013compulsive disorder. J Psychiatr Res 47(4):494\u2013504","journal-title":"J Psychiatr Res"},{"issue":"7","key":"1320_CR34","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00406-012-0304-0","volume":"262","author":"B Zurowski","year":"2012","unstructured":"Zurowski B, Kordon A, Weber-Fahr W, Voderholzer U, Kuelz AK, Freyer T et al (2012) Relevance of orbitofrontal neurochemistry for the outcome of cognitive-behavioural therapy in patients with obsessive\u2013compulsive disorder. Eur Arch Psychiatry Clin Neurosci 262(7):617\u2013624","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"3","key":"1320_CR35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1176\/appi.ajp.2013.13040574","volume":"171","author":"SJ Wit De","year":"2014","unstructured":"De Wit SJ, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Mench\u00f3n JM et al (2014) Multicenter voxel-based morphometry mega-analysis of structural brain scans in obsessive\u2013compulsive disorder. Am J Psychiatry 171(3):340\u2013349","journal-title":"Am J Psychiatry"},{"issue":"12","key":"1320_CR36","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1038\/npp.2017.77","volume":"42","author":"J O\u2019Neill","year":"2017","unstructured":"O\u2019Neill J, Piacentini J, Chang S, Ly R, Lai TM, Armstrong CC et al (2017) Glutamate in pediatric obsessive\u2013compulsive disorder and response to cognitive-behavioral therapy: randomized clinical trial. Neuropsychopharmacology 42(12):2414","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"1320_CR37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3349\/ymj.2004.45.1.90","volume":"45","author":"RS Diler","year":"2004","unstructured":"Diler RS, Kibar M, Avci A (2004) Pharmacotherapy and regional cerebral blood flow in children with obsessive compulsive disorder. Yonsei Med J 45(1):90\u201399","journal-title":"Yonsei Med J"},{"key":"1320_CR38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.janxdis.2018.07.002","volume":"58","author":"D Fatori","year":"2018","unstructured":"Fatori D, de Bragan\u00e7a Pereira CA, Asbahr FR, Requena G, Alvarenga PG, de Mathis MA et al (2018) Adaptive treatment strategies for children and adolescents with obsessive\u2013compulsive disorder: a sequential multiple assignment randomized trial. J Anxiety Disord 58:42\u201350","journal-title":"J Anxiety Disord"},{"issue":"10","key":"1320_CR39","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jaac.2015.06.020","volume":"54","author":"MC Batistuzzo","year":"2015","unstructured":"Batistuzzo MC, Balardin JB, Martin MdGM, Hoexter MQ, Bernardes ET, Borcato S et al (2015) Reduced prefrontal activation in pediatric patients with obsessive\u2013compulsive disorder during verbal episodic memory encoding. J Am Acad Child Adolesc Psychiatry 54(10):849\u2013858","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"7","key":"1320_CR40","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/00004583-199707000-00021","volume":"36","author":"J Kaufman","year":"1997","unstructured":"Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36(7):980\u2013988","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"11","key":"1320_CR41","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","volume":"46","author":"WK Goodman","year":"1989","unstructured":"Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL et al (1989) The Yale-Brown obsessive compulsive scale: I. development, use, and reliability. Arch Gen Psychiatry 46(11):1006\u20131011","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"1320_CR42","first-page":"979","volume":"21","author":"E Poznanski","year":"1985","unstructured":"Poznanski E, Freeman L, Mokros H (1985) Children\u2019s Depression Rating Scale-Revisited (1984). Psychopharmacol Bull 21(4):979\u2013989","journal-title":"Psychopharmacol Bull"},{"issue":"4","key":"1320_CR43","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00004583-199704000-00018","volume":"36","author":"B Birmaher","year":"1997","unstructured":"Birmaher B, Khetarpal S, Brent D, Cully M, Balach L, Kaufman J et al (1997) The Screen for Child Anxiety Related Emotional Disorders (SCARED): scale construction and psychometric characteristics. J Am Acad Child Adolesc Psychiatry 36(4):545\u2013553","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"6","key":"1320_CR44","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/00004583-199706000-00023","volume":"36","author":"L Scahill","year":"1997","unstructured":"Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK et al (1997) Children\u2019s Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 36(6):844\u2013852","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"3","key":"1320_CR45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1590\/S1516-44462008000300003","volume":"30","author":"EC Miguel","year":"2008","unstructured":"Miguel EC, Ferr\u00e3o YA, Ros\u00e1rio MCd, Mathis MAd, Torres AR, Fontenelle LF et al (2008) The Brazilian Research Consortium on Obsessive\u2013compulsive Spectrum Disorders: recruitment, assessment instruments, methods for the development of multicenter collaborative studies and preliminary results. Rev Bras Psiquiatr 30(3):185\u2013196","journal-title":"Rev Bras Psiquiatr"},{"issue":"3","key":"1320_CR46","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"RS Desikan","year":"2006","unstructured":"Desikan RS, S\u00e9gonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D et al (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31(3):968\u2013980","journal-title":"Neuroimage"},{"issue":"3","key":"1320_CR47","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C et al (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33(3):341\u2013355","journal-title":"Neuron"},{"issue":"6","key":"1320_CR48","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1590\/S1807-59322009000600005","volume":"64","author":"V Fossaluza","year":"2009","unstructured":"Fossaluza V, Diniz JB, Pereira BdB, Miguel EC, Pereira CAB (2009) Sequential allocation to balance prognostic factors in a psychiatric clinical trial. Clinics (Sao Paulo) 64(6):511\u2013518","journal-title":"Clinics (Sao Paulo)"},{"issue":"1","key":"1320_CR49","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/wps.20299","volume":"15","author":"D Mataix-Cols","year":"2016","unstructured":"Mataix-Cols D, de la Cruz LF, Nordsletten AE, Lenhard F, Isomura K, Simpson HB (2016) Towards an international expert consensus for defining treatment response, remission, recovery and relapse in obsessive\u2013compulsive disorder. World Psychiatry 15(1):80\u201381","journal-title":"World Psychiatry"},{"key":"1320_CR50","volume-title":"Exploratory data analysis","author":"JW Tukey","year":"1977","unstructured":"Tukey JW (1977) Exploratory data analysis, vol 2. Addison-Wesley, Boston"},{"issue":"3","key":"1320_CR51","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1176\/appi.ajp.2014.14040525","volume":"172","author":"CM Gillan","year":"2015","unstructured":"Gillan CM, Apergis-Schoute AM, Morein-Zamir S, Urcelay GP, Sule A, Fineberg NA et al (2015) Functional neuroimaging of avoidance habits in obsessive\u2013compulsive disorder. Am J Psychiatry 172(3):284\u2013293","journal-title":"Am J Psychiatry"},{"issue":"6","key":"1320_CR52","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.neubiorev.2009.01.003","volume":"33","author":"C Huyser","year":"2009","unstructured":"Huyser C, Veltman DJ, de Haan E, Boer F (2009) Paediatric obsessive\u2013compulsive disorder, a neurodevelopmental disorder?: evidence from neuroimaging. Neurosci Biobehav Rev 33(6):818\u2013830","journal-title":"Neurosci Biobehav Rev"},{"issue":"9","key":"1320_CR53","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jaac.2010.05.006","volume":"49","author":"JC Britton","year":"2010","unstructured":"Britton JC, Rauch SL, Rosso IM, Killgore WD, Price LM, Ragan J et al (2010) Cognitive inflexibility and frontal-cortical activation in pediatric obsessive\u2013compulsive disorder. J Am Acad Child Adolesc Psychiatry 49(9):944\u2013953","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"1","key":"1320_CR54","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biopsych.2008.06.019","volume":"65","author":"J-Y Rotge","year":"2009","unstructured":"Rotge J-Y, Guehl D, Dilharreguy B, Tignol J, Bioulac B, Allard M et al (2009) Meta-analysis of brain volume changes in obsessive\u2013compulsive disorder. Biol Psychiatry 65(1):75\u201383","journal-title":"Biol Psychiatry"},{"issue":"5","key":"1320_CR55","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1192\/bjp.bp.108.055046","volume":"195","author":"J Radua","year":"2009","unstructured":"Radua J, Mataix-Cols D (2009) Voxel-wise meta-analysis of grey matter changes in obsessive\u2013compulsive disorder. Br J Psychiatry 195(5):393\u2013402","journal-title":"Br J Psychiatry"},{"issue":"10","key":"1320_CR56","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/brain\/awq229","volume":"133","author":"A Braber den","year":"2010","unstructured":"den Braber A, van\u2019t Ent D, Cath DC, Wagner J, Boomsma DI, de Geus EJ (2010) Brain activation during cognitive planning in twins discordant or concordant for obsessive\u2013compulsive symptoms. Brain 133(10):3123\u20133140","journal-title":"Brain"},{"issue":"4","key":"1320_CR57","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/brain\/awn267","volume":"132","author":"OA Heuvel van den","year":"2009","unstructured":"van den Heuvel OA, Remijnse PL, Mataix-Cols D, Vrenken H, Groenewegen HJ, Uylings HB et al (2009) The major symptom dimensions of obsessive\u2013compulsive disorder are mediated by partially distinct neural systems. Brain 132(4):853\u2013868","journal-title":"Brain"},{"issue":"1","key":"1320_CR58","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1176\/appi.ajp.2014.13101306","volume":"172","author":"D Yu","year":"2014","unstructured":"Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER et al (2014) Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette\u2019s syndrome and OCD. Am J Psychiatry 172(1):82\u201393","journal-title":"Am J Psychiatry"},{"issue":"4","key":"1320_CR59","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/archpsyc.60.4.415","volume":"60","author":"BS Peterson","year":"2003","unstructured":"Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R et al (2003) Basal ganglia volumes in patients with Gilles de la Tourette syndrome. Arch Gen Psychiatry 60(4):415\u2013424","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"1320_CR60","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/mp.2014.3","volume":"20","author":"P Shaw","year":"2015","unstructured":"Shaw P, Sharp W, Sudre G, Wharton A, Greenstein D, Raznahan A et al (2015) Subcortical and cortical morphological anomalies as an endophenotype in obsessive\u2013compulsive disorder. Mol Psychiatry 20(2):224\u2013231","journal-title":"Mol Psychiatry"},{"issue":"7","key":"1320_CR61","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/00004583-199607000-00017","volume":"35","author":"JN Giedd","year":"1996","unstructured":"Giedd JN, Rapoport JL, Leonard HL, Richter D, Swedo SE (1996) Case study: acute basal ganglia enlargement and obsessive\u2013compulsive symptoms in an adolescent boy. J Am Acad Child Adolesc Psychiatry 35(7):913\u2013915","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"1320_CR62","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0887-8994(03)00413-2","volume":"30","author":"P Pavone","year":"2004","unstructured":"Pavone P, Bianchini R, Parano E, Incorpora G, Rizzo R, Mazzone L et al (2004) Anti-brain antibodies in PANDAS versus uncomplicated streptococcal infection. Pediatr Neurol 30(2):107\u2013110","journal-title":"Pediatr Neurol"},{"issue":"2","key":"1320_CR63","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.eurpsy.2014.11.008","volume":"30","author":"P Vidal-Ribas","year":"2015","unstructured":"Vidal-Ribas P, Stringaris A, R\u00fcck C, Serlachius E, Lichtenstein P, Mataix-Cols D (2015) Are stressful life events causally related to the severity of obsessive\u2013compulsive symptoms? A monozygotic twin difference study. Eur Psychiatry 30(2):309\u2013316","journal-title":"Eur Psychiatry"},{"issue":"4","key":"1320_CR64","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/JCP.0b013e31825cce05","volume":"32","author":"F Benedetti","year":"2012","unstructured":"Benedetti F, Poletti S, Radaelli D, Pozzi E, Giacosa C, Ruffini C et al (2012) Caudate gray matter volume in obsessive\u2013compulsive disorder is influenced by adverse childhood experiences and ongoing drug treatment. J Clin Psychopharmacol 32(4):544\u2013547","journal-title":"J Clin Psychopharmacol"},{"issue":"1","key":"1320_CR65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145701002681","volume":"5","author":"ES Hansen","year":"2002","unstructured":"Hansen ES, Hasselbalch S, Law I, Bolwig TG (2002) The caudate nucleus in obsessive\u2013compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study. Int J Neuropsychopharmacol 5(1):1\u201310","journal-title":"Int J Neuropsychopharmacol"},{"issue":"2","key":"1320_CR66","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0925-4927(03)00069-6","volume":"124","author":"E Nakatani","year":"2003","unstructured":"Nakatani E, Nakgawa A, Ohara Y, Goto S, Uozumi N, Iwakiri M et al (2003) Effects of behavior therapy on regional cerebral blood flow in obsessive\u2013compulsive disorder. Psychiatry Res Neuroimaging 124(2):113\u2013120","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"6","key":"1320_CR67","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/00004583-199806000-00017","volume":"37","author":"GJ Moore","year":"1998","unstructured":"Moore GJ, MacMaster FP, Stewart C, Rosenberg DR (1998) Case Study: caudate glutamatergic changes with paroxetine therapy for pediatric obsessive\u2013compulsive disorder. J Am Acad Child Adolesc Psychiatry 37(6):663\u2013667","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"8","key":"1320_CR68","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/00004583-200108000-00011","volume":"40","author":"J Bolton","year":"2001","unstructured":"Bolton J, Moore GJ, MacMillan S, Stewart CM, Rosenberg DR (2001) Case study: caudate glutamatergic changes with paroxetine persist after medication discontinuation in pediatric OCD. J Am Acad Child Adolesc Psychiatry 40(8):903\u2013906","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"6","key":"1320_CR69","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.biopsych.2005.04.021","volume":"58","author":"AA Valente","year":"2005","unstructured":"Valente AA, Miguel EC, Castro CC, Amaro E, Duran FL, Buchpiguel CA et al (2005) Regional gray matter abnormalities in obsessive\u2013compulsive disorder: a voxel-based morphometry study. Biol Psychiatry 58(6):479\u2013487","journal-title":"Biol Psychiatry"},{"issue":"3","key":"1320_CR70","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1001\/archpsyc.59.3.250","volume":"59","author":"S Saxena","year":"2002","unstructured":"Saxena S, Brody AL, Ho ML, Alborzian S, Maidment KM, Zohrabi N et al (2002) Differential cerebral metabolic changes with paroxetine treatment of obsessive\u2013compulsive disorder vs major depression. Arch Gen Psychiatry 59(3):250\u2013261","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"1320_CR71","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/nimg.2002.1174","volume":"17","author":"ED Burgund","year":"2002","unstructured":"Burgund ED, Kang HC, Kelly JE, Buckner RL, Snyder AZ, Petersen SE et al (2002) The feasibility of a common stereotactic space for children and adults in fMRI studies of development. Neuroimage 17(1):184\u2013200","journal-title":"Neuroimage"},{"issue":"6","key":"1320_CR72","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.neubiorev.2006.06.001","volume":"30","author":"RK Lenroot","year":"2006","unstructured":"Lenroot RK, Giedd JN (2006) Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neurosci Biobehav Rev 30(6):718\u2013729","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"1320_CR73","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1017\/S0954579408000606","volume":"20","author":"TV Maia","year":"2008","unstructured":"Maia TV, Cooney RE, Peterson BS (2008) The neural bases of obsessive\u2013compulsive disorder in children and adults. Dev Psychopathol 20(4):1251\u20131283","journal-title":"Dev Psychopathol"}],"container-title":["European Child & Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-019-01320-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00787-019-01320-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-019-01320-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T23:35:06Z","timestamp":1586388906000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00787-019-01320-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":73,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1320"],"URL":"https:\/\/doi.org\/10.1007\/s00787-019-01320-w","relation":{},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"value":"1018-8827","type":"print"},{"value":"1435-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,10]]},"assertion":[{"value":"10 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors report no potential conflicts of interest. Dr. Vattimo confirms he had full access to all the data in the study, and takes responsibility for the integrity of the data and the accuracy of the data analysis.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}