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CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) is a European Union (EU) funded training network aimed at investigating the causes of individual differences in common childhood and adolescent psychopathology, especially depression, anxiety, and attention deficit hyperactivity disorder. CAPICE brings together eight birth and childhood cohorts as well as other cohorts from the EArly Genetics and Life course Epidemiology (EAGLE) consortium, including twin cohorts, with unique longitudinal data on environmental exposures and mental health problems, and genetic data on participants. Here we describe the objectives, summarize the methodological approaches and initial results, and present the dissemination strategy of the CAPICE network. Besides identifying genetic and epigenetic variants associated with these phenotypes, analyses have been performed to shed light on the role of genetic factors and the interplay with the environment in influencing the persistence of symptoms across the lifespan. Data harmonization and building an advanced data catalogue are also part of the work plan. Findings will be disseminated to non-academic parties, in close collaboration with the Global Alliance of Mental Illness Advocacy Networks-Europe (GAMIAN-Europe).<\/jats:p>","DOI":"10.1007\/s00787-020-01713-2","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T19:16:13Z","timestamp":1611170173000},"page":"829-839","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Overview of CAPICE\u2014Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe\u2014an EU Marie Sk\u0142odowska-Curie International Training Network"],"prefix":"10.1007","volume":"31","author":[{"given":"Hema Sekhar 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A comprehensive list of grants funding is available on the ALSPAC website. ().GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Avon Longitudinal Study of Parents and Children (ALSPAC)"}},{"value":"CATSS was supported by the Swedish Council for Working Life, funds under the ALF agreement, the S\u00f6derstr\u00f6m K\u00f6nigska Foundation and the Swedish Research Council (Medicine, Humanities and Social Science, and SIMSAM).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"The Child and Adolescent Twin Study in Sweden study (CATSS)"}},{"value":"The generation and management of GWAS genotype data for the Generation R Study was done at the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, the Netherlands. We thank Pascal Arp, Mila Jhamai, Marijn Verkerk, Lizbeth Herrera and Marjolein Peters for their help in creating, managing and QC of the GWAS database. The general design of Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, the Netherlands Organization for Health Research and Development (ZonMw), the Netherlands Organisation for Scientific Research (NWO), the Ministry of Health, Welfare and Sport and the Ministry of Youth and Families. This project has received funding from the European Union\u2019s Horizon 2020 research and innovation programme under grant agreements No 633595 (DynaHEALTH) and 733206 (LIFECYCLE).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Generation R study"}},{"value":"MOBA are supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH\/NIEHS (contract noN01-ES-75558), NIH\/NINDS (Grant No.1 UO1 NS 047537-01 and Grant No.2 UO1 NS 047537-06A1). Genotyping and data access was funded by the the Research Council of Norway grant agreements 229624 \u201cHARVEST\u201d, 223273 \u201cNORMENT\u201d, and 262177 \u201cIntergenerational Transmission of Internalizing and Externalizing Psychopathological Spectra\u201d.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"The Norwegian Mother and Child Cohort Study (MOBA)"}},{"value":"Data collection in the NTR was supported by NWO: Twin-family database for behavior genetics and genomics studies (480-04-004); \u201cSpinozapremie\u201d (NWO\/SPI 56-464-14192; \u201cGenetic and Family influences on Adolescent psychopathology and Wellness\u201d (NWO 463-06-001); \u201cA twin-sib study of adolescent wellness\u201d (NWO-VENI 451-04-034); ZonMW \u201cGenetic influences on stability and change in psychopathology from childhood to young adulthood\u201d (912-10-020); \u201cNetherlands Twin Registry Repository\u201d (480-15-001\/674); \u201cBiobanking and Biomolecular Resources Research Infrastructure\u201d (BBMRI-NL (184.021.007). We acknowledge FP7-HEALTH-F4-2007, grant agreement no. 201413 (ENGAGE), and the FP7\/2007\u20132013 funded ACTION (grant agreement no. 602768) and the European Research Council (ERC-230374). Part of the genotyping was funded by the Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health, Rutgers University Cell and DNA Repository (NIMH U24 MH068457-06), the Avera Institute, Sioux Falls, South Dakota (USA) and the National Institutes of Health (NIH R01 HD042157-01A1, MH081802, Grand Opportunity grants 1RC2 MH089951 and 1RC2 MH089995).","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"The Netherlands Twin Register\u00a0(NTR)"}},{"value":"NFBCC1986 study has received financial support from EU QLG1-CT-2000-01643 (EUROBLCS) Grant no. E51560, NorFA Grant no. 731, 20056, 30167, USA\/NIHH 2000 G DF682 Grant no. 50945, NIHM\/MH063706, H2020-633595 DynaHEALTH action and Academy of Finland EGEA-project (285547).","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"The Northern Finland Birth Cohorts 1986 (NFBC1986)"}},{"value":"Supported by The Swedish Council for Working Life and the Swedish Research Council.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Twin study of Child and Adolescent Development (TCHAD)"}},{"value":"TEDS is supported by a program grant to RP from the UK Medical Research Council (MR\/M021475\/1), with additional support from the US National Institutes of Health (AG046938). The research leading to these results has also received funding from the European Research Council under the European Union\u2019s Seventh Framework Programme (FP7\/2007\u20132013)\/grant agreement no. 602768. RP is supported by a Medical Research Council Professorship award (G19\/2).","order":10,"name":"Ethics","group":{"name":"EthicsHeading","label":"Twins Early Development Study (TEDS)"}}]}}