{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:07:30Z","timestamp":1761102450845,"version":"3.37.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100006221","name":"United States - Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2017369"],"award-info":[{"award-number":["2017369"]}],"id":[{"id":"10.13039\/100006221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"SNSF","doi-asserted-by":"crossref","award":["324730_144260","PZ00P1_174206"],"award-info":[{"award-number":["324730_144260","PZ00P1_174206"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCCR","award":["51NF40-185897"],"award-info":[{"award-number":["51NF40-185897"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s00787-021-01780-z","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T10:10:03Z","timestamp":1618827003000},"page":"1367-1375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Stimulant treatment effectiveness, safety and risk for psychosis in individuals with 22q11.2 deletion syndrome"],"prefix":"10.1007","volume":"31","author":[{"given":"Dana","family":"Basel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela","family":"Mosheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Maeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maude","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shachar","family":"Shani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnie","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Eliez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doron","family":"Gothelf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"1780_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.71","author":"DM McDonald-McGinn","year":"2015","unstructured":"McDonald-McGinn DM, Sullivan KE, Marino B et al (2015) 22Q11.2 Deletion Syndrome. Nat Rev Dis Prim. https:\/\/doi.org\/10.1038\/nrdp.2015.71","journal-title":"Nat Rev Dis Prim"},{"key":"1780_CR2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070864","author":"M Schneider","year":"2014","unstructured":"Schneider M, Debban\u00e9 M, Bassett AS et al (2014) Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the international consortium on brain and behavior in 22q11.2 deletion syndrome. Am J Psychiatry. https:\/\/doi.org\/10.1176\/appi.ajp.2013.13070864","journal-title":"Am J Psychiatry"},{"key":"1780_CR3","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.942","author":"G Polanczyk","year":"2007","unstructured":"Polanczyk G, De Lima MS, Horta BL et al (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. https:\/\/doi.org\/10.1176\/ajp.2007.164.6.942","journal-title":"Am J Psychiatry"},{"key":"1780_CR4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3482","author":"R Thomas","year":"2015","unstructured":"Thomas R, Sanders S, Doust J et al (2015) Prevalence of attention-deficit\/hyperactivity disorder: a systematic review and meta-analysis. Pediatrics. https:\/\/doi.org\/10.1542\/peds.2014-3482","journal-title":"Pediatrics"},{"key":"1780_CR5","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1097\/CHI.0b013e3181b76683","volume":"48","author":"T Green","year":"2009","unstructured":"Green T, Gothelf D, Glaser B et al (2009) Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 Deletion) syndrome. J Am Acad Child Adolesc Psychiatry 48:1060\u20131068. https:\/\/doi.org\/10.1097\/CHI.0b013e3181b76683","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1780_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-019-01326-4","author":"M Mosheva","year":"2019","unstructured":"Mosheva M, Korotkin L, Gur RE et al (2019) Effectiveness and side effects of psychopharmacotherapy in individuals with 22q112 deletion syndrome with comorbid psychiatric disorders: a systematic review. Eur Child Adolesc Psychiatry. https:\/\/doi.org\/10.1007\/s00787-019-01326-4","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"1780_CR7","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1542\/peds.2008-0185","volume":"123","author":"AD Mosholder","year":"2009","unstructured":"Mosholder AD, Gelperin K, Hammad TA et al (2009) Hallucinations and other psychotic symptoms associated with the use of attention-deficit\/hyperactivity disorder drugs in children. Pediatrics 123:611\u2013616. https:\/\/doi.org\/10.1542\/peds.2008-0185","journal-title":"Pediatrics"},{"key":"1780_CR8","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1056\/NEJMoa1813751","volume":"380","author":"LV Moran","year":"2019","unstructured":"Moran LV, Ongur D, Hsu J et al (2019) Psychosis with methylphenidate or amphetamine in patients with ADHD. N Engl J Med 380:1128\u20131138. https:\/\/doi.org\/10.1056\/NEJMoa1813751","journal-title":"N Engl J Med"},{"key":"1780_CR9","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1089\/cap.2011.0042","volume":"21","author":"T Green","year":"2011","unstructured":"Green T, Weinberger R, Diamond A et al (2011) The effect of methylphenidate on prefrontal cognitive functioning, inattention, and hyperactivity in velocardiofacial syndrome. J Child Adolesc Psychopharmacol 21:589\u2013595. https:\/\/doi.org\/10.1089\/cap.2011.0042","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"1780_CR10","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.4088\/JCP.v64n1004","volume":"64","author":"D Gothelf","year":"2003","unstructured":"Gothelf D, Gruber R, Presburger G et al (2003) Methylphenidate treatment for attention-deficit\/hyperactivity disorder in children and adolescents with velocardiofacial syndrome: an open label study. J Clin Psychiatry 64:1163\u20131169","journal-title":"J Clin Psychiatry"},{"key":"1780_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.161","author":"RE Gur","year":"2017","unstructured":"Gur RE, Bassett AS, McDonald-Mcginn DM et al (2017) A neurogenetic model for the study of schizophrenia spectrum disorders: the International 22q11.2 Deletion Syndrome Brain Behavior Consortium. Mol Psychiatry. https:\/\/doi.org\/10.1038\/mp.2017.161","journal-title":"Mol Psychiatry"},{"key":"1780_CR12","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1097\/00004583-199707000-00021","volume":"36","author":"J Kaufman","year":"1997","unstructured":"Kaufman J, Birmaher B, Brent D et al (1997) Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980\u2013988. https:\/\/doi.org\/10.1097\/00004583-199707000-00021","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1780_CR13","doi-asserted-by":"crossref","unstructured":"First M, Spitzer R, Gibbon M, Williams J (1996) Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID-I)","DOI":"10.1037\/t07827-000"},{"key":"1780_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/00004583-200001000-00017","volume":"39","author":"W Reich","year":"2000","unstructured":"Reich W (2000) Diagnostic interview for children and adolescents (DICA). J Am Acad Child Adolesc Psychiatry 39:59\u201366. https:\/\/doi.org\/10.1097\/00004583-200001000-00017","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1780_CR15","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1111\/jcpp.12684","volume":"58","author":"JM Swanson","year":"2017","unstructured":"Swanson JM, Arnold LE, Molina BSG et al (2017) Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit\/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression. J Child Psychol Psychiatry Allied Discip 58:663\u2013678. https:\/\/doi.org\/10.1111\/jcpp.12684","journal-title":"J Child Psychol Psychiatry Allied Discip"},{"key":"1780_CR16","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e318054e724","author":"S Pliszka","year":"2007","unstructured":"Pliszka S, Bernet W, Bukstein O et al (2007) Practice parameter for the assessment and treatment of children and adolescents with attention-deficit\/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. https:\/\/doi.org\/10.1097\/chi.0b013e318054e724","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1780_CR17","doi-asserted-by":"crossref","unstructured":"Guy W (1976) CGI Clinical Global Impressions. In: ECDEU Assess. Man. pp 217\u2013222","DOI":"10.1037\/t48216-000"},{"key":"1780_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/ajmg.b.31247","volume":"159B","author":"T Green","year":"2012","unstructured":"Green T, Avda S, Dotan I et al (2012) Phenotypic psychiatric characterization of children with Williams syndrome and response of those with ADHD to methylphenidate treatment. Am J Med Genet Part B Neuropsychiatr Genet 159B:13\u201320. https:\/\/doi.org\/10.1002\/ajmg.b.31247","journal-title":"Am J Med Genet Part B Neuropsychiatr Genet"},{"key":"1780_CR19","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1089\/cap.2015.0229","volume":"26","author":"M Mosheva","year":"2016","unstructured":"Mosheva M, Mekori E, Kantor S et al (2016) Do antidepressants induce psychosis in children and adolescents? a naturalistic study in ambulatory pediatric population. J Child Adolesc Psychopharmacol 26:478\u2013484. https:\/\/doi.org\/10.1089\/cap.2015.0229","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"1780_CR20","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199606000-00007","author":"HM Lachman","year":"1996","unstructured":"Lachman HM, Papolos DF, Saito T et al (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. https:\/\/doi.org\/10.1097\/00008571-199606000-00007","journal-title":"Pharmacogenetics"},{"key":"1780_CR21","doi-asserted-by":"publisher","DOI":"10.1207\/s15328031us0104_02","author":"H Goldstein","year":"2002","unstructured":"Goldstein H, Browne W, Rasbash J (2002) Partitioning variation in multilevel models. Underst Stat. https:\/\/doi.org\/10.1207\/s15328031us0104_02","journal-title":"Underst Stat"},{"key":"1780_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/s2215-0366(19)30189-0","author":"C Hollis","year":"2019","unstructured":"Hollis C, Chen Q, Chang Z et al (2019) Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study. Lancet Psychiatry. https:\/\/doi.org\/10.1016\/s2215-0366(19)30189-0","journal-title":"Lancet Psychiatry"},{"key":"1780_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.216","author":"KKC Man","year":"2016","unstructured":"Man KKC, Coghill D, Chan EW et al (2016) Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system. Transl Psychiatry. https:\/\/doi.org\/10.1038\/tp.2016.216","journal-title":"Transl Psychiatry"},{"key":"1780_CR24","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.7.1149","author":"RG Ross","year":"2006","unstructured":"Ross RG (2006) Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder. Am J Psychiatry. https:\/\/doi.org\/10.1176\/ajp.2006.163.7.1149","journal-title":"Am J Psychiatry"},{"key":"1780_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2013.06.004","author":"S Dalsgaard","year":"2014","unstructured":"Dalsgaard S, Mortensen PB, Frydenberg M et al (2014) Association between attention-deficit hyperactivity disorder in childhood and schizophrenia later in adulthood. Eur Psychiatry. https:\/\/doi.org\/10.1016\/j.eurpsy.2013.06.004","journal-title":"Eur Psychiatry"},{"key":"1780_CR26","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx113","author":"M Niarchou","year":"2017","unstructured":"Niarchou M, Calkins ME, Moore TM et al (2017) Attention deficit hyperactivity disorder symptoms and psychosis in 22q11.2 deletion syndrome. Schizophr Bull. https:\/\/doi.org\/10.1093\/schbul\/sbx113","journal-title":"Schizophr Bull"},{"key":"1780_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.07.044","author":"M Niarchou","year":"2019","unstructured":"Niarchou M, Chawner SJRA, Fiksinski A et al (2019) Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome. Schizophr Res. https:\/\/doi.org\/10.1016\/j.schres.2018.07.044","journal-title":"Schizophr Res"},{"key":"1780_CR28","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145707008085","author":"E Michaelovsky","year":"2008","unstructured":"Michaelovsky E, Gothelf D, Korostishevsky M et al (2008) Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS. Int J Neuropsychopharmacol. https:\/\/doi.org\/10.1017\/S1461145707008085","journal-title":"Int J Neuropsychopharmacol"},{"key":"1780_CR29","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200405000-00009","author":"A Charach","year":"2004","unstructured":"Charach A, Ickowicz A, Schachar R (2004) Stimulant treatment over five years: adherence, effectiveness, and adverse effects. J Am Acad Child Adolesc Psychiatry. https:\/\/doi.org\/10.1097\/00004583-200405000-00009","journal-title":"J Am Acad Child Adolesc Psychiatry"}],"container-title":["European Child & Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-021-01780-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00787-021-01780-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-021-01780-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:10:31Z","timestamp":1661332231000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00787-021-01780-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["1780"],"URL":"https:\/\/doi.org\/10.1007\/s00787-021-01780-z","relation":{},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"type":"print","value":"1018-8827"},{"type":"electronic","value":"1435-165X"}],"subject":[],"published":{"date-parts":[[2021,4,19]]},"assertion":[{"value":"2 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}